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Items: 32


Drug-induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias.

Passini E, Trovato C, Morissette P, Sannajust F, Bueno-Orovio A, Rodriguez B.

Br J Pharmacol. 2019 Jul 4. doi: 10.1111/bph.14786. [Epub ahead of print]


Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D.

Zhou X, Bueno-Orovio A, Schilling RJ, Kirkby C, Denning C, Rajamohan D, Burrage K, Tinker A, Rodriguez B, Harmer SC.

Front Physiol. 2019 Mar 18;10:259. doi: 10.3389/fphys.2019.00259. eCollection 2019.


Electrocardiogram phenotypes in hypertrophic cardiomyopathy caused by distinct mechanisms: apico-basal repolarization gradients vs. Purkinje-myocardial coupling abnormalities.

Lyon A, Bueno-Orovio A, Zacur E, Ariga R, Grau V, Neubauer S, Watkins H, Rodriguez B, Mincholé A.

Europace. 2018 Nov 1;20(suppl_3):iii102-iii112. doi: 10.1093/europace/euy226.


Commentary: Atrial Rotor Dynamics Under Complex Fractional Order Diffusion.

Bueno-Orovio A.

Front Physiol. 2018 Oct 4;9:1386. doi: 10.3389/fphys.2018.01386. eCollection 2018. No abstract available.


Slow Recovery of Excitability Increases Ventricular Fibrillation Risk as Identified by Emulation.

Lawson BA, Burrage K, Burrage P, Drovandi CC, Bueno-Orovio A.

Front Physiol. 2018 Aug 28;9:1114. doi: 10.3389/fphys.2018.01114. eCollection 2018.


Strategies of data layout and cache writing for input-output optimization in high performance scientific computing: Applications to the forward electrocardiographic problem.

Cardone-Noott L, Rodriguez B, Bueno-Orovio A.

PLoS One. 2018 Aug 23;13(8):e0202410. doi: 10.1371/journal.pone.0202410. eCollection 2018.


From ionic to cellular variability in human atrial myocytes: an integrative computational and experimental study.

Muszkiewicz A, Liu X, Bueno-Orovio A, Lawson BAJ, Burrage K, Casadei B, Rodriguez B.

Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H895-H916. doi: 10.1152/ajpheart.00477.2017. Epub 2017 Dec 22.


Corrigendum: The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study.

Britton OJ, Bueno-Orovio A, Virág L, Varró A, Rodriguez B.

Front Physiol. 2017 Nov 17;8:954. doi: 10.3389/fphys.2017.00954. eCollection 2017.


Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity.

Passini E, Britton OJ, Lu HR, Rohrbacher J, Hermans AN, Gallacher DJ, Greig RJH, Bueno-Orovio A, Rodriguez B.

Front Physiol. 2017 Sep 12;8:668. doi: 10.3389/fphys.2017.00668. eCollection 2017.


Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics.

Sánchez C, Bueno-Orovio A, Pueyo E, Rodríguez B.

Front Bioeng Biotechnol. 2017 May 8;5:29. doi: 10.3389/fbioe.2017.00029. eCollection 2017.


The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study.

Britton OJ, Bueno-Orovio A, Virág L, Varró A, Rodriguez B.

Front Physiol. 2017 May 5;8:278. doi: 10.3389/fphys.2017.00278. eCollection 2017. Erratum in: Front Physiol. 2017 Nov 17;8:954.


Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart.

Santos D, Orini M, Zhou X, Bueno-Orovio A, Hanson B, Taggart P, Hayward M, Rodriguez B, Lambiase P.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:157-160. doi: 10.1109/EMBC.2016.7590664.


Human ventricular activation sequence and the simulation of the electrocardiographic QRS complex and its variability in healthy and intraventricular block conditions.

Cardone-Noott L, Bueno-Orovio A, Mincholé A, Zemzemi N, Rodriguez B.

Europace. 2016 Dec;18(suppl 4):iv4-iv15. doi: 10.1093/europace/euw346.


Reply to the Editor-On misuse of null hypothesis testing: Analysis of biophysical model simulations.

Liberos A, Bueno-Orovio A, Rodrigo M, Ravens U, Hernandez-Romero I, Fernandez-Aviles F, Guillem MS, Rodriguez B, Climent AM.

Heart Rhythm. 2017 Apr;14(4):e50-e51. doi: 10.1016/j.hrthm.2016.12.011. Epub 2016 Dec 15. No abstract available.


Balance between sodium and calcium currents underlying chronic atrial fibrillation termination: An in silico intersubject variability study.

Liberos A, Bueno-Orovio A, Rodrigo M, Ravens U, Hernandez-Romero I, Fernandez-Aviles F, Guillem MS, Rodriguez B, Climent AM.

Heart Rhythm. 2016 Dec;13(12):2358-2365. doi: 10.1016/j.hrthm.2016.08.028. Epub 2016 Aug 26.


Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase.

Reilly SN, Liu X, Carnicer R, Recalde A, Muszkiewicz A, Jayaram R, Carena MC, Wijesurendra R, Stefanini M, Surdo NC, Lomas O, Ratnatunga C, Sayeed R, Krasopoulos G, Rajakumar T, Bueno-Orovio A, Verheule S, Fulga TA, Rodriguez B, Schotten U, Casadei B.

Sci Transl Med. 2016 May 25;8(340):340ra74. doi: 10.1126/scitranslmed.aac4296.


