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Items: 50


Cannabinoid Interactions with Proteins: Insights from Structural Studies.

Bukiya AN, Dopico AM.

Adv Exp Med Biol. 2019;1162:39-50. doi: 10.1007/978-3-030-21737-2_3. Review.


Physiology of the Endocannabinoid System During Development.

Bukiya AN.

Adv Exp Med Biol. 2019;1162:13-37. doi: 10.1007/978-3-030-21737-2_2. Review.


Molecular Determinants of Cholesterol Binding to Soluble and Transmembrane Protein Domains.

Ounjian J, Bukiya AN, Rosenhouse-Dantsker A.

Adv Exp Med Biol. 2019;1135:47-66. doi: 10.1007/978-3-030-14265-0_3. Review.


Fetal Cerebral Artery Mitochondrion as Target of Prenatal Alcohol Exposure.

Bukiya AN.

Int J Environ Res Public Health. 2019 May 7;16(9). pii: E1586. doi: 10.3390/ijerph16091586. Review.


Gestational Age-Dependent Interplay between Endocannabinoid Receptors and Alcohol in Fetal Cerebral Arteries.

Simakova M, Tobiasz A, Sullivan RD, Bisen S, Duncan J, Sullivan JP, Davison S, Tate DL, Barnett S, Mari G, Dopico AM, Bukiya AN.

J Drug Alcohol Res. 2019;8. pii: 236068. doi: 10.4303/jdar/236068.


Prenatal Alcohol Exposure, Anesthesia, and Fetal Loss in Baboon Model of Pregnancy.

North K, Tobiasz A, Sullivan RD, Bursac Z, Duncan J, Sullivan JP, Davison S, Tate DL, Barnett S, Mari G, Bukiya AN.

J Drug Alcohol Res. 2018 Jun;7. pii: 236064.


Regulation of BK Channel Activity by Cholesterol and Its Derivatives.

Bukiya AN, Dopico AM.

Adv Exp Med Biol. 2019;1115:53-75. doi: 10.1007/978-3-030-04278-3_3. Review.


Cholesterol intake and statin use regulate neuronal G protein-gated inwardly rectifying potassium channels.

Bukiya AN, Blank PS, Rosenhouse-Dantsker A.

J Lipid Res. 2019 Jan;60(1):19-29. doi: 10.1194/jlr.M081240. Epub 2018 Nov 12.


Proteomic Analysis of Baboon Cerebral Artery Reveals Potential Pathways of Damage by Prenatal Alcohol Exposure.

Bisen S, Kakhniashvili D, Johnson DL, Bukiya AN.

Mol Cell Proteomics. 2019 Feb;18(2):294-307. doi: 10.1074/mcp.RA118.001047. Epub 2018 Nov 9.


Extra-endothelial TRPV1 channels participate in alcohol and caffeine actions on cerebral artery diameter.

North KC, Chang J, Bukiya AN, Dopico AM.

Alcohol. 2018 Dec;73:45-55. doi: 10.1016/j.alcohol.2018.04.002. Epub 2018 Apr 26.


Large conductance voltage- and calcium-gated potassium channels (BK) in cerebral artery myocytes of perinatal fetal primates share several major characteristics with the adult phenotype.

Bisen S, Simakova MN, Dopico AM, Bukiya AN.

PLoS One. 2018 Sep 13;13(9):e0203199. doi: 10.1371/journal.pone.0203199. eCollection 2018.


Calcium- and voltage-gated BK channels in vascular smooth muscle.

Dopico AM, Bukiya AN, Jaggar JH.

Pflugers Arch. 2018 Sep;470(9):1271-1289. doi: 10.1007/s00424-018-2151-y. Epub 2018 May 11. Review.


Fetal Cerebral Circulation as Target of Maternal Alcohol Consumption.

Bukiya AN, Dopico AM.

Alcohol Clin Exp Res. 2018 Jun;42(6):1006-1018. doi: 10.1111/acer.13755. Epub 2018 May 9. Review.


