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Pyonitrins A-D: Chimeric Natural Products Produced by Pseudomonas protegens.

Mevers E, Saurí J, Helfrich EJN, Henke M, Barns KJ, Bugni TS, Andes D, Currie CR, Clardy J.

J Am Chem Soc. 2019 Oct 16. doi: 10.1021/jacs.9b09739. [Epub ahead of print]


Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani.

Ortega HE, Ferreira LLG, Melo WGP, Oliveira ALL, Ramos Alvarenga RF, Lopes NP, Bugni TS, Andricopulo AD, Pupo MT.

PLoS Negl Trop Dis. 2019 Aug 5;13(8):e0007643. doi: 10.1371/journal.pntd.0007643. eCollection 2019 Aug.


Madurastatin D1 and D2, Oxazoline Containing Siderophores Isolated from an Actinomadura sp.

Yan JX, Chevrette MG, Braun DR, Harper MK, Currie CR, Bugni TS.

Org Lett. 2019 Aug 16;21(16):6275-6279. doi: 10.1021/acs.orglett.9b02159. Epub 2019 Aug 5.


Bulbiferates A and B: Antibacterial Acetamidohydroxybenzoates from a Marine Proteobacterium, Microbulbifer sp.

Jayanetti DR, Braun DR, Barns KJ, Rajski SR, Bugni TS.

J Nat Prod. 2019 Jul 26;82(7):1930-1934. doi: 10.1021/acs.jnatprod.9b00312. Epub 2019 Jun 4.


Omics Technologies to Understand Activation of a Biosynthetic Gene Cluster in Micromonospora sp. WMMB235: Deciphering Keyicin Biosynthesis.

Acharya D, Miller I, Cui Y, Braun DR, Berres ME, Styles MJ, Li L, Kwan J, Rajski SR, Blackwell HE, Bugni TS.

ACS Chem Biol. 2019 Jun 21;14(6):1260-1270. doi: 10.1021/acschembio.9b00223. Epub 2019 Jun 7.


The antimicrobial potential of Streptomyces from insect microbiomes.

Chevrette MG, Carlson CM, Ortega HE, Thomas C, Ananiev GE, Barns KJ, Book AJ, Cagnazzo J, Carlos C, Flanigan W, Grubbs KJ, Horn HA, Hoffmann FM, Klassen JL, Knack JJ, Lewin GR, McDonald BR, Muller L, Melo WGP, Pinto-Tomás AA, Schmitz A, Wendt-Pienkowski E, Wildman S, Zhao M, Zhang F, Bugni TS, Andes DR, Pupo MT, Currie CR.

Nat Commun. 2019 Jan 31;10(1):516. doi: 10.1038/s41467-019-08438-0.


Biemamides A-E, Inhibitors of the TGF-β Pathway That Block the Epithelial to Mesenchymal Transition.

Zhang F, Braun DR, Ananiev GE, Hoffmann FM, Tsai IW, Rajski SR, Bugni TS.

Org Lett. 2018 Sep 21;20(18):5529-5532. doi: 10.1021/acs.orglett.8b01871. Epub 2018 Aug 30.


Draft Genome Sequence of Micromonospora sp. Strain WMMA1996, a Marine Sponge-Associated Bacterium.

Braun DR, Chevrette MG, Acharya DD, Currie CR, Rajski SR, Bugni TS.

Genome Announc. 2018 Feb 22;6(8). pii: e00077-18. doi: 10.1128/genomeA.00077-18.


Complete Genome Sequence of Dietzia sp. Strain WMMA184, a Marine Coral-Associated Bacterium.

Braun DR, Chevrette MG, Acharya D, Currie CR, Rajski SR, Ritchie KB, Bugni TS.

Genome Announc. 2018 Feb 1;6(5). pii: e01582-17. doi: 10.1128/genomeA.01582-17.


Accessing chemical diversity from the uncultivated symbionts of small marine animals.

Smith TE, Pond CD, Pierce E, Harmer ZP, Kwan J, Zachariah MM, Harper MK, Wyche TP, Matainaho TK, Bugni TS, Barrows LR, Ireland CM, Schmidt EW.

Nat Chem Biol. 2018 Feb;14(2):179-185. doi: 10.1038/nchembio.2537. Epub 2018 Jan 1.


Coculture of Marine Invertebrate-Associated Bacteria and Interdisciplinary Technologies Enable Biosynthesis and Discovery of a New Antibiotic, Keyicin.

Adnani N, Chevrette MG, Adibhatla SN, Zhang F, Yu Q, Braun DR, Nelson J, Simpkins SW, McDonald BR, Myers CL, Piotrowski JS, Thompson CJ, Currie CR, Li L, Rajski SR, Bugni TS.

