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Items: 1 to 50 of 229

1.

The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer's Disease.

Cellai L, Carvalho K, Faivre E, Deleau A, Vieau D, Buée L, Blum D, Mériaux C, Gomez-Murcia V.

Front Neurosci. 2018 Aug 3;12:520. doi: 10.3389/fnins.2018.00520. eCollection 2018. Review.

2.

Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease.

Faivre E, Coelho JE, Zornbach K, Malik E, Baqi Y, Schneider M, Cellai L, Carvalho K, Sebda S, Figeac M, Eddarkaoui S, Caillierez R, Chern Y, Heneka M, Sergeant N, Müller CE, Halle A, Buée L, Lopes LV, Blum D.

Front Mol Neurosci. 2018 Jul 12;11:235. doi: 10.3389/fnmol.2018.00235. eCollection 2018.

3.

The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease.

Blum D, Chern Y, Domenici MR, Buée L, Lin CY, Rea W, Ferré S, Popoli P.

J Caffeine Adenosine Res. 2018 Jun 1;8(2):43-58. doi: 10.1089/caff.2018.0006. Review.

4.

A-kinase anchor protein 4 precursor (pro-AKAP4) in human spermatozoa.

Jumeau F, Sigala J, Dossou-Gbete F, Frimat K, Barbotin AL, Buée L, Béhal H, Sergeant N, Mitchell V.

Andrology. 2018 Jul 8. doi: 10.1111/andr.12524. [Epub ahead of print]

PMID:
29984477
5.

Tau/DDX6 interaction increases microRNA activity.

Chauderlier A, Gilles M, Spolcova A, Caillierez R, Chwastyniak M, Kress M, Drobecq H, Bonnefoy E, Pinet F, Weil D, Buée L, Galas MC, Lefebvre B.

Biochim Biophys Acta Gene Regul Mech. 2018 Aug;1861(8):762-772. doi: 10.1016/j.bbagrm.2018.06.006. Epub 2018 Jun 30.

PMID:
29966762
6.

Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors.

Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, Baqi Y, Müller CE, Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV.

Mol Psychiatry. 2018 Jun 27. doi: 10.1038/s41380-018-0110-9. [Epub ahead of print]

PMID:
29950682
7.

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

Laurent C, Buée L, Blum D.

Biomed J. 2018 Feb;41(1):21-33. doi: 10.1016/j.bj.2018.01.003. Epub 2018 Mar 20. Review.

8.

Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer's Disease.

Lee CC, Chang CP, Lin CJ, Lai HL, Kao YH, Cheng SJ, Chen HM, Liao YP, Faivre E, Buée L, Blum D, Fang JM, Chern Y.

Mol Neurobiol. 2018 Apr 4. doi: 10.1007/s12035-018-1030-z. [Epub ahead of print]

PMID:
29616397
9.

New phenylaniline derivatives as modulators of amyloid protein precursor metabolism.

Gay M, Carato P, Coevoet M, Renault N, Larchanché PE, Barczyk A, Yous S, Buée L, Sergeant N, Melnyk P.

Bioorg Med Chem. 2018 May 1;26(8):2151-2164. doi: 10.1016/j.bmc.2018.03.016. Epub 2018 Mar 12.

PMID:
29559198
10.

Study of AMPK-Regulated Metabolic Fluxes in Neurons Using the Seahorse XFe Analyzer.

Marinangeli C, Kluza J, Marchetti P, Buée L, Vingtdeux V.

Methods Mol Biol. 2018;1732:289-305. doi: 10.1007/978-1-4939-7598-3_19.

PMID:
29480483
11.

Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers.

Hanon O, Vidal JS, Lehmann S, Bombois S, Allinquant B, Tréluyer JM, Gelé P, Delmaire C, Blanc F, Mangin JF, Buée L, Touchon J, Hugon J, Vellas B, Galbrun E, Benetos A, Berrut G, Paillaud E, Wallon D, Castelnovo G, Volpe-Gillot L, Paccalin M, Robert PH, Godefroy O, Dantoine T, Camus V, Belmin J, Vandel P, Novella JL, Duron E, Rigaud AS, Schraen-Maschke S, Gabelle A; BALTAZAR study group.