Voltage-Sensitive Potassium Channels of the BK Type and Their Coding Genes Are Alcohol Targets in Neurons.

Dopico AM, Bukiya AN, Bettinger JC.

Handb Exp Pharmacol. 2018;248:281-309. doi: 10.1007/164_2017_78. Review.


The Effect of Prenatal Alcohol Exposure on Fetal Growth and Cardiovascular Parameters in a Baboon Model of Pregnancy.

Tobiasz AM, Duncan JR, Bursac Z, Sullivan RD, Tate DL, Dopico AM, Bukiya AN, Mari G.

Reprod Sci. 2018 Jul;25(7):1116-1123. doi: 10.1177/1933719117734317. Epub 2017 Oct 5.


Statin therapy exacerbates alcohol-induced constriction of cerebral arteries via modulation of ethanol-induced BK channel inhibition in vascular smooth muscle.

Simakova MN, Bisen S, Dopico AM, Bukiya AN.

Biochem Pharmacol. 2017 Dec 1;145:81-93. doi: 10.1016/j.bcp.2017.08.022. Epub 2017 Sep 1.


Regulation of Ca2+-Sensitive K+ Channels by Cholesterol and Bile Acids via Distinct Channel Subunits and Sites.

Dopico AM, Bukiya AN.

Curr Top Membr. 2017;80:53-93. doi: 10.1016/bs.ctm.2017.07.001. Epub 2017 Aug 23. Review.


Maternal alcohol exposure during mid-pregnancy dilates fetal cerebral arteries via endocannabinoid receptors.

Seleverstov O, Tobiasz A, Jackson JS, Sullivan R, Ma D, Sullivan JP, Davison S, Akkhawattanangkul Y, Tate DL, Costello T, Barnett S, Li W, Mari G, Dopico AM, Bukiya AN.

Alcohol. 2017 Jun;61:51-61. doi: 10.1016/j.alcohol.2017.01.014. Epub 2017 May 18.


Common structural features of cholesterol binding sites in crystallized soluble proteins.

Bukiya AN, Dopico AM.

J Lipid Res. 2017 Jun;58(6):1044-1054. doi: 10.1194/jlr.R073452. Epub 2017 Apr 18. Review.


Synergistic activation of G protein-gated inwardly rectifying potassium channels by cholesterol and PI(4,5)P2.

Bukiya AN, Rosenhouse-Dantsker A.

Biochim Biophys Acta Biomembr. 2017 Jul;1859(7):1233-1241. doi: 10.1016/j.bbamem.2017.03.023. Epub 2017 Apr 1.


Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus.

Bukiya AN, Durdagi S, Noskov S, Rosenhouse-Dantsker A.

J Biol Chem. 2017 Apr 14;292(15):6135-6147. doi: 10.1074/jbc.M116.753350. Epub 2017 Feb 17.


Differential distribution and functional impact of BK channel beta1 subunits across mesenteric, coronary, and different cerebral arteries of the rat.

Kuntamallappanavar G, Bisen S, Bukiya AN, Dopico AM.

Pflugers Arch. 2017 Feb;469(2):263-277. doi: 10.1007/s00424-016-1929-z. Epub 2016 Dec 24.


Distinct mechanisms underlying cholesterol protection against alcohol-induced BK channel inhibition and resulting vasoconstriction.

Bisen S, Seleverstov O, Belani J, Rychnovsky S, Dopico AM, Bukiya AN.

Biochim Biophys Acta. 2016 Nov;1861(11):1756-1766. doi: 10.1016/j.bbalip.2016.08.013. Epub 2016 Aug 24.


Modulation of BK Channels by Ethanol.

Dopico AM, Bukiya AN, Kuntamallappanavar G, Liu J.

Int Rev Neurobiol. 2016;128:239-79. doi: 10.1016/bs.irn.2016.03.019. Epub 2016 May 12. Review.


Age-Dependent Susceptibility to Alcohol-Induced Cerebral Artery Constriction.