ACS Chem Biol. 2017 Dec 15;12(12):3093-3102. doi: 10.1021/acschembio.7b00688. Epub 2017 Nov 22.


Thalassosamide, a Siderophore Discovered from the Marine-Derived Bacterium Thalassospira profundimaris.

Zhang F, Barns K, Hoffmann FM, Braun DR, Andes DR, Bugni TS.

J Nat Prod. 2017 Sep 22;80(9):2551-2555. doi: 10.1021/acs.jnatprod.7b00328. Epub 2017 Aug 25.


Chemical Genomics, Structure Elucidation, and in Vivo Studies of the Marine-Derived Anticlostridial Ecteinamycin.

Wyche TP, Alvarenga RFR, Piotrowski JS, Duster MN, Warrack SR, Cornilescu G, De Wolfe TJ, Hou Y, Braun DR, Ellis GA, Simpkins SW, Nelson J, Myers CL, Steele J, Mori H, Safdar N, Markley JL, Rajski SR, Bugni TS.

ACS Chem Biol. 2017 Sep 15;12(9):2287-2295. doi: 10.1021/acschembio.7b00388. Epub 2017 Jul 26.


Natural Product Discovery Using Planes of Principal Component Analysis in R (PoPCAR).

Chanana S, Thomas CS, Braun DR, Hou Y, Wyche TP, Bugni TS.

Metabolites. 2017 Jul 13;7(3). pii: E34. doi: 10.3390/metabo7030034.


Brackish habitat dictates cultivable Actinobacterial diversity from marine sponges.

Ellis GA, Thomas CS, Chanana S, Adnani N, Szachowicz E, Braun DR, Harper MK, Wyche TP, Bugni TS.

PLoS One. 2017 Jul 10;12(7):e0176968. doi: 10.1371/journal.pone.0176968. eCollection 2017.


Progressive Stereo Locking (PSL): A Residual Dipolar Coupling Based Force Field Method for Determining the Relative Configuration of Natural Products and Other Small Molecules.

Cornilescu G, Ramos Alvarenga RF, Wyche TP, Bugni TS, Gil RR, Cornilescu CC, Westler WM, Markley JL, Schwieters CD.

ACS Chem Biol. 2017 Aug 18;12(8):2157-2163. doi: 10.1021/acschembio.7b00281. Epub 2017 Jul 12.


Symbiosis-inspired approaches to antibiotic discovery.

Adnani N, Rajski SR, Bugni TS.

Nat Prod Rep. 2017 Jul 6;34(7):784-814. doi: 10.1039/c7np00009j. Review.


Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides.

Wyche TP, Ruzzini AC, Beemelmanns C, Kim KH, Klassen JL, Cao S, Poulsen M, Bugni TS, Currie CR, Clardy J.

Org Lett. 2017 Apr 7;19(7):1772-1775. doi: 10.1021/acs.orglett.7b00545. Epub 2017 Mar 22.


Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39.

Beemelmanns C, Ramadhar TR, Kim KH, Klassen JL, Cao S, Wyche TP, Hou Y, Poulsen M, Bugni TS, Currie CR, Clardy J.

Org Lett. 2017 Mar 3;19(5):1000-1003. doi: 10.1021/acs.orglett.6b03831. Epub 2017 Feb 16.


Draft Genome Sequence of Micromonospora sp. Strain WMMB235, a Marine Ascidian-Associated Bacterium.

Adnani N, Braun DR, McDonald BR, Chevrette MG, Currie CR, Bugni TS.

Genome Announc. 2017 Jan 12;5(2). pii: e01369-16. doi: 10.1128/genomeA.01369-16.


Evidence that oxidative dephosphorylation by the nonheme Fe(II), α-ketoglutarate:UMP oxygenase occurs by stereospecific hydroxylation.

Goswami A, Liu X, Cai W, Wyche TP, Bugni TS, Meurillon M, Peyrottes S, Perigaud C, Nonaka K, Rohr J, Van Lanen SG.

FEBS Lett. 2017 Feb;591(3):468-478. doi: 10.1002/1873-3468.12554. Epub 2017 Jan 25.


Complete Genome Sequence of Rhodococcus sp. Strain WMMA185, a Marine Sponge-Associated Bacterium.

Adnani N, Braun DR, McDonald BR, Chevrette MG, Currie CR, Bugni TS.

Genome Announc. 2016 Dec 15;4(6). pii: e01406-16. doi: 10.1128/genomeA.01406-16.


Micromonohalimanes A and B: Antibacterial Halimane-Type Diterpenoids from a Marine Micromonospora Species.