Alzheimers Dement. 2018 Jul;14(7):858-868. doi: 10.1016/j.jalz.2018.01.004. Epub 2018 Feb 17.

12.

Mutual Relationship between Tau and Central Insulin Signalling: Consequences for AD and Tauopathies?

Gratuze M, Joly-Amado A, Vieau D, Buée L, Blum D.

Neuroendocrinology. 2018;107(2):181-195. doi: 10.1159/000487641. Epub 2018 Feb 13.

13.

Relevance of Follow-Up in Patients with Core Clinical Criteria for Alzheimer Disease and Normal CSF Biomarkers.

Vercruysse O, Paquet C, Gabelle A, Delbeuck X, Blanc F, Wallon D, Dumurgier J, Magnin E, Martinaud O, Jung B, Bousiges O, Lehmann S, Delaby C, Quillard-Murain M, Peoc H K, Laplanche JL, Bouaziz-Amar E, Hannequin D, Sablonniere B, Buee L, Hugon J, Schraen S, Pasquier F, Bombois S, For The E-Plm Group.

Curr Alzheimer Res. 2018;15(7):691-700. doi: 10.2174/1567205015666180110113238.

PMID:
29318973
14.

What is the evidence that tau pathology spreads through prion-like propagation?

Mudher A, Colin M, Dujardin S, Medina M, Dewachter I, Alavi Naini SM, Mandelkow EM, Mandelkow E, Buée L, Goedert M, Brion JP.

Acta Neuropathol Commun. 2017 Dec 19;5(1):99. doi: 10.1186/s40478-017-0488-7. Review.

15.

Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat.

d'Orange M, Aurégan G, Cheramy D, Gaudin-Guérif M, Lieger S, Guillermier M, Stimmer L, Joséphine C, Hérard AS, Gaillard MC, Petit F, Kiessling MC, Schmitz C, Colin M, Buée L, Panayi F, Diguet E, Brouillet E, Hantraye P, Bemelmans AP, Cambon K.

Brain. 2018 Feb 1;141(2):535-549. doi: 10.1093/brain/awx342.

16.

Atypical, non-standard functions of the microtubule associated Tau protein.

Sotiropoulos I, Galas MC, Silva JM, Skoulakis E, Wegmann S, Maina MB, Blum D, Sayas CL, Mandelkow EM, Mandelkow E, Spillantini MG, Sousa N, Avila J, Medina M, Mudher A, Buee L.

Acta Neuropathol Commun. 2017 Nov 29;5(1):91. doi: 10.1186/s40478-017-0489-6. Review.

17.

EuroTau: towing scientists to tau without tautology.

Mudher A, Brion JP, Avila J, Medina M, Buée L.

Acta Neuropathol Commun. 2017 Nov 29;5(1):90. doi: 10.1186/s40478-017-0491-z. No abstract available.

18.

[Tau and cognitive disorders: a role for T lymphocytes].

Laurent C, Dorothée G, Hunot S, Martin E, Delarasse C, Buée L, Blum D.

Med Sci (Paris). 2017 Oct;33(10):817-819. doi: 10.1051/medsci/20173310002. Epub 2017 Oct 10. French. No abstract available.

19.

Alternative promoter usage generates novel shorter MAPT mRNA transcripts in Alzheimer's disease and progressive supranuclear palsy brains.

Huin V, Buée L, Behal H, Labreuche J, Sablonnière B, Dhaenens CM.

Sci Rep. 2017 Oct 3;7(1):12589. doi: 10.1038/s41598-017-12955-7.

20.

Update on tauopathies.

Lebouvier T, Pasquier F, Buée L.

Curr Opin Neurol. 2017 Dec;30(6):589-598. doi: 10.1097/WCO.0000000000000502. Review.

PMID:
28914736
21.

Tau deletion promotes brain insulin resistance.

Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy P, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, Eddarkaoui S, Vallez E, Vieau D, Humez S, Faivre E, Grenier-Boley B, Outeiro TF, Staels B, Amouyel P, Balschun D, Buee L, Blum D.

J Exp Med. 2017 Aug 7;214(8):2257-2269. doi: 10.1084/jem.20161731. Epub 2017 Jun 26.

22.

Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly.

Shelkovnikova TA, Dimasi P, Kukharsky MS, An H, Quintiero A, Schirmer C, Buée L, Galas MC, Buchman VL.

Cell Death Dis. 2017 May 11;8(5):e2788. doi: 10.1038/cddis.2017.199.

23.

Amyloid precursor protein reduction enhances the formation of neurofibrillary tangles in a mutant tau transgenic mouse model.

Vanden Dries V, Stygelbout V, Pierrot N, Yilmaz Z, Suain V, De Decker R, Buée L, Octave JN, Brion JP, Leroy K.

Neurobiol Aging. 2017 Jul;55:202-212. doi: 10.1016/j.neurobiolaging.2017.03.031. Epub 2017 Apr 5.

PMID:
28464981
24.

Defining the human sperm microtubulome: an integrated genomics approach.

Jumeau F, Chalmel F, Fernandez-Gomez FJ, Carpentier C, Obriot H, Tardivel M, Caillet-Boudin ML, Rigot JM, Rives N, Buée L, Sergeant N, Mitchell V.

Biol Reprod. 2017 Jan 1;96(1):93-106. doi: 10.1095/biolreprod.116.143479.

PMID:
28395323
25.
26.

Two-Dimensional Electrophoresis Protocols to Analyze the Microtubule-Associated Tau Proteins from Several Biological Sources.

Sergeant N, Fernandez-Gomez FJ, Obriot H, Eddarkaoui S, Buée-Scherrer V, Buée L.

Methods Mol Biol. 2017;1523:251-261.

PMID:
27975254
27.

Omics analysis of mouse brain models of human diseases.

Paban V, Loriod B, Villard C, Buee L, Blum D, Pietropaolo S, Cho YH, Gory-Faure S, Mansour E, Gharbi A, Alescio-Lautier B.

Gene. 2017 Feb 5;600:90-100. doi: 10.1016/j.gene.2016.11.022. Epub 2016 Nov 18.

PMID:
27871923
28.

Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy.

Laurent C, Dorothée G, Hunot S, Martin E, Monnet Y, Duchamp M, Dong Y, Légeron FP, Leboucher A, Burnouf S, Faivre E, Carvalho K, Caillierez R, Zommer N, Demeyer D, Jouy N, Sazdovitch V, Schraen-Maschke S, Delarasse C, Buée L, Blum D.

Brain. 2017 Jan;140(1):184-200. doi: 10.1093/brain/aww270. Epub 2016 Nov 5.

29.

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies.

Tardivel M, Bégard S, Bousset L, Dujardin S, Coens A, Melki R, Buée L, Colin M.

Acta Neuropathol Commun. 2016 Nov 4;4(1):117.

30.

The MAPT gene is differentially methylated in the progressive supranuclear palsy brain.

Huin V, Deramecourt V, Caparros-Lefebvre D, Maurage CA, Duyckaerts C, Kovari E, Pasquier F, Buée-Scherrer V, Labreuche J, Behal H, Buée L, Dhaenens CM, Sablonnière B.

Mov Disord. 2016 Dec;31(12):1883-1890. doi: 10.1002/mds.26820. Epub 2016 Oct 6.

PMID:
27709663
31.

Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin.

Mansuroglu Z, Benhelli-Mokrani H, Marcato V, Sultan A, Violet M, Chauderlier A, Delattre L, Loyens A, Talahari S, Bégard S, Nesslany F, Colin M, Souès S, Lefebvre B, Buée L, Galas MC, Bonnefoy E.

Sci Rep. 2016 Sep 8;6:33047. doi: 10.1038/srep33047.

32.

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.

