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The Structure and Dynamics of C. elegans Tubulin Reveals the Mechanistic Basis of Microtubule Growth.

Chaaban S, Jariwala S, Hsu CT, Redemann S, Kollman JM, Müller-Reichert T, Sept D, Bui KH, Brouhard GJ.

Dev Cell. 2018 Oct 22;47(2):191-204.e8. doi: 10.1016/j.devcel.2018.08.023. Epub 2018 Sep 20.


Characterization of Senescence of Human Adipose-Derived Stem Cells After Long-Term Expansion.

Truong NC, Bui KH, Van Pham P.

Adv Exp Med Biol. 2018 Sep 22. doi: 10.1007/5584_2018_235. [Epub ahead of print]


Nanostructure, osteopontin, and mechanical properties of calcitic avian eggshell.

Athanasiadou D, Jiang W, Goldbaum D, Saleem A, Basu K, Pacella MS, Böhm CF, Chromik RR, Hincke MT, Rodríguez-Navarro AB, Vali H, Wolf SE, Gray JJ, Bui KH, McKee MD.

Sci Adv. 2018 Mar 30;4(3):eaar3219. doi: 10.1126/sciadv.aar3219. eCollection 2018 Mar.


Microtubule Inner Proteins: A Meshwork of Luminal Proteins Stabilizing the Doublet Microtubule.

Ichikawa M, Bui KH.

Bioessays. 2018 Mar;40(3). doi: 10.1002/bies.201700209. Epub 2018 Feb 12. Review.


In Vitro Production of Cartilage Tissue from Rabbit Bone Marrow-Derived Mesenchymal Stem Cells and Polycaprolactone Scaffold.

Dao TT, Vu NB, Pham LH, Van Gia L, Le HT, Phi LT, Bui KH, Le PT, Van Pham P.

Adv Exp Med Biol. 2018 Jan 4. doi: 10.1007/5584_2017_133. [Epub ahead of print]


Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children.

Zhou W, Johnson TN, Bui KH, Cheung SYA, Li J, Xu H, Al-Huniti N, Zhou D.

Clin Pharmacol Ther. 2018 Jul;104(1):188-200. doi: 10.1002/cpt.905. Epub 2017 Nov 20.


Population Exposure-Response Modeling Supported Selection of Naloxegol Doses in Phase III Studies in Patients With Opioid-Induced Constipation.

Al-Huniti N, Xu H, Zhou D, Aksenov S, Fox R, Bui KH.

CPT Pharmacometrics Syst Pharmacol. 2017 Oct;6(10):705-711. doi: 10.1002/psp4.12229. Epub 2017 Sep 25.


Capturing protein communities by structural proteomics in a thermophilic eukaryote.

Kastritis PL, O'Reilly FJ, Bock T, Li Y, Rogon MZ, Buczak K, Romanov N, Betts MJ, Bui KH, Hagen WJ, Hennrich ML, Mackmull MT, Rappsilber J, Russell RB, Bork P, Beck M, Gavin AC.

Mol Syst Biol. 2017 Jul 25;13(7):936. doi: 10.15252/msb.20167412.


Pharmacometric Modeling of Naloxegol Efficacy and Safety: Impact on Dose and Label.

Al-Huniti N, Zhou D, Xu H, Aksenov S, Bui KH, Fox R, Helmlinger G, Stanski D.

Clin Pharmacol Ther. 2017 Nov;102(5):741-744. doi: 10.1002/cpt.719. Epub 2017 May 26. Review.


Population pharmacokinetic analysis of lanicemine (AZD6765), an NMDA channel blocker, in healthy subjects and patients with major depressive disorder.

Agbo F, Bui KH, Zhou D.

J Clin Pharm Ther. 2017 Oct;42(5):539-546. doi: 10.1111/jcpt.12541. Epub 2017 May 4.


Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins.

Ichikawa M, Liu D, Kastritis PL, Basu K, Hsu TC, Yang S, Bui KH.

Nat Commun. 2017 May 2;8:15035. doi: 10.1038/ncomms15035.


X-Ray Crystallography and Electron Microscopy of Cross- and Multi-Module Nonribosomal Peptide Synthetase Proteins Reveal a Flexible Architecture.

Tarry MJ, Haque AS, Bui KH, Schmeing TM.

Structure. 2017 May 2;25(5):783-793.e4. doi: 10.1016/j.str.2017.03.014. Epub 2017 Apr 20.


Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study.

