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Items: 1 to 50 of 58

1.

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species.

Sang JC, Lee JE, Dear AJ, De S, Meisl G, Thackray AM, Bujdoso R, Knowles TPJ, Klenerman D.

Chem Sci. 2019 Mar 25;10(17):4588-4597. doi: 10.1039/c8sc05627g. eCollection 2019 May 7.

2.

Direct Observation of Murine Prion Protein Replication in Vitro.

Sang JC, Meisl G, Thackray AM, Hong L, Ponjavic A, Knowles TPJ, Bujdoso R, Klenerman D.

J Am Chem Soc. 2018 Nov 7;140(44):14789-14798. doi: 10.1021/jacs.8b08311. Epub 2018 Oct 23.

3.

Mammalian prion propagation in PrP transgenic Drosophila.

Thackray AM, Andréoletti O, Bujdoso R.

Brain. 2018 Sep 1;141(9):2700-2710. doi: 10.1093/brain/awy183.

4.

The use of PrP transgenic Drosophila to replace and reduce vertebrate hosts in the bioassay of mammalian prion infectivity.

Thackray AM, Andréoletti O, Bujdoso R.

F1000Res. 2018 May 15;7:595. doi: 10.12688/f1000research.14753.1. eCollection 2018.

5.

Genetic human prion disease modelled in PrP transgenic Drosophila.

Thackray AM, Cardova A, Wolf H, Pradl L, Vorberg I, Jackson WS, Bujdoso R.

Biochem J. 2017 Sep 20;474(19):3253-3267. doi: 10.1042/BCJ20170462.

6.

Bioassay of prion-infected blood plasma in PrP transgenic Drosophila.

Thackray AM, Andreoletti O, Bujdoso R.

Biochem J. 2016 Dec 1;473(23):4399-4412. Epub 2016 Oct 12.

PMID:
27733649
7.

Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response.

Bujdoso R, Landgraf M, Jackson WS, Thackray AM.

World J Virol. 2015 Aug 12;4(3):188-97. doi: 10.5501/wjv.v4.i3.188. Review.

8.

Leukoreduction and blood-borne vCJD transmission risk.

Douet JY, Bujdoso R, Andréoletti O.

Curr Opin Hematol. 2015 Jan;22(1):36-40. doi: 10.1097/MOH.0000000000000101. Review.

PMID:
25402620
9.

Polymorphisms at amino acid residues 141 and 154 influence conformational variation in ovine PrP.

Yang S, Thackray AM, Hopkins L, Monie TP, Burke DF, Bujdoso R.

Biomed Res Int. 2014;2014:372491. doi: 10.1155/2014/372491. Epub 2014 Jul 14.

10.

Prion-induced and spontaneous formation of transmissible toxicity in PrP transgenic Drosophila.

Thackray AM, Di Y, Zhang C, Wolf H, Pradl L, Vorberg I, Andréoletti O, Bujdoso R.

Biochem J. 2014 Oct 1;463(1):31-40. doi: 10.1042/BJ20140129.

PMID:
25000212
11.

Cytosolic PrP can participate in prion-mediated toxicity.

Thackray AM, Zhang C, Arndt T, Bujdoso R.

J Virol. 2014 Jul;88(14):8129-38. doi: 10.1128/JVI.00732-14. Epub 2014 May 7.

12.

Single protein molecule detection by glass nanopores.

Li W, Bell NA, Hernández-Ainsa S, Thacker VV, Thackray AM, Bujdoso R, Keyser UF.

ACS Nano. 2013 May 28;7(5):4129-34. doi: 10.1021/nn4004567. Epub 2013 Apr 22.

PMID:
23607870
13.

Strain typing of classical scrapie by transgenic mouse bioassay using protein misfolding cyclic amplification to replace primary passage.

Beck KE, Thorne L, Lockey R, Vickery CM, Terry LA, Bujdoso R, Spiropoulos J.

