Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 127


Probing Pedomorphy and Prolonged Lifespan in Naked Mole-Rats and Dwarf Mice.

Buffenstein R, Lewis KN, Gibney PA, Narayan V, Grimes KM, Smith M, Lin TD, Brown-Borg HM.

Physiology (Bethesda). 2020 Mar 1;35(2):96-111. doi: 10.1152/physiol.00032.2019.


Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation.

Lee BP, Smith M, Buffenstein R, Harries LW.

Geroscience. 2020 Jan 11. doi: 10.1007/s11357-019-00150-7. [Epub ahead of print]


Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity.

Hilton HG, Rubinstein ND, Janki P, Ireland AT, Bernstein N, Fong NL, Wright KM, Smith M, Finkle D, Martin-McNulty B, Roy M, Imai DM, Jojic V, Buffenstein R.

PLoS Biol. 2019 Nov 21;17(11):e3000528. doi: 10.1371/journal.pbio.3000528. eCollection 2019 Nov.


Response to comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'.

Ruby JG, Smith M, Buffenstein R.

Elife. 2019 Jul 9;8. pii: e47047. doi: 10.7554/eLife.47047.


Evidence for hormonal control of heart regenerative capacity during endothermy acquisition.

Hirose K, Payumo AY, Cutie S, Hoang A, Zhang H, Guyot R, Lunn D, Bigley RB, Yu H, Wang J, Smith M, Gillett E, Muroy SE, Schmid T, Wilson E, Field KA, Reeder DM, Maden M, Yartsev MM, Wolfgang MJ, Grützner F, Scanlan TS, Szweda LI, Buffenstein R, Hu G, Flamant F, Olgin JE, Huang GN.

Science. 2019 Apr 12;364(6436):184-188. doi: 10.1126/science.aar2038. Epub 2019 Mar 7.


Correction to: A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence.

Lewis KN, Rubinstein ND, Buffenstein R.

Geroscience. 2018 Jun;40(3):357-358. doi: 10.1007/s11357-018-0023-1.


A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence.

Lewis KN, Rubinstein ND, Buffenstein R.

Geroscience. 2018 Apr;40(2):105-121. doi: 10.1007/s11357-018-0014-2. Epub 2018 Apr 20. Erratum in: Geroscience. 2018 May 31;:.


Naked Mole-Rat mortality rates defy gompertzian laws by not increasing with age.

Ruby JG, Smith M, Buffenstein R.

Elife. 2018 Jan 24;7. pii: e31157. doi: 10.7554/eLife.31157.


The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent.

Grimes KM, Barefield DY, Kumar M, McNamara JW, Weintraub ST, de Tombe PP, Sadayappan S, Buffenstein R.

Pflugers Arch. 2017 Dec;469(12):1603-1613. doi: 10.1007/s00424-017-2046-3. Epub 2017 Aug 5.


Extended Postnatal Brain Development in the Longest-Lived Rodent: Prolonged Maintenance of Neotenous Traits in the Naked Mole-Rat Brain.

Orr ME, Garbarino VR, Salinas A, Buffenstein R.

Front Neurosci. 2016 Nov 8;10:504. eCollection 2016.


Cutting back on the essentials: Can manipulating intake of specific amino acids modulate health and lifespan?

Brown-Borg HM, Buffenstein R.

Ageing Res Rev. 2017 Oct;39:87-95. doi: 10.1016/j.arr.2016.08.007. Epub 2016 Aug 26. Review.


Unraveling the message: insights into comparative genomics of the naked mole-rat.

Lewis KN, Soifer I, Melamud E, Roy M, McIsaac RS, Hibbs M, Buffenstein R.

Mamm Genome. 2016 Aug;27(7-8):259-78. doi: 10.1007/s00335-016-9648-5. Epub 2016 Jun 30. Review.


Mechanisms regulating proteostasis are involved in sympatric speciation of the blind mole rat, Spalax galili.

Rodriguez KA, Li K, Nevo E, Buffenstein R.

Autophagy. 2016;12(4):703-4. doi: 10.1080/15548627.2016.1143592. Erratum in: Autophagy. 2016 Jun 2;12(6):1069.


From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span.

McIsaac RS, Lewis KN, Gibney PA, Buffenstein R.

