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Items: 1 to 50 of 224

1.

Metadherin enhances vulnerability of cancer cells to ferroptosis.

Bi J, Yang S, Li L, Dai Q, Borcherding N, Wagner BA, Buettner GR, Spitz DR, Leslie KK, Zhang J, Meng X.

Cell Death Dis. 2019 Sep 17;10(10):682. doi: 10.1038/s41419-019-1897-2.

2.

First-in-Human Phase I Clinical Trial of Pharmacologic Ascorbate Combined with Radiation and Temozolomide for Newly Diagnosed Glioblastoma.

Allen BG, Bodeker KL, Smith MC, Monga V, Sandhu S, Hohl R, Carlisle T, Brown H, Hollenbeck N, Vollstedt S, Greenlee JD, Howard MA, Mapuskar KA, Seyedin SN, Caster JM, Jones KA, Cullen JJ, Berg D, Wagner BA, Buettner GR, TenNapel MJ, Smith BJ, Spitz DR, Buatti JM.

Clin Cancer Res. 2019 Aug 19. doi: 10.1158/1078-0432.CCR-19-0594. [Epub ahead of print]

PMID:
31427282
3.

Response to letter regarding "An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses".

Spitz DR, Buettner GR, Limoli CL.

Radiother Oncol. 2019 Oct;139:64-65. doi: 10.1016/j.radonc.2019.07.009. Epub 2019 Aug 16. No abstract available.

PMID:
31427044
4.

Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism.

Petronek MS, Spitz DR, Buettner GR, Allen BG.

Cancers (Basel). 2019 Jul 30;11(8). pii: E1077. doi: 10.3390/cancers11081077. Review.

5.

Pharmacologic Ascorbate Primes Pancreatic Cancer Cells for Death by Rewiring Cellular Energetics and Inducing DNA Damage.

Buranasudja V, Doskey CM, Gibson AR, Wagner BA, Du J, Gordon DJ, Koppenhafer SL, Cullen JJ, Buettner GR.

Mol Cancer Res. 2019 Oct;17(10):2102-2114. doi: 10.1158/1541-7786.MCR-19-0381. Epub 2019 Jul 23.

PMID:
31337671
6.

Assessment of the Stability of Supraphysiological Ascorbate in Human Blood: Appropriate Handling of Samples from Clinical Trials for Measurements of Pharmacological Ascorbate.

Petronek MS, Wagner BA, Hollenbeck NJ, Caster JM, Spitz DR, Cullen JJ, Buettner GR, Allen BG.

Radiat Res. 2019 Jun;191(6):491-496. doi: 10.1667/RR15328.1. Epub 2019 Apr 30.

PMID:
31039080
7.

An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses.

Spitz DR, Buettner GR, Petronek MS, St-Aubin JJ, Flynn RT, Waldron TJ, Limoli CL.

Radiother Oncol. 2019 Oct;139:23-27. doi: 10.1016/j.radonc.2019.03.028. Epub 2019 Apr 19.

PMID:
31010709
8.

Nox2 NADPH oxidase is dispensable for platelet activation or arterial thrombosis in mice.

Sonkar VK, Kumar R, Jensen M, Wagner BA, Sharathkumar AA, Miller FJ Jr, Fasano M, Lentz SR, Buettner GR, Dayal S.

Blood Adv. 2019 Apr 23;3(8):1272-1284. doi: 10.1182/bloodadvances.2018025569.

9.

The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome.

Traber MG, Buettner GR, Bruno RS.

Redox Biol. 2019 Feb;21:101091. doi: 10.1016/j.redox.2018.101091. Epub 2018 Dec 26. Review.

10.

Methylseleninic Acid Induces Lipid Peroxidation and Radiation Sensitivity in Head and Neck Cancer Cells.

Lafin JT, Sarsour EH, Kalen AL, Wagner BA, Buettner GR, Goswami PC.

Int J Mol Sci. 2019 Jan 8;20(1). pii: E225. doi: 10.3390/ijms20010225.

11.