Batalha VL, Ferreira DG, Coelho JE, Valadas JS, Gomes R, Temido-Ferreira M, Shmidt T, Baqi Y, Buée L, Müller CE, Hamdane M, Outeiro TF, Bader M, Meijsing SH, Sadri-Vakili G, Blum D, Lopes LV.

Sci Rep. 2016 Aug 11;6:31493. doi: 10.1038/srep31493.

33.

High-Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo.

Audouard E, Houben S, Masaracchia C, Yilmaz Z, Suain V, Authelet M, De Decker R, Buée L, Boom A, Leroy K, Ando K, Brion JP.

Am J Pathol. 2016 Oct;186(10):2709-22. doi: 10.1016/j.ajpath.2016.06.008. Epub 2016 Aug 3.

PMID:
27497324
34.

Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation.

Papegaey A, Eddarkaoui S, Deramecourt V, Fernandez-Gomez FJ, Pantano P, Obriot H, Machala C, Anquetil V, Camuzat A, Brice A, Maurage CA, Le Ber I, Duyckaerts C, Buée L, Sergeant N, Buée-Scherrer V.

Acta Neuropathol Commun. 2016 Jul 19;4(1):74. doi: 10.1186/s40478-016-0345-0.

35.

Increased tauopathy drives microglia-mediated clearance of beta-amyloid.

Chen W, Abud EA, Yeung ST, Lakatos A, Nassi T, Wang J, Blum D, Buée L, Poon WW, Blurton-Jones M.

Acta Neuropathol Commun. 2016 Jun 23;4(1):63. doi: 10.1186/s40478-016-0336-1.

36.

AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo.

Domise M, Didier S, Marinangeli C, Zhao H, Chandakkar P, Buée L, Viollet B, Davies P, Marambaud P, Vingtdeux V.

Sci Rep. 2016 May 27;6:26758. doi: 10.1038/srep26758.

37.

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology.

Dourlen P, Fernandez-Gomez FJ, Dupont C, Grenier-Boley B, Bellenguez C, Obriot H, Caillierez R, Sottejeau Y, Chapuis J, Bretteville A, Abdelfettah F, Delay C, Malmanche N, Soininen H, Hiltunen M, Galas MC, Amouyel P, Sergeant N, Buée L, Lambert JC, Dermaut B.

Mol Psychiatry. 2017 Jun;22(6):874-883. doi: 10.1038/mp.2016.59. Epub 2016 Apr 26.

38.

Monoaminergic neuropathology in Alzheimer's disease.

Šimić G, Babić Leko M, Wray S, Harrington CR, Delalle I, Jovanov-Milošević N, Bažadona D, Buée L, de Silva R, Di Giovanni G, Wischik CM, Hof PR.

Prog Neurobiol. 2017 Apr;151:101-138. doi: 10.1016/j.pneurobio.2016.04.001. Epub 2016 Apr 12. Review.

39.

Differential Mass Spectrometry Profiles of Tau Protein in the Cerebrospinal Fluid of Patients with Alzheimer's Disease, Progressive Supranuclear Palsy, and Dementia with Lewy Bodies.

Barthélemy NR, Gabelle A, Hirtz C, Fenaille F, Sergeant N, Schraen-Maschke S, Vialaret J, Buée L, Junot C, Becher F, Lehmann S.

J Alzheimers Dis. 2016;51(4):1033-43. doi: 10.3233/JAD-150962.

PMID:
26923020
40.

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective Strategies.

Šimić G, Babić Leko M, Wray S, Harrington C, Delalle I, Jovanov-Milošević N, Bažadona D, Buée L, de Silva R, Di Giovanni G, Wischik C, Hof PR.

Biomolecules. 2016 Jan 6;6(1):6. doi: 10.3390/biom6010006. Review.

41.

Tau Protein Quantification in Human Cerebrospinal Fluid by Targeted Mass Spectrometry at High Sequence Coverage Provides Insights into Its Primary Structure Heterogeneity.

Barthélemy NR, Fenaille F, Hirtz C, Sergeant N, Schraen-Maschke S, Vialaret J, Buée L, Gabelle A, Junot C, Lehmann S, Becher F.

