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Items: 1 to 50 of 57

1.

PINK1 deficiency is associated with increased deficits of adult hippocampal neurogenesis and lowers the threshold for stress-induced depression in mice.

Agnihotri SK, Sun L, Yee BK, Shen R, Akundi RS, Zhi L, Duncan MJ, Cass WA, Büeler H.

Behav Brain Res. 2019 May 2;363:161-172. doi: 10.1016/j.bbr.2019.02.006. Epub 2019 Feb 5.

PMID:
30735759
2.

Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death.

Sun L, Shen R, Agnihotri SK, Chen Y, Huang Z, Büeler H.

Sci Rep. 2018 Jan 10;8(1):383. doi: 10.1038/s41598-017-18786-w.

3.

Loss of PINK1 leads to metabolic deficits in adult neural stem cells and impedes differentiation of newborn neurons in the mouse hippocampus.

Agnihotri SK, Shen R, Li J, Gao X, Büeler H.

FASEB J. 2017 Jul;31(7):2839-2853. doi: 10.1096/fj.201600960RR. Epub 2017 Mar 21.

PMID:
28325755
4.

Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease.

Triplett JC, Zhang Z, Sultana R, Cai J, Klein JB, Büeler H, Butterfield DA.

J Neurochem. 2015 Jun;133(5):750-65. doi: 10.1111/jnc.13039. Epub 2015 Mar 1.

5.

The use of an adeno-associated viral vector for efficient bicistronic expression of two genes in the central nervous system.

Hutson TH, Kathe C, Menezes SC, Rooney MC, Bueler H, Moon LD.

Methods Mol Biol. 2014;1162:189-207. doi: 10.1007/978-1-4939-0777-9_16.

6.

Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice.

Sanchez G, Varaschin RK, Büeler H, Marcogliese PC, Park DS, Trudeau LE.

PLoS One. 2014 Apr 14;9(4):e94826. doi: 10.1371/journal.pone.0094826. eCollection 2014.

7.

Mitochondrial and cytosolic roles of PINK1 shape induced regulatory T-cell development and function.

Ellis GI, Zhi L, Akundi R, Büeler H, Marti F.

Eur J Immunol. 2013 Dec;43(12):3355-60. doi: 10.1002/eji.201343571. Epub 2013 Sep 14.

8.

Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons.

Wang R, Li JJ, Diao S, Kwak YD, Liu L, Zhi L, Büeler H, Bhat NR, Williams RW, Park EA, Liao FF.

Cell Metab. 2013 May 7;17(5):685-94. doi: 10.1016/j.cmet.2013.03.016.

9.

Shared and cell type-specific mitochondrial defects and metabolic adaptations in primary cells from PINK1-deficient mice.

Akundi RS, Zhi L, Sullivan PG, Büeler H.

Neurodegener Dis. 2013;12(3):136-49. doi: 10.1159/000345689. Epub 2012 Dec 29.

PMID:
23295771
10.

PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis.

Akundi RS, Zhi L, Büeler H.

Neurobiol Dis. 2012 Jan;45(1):469-78. doi: 10.1016/j.nbd.2011.08.034. Epub 2011 Sep 16.

11.

Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice.

Akundi RS, Huang Z, Eason J, Pandya JD, Zhi L, Cass WA, Sullivan PG, Büeler H.

PLoS One. 2011 Jan 13;6(1):e16038. doi: 10.1371/journal.pone.0016038.

12.

Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways.

Saini N, Oelhafen S, Hua H, Georgiev O, Schaffner W, Büeler H.

Neurobiol Dis. 2010 Oct;40(1):82-92. doi: 10.1016/j.nbd.2010.05.011. Epub 2010 May 17.

PMID:
20483372
13.

Mitochondrial dynamics, cell death and the pathogenesis of Parkinson's disease.

Büeler H.

Apoptosis. 2010 Nov;15(11):1336-53. doi: 10.1007/s10495-010-0465-0. Review.

PMID:
20131004
14.

Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction.

Sulg M, Kirjavainen A, Pajusola K, Bueler H, Ylikoski J, Laiho M, Pirvola U.