PLoS One. 2013;8(3):e57851. doi: 10.1371/journal.pone.0057851. Epub 2013 Mar 5.

14.

Evidence for co-infection of ovine prion strains in classical scrapie isolates.

Thackray AM, Lockey R, Beck KE, Spiropoulos J, Bujdoso R.

J Comp Pathol. 2012 Aug-Oct;147(2-3):316-29. doi: 10.1016/j.jcpa.2012.01.009. Epub 2012 Apr 21.

PMID:
22522075
15.

Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival.

Thackray AM, Muhammad F, Zhang C, Di Y, Jahn TR, Landgraf M, Crowther DC, Evers JF, Bujdoso R.

Biochem J. 2012 Jun 15;444(3):487-95. doi: 10.1042/BJ20112141.

PMID:
22435640
16.

Prion-induced toxicity in PrP transgenic Drosophila.

Thackray AM, Muhammad F, Zhang C, Denyer M, Spiropoulos J, Crowther DC, Bujdoso R.

Exp Mol Pathol. 2012 Apr;92(2):194-201. doi: 10.1016/j.yexmp.2012.01.005. Epub 2012 Jan 31.

PMID:
22314254
17.

Propagation of ovine prions from "poor" transmitter scrapie isolates in ovine PrP transgenic mice.

Thackray AM, Hopkins L, Lockey R, Spiropoulos J, Bujdoso R.

Exp Mol Pathol. 2012 Feb;92(1):167-74. doi: 10.1016/j.yexmp.2011.11.004. Epub 2011 Nov 19.

PMID:
22120785
18.

Emergence of multiple prion strains from single isolates of ovine scrapie.

Thackray AM, Hopkins L, Lockey R, Spiropoulos J, Bujdoso R.

J Gen Virol. 2011 Jun;92(Pt 6):1482-91. doi: 10.1099/vir.0.028886-0. Epub 2011 Jan 26.

PMID:
21270287
19.

Perturbation of T-cell development by insertional mutation of a PrP transgene.

Zabel M, Greenwood C, Thackray AM, Pulford B, Rens W, Bujdoso R.

Immunology. 2009 Jun;127(2):226-36. doi: 10.1111/j.1365-2567.2008.02944.x. Epub 2008 Oct 21.

20.

Molecular and transmission characteristics of primary-passaged ovine scrapie isolates in conventional and ovine PrP transgenic mice.

Thackray AM, Hopkins L, Spiropoulos J, Bujdoso R.

J Virol. 2008 Nov;82(22):11197-207. doi: 10.1128/JVI.01454-08. Epub 2008 Sep 3.

21.

Copper-induced structural changes in the ovine prion protein are influenced by a polymorphism at codon 112.

Yang S, Thackray AM, Fitzmaurice TJ, Bujdoso R.

Biochim Biophys Acta. 2008 Apr;1784(4):683-92. doi: 10.1016/j.bbapap.2008.01.011. Epub 2008 Jan 31.

PMID:
18280261
22.

Alteration of B-cell subsets enhances neuroinvasion in mouse scrapie infection.

von Poser-Klein C, Flechsig E, Hoffmann T, Schwarz P, Harms H, Bujdoso R, Aguzzi A, Klein MA.

J Virol. 2008 Apr;82(7):3791-5. doi: 10.1128/JVI.02036-07. Epub 2008 Jan 16.

23.

The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2.

Fitzmaurice TJ, Burke DF, Hopkins L, Yang S, Yu S, Sy MS, Thackray AM, Bujdoso R.

Biochem J. 2008 Jan 15;409(2):367-75.

PMID:
17931166
24.

Mouse-adapted ovine scrapie prion strains are characterized by different conformers of PrPSc.

Thackray AM, Hopkins L, Klein MA, Bujdoso R.

J Virol. 2007 Nov;81(22):12119-27. Epub 2007 Aug 29.

25.
26.
27.
28.

