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Items: 1 to 50 of 220

1.

Protein Disaggregation in Multicellular Organisms.

Nillegoda NB, Wentink AS, Bukau B.

Trends Biochem Sci. 2018 Apr;43(4):285-300. doi: 10.1016/j.tibs.2018.02.003. Epub 2018 Feb 28. Review.

PMID:
29501325
2.

A prion-like domain in Hsp42 drives chaperone-facilitated aggregation of misfolded proteins.

Grousl T, Ungelenk S, Miller S, Ho CT, Khokhrina M, Mayer MP, Bukau B, Mogk A.

J Cell Biol. 2018 Apr 2;217(4):1269-1285. doi: 10.1083/jcb.201708116. Epub 2018 Jan 23.

PMID:
29362223
3.

Cellular Handling of Protein Aggregates by Disaggregation Machines.

Mogk A, Bukau B, Kampinga HH.

Mol Cell. 2018 Jan 18;69(2):214-226. doi: 10.1016/j.molcel.2018.01.004. Review.

PMID:
29351843
4.

Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria.

Lee C, Franke KB, Kamal SM, Kim H, Lünsdorf H, Jäger J, Nimtz M, Trček J, Jänsch L, Bukau B, Mogk A, Römling U.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E273-E282. doi: 10.1073/pnas.1712051115. Epub 2017 Dec 20.

5.

Nucleotide Exchange Factors for Hsp70 Chaperones.

Rampelt H, Mayer MP, Bukau B.

Methods Mol Biol. 2018;1709:179-188. doi: 10.1007/978-1-4939-7477-1_13.

PMID:
29177659
6.

Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control.

Carroni M, Franke KB, Maurer M, Jäger J, Hantke I, Gloge F, Linder D, Gremer S, Turgay K, Bukau B, Mogk A.

Elife. 2017 Nov 22;6. pii: e30120. doi: 10.7554/eLife.30120.

7.

In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging.

Kirstein J, Arnsburg K, Scior A, Szlachcic A, Guilbride DL, Morimoto RI, Bukau B, Nillegoda NB.

Aging Cell. 2017 Dec;16(6):1414-1424. doi: 10.1111/acel.12686. Epub 2017 Oct 10.

8.

Role for ribosome-associated complex and stress-seventy subfamily B (RAC-Ssb) in integral membrane protein translation.

Acosta-Sampson L, Döring K, Lin Y, Yu VY, Bukau B, Kramer G, Cate JHD.

J Biol Chem. 2017 Dec 1;292(48):19610-19627. doi: 10.1074/jbc.M117.813857. Epub 2017 Oct 2.

PMID:
28972146
9.

Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux.

Zemva J, Fink CA, Fleming TH, Schmidt L, Loft A, Herzig S, Knieß RA, Mayer M, Bukau B, Nawroth PP, Tyedmers J.

Redox Biol. 2017 Oct;13:674-686. doi: 10.1016/j.redox.2017.08.007. Epub 2017 Aug 12.

10.

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.

Deville C, Carroni M, Franke KB, Topf M, Bukau B, Mogk A, Saibil HR.

Sci Adv. 2017 Aug 4;3(8):e1701726. doi: 10.1126/sciadv.1701726. eCollection 2017 Aug.

11.

Profiling Ssb-Nascent Chain Interactions Reveals Principles of Hsp70-Assisted Folding.

Döring K, Ahmed N, Riemer T, Suresh HG, Vainshtein Y, Habich M, Riemer J, Mayer MP, O'Brien EP, Kramer G, Bukau B.

Cell. 2017 Jul 13;170(2):298-311.e20. doi: 10.1016/j.cell.2017.06.038.

PMID:
28708998
12.

The Hsp40 J-domain modulates Hsp70 conformation and ATPase activity with a semi-elliptical spring.

Bascos NAD, Mayer MP, Bukau B, Landry SJ.

Protein Sci. 2017 Sep;26(9):1838-1851. doi: 10.1002/pro.3223. Epub 2017 Jul 17.

PMID:
28685898
13.

Substrate binding by the yeast Hsp110 nucleotide exchange factor and molecular chaperone Sse1 is not obligate for its biological activities.

Garcia VM, Nillegoda NB, Bukau B, Morano KA.

Mol Biol Cell. 2017 Jul 15;28(15):2066-2075. doi: 10.1091/mbc.E17-01-0070. Epub 2017 May 24.