Pharmacological Ascorbate as a Means of Sensitizing Cancer Cells to Radio-Chemotherapy While Protecting Normal Tissue.

Schoenfeld JD, Alexander MS, Waldron TJ, Sibenaller ZA, Spitz DR, Buettner GR, Allen BG, Cullen JJ.

Semin Radiat Oncol. 2019 Jan;29(1):25-32. doi: 10.1016/j.semradonc.2018.10.006. Review.

PMID:
30573181
12.

Enhanced Pharmacological Ascorbate Oxidation Radiosensitizes Pancreatic Cancer.

Alexander MS, O'Leary BR, Wilkes JG, Gibson AR, Wagner BA, Du J, Sarsour E, Hwang RF, Buettner GR, Cullen JJ.

Radiat Res. 2019 Jan;191(1):43-51. doi: 10.1667/RR15189.1. Epub 2018 Oct 30.

PMID:
30376411
13.

Pharmacologic Ascorbate Reduces Radiation-Induced Normal Tissue Toxicity and Enhances Tumor Radiosensitization in Pancreatic Cancer.

Alexander MS, Wilkes JG, Schroeder SR, Buettner GR, Wagner BA, Du J, Gibson-Corley K, O'Leary BR, Spitz DR, Buatti JM, Berg DJ, Bodeker KL, Vollstedt S, Brown HA, Allen BG, Cullen JJ.

Cancer Res. 2018 Dec 15;78(24):6838-6851. doi: 10.1158/0008-5472.CAN-18-1680. Epub 2018 Sep 25.

14.

Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface.

Wert KJ, Velez G, Cross MR, Wagner BA, Teoh-Fitzgerald ML, Buettner GR, McAnany JJ, Olivier A, Tsang SH, Harper MM, Domann FE, Bassuk AG, Mahajan VB.

Free Radic Biol Med. 2018 Aug 20;124:408-419. doi: 10.1016/j.freeradbiomed.2018.06.024. Epub 2018 Jun 22.

15.

Corrigendum to: Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells [Redox Biol. (2018) 82-87].

Brandt KE, Falls KC, Schoenfeld JD, Rodman SN 3rd, Gu Z, Zhan F, Cullen JJ, Wagner BA, Buettner GR, Allen BG, Berg DJ, Spitz DR, Fath MA.

Redox Biol. 2018 Jun 8:100935. doi: 10.1016/j.redox.2018.06.001. [Epub ahead of print] No abstract available.

16.

Calculated cell-specific intracellular hydrogen peroxide concentration: Relevance in cancer cell susceptibility during ascorbate therapy.

Erudaitius D, Mantooth J, Huang A, Soliman J, Doskey CM, Buettner GR, Rodgers VGJ.

Free Radic Biol Med. 2018 May 20;120:356-367. doi: 10.1016/j.freeradbiomed.2018.03.044. Epub 2018 Mar 27.

17.

Pharmacologic ascorbate (P-AscH-) suppresses hypoxia-inducible Factor-1α (HIF-1α) in pancreatic adenocarcinoma.

Wilkes JG, O'Leary BR, Du J, Klinger AR, Sibenaller ZA, Doskey CM, Gibson-Corley KN, Alexander MS, Tsai S, Buettner GR, Cullen JJ.

Clin Exp Metastasis. 2018 Feb;35(1-2):37-51. doi: 10.1007/s10585-018-9876-z. Epub 2018 Feb 2.

18.

Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner.

Heer CD, Davis AB, Riffe DB, Wagner BA, Falls KC, Allen BG, Buettner GR, Beardsley RA, Riley DP, Spitz DR.

Antioxidants (Basel). 2018 Jan 19;7(1). pii: E18. doi: 10.3390/antiox7010018.

19.

Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models.

Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Bradley MD, Wagner BA, Buettner GR, Monga V, Milhem M, Spitz DR, Allen BG.

Redox Biol. 2018 Apr;14:417-422. doi: 10.1016/j.redox.2017.09.012. Epub 2017 Sep 28.

20.

Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells.