Ann N Y Acad Sci. 2016 Jan;1363:155-70. doi: 10.1111/nyas.13032. Review.


Reaching Out to Send a Message: Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat.

Triplett JC, Swomley AM, Kirk J, Grimes KM, Lewis KN, Orr ME, Rodriguez KA, Cai J, Klein JB, Buffenstein R, Butterfield DA.

Neurochem Res. 2016 Jul;41(7):1625-34. doi: 10.1007/s11064-016-1877-1. Epub 2016 Mar 2.


Determinants of rodent longevity in the chaperone-protein degradation network.

Rodriguez KA, Valentine JM, Kramer DA, Gelfond JA, Kristan DM, Nevo E, Buffenstein R.

Cell Stress Chaperones. 2016 May;21(3):453-66. doi: 10.1007/s12192-016-0672-x. Epub 2016 Feb 19.


Oxidative stress and life histories: unresolved issues and current needs.

Speakman JR, Blount JD, Bronikowski AM, Buffenstein R, Isaksson C, Kirkwood TB, Monaghan P, Ozanne SE, Beaulieu M, Briga M, Carr SK, Christensen LL, Cochemé HM, Cram DL, Dantzer B, Harper JM, Jurk D, King A, Noguera JC, Salin K, Sild E, Simons MJ, Smith S, Stier A, Tobler M, Vitikainen E, Peaker M, Selman C.

Ecol Evol. 2015 Nov 17;5(24):5745-57. doi: 10.1002/ece3.1790. eCollection 2015 Dec.


Homology cluster differential expression analysis for interspecies mRNA-Seq experiments.

Gelfond JA, Ibrahim JG, Chen MH, Sun W, Lewis K, Kinahan S, Hibbs M, Buffenstein R.

Stat Appl Genet Mol Biol. 2015 Dec;14(6):507-16. doi: 10.1515/sagmb-2014-0056.


Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity.

Ma S, Lee SG, Kim EB, Park TJ, Seluanov A, Gorbunova V, Buffenstein R, Seravalli J, Gladyshev VN.

Cell Rep. 2015 Nov 17;13(7):1319-1326. doi: 10.1016/j.celrep.2015.10.014. Epub 2015 Nov 5.


Multifactorial processes to slowing the biological clock: Insights from a comparative approach.

Sanchez JR, Milton SL, Corbit KC, Buffenstein R.

Exp Gerontol. 2015 Nov;71:27-37. doi: 10.1016/j.exger.2015.08.017. Epub 2015 Sep 4. Review.


Sympatric speciation revealed by genome-wide divergence in the blind mole rat Spalax.

Li K, Hong W, Jiao H, Wang GD, Rodriguez KA, Buffenstein R, Zhao Y, Nevo E, Zhao H.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11905-10. doi: 10.1073/pnas.1514896112. Epub 2015 Sep 4.


Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity.

Triplett JC, Tramutola A, Swomley A, Kirk J, Grimes K, Lewis K, Orr M, Rodriguez K, Cai J, Klein JB, Perluigi M, Buffenstein R, Butterfield DA.

Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2213-24. doi: 10.1016/j.bbadis.2015.08.002. Epub 2015 Aug 4.


Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.

Ma S, Yim SH, Lee SG, Kim EB, Lee SR, Chang KT, Buffenstein R, Lewis KN, Park TJ, Miller RA, Clish CB, Gladyshev VN.

Cell Metab. 2015 Aug 4;22(2):332-43. doi: 10.1016/j.cmet.2015.07.005.


Metabolic clues to salubrious longevity in the brain of the longest-lived rodent: the naked mole-rat.

Triplett JC, Swomley A, Kirk J, Lewis K, Orr M, Rodriguez K, Cai J, Klein JB, Buffenstein R, Butterfield DA.

J Neurochem. 2015 Aug;134(3):538-50. doi: 10.1111/jnc.13149. Epub 2015 Jun 3.


Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates.

Garbarino VR, Orr ME, Rodriguez KA, Buffenstein R.

Arch Biochem Biophys. 2015 Jun 15;576:8-16. doi: 10.1016/ Epub 2015 Apr 1. Review.


Regulation of Nrf2 signaling and longevity in naturally long-lived rodents.