Zhang Y, Adnani N, Braun DR, Ellis GA, Barns KJ, Parker-Nance S, Guzei IA, Bugni TS.

J Nat Prod. 2016 Nov 23;79(11):2968-2972. Epub 2016 Nov 4.


Structure elucidation of uniformly 13C labeled small molecule natural products.

Reibarkh M, Wyche TP, Saurí J, Bugni TS, Martin GE, Williamson RT.

Magn Reson Chem. 2015 Dec;53(12):i. doi: 10.1002/mrc.4384.


Structure elucidation of uniformly (13)C labeled small molecule natural products.

Reibarkh M, Wyche TP, Saurí J, Bugni TS, Martin GE, Thomas Williamson R.

Magn Reson Chem. 2015 Dec;53(12):996-1002. doi: 10.1002/mrc.4333.


Investigation of Interspecies Interactions within Marine Micromonosporaceae Using an Improved Co-Culture Approach.

Adnani N, Vazquez-Rivera E, Adibhatla SN, Ellis GA, Braun DR, Bugni TS.

Mar Drugs. 2015 Sep 24;13(10):6082-98. doi: 10.3390/md13106082.


Application of 3D NMR for Structure Determination of Peptide Natural Products.

Zhang F, Adnani N, Vazquez-Rivera E, Braun DR, Tonelli M, Andes DR, Bugni TS.

J Org Chem. 2015 Sep 4;80(17):8713-9. doi: 10.1021/acs.joc.5b01486. Epub 2015 Aug 21.


Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivo.

Wyche TP, Dammalapati A, Cho H, Harrison AD, Kwon GS, Chen H, Bugni TS, Jaskula-Sztul R.

Cancer Gene Ther. 2014 Dec;21(12):518-25. doi: 10.1038/cgt.2014.57. Epub 2014 Nov 21.


Forazoline A: marine-derived polyketide with antifungal in vivo efficacy.

Wyche TP, Piotrowski JS, Hou Y, Braun D, Deshpande R, McIlwain S, Ong IM, Myers CL, Guzei IA, Westler WM, Andes DR, Bugni TS.

Angew Chem Int Ed Engl. 2014 Oct 20;53(43):11583-6. doi: 10.1002/anie.201405990. Epub 2014 Sep 4.


Species specificity of symbiosis and secondary metabolism in ascidians.

Tianero MD, Kwan JC, Wyche TP, Presson AP, Koch M, Barrows LR, Bugni TS, Schmidt EW.

ISME J. 2015 Mar;9(3):615-28. doi: 10.1038/ismej.2014.152. Epub 2014 Aug 29.


Host control of symbiont natural product chemistry in cryptic populations of the tunicate Lissoclinum patella.

Kwan JC, Tianero MD, Donia MS, Wyche TP, Bugni TS, Schmidt EW.

PLoS One. 2014 May 2;9(5):e95850. doi: 10.1371/journal.pone.0095850. eCollection 2014.


Solwaric acids A and B, antibacterial aromatic acids from a marine Solwaraspora sp.

Ellis GA, Wyche TP, Fry CG, Braun DR, Bugni TS.

Mar Drugs. 2014 Feb 14;12(2):1013-22. doi: 10.3390/md12021013.


Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC-TT cell line.

Tesfazghi S, Eide J, Dammalapati A, Korlesky C, Wyche TP, Bugni TS, Chen H, Jaskula-Sztul R.

Cancer Med. 2013 Oct;2(5):734-43. doi: 10.1002/cam4.118. Epub 2013 Sep 17.


Activation of the nuclear factor E2-related factor 2 pathway by novel natural products halomadurones A-D and a synthetic analogue.

Wyche TP, Standiford M, Hou Y, Braun D, Johnson DA, Johnson JA, Bugni TS.

Mar Drugs. 2013 Dec 16;11(12):5089-99. doi: 10.3390/md11125089.


Total Syntheses of Proposed (±)-Trichodermatides B and C.

Li Q, Xu YS, Ellis GA, Bugni TS, Tang Y, Hsung RP.

Tetrahedron Lett. 2013 Oct 9;54(41). doi: 10.1016/j.tetlet.2013.07.137.


Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA.

Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f. Review.


Baeyer-Villiger C-C bond cleavage reaction in gilvocarcin and jadomycin biosynthesis.

Tibrewal N, Pahari P, Wang G, Kharel MK, Morris C, Downey T, Hou Y, Bugni TS, Rohr J.

J Am Chem Soc. 2012 Nov 7;134(44):18181-4. doi: 10.1021/ja3081154. Epub 2012 Oct 29.


Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by p450 enzymes.