Sanacora G, Johnson MR, Khan A, Atkinson SD, Riesenberg RR, Schronen JP, Burke MA, Zajecka JM, Barra L, Su HL, Posener JA, Bui KH, Quirk MC, Piser TM, Mathew SJ, Pathak S.

Neuropsychopharmacology. 2017 Mar;42(4):844-853. doi: 10.1038/npp.2016.224. Epub 2016 Sep 29.


Nuclear pore assembly proceeds by an inside-out extrusion of the nuclear envelope.

Otsuka S, Bui KH, Schorb M, Hossain MJ, Politi AZ, Koch B, Eltsov M, Beck M, Ellenberg J.

Elife. 2016 Sep 15;5. pii: e19071. doi: 10.7554/eLife.19071.


Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children.

Zhou W, Johnson TN, Xu H, Cheung S, Bui KH, Li J, Al-Huniti N, Zhou D.

CPT Pharmacometrics Syst Pharmacol. 2016 Sep;5(9):475-83. doi: 10.1002/psp4.12101. Epub 2016 Aug 27.


Pre-assembled Nuclear Pores Insert into the Nuclear Envelope during Early Development.

Hampoelz B, Mackmull MT, Machado P, Ronchi P, Bui KH, Schieber N, Santarella-Mellwig R, Necakov A, Andrés-Pons A, Philippe JM, Lecuit T, Schwab Y, Beck M.

Cell. 2016 Jul 28;166(3):664-678. doi: 10.1016/j.cell.2016.06.015. Epub 2016 Jul 7.


Molecular architecture of the inner ring scaffold of the human nuclear pore complex.

Kosinski J, Mosalaganti S, von Appen A, Teimer R, DiGuilio AL, Wan W, Bui KH, Hagen WJ, Briggs JA, Glavy JS, Hurt E, Beck M.

Science. 2016 Apr 15;352(6283):363-5. doi: 10.1126/science.aaf0643.


Isolation and proliferation of umbilical cord tissue derived mesenchymal stem cells for clinical applications.

Van Pham P, Truong NC, Le PT, Tran TD, Vu NB, Bui KH, Phan NK.

Cell Tissue Bank. 2016 Jun;17(2):289-302. doi: 10.1007/s10561-015-9541-6. Epub 2015 Dec 17.


In situ structural analysis of the human nuclear pore complex.

von Appen A, Kosinski J, Sparks L, Ori A, DiGuilio AL, Vollmer B, Mackmull MT, Banterle N, Parca L, Kastritis P, Buczak K, Mosalaganti S, Hagen W, Andres-Pons A, Lemke EA, Bork P, Antonin W, Glavy JS, Bui KH, Beck M.

Nature. 2015 Oct 1;526(7571):140-143. doi: 10.1038/nature15381. Epub 2015 Sep 23.


Population pharmacokinetics of naloxegol in a population of 1247 healthy subjects and patients.

Al-Huniti N, Chapel S, Xu H, Bui KH, Sostek M.

Br J Clin Pharmacol. 2016 Jan;81(1):89-100. doi: 10.1111/bcp.12756. Epub 2015 Oct 27.


α- and β-Tubulin Lattice of the Axonemal Microtubule Doublet and Binding Proteins Revealed by Single Particle Cryo-Electron Microscopy and Tomography.

Maheshwari A, Obbineni JM, Bui KH, Shibata K, Toyoshima YY, Ishikawa T.

Structure. 2015 Sep 1;23(9):1584-1595. doi: 10.1016/j.str.2015.06.017. Epub 2015 Jul 23.


Effect of multiple intravenous doses of lanicemine (AZD6765) on the pharmacokinetics of midazolam in healthy subjects.

Bui KH, Zhou D, Agbo F, Guo J.

J Clin Pharmacol. 2015 Sep;55(9):1024-30. doi: 10.1002/jcph.515. Epub 2015 Jun 2.


Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold.

Gaik M, Flemming D, von Appen A, Kastritis P, Mücke N, Fischer J, Stelter P, Ori A, Bui KH, Baßler J, Barbar E, Beck M, Hurt E.

J Cell Biol. 2015 Feb 2;208(3):283-97. doi: 10.1083/jcb.201411003.


Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties.

Ostenfeld MS, Jeppesen DK, Laurberg JR, Boysen AT, Bramsen JB, Primdal-Bengtson B, Hendrix A, Lamy P, Dagnaes-Hansen F, Rasmussen MH, Bui KH, Fristrup N, Christensen EI, Nordentoft I, Morth JP, Jensen JB, Pedersen JS, Beck M, Theodorescu D, Borre M, Howard KA, Dyrskjøt L, Ørntoft TF.