Lewis KN, Wason E, Edrey YH, Kristan DM, Nevo E, Buffenstein R.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3722-7. doi: 10.1073/pnas.1417566112. Epub 2015 Mar 9.


Gene expression defines natural changes in mammalian lifespan.

Fushan AA, Turanov AA, Lee SG, Kim EB, Lobanov AV, Yim SH, Buffenstein R, Lee SR, Chang KT, Rhee H, Kim JS, Yang KS, Gladyshev VN.

Aging Cell. 2015 Jun;14(3):352-65. doi: 10.1111/acel.12283. Epub 2015 Feb 9. Review.


Long-lived species have improved proteostasis compared to phylogenetically-related shorter-lived species.

Pride H, Yu Z, Sunchu B, Mochnick J, Coles A, Zhang Y, Buffenstein R, Hornsby PJ, Austad SN, Pérez VI.

Biochem Biophys Res Commun. 2015 Feb 20;457(4):669-75. doi: 10.1016/j.bbrc.2015.01.046. Epub 2015 Jan 21.


Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent.

Orr ME, Garbarino VR, Salinas A, Buffenstein R.

Neurobiol Aging. 2015 Mar;36(3):1496-504. doi: 10.1016/j.neurobiolaging.2014.12.004. Epub 2014 Dec 12.


Questioning the preclinical paradigm: natural, extreme biology as an alternative discovery platform.

Buffenstein R, Nelson OL, Corbit KC.

Aging (Albany NY). 2014 Nov;6(11):913-20. Review.


Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice.

Rodriguez KA, Dodds SG, Strong R, Galvan V, Sharp ZD, Buffenstein R.

Front Mol Neurosci. 2014 Nov 4;7:83. doi: 10.3389/fnmol.2014.00083. eCollection 2014.


Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.

Fang X, Seim I, Huang Z, Gerashchenko MV, Xiong Z, Turanov AA, Zhu Y, Lobanov AV, Fan D, Yim SH, Yao X, Ma S, Yang L, Lee SG, Kim EB, Bronson RT, Šumbera R, Buffenstein R, Zhou X, Krogh A, Park TJ, Zhang G, Wang J, Gladyshev VN.

Cell Rep. 2014 Sep 11;8(5):1354-64. doi: 10.1016/j.celrep.2014.07.030. Epub 2014 Aug 28.


A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition.

Rodriguez KA, Osmulski PA, Pierce A, Weintraub ST, Gaczynska M, Buffenstein R.

Biochim Biophys Acta. 2014 Nov;1842(11):2060-72. doi: 10.1016/j.bbadis.2014.07.005. Epub 2014 Jul 10.


And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat.

Grimes KM, Reddy AK, Lindsey ML, Buffenstein R.

Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H284-91. doi: 10.1152/ajpheart.00305.2014. Epub 2014 Jun 6.


The first international mini-symposium on methionine restriction and lifespan.

Ables GP, Brown-Borg HM, Buffenstein R, Church CD, Elshorbagy AK, Gladyshev VN, Huang TH, Miller RA, Mitchell JR, Richie JP, Rogina B, Stipanuk MH, Orentreich DS, Orentreich N.

Front Genet. 2014 May 9;5:122. doi: 10.3389/fgene.2014.00122. eCollection 2014.


Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.

Orr ME, Salinas A, Buffenstein R, Oddo S.

Neurobiol Aging. 2014 Jun;35(6):1233-42. doi: 10.1016/j.neurobiolaging.2013.12.006. Epub 2013 Dec 14.


Cardiac function of the naked mole-rat: ecophysiological responses to working underground.

Grimes KM, Voorhees A, Chiao YA, Han HC, Lindsey ML, Buffenstein R.

Am J Physiol Heart Circ Physiol. 2014 Mar 1;306(5):H730-7. doi: 10.1152/ajpheart.00831.2013. Epub 2013 Dec 20.


Oxidative damage and amyloid-β metabolism in brain regions of the longest-lived rodents.

Edrey YH, Oddo S, Cornelius C, Caccamo A, Calabrese V, Buffenstein R.

J Neurosci Res. 2014 Feb;92(2):195-205. doi: 10.1002/jnr.23320. Epub 2013 Nov 22.


Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination.