Brandt KE, Falls KC, Schoenfeld JD, Rodman SN, Gu Z, Zhan F, Cullen JJ, Wagner BA, Buettner GR, Allen BG, Berg DJ, Spitz DR, Fath MA.

Redox Biol. 2018 Apr;14:82-87. doi: 10.1016/j.redox.2017.08.017. Epub 2017 Aug 26. Erratum in: Redox Biol. 2018 Jun 8;:.

21.

O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.

Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T, Berg DJ, Zhang J, Keech J, Parekh KR, Bhatia S, Monga V, Bodeker KL, Ahmann L, Vollstedt S, Brown H, Kauffman EPS, Schall ME, Hohl RJ, Clamon GH, Greenlee JD, Howard MA, Schultz MK, Smith BJ, Riley DP, Domann FE, Cullen JJ, Buettner GR, Buatti JM, Spitz DR, Allen BG.

Cancer Cell. 2017 Aug 14;32(2):268. doi: 10.1016/j.ccell.2017.07.008. No abstract available.

22.

Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging.

Son JM, Sarsour EH, Kakkerla Balaraju A, Fussell J, Kalen AL, Wagner BA, Buettner GR, Goswami PC.

Aging Cell. 2017 Oct;16(5):1136-1145. doi: 10.1111/acel.12649. Epub 2017 Jul 31.

23.

O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.

Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T, Berg DJ, Zhang J, Keech J, Parekh KR, Bhatia S, Monga V, Bodeker KL, Ahmann L, Vollstedt S, Brown H, Shanahan Kauffman EP, Schall ME, Hohl RJ, Clamon GH, Greenlee JD, Howard MA, Schultz MK, Smith BJ, Riley DP, Domann FE, Cullen JJ, Buettner GR, Buatti JM, Spitz DR, Allen BG.

Cancer Cell. 2017 Apr 10;31(4):487-500.e8. doi: 10.1016/j.ccell.2017.02.018. Epub 2017 Mar 30. Erratum in: Cancer Cell. 2017 Aug 14;32(2):268.

24.

Peroxiporin Expression Is an Important Factor for Cancer Cell Susceptibility to Therapeutic H2O2: Implications for Pharmacological Ascorbate Therapy.

Erudaitius D, Huang A, Kazmi S, Buettner GR, Rodgers VG.

PLoS One. 2017 Jan 20;12(1):e0170442. doi: 10.1371/journal.pone.0170442. eCollection 2017.

25.

Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy.

Doskey CM, Buranasudja V, Wagner BA, Wilkes JG, Du J, Cullen JJ, Buettner GR.

Redox Biol. 2016 Dec;10:274-284. doi: 10.1016/j.redox.2016.10.010. Epub 2016 Oct 28.

26.

Antioxidant-Mediated Modulation of Protein Reactivity for 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite.

Anderson DG, Florang VR, Schamp JH, Buettner GR, Doorn JA.

Chem Res Toxicol. 2016 Jul 18;29(7):1098-107. doi: 10.1021/acs.chemrestox.5b00528. Epub 2016 Jun 15.

27.

Direct spectrophotometric measurement of supra-physiological levels of ascorbate in plasma.

Witmer JR, Wetherell BJ, Wagner BA, Du J, Cullen JJ, Buettner GR.

Redox Biol. 2016 Aug;8:298-304. doi: 10.1016/j.redox.2016.02.004. Epub 2016 Feb 13.

28.

In vivo imaging of free radicals produced by multivitamin-mineral supplements.

Rabovsky AB, Buettner GR, Fink B.

BMC Nutr. 2015 Dec;1. pii: 32. Epub 2015 Nov 14.

29.

Monohydroxylated Polybrominated Diphenyl Ethers (OH-PBDEs) and Dihydroxylated Polybrominated Biphenyls (Di-OH-PBBs): Novel Photoproducts of 2,6-Dibromophenol.

Zhao H, Jiang J, Wang Y, Lehmler HJ, Buettner GR, Quan X, Chen J.