14.

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes.

Nillegoda NB, Stank A, Malinverni D, Alberts N, Szlachcic A, Barducci A, De Los Rios P, Wade RC, Bukau B.

Elife. 2017 May 15;6. pii: e24560. doi: 10.7554/eLife.24560.

15.

The growing world of small heat shock proteins: from structure to functions.

Carra S, Alberti S, Arrigo PA, Benesch JL, Benjamin IJ, Boelens W, Bartelt-Kirbach B, Brundel BJJM, Buchner J, Bukau B, Carver JA, Ecroyd H, Emanuelsson C, Finet S, Golenhofen N, Goloubinoff P, Gusev N, Haslbeck M, Hightower LE, Kampinga HH, Klevit RE, Liberek K, Mchaourab HS, McMenimen KA, Poletti A, Quinlan R, Strelkov SV, Toth ME, Vierling E, Tanguay RM.

Cell Stress Chaperones. 2017 Jul;22(4):601-611. doi: 10.1007/s12192-017-0787-8. Epub 2017 Mar 31. Review.

16.

Mutant Analysis Reveals Allosteric Regulation of ClpB Disaggregase.

Franke KB, Bukau B, Mogk A.

Front Mol Biosci. 2017 Feb 22;4:6. doi: 10.3389/fmolb.2017.00006. eCollection 2017.

17.

Hsp70 displaces small heat shock proteins from aggregates to initiate protein refolding.

Żwirowski S, Kłosowska A, Obuchowski I, Nillegoda NB, Piróg A, Ziętkiewicz S, Bukau B, Mogk A, Liberek K.

EMBO J. 2017 Mar 15;36(6):783-796. doi: 10.15252/embj.201593378. Epub 2017 Feb 20.

18.

Role of sHsps in organizing cytosolic protein aggregation and disaggregation.

Mogk A, Bukau B.

Cell Stress Chaperones. 2017 Jul;22(4):493-502. doi: 10.1007/s12192-017-0762-4. Epub 2017 Jan 24. Review.

19.

Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding.

Ungelenk S, Moayed F, Ho CT, Grousl T, Scharf A, Mashaghi A, Tans S, Mayer MP, Mogk A, Bukau B.

Nat Commun. 2016 Nov 30;7:13673. doi: 10.1038/ncomms13673.

20.

Aggregation-induced changes in the chemical exchange saturation transfer (CEST) signals of proteins.

Goerke S, Milde KS, Bukowiecki R, Kunz P, Klika KD, Wiglenda T, Mogk A, Wanker EE, Bukau B, Ladd ME, Bachert P, Zaiss M.

NMR Biomed. 2017 Jan;30(1). doi: 10.1002/nbm.3665. Epub 2016 Nov 11.

PMID:
27859838
21.

Alternative modes of client binding enable functional plasticity of Hsp70.

Mashaghi A, Bezrukavnikov S, Minde DP, Wentink AS, Kityk R, Zachmann-Brand B, Mayer MP, Kramer G, Bukau B, Tans SJ.

Nature. 2016 Nov 17;539(7629):448-451. doi: 10.1038/nature20137. Epub 2016 Oct 26.

PMID:
27783598
22.

SecA Cotranslationally Interacts with Nascent Substrate Proteins In Vivo.

Huber D, Jamshad M, Hanmer R, Schibich D, Döring K, Marcomini I, Kramer G, Bukau B.

J Bacteriol. 2016 Dec 28;199(2). pii: e00622-16. doi: 10.1128/JB.00622-16. Print 2017 Jan 15.

23.

Bacterial and Yeast AAA+ Disaggregases ClpB and Hsp104 Operate through Conserved Mechanism Involving Cooperation with Hsp70.

Kummer E, Szlachcic A, Franke KB, Ungelenk S, Bukau B, Mogk A.

J Mol Biol. 2016 Oct 23;428(21):4378-4391. doi: 10.1016/j.jmb.2016.09.003. Epub 2016 Sep 9.

PMID:
27616763
24.

Structural analysis of a signal peptide inside the ribosome tunnel by DNP MAS NMR.

Lange S, Franks WT, Rajagopalan N, Döring K, Geiger MA, Linden A, van Rossum BJ, Kramer G, Bukau B, Oschkinat H.

Sci Adv. 2016 Aug 19;2(8):e1600379. doi: 10.1126/sciadv.1600379. eCollection 2016 Aug.