Anomalous Diffusion in Cardiac Tissue as an Index of Myocardial Microstructure.

Bueno-Orovio A, Teh I, Schneider JE, Burrage K, Grau V.

IEEE Trans Med Imaging. 2016 Sep;35(9):2200-2207. doi: 10.1109/TMI.2016.2548503. Epub 2016 May 2.


Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm.

Muszkiewicz A, Britton OJ, Gemmell P, Passini E, Sánchez C, Zhou X, Carusi A, Quinn TA, Burrage K, Bueno-Orovio A, Rodriguez B.

Prog Biophys Mol Biol. 2016 Jan;120(1-3):115-27. doi: 10.1016/j.pbiomolbio.2015.12.002. Epub 2015 Dec 14.


On the Order of the Fractional Laplacian in Determining the Spatio-Temporal Evolution of a Space-Fractional Model of Cardiac Electrophysiology.

Cusimano N, Bueno-Orovio A, Turner I, Burrage K.

PLoS One. 2015 Dec 2;10(12):e0143938. doi: 10.1371/journal.pone.0143938. eCollection 2015.


Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop.

Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RA, Carapella V, Cardone-Noott L, Daniels MJ, Davies MR, Dutta S, Ghetti A, Grau V, Harmer S, Kopljar I, Lambiase P, Lu HR, Lyon A, Minchole A, Muszkiewicz A, Oster J, Paci M, Passini E, Severi S, Taggart P, Tinker A, Valentin JP, Varro A, Wallman M, Zhou X.

Europace. 2016 Sep;18(9):1287-98. doi: 10.1093/europace/euv320. Epub 2015 Nov 29.


In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes.

Zhou X, Bueno-Orovio A, Orini M, Hanson B, Hayward M, Taggart P, Lambiase PD, Burrage K, Rodriguez B.

Circ Res. 2016 Jan 22;118(2):266-78. doi: 10.1161/CIRCRESAHA.115.307836. Epub 2015 Nov 24.


Basis for the Induction of Tissue-Level Phase-2 Reentry as a Repolarization Disorder in the Brugada Syndrome.

Bueno-Orovio A, Cherry EM, Evans SJ, Fenton FH.

Biomed Res Int. 2015;2015:197586. doi: 10.1155/2015/197586. Epub 2015 Oct 25.


Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy.

Passini E, Mincholé A, Coppini R, Cerbai E, Rodriguez B, Severi S, Bueno-Orovio A.

J Mol Cell Cardiol. 2016 Jul;96:72-81. doi: 10.1016/j.yjmcc.2015.09.003. Epub 2015 Sep 16.


ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk.

Mincholé A, Bueno-Orovio A, Laguna P, Pueyo E, Rodriguez B.

J Electrocardiol. 2015 Sep-Oct;48(5):867-73. doi: 10.1016/j.jelectrocard.2015.06.006. Epub 2015 Jun 6.


Inter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation.

Sánchez C, Bueno-Orovio A, Wettwer E, Loose S, Simon J, Ravens U, Pueyo E, Rodriguez B.

PLoS One. 2014 Aug 26;9(8):e105897. doi: 10.1371/journal.pone.0105897. eCollection 2014.


Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization.

Bueno-Orovio A, Kay D, Grau V, Rodriguez B, Burrage K.

J R Soc Interface. 2014 Aug 6;11(97):20140352. doi: 10.1098/rsif.2014.0352.


Slow adaptation of ventricular repolarization as a cause of arrhythmia?

Bueno-Orovio A, Hanson BM, Gill JS, Taggart P, Rodriguez B.

Methods Inf Med. 2014;53(4):320-3. doi: 10.3414/ME13-02-0039. Epub 2014 May 9.


Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology.

Britton OJ, Bueno-Orovio A, Van Ammel K, Lu HR, Towart R, Gallacher DJ, Rodriguez B.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):E2098-105. doi: 10.1073/pnas.1304382110. Epub 2013 May 20.


Na/K pump regulation of cardiac repolarization: insights from a systems biology approach.

Bueno-Orovio A, Sánchez C, Pueyo E, Rodriguez B.

Pflugers Arch. 2014 Feb;466(2):183-93. doi: 10.1007/s00424-013-1293-1. Epub 2013 May 15. Review.


In vivo human left-to-right ventricular differences in rate adaptation transiently increase pro-arrhythmic risk following rate acceleration.

Bueno-Orovio A, Hanson BM, Gill JS, Taggart P, Rodriguez B.

PLoS One. 2012;7(12):e52234. doi: 10.1371/journal.pone.0052234. Epub 2012 Dec 20.


The Na+/K+ pump is an important modulator of refractoriness and rotor dynamics in human atrial tissue.

Sánchez C, Corrias A, Bueno-Orovio A, Davies M, Swinton J, Jacobson I, Laguna P, Pueyo E, Rodríguez B.

Am J Physiol Heart Circ Physiol. 2012 Mar 1;302(5):H1146-59. doi: 10.1152/ajpheart.00668.2011. Epub 2011 Dec 23.


Minimal model for human ventricular action potentials in tissue.

Bueno-Orovio A, Cherry EM, Fenton FH.

J Theor Biol. 2008 Aug 7;253(3):544-60. doi: 10.1016/j.jtbi.2008.03.029. Epub 2008 Apr 8.


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