Environ Sci Technol. 2015 Dec 15;49(24):14120-8. doi: 10.1021/acs.est.5b03637. Epub 2015 Nov 16.

30.

Breaking the dogma: PCB-derived semiquinone free radicals do not form covalent adducts with DNA, GSH, and amino acids.

Wangpradit O, Rahaman A, Mariappan SV, Buettner GR, Robertson LW, Luthe G.

Environ Sci Pollut Res Int. 2016 Feb;23(3):2138-47. doi: 10.1007/s11356-015-5007-4. Epub 2015 Sep 23.

31.

Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture.

Doskey CM, van 't Erve TJ, Wagner BA, Buettner GR.

PLoS One. 2015 Jul 14;10(7):e0132572. doi: 10.1371/journal.pone.0132572. eCollection 2015.

32.

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.

Rasmussen TP, Wu Y, Joiner ML, Koval OM, Wilson NR, Luczak ED, Wang Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto J, McCormick ML, Kutschke W, Weiss RM, Yu L, Boudreau RL, Abel ED, Zhan F, Spitz DR, Buettner GR, Song LS, Zingman LV, Anderson ME.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9129-34. doi: 10.1073/pnas.1504705112. Epub 2015 Jul 7.

33.

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer.

Du J, Cieslak JA 3rd, Welsh JL, Sibenaller ZA, Allen BG, Wagner BA, Kalen AL, Doskey CM, Strother RK, Button AM, Mott SL, Smith B, Tsai S, Mezhir J, Goswami PC, Spitz DR, Buettner GR, Cullen JJ.

Cancer Res. 2015 Aug 15;75(16):3314-26. doi: 10.1158/0008-5472.CAN-14-1707. Epub 2015 Jun 16.

34.

Role of labile iron in the toxicity of pharmacological ascorbate.

Du J, Wagner BA, Buettner GR, Cullen JJ.

Free Radic Biol Med. 2015 Jul;84:289-295. doi: 10.1016/j.freeradbiomed.2015.03.033. Epub 2015 Apr 7.

35.

Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer.

Cieslak JA, Strother RK, Rawal M, Du J, Doskey CM, Schroeder SR, Button A, Wagner BA, Buettner GR, Cullen JJ.

Free Radic Biol Med. 2015 Jun;83:227-37. doi: 10.1016/j.freeradbiomed.2015.02.018. Epub 2015 Feb 26.

36.

The heritability of hemolysis in stored human red blood cells.

Van 't Erve TJ, Wagner BA, Martin SM, Knudson CM, Blendowski R, Keaton M, Holt T, Hess JR, Buettner GR, Ryckman KK, Darbro BW, Murray JC, Raife TJ.

Transfusion. 2015 Jun;55(6):1178-85. doi: 10.1111/trf.12992. Epub 2015 Feb 2.

37.

Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma.

O'Leary BR, Fath MA, Bellizzi AM, Hrabe JE, Button AM, Allen BG, Case AJ, Altekruse S, Wagner BA, Buettner GR, Lynch CF, Hernandez BY, Cozen W, Beardsley RA, Keene J, Henry MD, Domann FE, Spitz DR, Mezhir JJ.

Clin Cancer Res. 2015 Apr 1;21(7):1741-51. doi: 10.1158/1078-0432.CCR-14-1959. Epub 2015 Jan 29.

38.

Moving free radical and redox biology ahead in the next decade(s).

Buettner GR.

Free Radic Biol Med. 2015 Jan;78:236-8. doi: 10.1016/j.freeradbiomed.2014.10.578. Epub 2014 Nov 4. No abstract available.

39.

Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes.

Xiao W, Sarsour EH, Wagner BA, Doskey CM, Buettner GR, Domann FE, Goswami PC.

Arch Toxicol. 2016 Feb;90(2):319-32. doi: 10.1007/s00204-014-1407-3. Epub 2014 Nov 23.

40.

The 'mitoflash' probe cpYFP does not respond to superoxide.

Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP.

Nature. 2014 Oct 23;514(7523):E12-4. doi: 10.1038/nature13858. No abstract available.