25.

Global profiling of SRP interaction with nascent polypeptides.

Schibich D, Gloge F, Pöhner I, Björkholm P, Wade RC, von Heijne G, Bukau B, Kramer G.

Nature. 2016 Aug 11;536(7615):219-23. Epub 2016 Aug 3.

PMID:
27487212
26.

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation.

Yonashiro R, Tahara EB, Bengtson MH, Khokhrina M, Lorenz H, Chen KC, Kigoshi-Tansho Y, Savas JN, Yates JR, Kay SA, Craig EA, Mogk A, Bukau B, Joazeiro CA.

Elife. 2016 Mar 4;5:e11794. doi: 10.7554/eLife.11794.

27.

Trigger Factor Reduces the Force Exerted on the Nascent Chain by a Cotranslationally Folding Protein.

Nilsson OB, Müller-Lucks A, Kramer G, Bukau B, von Heijne G.

J Mol Biol. 2016 Mar 27;428(6):1356-1364. doi: 10.1016/j.jmb.2016.02.014. Epub 2016 Feb 18.

PMID:
26906929
28.

Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding.

Nissley DA, Sharma AK, Ahmed N, Friedrich UA, Kramer G, Bukau B, O'Brien EP.

Nat Commun. 2016 Feb 18;7:10341. doi: 10.1038/ncomms10341.

29.

Physical Origins of Codon Positions That Strongly Influence Cotranslational Folding: A Framework for Controlling Nascent-Protein Folding.

Sharma AK, Bukau B, O'Brien EP.

J Am Chem Soc. 2016 Feb 3;138(4):1180-95. doi: 10.1021/jacs.5b08145. Epub 2016 Jan 21.

PMID:
26716464
30.

Incomplete proteasomal degradation of green fluorescent proteins in the context of tandem fluorescent protein timers.

Khmelinskii A, Meurer M, Ho CT, Besenbeck B, Füller J, Lemberg MK, Bukau B, Mogk A, Knop M.

Mol Biol Cell. 2016 Jan 15;27(2):360-70. doi: 10.1091/mbc.E15-07-0525. Epub 2015 Nov 25.

31.

Metazoan Hsp70-based protein disaggregases: emergence and mechanisms.

Nillegoda NB, Bukau B.

Front Mol Biosci. 2015 Oct 9;2:57. doi: 10.3389/fmolb.2015.00057. eCollection 2015. Review.

32.

Systemic control of protein synthesis through sequestration of translation and ribosome biogenesis factors during severe heat stress.

Cherkasov V, Grousl T, Theer P, Vainshtein Y, Glässer C, Mongis C, Kramer G, Stoecklin G, Knop M, Mogk A, Bukau B.

FEBS Lett. 2015 Nov 30;589(23):3654-64. doi: 10.1016/j.febslet.2015.10.010. Epub 2015 Oct 17.

33.

Operon structure and cotranslational subunit association direct protein assembly in bacteria.

Shieh YW, Minguez P, Bork P, Auburger JJ, Guilbride DL, Kramer G, Bukau B.

Science. 2015 Nov 6;350(6261):678-80. doi: 10.1126/science.aac8171. Epub 2015 Sep 24.

34.

Pathways of allosteric regulation in Hsp70 chaperones.

Kityk R, Vogel M, Schlecht R, Bukau B, Mayer MP.

Nat Commun. 2015 Sep 18;6:8308. doi: 10.1038/ncomms9308.

35.

Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils.

Gao X, Carroni M, Nussbaum-Krammer C, Mogk A, Nillegoda NB, Szlachcic A, Guilbride DL, Saibil HR, Mayer MP, Bukau B.

Mol Cell. 2015 Sep 3;59(5):781-93. doi: 10.1016/j.molcel.2015.07.012. Epub 2015 Aug 20.

36.

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation.

Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, Arnsburg K, Gao X, Scior A, Aebersold R, Guilbride DL, Wade RC, Morimoto RI, Mayer MP, Bukau B.

Nature. 2015 Aug 13;524(7564):247-51. doi: 10.1038/nature14884. Epub 2015 Aug 5.

37.

Cooperation of Hsp70 and Hsp100 chaperone machines in protein disaggregation.

Mogk A, Kummer E, Bukau B.