Reilly CA, Henion F, Bugni TS, Ethirajan M, Stockmann C, Pramanik KC, Srivastava SK, Yost GS.

Chem Res Toxicol. 2013 Jan 18;26(1):55-66. doi: 10.1021/tx300366k. Epub 2012 Nov 6.


Probing the regiospecificity of enzyme-catalyzed steroid glycosylation.

Zhou M, Hou Y, Hamza A, Pain C, Zhan CG, Bugni TS, Thorson JS.

Org Lett. 2012 Nov 2;14(21):5424-7. doi: 10.1021/ol3024924. Epub 2012 Oct 18. Erratum in: Org Lett. 2012 Dec 21;14(24):6381. Pain, Christophe [added].


Structure and biosynthesis of the antibiotic bottromycin D.

Hou Y, Tianero MD, Kwan JC, Wyche TP, Michel CR, Ellis GA, Vazquez-Rivera E, Braun DR, Rose WE, Schmidt EW, Bugni TS.

Org Lett. 2012 Oct 5;14(19):5050-3. doi: 10.1021/ol3022758. Epub 2012 Sep 17.


Stereoselective preparation of cyclobutanes with four different substituents: total synthesis and structural revision of pipercyclobutanamide A and piperchabamide G.

Liu R, Zhang M, Wyche TP, Winston-McPherson GN, Bugni TS, Tang W.

Angew Chem Int Ed Engl. 2012 Jul 23;51(30):7503-6. doi: 10.1002/anie.201203379. Epub 2012 Jun 19. No abstract available.


Microtermolides A and B from termite-associated Streptomyces sp. and structural revision of vinylamycin.

Carr G, Poulsen M, Klassen JL, Hou Y, Wyche TP, Bugni TS, Currie CR, Clardy J.

Org Lett. 2012 Jun 1;14(11):2822-5. doi: 10.1021/ol301043p. Epub 2012 May 16.


Microbial strain prioritization using metabolomics tools for the discovery of natural products.

Hou Y, Braun DR, Michel CR, Klassen JL, Adnani N, Wyche TP, Bugni TS.

Anal Chem. 2012 May 15;84(10):4277-83. doi: 10.1021/ac202623g. Epub 2012 May 3.


Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus.

Lim FY, Hou Y, Chen Y, Oh JH, Lee I, Bugni TS, Keller NP.

Appl Environ Microbiol. 2012 Jun;78(12):4117-25. doi: 10.1128/AEM.07710-11. Epub 2012 Apr 6. Erratum in: Appl Environ Microbiol. 2012 Sep;78(17):6395.


Peptidolipins B-F, antibacterial lipopeptides from an ascidian-derived Nocardia sp.

Wyche TP, Hou Y, Vazquez-Rivera E, Braun D, Bugni TS.

J Nat Prod. 2012 Apr 27;75(4):735-40. doi: 10.1021/np300016r. Epub 2012 Apr 6.


Universal quantification of structurally diverse natural products using an evaporative light scattering detector.

Adnani N, Michel CR, Bugni TS.

J Nat Prod. 2012 Apr 27;75(4):802-6. doi: 10.1021/np300034c. Epub 2012 Apr 3.


New tetromycin derivatives with anti-trypanosomal and protease inhibitory activities.

Pimentel-Elardo SM, Buback V, Gulder TA, Bugni TS, Reppart J, Bringmann G, Ireland CM, Schirmeister T, Hentschel U.

Mar Drugs. 2011;9(10):1682-97. doi: 10.3390/md9101682. Epub 2011 Sep 26.


Selective quantification by 2D HSQC0 spectroscopy of thiocoraline in an extract from a sponge-derived Verrucosispora sp.

Hu K, Wyche TP, Bugni TS, Markley JL.

J Nat Prod. 2011 Oct 28;74(10):2295-8. doi: 10.1021/np200503c. Epub 2011 Sep 16.


First natural analogs of the cytotoxic thiodepsipeptide thiocoraline A from a marine Verrucosispora sp.

Wyche TP, Hou Y, Braun D, Cohen HC, Xiong MP, Bugni TS.

J Org Chem. 2011 Aug 19;76(16):6542-7. doi: 10.1021/jo200661n. Epub 2011 Jul 20.


WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.

Coombs GS, Yu J, Canning CA, Veltri CA, Covey TM, Cheong JK, Utomo V, Banerjee N, Zhang ZH, Jadulco RC, Concepcion GP, Bugni TS, Harper MK, Mihalek I, Jones CM, Ireland CM, Virshup DM.

J Cell Sci. 2010 Oct 1;123(Pt 19):3357-67. doi: 10.1242/jcs.072132. Epub 2010 Sep 7.

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