41.

Forkhead box M1 regulates quiescence-associated radioresistance of human head and neck squamous carcinoma cells.

Eckers JC, Kalen AL, Sarsour EH, Tompkins VS, Janz S, Son JM, Doskey CM, Buettner GR, Goswami PC.

Radiat Res. 2014 Oct;182(4):420-9. doi: 10.1667/RR13726.1. Epub 2014 Sep 17.

42.

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.

Ozden O, Park SH, Wagner BA, Song HY, Zhu Y, Vassilopoulos A, Jung B, Buettner GR, Gius D.

Free Radic Biol Med. 2014 Nov;76:163-172. doi: 10.1016/j.freeradbiomed.2014.08.001. Epub 2014 Aug 22.

43.

Heritability of glutathione and related metabolites in stored red blood cells.

van 't Erve TJ, Doskey CM, Wagner BA, Hess JR, Darbro BW, Ryckman KK, Murray JC, Raife TJ, Buettner GR.

Free Radic Biol Med. 2014 Nov;76:107-13. doi: 10.1016/j.freeradbiomed.2014.07.040. Epub 2014 Aug 7.

44.

The heritability of metabolite concentrations in stored human red blood cells.

van 't Erve TJ, Wagner BA, Martin SM, Knudson CM, Blendowski R, Keaton M, Holt T, Hess JR, Buettner GR, Ryckman KK, Darbro BW, Murray JC, Raife TJ.

Transfusion. 2014 Aug;54(8):2055-63. doi: 10.1111/trf.12605. Epub 2014 Mar 6.

45.

Extracellular superoxide dismutase suppresses hypoxia-inducible factor-1α in pancreatic cancer.

Sibenaller ZA, Welsh JL, Du C, Witmer JR, Schrock HE, Du J, Buettner GR, Goswami PC, Cieslak JA 3rd, Cullen JJ.

Free Radic Biol Med. 2014 Apr;69:357-66. doi: 10.1016/j.freeradbiomed.2014.02.002. Epub 2014 Feb 7.

46.

Pharmacological ascorbate and ionizing radiation (IR) increase labile iron in pancreatic cancer.

Moser JC, Rawal M, Wagner BA, Du J, Cullen JJ, Buettner GR.

Redox Biol. 2013 Nov 26;2:22-7. doi: 10.1016/j.redox.2013.11.005. eCollection 2013.

47.

The concentration of glutathione in human erythrocytes is a heritable trait.

van 't Erve TJ, Wagner BA, Ryckman KK, Raife TJ, Buettner GR.

Free Radic Biol Med. 2013 Dec;65:742-749. doi: 10.1016/j.freeradbiomed.2013.08.002. Epub 2013 Aug 9.

48.

An Assay for the Rate of Removal of Extracellular Hydrogen Peroxide by Cells.

Wagner BA, Witmer JR, van 't Erve TJ, Buettner GR.

Redox Biol. 2013;1(1):210-217.

49.

CaMKII is essential for the proasthmatic effects of oxidation.

Sanders PN, Koval OM, Jaffer OA, Prasad AM, Businga TR, Scott JA, Hayden PJ, Luczak ED, Dickey DD, Allamargot C, Olivier AK, Meyerholz DK, Robison AJ, Winder DG, Blackwell TS, Dworski R, Sammut D, Wagner BA, Buettner GR, Pope RM, Miller FJ Jr, Dibbern ME, Haitchi HM, Mohler PJ, Howarth PH, Zabner J, Kline JN, Grumbach IM, Anderson ME.

Sci Transl Med. 2013 Jul 24;5(195):195ra97. doi: 10.1126/scitranslmed.3006135.

50.

Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation.

Rawal M, Schroeder SR, Wagner BA, Cushing CM, Welsh JL, Button AM, Du J, Sibenaller ZA, Buettner GR, Cullen JJ.

Cancer Res. 2013 Aug 15;73(16):5232-41. doi: 10.1158/0008-5472.CAN-13-0470. Epub 2013 Jun 13.

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