Front Mol Biosci. 2015 May 19;2:22. doi: 10.3389/fmolb.2015.00022. eCollection 2015. Review.

38.

Signature of protein unfolding in chemical exchange saturation transfer imaging.

Goerke S, Zaiss M, Kunz P, Klika KD, Windschuh JD, Mogk A, Bukau B, Ladd ME, Bachert P.

NMR Biomed. 2015 Jul;28(7):906-13. doi: 10.1002/nbm.3317. Epub 2015 May 26.

PMID:
26010522
39.

Cell Biology. Finding nascent proteins the right home.

Kramer G, Guilbride DL, Bukau B.

Science. 2015 Apr 10;348(6231):182-3. doi: 10.1126/science.aab1335. No abstract available.

PMID:
25859030
40.

Prolonged starvation drives reversible sequestration of lipid biosynthetic enzymes and organelle reorganization in Saccharomyces cerevisiae.

Suresh HG, da Silveira Dos Santos AX, Kukulski W, Tyedmers J, Riezman H, Bukau B, Mogk A.

Mol Biol Cell. 2015 May 1;26(9):1601-15. doi: 10.1091/mbc.E14-11-1559. Epub 2015 Mar 11.

41.

Spatially organized aggregation of misfolded proteins as cellular stress defense strategy.

Miller SB, Mogk A, Bukau B.

J Mol Biol. 2015 Apr 10;427(7):1564-74. doi: 10.1016/j.jmb.2015.02.006. Epub 2015 Feb 11. Review.

PMID:
25681695
42.

Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition.

Miller SB, Ho CT, Winkler J, Khokhrina M, Neuner A, Mohamed MY, Guilbride DL, Richter K, Lisby M, Schiebel E, Mogk A, Bukau B.

EMBO J. 2015 Mar 12;34(6):778-97. doi: 10.15252/embj.201489524. Epub 2015 Feb 11.

43.

Mitochondria tether protein trash to rejuvenate cellular environments.

Mogk A, Bukau B.

Cell. 2014 Oct 23;159(3):471-2. doi: 10.1016/j.cell.2014.10.007.

44.

Monitoring protein misfolding by site-specific labeling of proteins in vivo.

Hsieh TY, Nillegoda NB, Tyedmers J, Bukau B, Mogk A, Kramer G.

PLoS One. 2014 Jun 10;9(6):e99395. doi: 10.1371/journal.pone.0099395. eCollection 2014.

45.

Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation.

Carroni M, Kummer E, Oguchi Y, Wendler P, Clare DK, Sinning I, Kopp J, Mogk A, Bukau B, Saibil HR.

Elife. 2014 Apr 30;3:e02481. doi: 10.7554/eLife.02481.

46.

Co-translational mechanisms of protein maturation.

Gloge F, Becker AH, Kramer G, Bukau B.

Curr Opin Struct Biol. 2014 Feb;24:24-33. doi: 10.1016/j.sbi.2013.11.004. Epub 2013 Dec 12. Review.

PMID:
24721450
47.

Coordination of translational control and protein homeostasis during severe heat stress.

Cherkasov V, Hofmann S, Druffel-Augustin S, Mogk A, Tyedmers J, Stoecklin G, Bukau B.

Curr Biol. 2013 Dec 16;23(24):2452-62. doi: 10.1016/j.cub.2013.09.058. Epub 2013 Nov 27.

48.

Functional analysis of Hsp70 inhibitors.

Schlecht R, Scholz SR, Dahmen H, Wegener A, Sirrenberg C, Musil D, Bomke J, Eggenweiler HM, Mayer MP, Bukau B.

PLoS One. 2013 Nov 12;8(11):e78443. doi: 10.1371/journal.pone.0078443. eCollection 2013. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/5a7961d9-a7ea-4b10-9b48-5b106c405b02.

49.

Telling right from wrong in life - cellular quality control.

Stoecklin G, Bukau B.

Nat Rev Mol Cell Biol. 2013 Oct;14(10):613-5. doi: 10.1038/nrm3662.

PMID:
24199228
50.

Selective ribosome profiling as a tool for studying the interaction of chaperones and targeting factors with nascent polypeptide chains and ribosomes.

Becker AH, Oh E, Weissman JS, Kramer G, Bukau B.

Nat Protoc. 2013 Nov;8(11):2212-39. doi: 10.1038/nprot.2013.133. Epub 2013 Oct 17.

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