Bukiya AN, Seleverstov O, Bisen S, Dopico AM.

J Drug Alcohol Res. 2016;5. pii: 236002. doi: 10.4303/jdar/236002. Epub 2016 Nov 27.


Endothelial Nitric Oxide Mediates Caffeine Antagonism of Alcohol-Induced Cerebral Artery Constriction.

Chang J, Fedinec AL, Kuntamallappanavar G, Leffler CW, Bukiya AN, Dopico AM.

J Pharmacol Exp Ther. 2016 Jan;356(1):106-15. doi: 10.1124/jpet.115.229054. Epub 2015 Nov 10.


Cholesterol increases the open probability of cardiac KACh currents.

Bukiya AN, Osborn CV, Kuntamallappanavar G, Toth PT, Baki L, Kowalsky G, Oh MJ, Dopico AM, Levitan I, Rosenhouse-Dantsker A.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2406-13. doi: 10.1016/j.bbamem.2015.07.007. Epub 2015 Jul 18.


Ethanol modulation of mammalian BK channels in excitable tissues: molecular targets and their possible contribution to alcohol-induced altered behavior.

Dopico AM, Bukiya AN, Martin GE.

Front Physiol. 2014 Dec 2;5:466. doi: 10.3389/fphys.2014.00466. eCollection 2014. Review.


Multi-generational pharmacophore modeling for ligands to the cholane steroid-recognition site in the β₁ modulatory subunit of the BKCa channel.

McMillan JE, Bukiya AN, Terrell CL, Patil SA, Miller DD, Dopico AM, Parrill AL.

J Mol Graph Model. 2014 Nov;54:174-83. doi: 10.1016/j.jmgm.2014.10.008. Epub 2014 Oct 24. Erratum in: J Mol Graph Model. 2015 Feb;55:149.


Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4.

Bukiya AN, McMillan J, Liu J, Shivakumar B, Parrill AL, Dopico AM.

J Biol Chem. 2014 Dec 19;289(51):35314-25. doi: 10.1074/jbc.M114.577825. Epub 2014 Nov 4.


Lipid regulation of BK channel function.

Dopico AM, Bukiya AN.

Front Physiol. 2014 Aug 22;5:312. doi: 10.3389/fphys.2014.00312. eCollection 2014. Review.


An alcohol-sensing site in the calcium- and voltage-gated, large conductance potassium (BK) channel.

Bukiya AN, Kuntamallappanavar G, Edwards J, Singh AK, Shivakumar B, Dopico AM.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9313-8. doi: 10.1073/pnas.1317363111. Epub 2014 Jun 9.


Type 2 ryanodine receptors are highly sensitive to alcohol.

Ye Y, Jian K, Jaggar JH, Bukiya AN, Dopico AM.

FEBS Lett. 2014 May 2;588(9):1659-65. doi: 10.1016/j.febslet.2014.03.005. Epub 2014 Mar 12.


Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel β1-subunit by a novel nonsteroidal agent.

Bukiya AN, McMillan JE, Fedinec AL, Patil SA, Miller DD, Leffler CW, Parrill AL, Dopico AM.

Mol Pharmacol. 2013 May;83(5):1030-44. doi: 10.1124/mol.112.083519. Epub 2013 Mar 1.


Distinct sensitivity of slo1 channel proteins to ethanol.

Liu J, Bukiya AN, Kuntamallappanavar G, Singh AK, Dopico AM.

Mol Pharmacol. 2013 Jan;83(1):235-44. doi: 10.1124/mol.112.081240. Epub 2012 Oct 23.


Calcium- and voltage-gated potassium (BK) channel activators in the 5β-cholanic acid-3α-ol analogue series with modifications in the lateral chain.

Bukiya AN, Patil SA, Li W, Miller DD, Dopico AM.

ChemMedChem. 2012 Oct;7(10):1784-92. doi: 10.1002/cmdc.201200290. Epub 2012 Sep 4.


Large conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol.

Dopico AM, Bukiya AN, Singh AK.