J Neurochem. 2010 Mar;112(6):1513-26. doi: 10.1111/j.1471-4159.2009.06563.x. Epub 2009 Dec 26.

15.

Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease.

Büeler H.

Exp Neurol. 2009 Aug;218(2):235-46. doi: 10.1016/j.expneurol.2009.03.006. Epub 2009 Mar 18. Review.

PMID:
19303005
16.
17.

DJ-1 and Parkin Modulate Dopamine-dependent Behavior and Inhibit MPTP-induced Nigral Dopamine Neuron Loss in Mice.

Paterna JC, Leng A, Weber E, Feldon J, Büeler H.

Mol Ther. 2007 Jun;15(6):1221. doi: 10.1038/sj.mt.6300154. Epub 2016 Dec 7. No abstract available.

18.

Predominant neuritic pathology induced by viral overexpression of alpha-synuclein in cell culture.

Zach S, Bueler H, Hengerer B, Gillardon F.

Cell Mol Neurobiol. 2007 Jun;27(4):505-15. Epub 2007 Mar 23.

PMID:
17380380
19.

DJ-1 and Parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice.

Paterna JC, Leng A, Weber E, Feldon J, Büeler H.

Mol Ther. 2007 Apr;15(4):698-704. Epub 2007 Feb 13. Erratum in: Mol Ther. 2007 Jun;15(6):1221.

20.

[Molecular mechanisms and genetics. Parkinson disease].

Büeler H.

Pharm Unserer Zeit. 2006;35(3):198-203. Review. German. No abstract available.

PMID:
16724523
23.

Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors.

Gruchała M, Bhardwaj S, Pajusola K, Roy H, Rissanen TT, Kokina I, Kholová I, Markkanen JE, Rutanen J, Heikura T, Alitalo K, Büeler H, Ylä-Herttuala S.

J Gene Med. 2004 May;6(5):545-54.

PMID:
15133765
24.

A mouse to remember.

Weissmann C, Büeler H.

Cell. 2004 Jan 23;116(2 Suppl):S111-3, 2 p following S113. No abstract available.

25.

Analysis of HER2 and HER4 in human myocardium to clarify the cardiotoxicity of trastuzumab (Herceptin).

Fuchs IB, Landt S, Bueler H, Kuehl U, Coupland S, Kleine-Tebbe A, Lichtenegger W, Schaller G.

Breast Cancer Res Treat. 2003 Nov;82(1):23-8.

PMID:
14672400
26.

Spatial and temporal organization of adeno-associated virus DNA replication in live cells.

Fraefel C, Bittermann AG, Büeler H, Heid I, Bächi T, Ackermann M.

J Virol. 2004 Jan;78(1):389-98.

27.

Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice.

Jalkanen J, Leppänen P, Pajusola K, Närvänen O, Mähönen A, Vähäkangas E, Greaves DR, Büeler H, Ylä-Herttuala S.

Mol Ther. 2003 Dec;8(6):903-10.

28.

Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1.

Dong Z, Ferger B, Paterna JC, Vogel D, Furler S, Osinde M, Feldon J, Büeler H.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12438-43. Epub 2003 Oct 6.

29.

Adeno-associated virus (AAV) vectors achieve prolonged transgene expression in mouse myocardium and arteries in vivo: a comparative study with adenovirus vectors.

Vassalli G, Büeler H, Dudler J, von Segesser LK, Kappenberger L.

Int J Cardiol. 2003 Aug;90(2-3):229-38.

PMID:
12957756
30.

Recombinant adeno-associated virus vector design and gene expression in the mammalian brain.

Paterna JC, Büeler H.

Methods. 2002 Oct;28(2):208-18. Review.

PMID:
12413419
31.

Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cells.

Pajusola K, Gruchala M, Joch H, Lüscher TF, Ylä-Herttuala S, Büeler H.

J Virol. 2002 Nov;76(22):11530-40.

33.

Lymphangiogenic gene therapy with minimal blood vascular side effects.

Saaristo A, Veikkola T, Tammela T, Enholm B, Karkkainen MJ, Pajusola K, Bueler H, Ylä-Herttuala S, Alitalo K.