Hamilton RT, Bhattacharya A, Walsh ME, Shi Y, Wei R, Zhang Y, Rodriguez KA, Buffenstein R, Chaudhuri AR, Van Remmen H.

PLoS One. 2013 Jun 4;8(6):e65725. doi: 10.1371/journal.pone.0065725. Print 2013.


Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer's disease.

Edrey YH, Medina DX, Gaczynska M, Osmulski PA, Oddo S, Caccamo A, Buffenstein R.

Neurobiol Aging. 2013 Oct;34(10):2352-60. doi: 10.1016/j.neurobiolaging.2013.03.032. Epub 2013 Apr 22.


Elevated protein carbonylation and oxidative stress do not affect protein structure and function in the long-living naked-mole rat: a proteomic approach.

De Waal EM, Liang H, Pierce A, Hamilton RT, Buffenstein R, Chaudhuri AR.

Biochem Biophys Res Commun. 2013 May 17;434(4):815-9. doi: 10.1016/j.bbrc.2013.04.019. Epub 2013 Apr 22.


Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus.

Shi Y, Pulliam DA, Liu Y, Hamilton RT, Jernigan AL, Bhattacharya A, Sloane LB, Qi W, Chaudhuri A, Buffenstein R, Ungvari Z, Austad SN, Van Remmen H.

Am J Physiol Regul Integr Comp Physiol. 2013 Mar 1;304(5):R343-55. doi: 10.1152/ajpregu.00139.2012. Epub 2013 Jan 16.


The naked mole-rat response to oxidative stress: just deal with it.

Lewis KN, Andziak B, Yang T, Buffenstein R.

Antioxid Redox Signal. 2013 Oct 20;19(12):1388-99. doi: 10.1089/ars.2012.4911. Epub 2012 Dec 7. Review.


Stress resistance in the naked mole-rat: the bare essentials - a mini-review.

Lewis KN, Mele J, Hornsby PJ, Buffenstein R.

Gerontology. 2012;58(5):453-62. doi: 10.1159/000335966. Epub 2012 May 10.


Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat.

Rodriguez KA, Edrey YH, Osmulski P, Gaczynska M, Buffenstein R.

PLoS One. 2012;7(5):e35890. doi: 10.1371/journal.pone.0035890. Epub 2012 May 2.


Getting to the heart of the matter: age-related changes in diastolic heart function in the longest-lived rodent, the naked mole rat.

Grimes KM, Lindsey ML, Gelfond JA, Buffenstein R.

J Gerontol A Biol Sci Med Sci. 2012 Apr;67(4):384-94. doi: 10.1093/gerona/glr222. Epub 2012 Feb 24.


Blunted neuronal calcium response to hypoxia in naked mole-rat hippocampus.

Peterson BL, Larson J, Buffenstein R, Park TJ, Fall CP.

PLoS One. 2012;7(2):e31568. doi: 10.1371/journal.pone.0031568. Epub 2012 Feb 21.


Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity.

Edrey YH, Casper D, Huchon D, Mele J, Gelfond JA, Kristan DM, Nevo E, Buffenstein R.

Aging Cell. 2012 Apr;11(2):213-22. doi: 10.1111/j.1474-9726.2011.00772.x. Epub 2011 Dec 29.


RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice.

Yu C, Li Y, Holmes A, Szafranski K, Faulkes CG, Coen CW, Buffenstein R, Platzer M, de Magalhães JP, Church GM.

PLoS One. 2011;6(11):e26729. doi: 10.1371/journal.pone.0026729. Epub 2011 Nov 3.


Genome sequencing reveals insights into physiology and longevity of the naked mole rat.

Kim EB, Fang X, Fushan AA, Huang Z, Lobanov AV, Han L, Marino SM, Sun X, Turanov AA, Yang P, Yim SH, Zhao X, Kasaikina MV, Stoletzki N, Peng C, Polak P, Xiong Z, Kiezun A, Zhu Y, Chen Y, Kryukov GV, Zhang Q, Peshkin L, Yang L, Bronson RT, Buffenstein R, Wang B, Han C, Li Q, Chen L, Zhao W, Sunyaev SR, Park TJ, Zhang G, Wang J, Gladyshev VN.

Nature. 2011 Oct 12;479(7372):223-7. doi: 10.1038/nature10533.

Supplemental Content

Loading ...
Support Center