Cancer Res. 2014 Oct 15;74(20):5758-71. doi: 10.1158/0008-5472.CAN-13-3512. Epub 2014 Sep 26.


Pharmacokinetics, metabolism and excretion of [(14)C]-lanicemine (AZD6765), a novel low-trapping N-methyl-d-aspartic acid receptor channel blocker, in healthy subjects.

Guo J, Zhou D, Grimm SW, Bui KH.

Xenobiotica. 2015 Mar;45(3):244-55. doi: 10.3109/00498254.2014.966175. Epub 2014 Sep 26.


Structure of dimeric axonemal dynein in cilia suggests an alternative mechanism of force generation.

Ueno H, Bui KH, Ishikawa T, Imai Y, Yamaguchi T, Ishikawa T.

Cytoskeleton (Hoboken). 2014 Jul;71(7):412-22. doi: 10.1002/cm.21180. Epub 2014 Jul 2.


Effects of the δ opioid agonist AZD2327 upon operant behaviors and assessment of its potential for abuse.

Hudzik TJ, Pietras MR, Caccese R, Bui KH, Yocca F, Paronis CA, Swedberg MD.

Pharmacol Biochem Behav. 2014 Sep;124:48-57. doi: 10.1016/j.pbb.2014.05.009. Epub 2014 May 22.


Integrated structural analysis of the human nuclear pore complex scaffold.

Bui KH, von Appen A, DiGuilio AL, Ori A, Sparks L, Mackmull MT, Bock T, Hagen W, Andrés-Pons A, Glavy JS, Beck M.

Cell. 2013 Dec 5;155(6):1233-43. doi: 10.1016/j.cell.2013.10.055.


Activated platelet-rich plasma improves adipose-derived stem cell transplantation efficiency in injured articular cartilage.

Van Pham P, Bui KH, Ngo DQ, Vu NB, Truong NH, Phan NL, Le DM, Duong TD, Nguyen TD, Le VT, Phan NK.

Stem Cell Res Ther. 2013 Aug 1;4(4):91. doi: 10.1186/scrt277.


Fourier ring correlation as a resolution criterion for super-resolution microscopy.

Banterle N, Bui KH, Lemke EA, Beck M.

J Struct Biol. 2013 Sep;183(3):363-367. doi: 10.1016/j.jsb.2013.05.004. Epub 2013 May 16.


3D structural analysis of flagella/cilia by cryo-electron tomography.

Bui KH, Ishikawa T.

Methods Enzymol. 2013;524:305-23. doi: 10.1016/B978-0-12-397945-2.00017-2.


Polarity and asymmetry in the arrangement of dynein and related structures in the Chlamydomonas axoneme.

Bui KH, Yagi T, Yamamoto R, Kamiya R, Ishikawa T.

J Cell Biol. 2012 Sep 3;198(5):913-25. doi: 10.1083/jcb.201201120.


Revisiting the supramolecular organization of photosystem II in Chlamydomonas reinhardtii.

Tokutsu R, Kato N, Bui KH, Ishikawa T, Minagawa J.

J Biol Chem. 2012 Sep 7;287(37):31574-81. doi: 10.1074/jbc.M111.331991. Epub 2012 Jul 16.


The right compound in the right assay at the right time: an integrated discovery DMPK strategy.

Ballard P, Brassil P, Bui KH, Dolgos H, Petersson C, Tunek A, Webborn PJ.

Drug Metab Rev. 2012 Aug;44(3):224-52. doi: 10.3109/03602532.2012.691099. Epub 2012 Jun 15. Review.


Comparative structural analysis of eukaryotic flagella and cilia from Chlamydomonas, Tetrahymena, and sea urchins.

Pigino G, Maheshwari A, Bui KH, Shingyoji C, Kamimura S, Ishikawa T.

J Struct Biol. 2012 May;178(2):199-206. doi: 10.1016/j.jsb.2012.02.012. Epub 2012 Mar 3.


Mouse respiratory cilia with the asymmetric axonemal structure on sparsely distributed ciliary cells can generate overall directional flow.

Ueno H, Ishikawa T, Bui KH, Gonda K, Ishikawa T, Yamaguchi T.

Nanomedicine. 2012 Oct;8(7):1081-7. doi: 10.1016/j.nano.2012.01.004. Epub 2012 Jan 31.