Elevated PrPC expression predisposes to increased HSV-1 pathogenicity.

Thackray AM, Bujdoso R.

Antivir Chem Chemother. 2006;17(1):41-52.

PMID:
16542005
29.
30.

Modification of blood cell PrP epitope exposure during prion disease.

Thackray AM, Ryder SJ, Bujdoso R.

Biochem J. 2005 Sep 1;390(Pt 2):563-71.

31.

Accelerated prion disease in the absence of interleukin-10.

Thackray AM, McKenzie AN, Klein MA, Lauder A, Bujdoso R.

J Virol. 2004 Dec;78(24):13697-707.

32.

Conformational variation between allelic variants of cell-surface ovine prion protein.

Thackray AM, Yang S, Wong E, Fitzmaurice TJ, Morgan-Warren RJ, Bujdoso R.

Biochem J. 2004 Jul 1;381(Pt 1):221-9.

34.

Recombinant single-chain Fv antibodies that recognize the p25 protein of the Maedi-Visna virus.

Celer V, Blazek D, Navrátilová I, Skládal P, Blacklaws B, Bujdoso R.

Folia Microbiol (Praha). 2003;48(3):435-40.

PMID:
12879760
35.

Subclinical prion disease induced by oral inoculation.

Thackray AM, Klein MA, Bujdoso R.

J Virol. 2003 Jul;77(14):7991-8.

36.
37.

Chronic subclinical prion disease induced by low-dose inoculum.

Thackray AM, Klein MA, Aguzzi A, Bujdoso R.

J Virol. 2002 Mar;76(5):2510-7.

38.
39.

Metal imbalance and compromised antioxidant function are early changes in prion disease.

Thackray AM, Knight R, Haswell SJ, Bujdoso R, Brown DR.

Biochem J. 2002 Feb 15;362(Pt 1):253-8.

42.

Molecular cloning and expression of DNA encoding ovine interleukin 2.

Bujdoso R, Williamson M, Roy D, Hunt P, Blacklaws B, Sargan D, McConnell I.

Cytokine. 1995 Apr;7(3):223-31.

PMID:
7543777
44.

Nomenclature of mycobacterial stress proteins (65 kDa antigens) and other members of the Hsp60 family.

Hunt P, Colston A, Bujdoso R.

Trends Microbiol. 1994 Aug;2(8):298. No abstract available.

PMID:
7981974
45.

Antigen recognition and activation of ovine gamma delta T cells.

Evans CW, Lund BT, McConnell I, Bujdoso R.

Immunology. 1994 Jun;82(2):229-37.

46.

New walking aid for primary mobilization of an infant with deficiency of all four limbs.

Balogh S, Gönczy T, Bujdosó R, Kullmann L.

Prosthet Orthot Int. 1994 Apr;18(1):49-51.

PMID:
8084750
47.

Expression of T19 (WC1) molecules by ovine lymphocytes.

Lund BT, Evans CW, Davis WC, McConnell I, Bujdoso R.

Vet Immunol Immunopathol. 1993 Nov;39(1-3):145-53.

PMID:
8310641
48.

Different rates of interleukin 2 receptor expression by ovine gamma/delta and alpha/beta T cells.

Bujdoso R, Lund BT, Evans CW, McConnell I.

Vet Immunol Immunopathol. 1993 Nov;39(1-3):109-14.

PMID:
8310635
49.

Cloning of a cDNA encoding the ovine interleukin-2 receptor 55-kDa protein, CD25.

Bujdoso R, Sargan D, Williamson M, McConnell I.

Gene. 1992 Apr 15;113(2):283-4.

PMID:
1572550
50.

The use of flow cytometry to detect transfected gene products.

Bujdoso R, Sargan D, Ballingall K, Sanderson A.

Methods Mol Biol. 1991;7:361-77. doi: 10.1385/0-89603-178-0:361.

PMID:
21416368

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