J Exp Med. 2002 Sep 16;196(6):719-30.

34.

Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes.

Saaristo A, Veikkola T, Enholm B, Hytönen M, Arola J, Pajusola K, Turunen P, Jeltsch M, Karkkainen MJ, Kerjaschki D, Bueler H, Ylä-Herttuala S, Alitalo K.

FASEB J. 2002 Jul;16(9):1041-9.

PMID:
12087065
35.

A model for gene therapy of human hereditary lymphedema.

Karkkainen MJ, Saaristo A, Jussila L, Karila KA, Lawrence EC, Pajusola K, Bueler H, Eichmann A, Kauppinen R, Kettunen MI, Yla-Herttuala S, Finegold DN, Ferrell RE, Alitalo K.

Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12677-82. Epub 2001 Oct 9.

37.

Gene transfer into neurons from hippocampal slices: comparison of recombinant Semliki Forest Virus, adenovirus, adeno-associated virus, lentivirus, and measles virus.

Ehrengruber MU, Hennou S, Büeler H, Naim HY, Déglon N, Lundstrom K.

Mol Cell Neurosci. 2001 May;17(5):855-71.

PMID:
11358483
38.

Influence of promoter and WHV post-transcriptional regulatory element on AAV-mediated transgene expression in the rat brain.

Paterna JC, Moccetti T, Mura A, Feldon J, Büeler H.

Gene Ther. 2000 Aug;7(15):1304-11.

39.
40.

Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2.

Azzouz M, Hottinger A, Paterna JC, Zurn AD, Aebischer P, Büeler H.

Hum Mol Genet. 2000 Mar 22;9(5):803-11.

PMID:
10749988
41.

Adenoviral and adeno-associated viral transfer of genes to the peripheral nervous system.

Glatzel M, Flechsig E, Navarro B, Klein MA, Paterna JC, Büeler H, Aguzzi A.

Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):442-7.

42.

Adeno-associated viral vectors for gene transfer and gene therapy.

Büeler H.

Biol Chem. 1999 Jun;380(6):613-22. Review.

PMID:
10430026
43.

The use of transgenic mice in the investigation of transmissible spongiform encephalopathies.

Weissmann C, Fischer M, Raeber A, Büeler H, Sailer A, Shmerling D, Rülicke T, Brandner S, Aguzzi A.

Rev Sci Tech. 1998 Apr;17(1):278-90. Review.

44.

The use of transgenic mice in the investigation of transmissible spongiform encephalopathies.

Weissmann C, Fischer M, Raeber A, Büeler H, Sailer A, Shmerling D, Rülicke T, Brandner S, Aguzzi A.

Int J Exp Pathol. 1996 Dec;77(6):283-93. Review. No abstract available.

46.

The role of PrP in pathogenesis of experimental scrapie.

Weissmann C, Fischer M, Raeber A, Büeler H, Sailer A, Shmerling D, Rülicke T, Brandner S, Aguzzi A.

Cold Spring Harb Symp Quant Biol. 1996;61:511-22. Review. No abstract available.

PMID:
9246477
47.

High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene.

Büeler H, Raeber A, Sailer A, Fischer M, Aguzzi A, Weissmann C.

Mol Med. 1994 Nov;1(1):19-30.

48.

No propagation of prions in mice devoid of PrP.

Sailer A, Büeler H, Fischer M, Aguzzi A, Weissmann C.

Cell. 1994 Jul 1;77(7):967-8. No abstract available.

PMID:
7912659
49.

PrP-deficient mice are resistant to scrapie.

Weissmann C, Büeler H, Fischer M, Sailer A, Aguzzi A, Aguet M.

Ann N Y Acad Sci. 1994 Jun 6;724:235-40.

PMID:
8030944
50.

Susceptibility to scrapie in mice is dependent on PrPC.

Weissmann C, Büeler H, Fischer M, Sauer A, Aguet M.

Philos Trans R Soc Lond B Biol Sci. 1994 Mar 29;343(1306):431-3. Review.

PMID:
7913762

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