Pharmacol Ther. 2012 Aug;135(2):133-50. doi: 10.1016/j.pharmthera.2012.05.002. Epub 2012 May 11. Review.


Multiple cholesterol recognition/interaction amino acid consensus (CRAC) motifs in cytosolic C tail of Slo1 subunit determine cholesterol sensitivity of Ca2+- and voltage-gated K+ (BK) channels.

Singh AK, McMillan J, Bukiya AN, Burton B, Parrill AL, Dopico AM.

J Biol Chem. 2012 Jun 8;287(24):20509-21. doi: 10.1074/jbc.M112.356261. Epub 2012 Apr 3.


Hypercholesterolemia induces up-regulation of KACh cardiac currents via a mechanism independent of phosphatidylinositol 4,5-bisphosphate and Gβγ.

Deng W, Bukiya AN, Rodríguez-Menchaca AA, Zhang Z, Baumgarten CM, Logothetis DE, Levitan I, Rosenhouse-Dantsker A.

J Biol Chem. 2012 Feb 10;287(7):4925-35. doi: 10.1074/jbc.M111.306134. Epub 2011 Dec 15.


The steroid interaction site in transmembrane domain 2 of the large conductance, voltage- and calcium-gated potassium (BK) channel accessory β1 subunit.

Bukiya AN, Singh AK, Parrill AL, Dopico AM.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20207-12. doi: 10.1073/pnas.1112901108. Epub 2011 Nov 28.


Smooth muscle cholesterol enables BK β1 subunit-mediated channel inhibition and subsequent vasoconstriction evoked by alcohol.

Bukiya AN, Vaithianathan T, Kuntamallappanavar G, Asuncion-Chin M, Dopico AM.

Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2410-23. doi: 10.1161/ATVBAHA.111.233965.


Specificity of cholesterol and analogs to modulate BK channels points to direct sterol-channel protein interactions.

Bukiya AN, Belani JD, Rychnovsky S, Dopico AM.

J Gen Physiol. 2011 Jan;137(1):93-110. doi: 10.1085/jgp.201010519. Epub 2010 Dec 13. Erratum in: J Gen Physiol. 2011 Apr;137(4):391.


Channel beta2-4 subunits fail to substitute for beta1 in sensitizing BK channels to lithocholate.

Bukiya AN, Vaithianathan T, Toro L, Dopico AM.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):995-1000. doi: 10.1016/j.bbrc.2009.10.091. Epub 2009 Oct 21.


The BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constriction.

Bukiya AN, Liu J, Dopico AM.

FEBS Lett. 2009 Sep 3;583(17):2779-84. doi: 10.1016/j.febslet.2009.07.019. Epub 2009 Jul 17.


Sizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels.

Mulholland PJ, Hopf FW, Bukiya AN, Martin GE, Liu J, Dopico AM, Bonci A, Treistman SN, Chandler LJ.

Alcohol Clin Exp Res. 2009 Jul;33(7):1125-35. doi: 10.1111/j.1530-0277.2009.00936.x. Epub 2009 Apr 9. Review.


Structural determinants of monohydroxylated bile acids to activate beta 1 subunit-containing BK channels.

Bukiya AN, McMillan J, Parrill AL, Dopico AM.

J Lipid Res. 2008 Nov;49(11):2441-51. doi: 10.1194/jlr.M800286-JLR200. Epub 2008 Jul 23.


Design and synthesis of hydroxy-alkynoic acids and their methyl esters as novel activators of BK channels.

Patil S, Bukiya AN, Li W, Dopico AM, Miller D.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3427-30. doi: 10.1016/j.bmcl.2008.03.080. Epub 2008 Apr 8.


The second transmembrane domain of the large conductance, voltage- and calcium-gated potassium channel beta(1) subunit is a lithocholate sensor.

Bukiya AN, Vaithianathan T, Toro L, Dopico AM.

FEBS Lett. 2008 Mar 5;582(5):673-8. doi: 10.1016/j.febslet.2008.01.036. Epub 2008 Jan 31.


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