J Proteome Res. 2016 Feb 5;15(2):667-76. doi: 10.1021/acs.jproteome.5b01001. Epub 2016 Jan 19.

PMID:
26742856
42.

MRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance.

García-Gómez BE, Fernández-Gómez FJ, Muñoz-Delgado E, Buée L, Blum D, Vidal CJ.

J Mol Neurosci. 2016 Apr;58(4):411-5. doi: 10.1007/s12031-015-0699-y. Epub 2015 Dec 23.

PMID:
26697857
43.

Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines.

Moas-Héloire V, Renault N, Batalha V, Arias AR, Marchivie M, Yous S, Deguine N, Buée L, Chavatte P, Blum D, Lopes L, Melnyk P, Agouridas L.

Eur J Med Chem. 2015 Dec 1;106:15-25. doi: 10.1016/j.ejmech.2015.10.030. Epub 2015 Oct 19.

PMID:
26513641
44.

The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory.

Marciniak E, Faivre E, Dutar P, Alves Pires C, Demeyer D, Caillierez R, Laloux C, Buée L, Blum D, Humez S.

Sci Rep. 2015 Oct 29;5:15862. doi: 10.1038/srep15862.

45.

Aβ1-40 and Aβ1-42 Plasmatic Levels In Stroke: Influence of Pre-Existing Cognitive Status and Stroke Characteristics.

Moulin S, Leys D, Schraen-Maschke S, Bombois S, Mendyk AM, Muhr-Tailleux A, Cordonnier C, Buee L, Pasquier F, Bordet R.

Curr Alzheimer Res. 2017;14(6):686-694. doi: 10.2174/1567205012666151027141730. Review.

PMID:
26502812
46.

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo.

Violet M, Chauderlier A, Delattre L, Tardivel M, Chouala MS, Sultan A, Marciniak E, Humez S, Binder L, Kayed R, Lefebvre B, Bonnefoy E, Buée L, Galas MC.

Neurobiol Dis. 2015 Oct;82:540-551. doi: 10.1016/j.nbd.2015.09.003. Epub 2015 Sep 16.

PMID:
26385829
47.

Central Nervous System and Peripheral Inflammatory Processes in Alzheimer's Disease: Biomarker Profiling Approach.

Delaby C, Gabelle A, Blum D, Schraen-Maschke S, Moulinier A, Boulanghien J, Séverac D, Buée L, Rème T, Lehmann S.

Front Neurol. 2015 Aug 24;6:181. doi: 10.3389/fneur.2015.00181. eCollection 2015.

48.

miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo.

Smith PY, Hernandez-Rapp J, Jolivette F, Lecours C, Bisht K, Goupil C, Dorval V, Parsi S, Morin F, Planel E, Bennett DA, Fernandez-Gomez FJ, Sergeant N, Buée L, Tremblay MÈ, Calon F, Hébert SS.

Hum Mol Genet. 2015 Dec 1;24(23):6721-35. doi: 10.1093/hmg/ddv377. Epub 2015 Sep 11.

49.

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.

Burlot MA, Braudeau J, Michaelsen-Preusse K, Potier B, Ayciriex S, Varin J, Gautier B, Djelti F, Audrain M, Dauphinot L, Fernandez-Gomez FJ, Caillierez R, Laprévote O, Bièche I, Auzeil N, Potier MC, Dutar P, Korte M, Buée L, Blum D, Cartier N.

Hum Mol Genet. 2015 Nov 1;24(21):5965-76. doi: 10.1093/hmg/ddv268. Epub 2015 Sep 10.

PMID:
26358780
50.

A geographical cluster of progressive supranuclear palsy in northern France.

Caparros-Lefebvre D, Golbe LI, Deramecourt V, Maurage CA, Huin V, Buée-Scherrer V, Obriot H, Sablonnière B, Caparros F, Buée L, Lees AJ.

Neurology. 2015 Oct 13;85(15):1293-300. doi: 10.1212/WNL.0000000000001997. Epub 2015 Sep 9.

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