Multiparameter exploration of piperazine derivatives as δ-opioid receptor agonists for CNS indications.

McCauley JP Jr, Dantzman CL, King MM, Ernst GE, Wang X, Brush K, Palmer WE, Frietze W, Andisik DW, Hoesch V, Doring K, Hulsizer J, Bui KH, Liu J, Hudzik TJ, Wesolowski SS.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1169-73. doi: 10.1016/j.bmcl.2011.11.088. Epub 2011 Dec 7.


4-Piperidin-4-ylidenemethyl-benzamides as δ-opioid receptor agonists for CNS indications: identifying clinical candidates.

Dantzman CL, King MM, Ernst GE, Wang X, McCauley JP Jr, Andisik DW, Brush K, Bui KH, Frietze W, Hoesch V, Liu J, Palmer WE, Spear N, Hudzik TJ, Wesolowski SS.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1174-8. doi: 10.1016/j.bmcl.2011.11.089. Epub 2011 Nov 30.


Cryoelectron tomography of radial spokes in cilia and flagella.

Pigino G, Bui KH, Maheshwari A, Lupetti P, Diener D, Ishikawa T.

J Cell Biol. 2011 Nov 14;195(4):673-87. doi: 10.1083/jcb.201106125. Epub 2011 Nov 7.


In vitro and in vivo metabolism of a selective δ-opioid receptor.

Guo J, Gu C, Zhou D, Elmore CS, Bui KH, Grimm SW.

Drug Metab Dispos. 2011 Oct;39(10):1883-94. doi: 10.1124/dmd.111.040980. Epub 2011 Jul 13.


Preclinical pharmacology of AZD2327: a highly selective agonist of the δ-opioid receptor.

Hudzik TJ, Maciag C, Smith MA, Caccese R, Pietras MR, Bui KH, Coupal M, Adam L, Payza K, Griffin A, Smagin G, Song D, Swedberg MD, Brown W.

J Pharmacol Exp Ther. 2011 Jul;338(1):195-204. doi: 10.1124/jpet.111.179432. Epub 2011 Mar 28.


Three-dimensional structural analysis of eukaryotic flagella/cilia by electron cryo-tomography.

Bui KH, Pigino G, Ishikawa T.

J Synchrotron Radiat. 2011 Jan;18(1):2-5. doi: 10.1107/S0909049510036812. Epub 2010 Nov 5.


Combining radio telemetry and automated blood sampling: a novel approach for integrative pharmacology and toxicology studies.

Kamendi HW, Brott DA, Chen Y, Litwin DC, Lengel DJ, Fonck C, Bui KH, Gorko MA, Bialecki RA.

J Pharmacol Toxicol Methods. 2010 Jul-Aug;62(1):30-9. doi: 10.1016/j.vascn.2010.04.014. Epub 2010 May 23.


Nucleotide-induced global conformational changes of flagellar dynein arms revealed by in situ analysis.

Movassagh T, Bui KH, Sakakibara H, Oiwa K, Ishikawa T.

Nat Struct Mol Biol. 2010 Jun;17(6):761-7. doi: 10.1038/nsmb.1832. Epub 2010 May 9.


Asymmetry of inner dynein arms and inter-doublet links in Chlamydomonas flagella.

Bui KH, Sakakibara H, Movassagh T, Oiwa K, Ishikawa T.

J Cell Biol. 2009 Aug 10;186(3):437-46. doi: 10.1083/jcb.200903082.


Molecular architecture of inner dynein arms in situ in Chlamydomonas reinhardtii flagella.

Bui KH, Sakakibara H, Movassagh T, Oiwa K, Ishikawa T.

J Cell Biol. 2008 Dec 1;183(5):923-32. doi: 10.1083/jcb.200808050. Epub 2008 Nov 24.


Mechanistic investigation of N,N-diethyl-4-(phenyl-piperidin-4-ylidenemethyl)-benzamide-induced insulin depletion in the rat and RINm5F cells.

Otieno MA, Bavuso N, Milano J, Foster-Brown L, Bui KH, Li Y, Hudzik T, Wescott D, Louden C, Dyroff M, Pognan F.

Toxicol Sci. 2008 Sep;105(1):221-9. doi: 10.1093/toxsci/kfn108. Epub 2008 Jun 6.


Metabolism and excretion of zafirlukast in dogs, rats, and mice.

Savidge RD, Bui KH, Birmingham BK, Morse JL, Spreen RC.

Drug Metab Dispos. 1998 Nov;26(11):1069-76.


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