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Items: 1 to 50 of 134

1.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Adbala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2018 Oct 4. pii: S1550-4131(18)30586-2. doi: 10.1016/j.cmet.2018.09.019. [Epub ahead of print]

PMID:
30318339
2.

Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling.

Shigemura M, Lecuona E, Angulo M, Homma T, Rodríguez DA, Gonzalez-Gonzalez FJ, Welch LC, Amarelle L, Kim SJ, Kaminski N, Budinger GRS, Solway J, Sznajder JI.

Sci Transl Med. 2018 Sep 5;10(457). pii: eaat1662. doi: 10.1126/scitranslmed.aat1662.

PMID:
30185650
3.

Extracorporeal Membrane Oxygenation Can Successfully Support Patients With Severe Acute Respiratory Distress Syndrome in Lieu of Mechanical Ventilation.

Kurihara C, Walter JM, Singer BD, Cajigas H, Shayan S, Al-Qamari A, DeCamp MM, Wunderink R, Budinger GRS, Bharat A.

Crit Care Med. 2018 Nov;46(11):e1070-e1073. doi: 10.1097/CCM.0000000000003354.

PMID:
30095500
4.

Targeting the Myofibroblast in Pulmonary Fibrosis.

Misharin AV, Budinger GRS.

Am J Respir Crit Care Med. 2018 Oct 1;198(7):834-835. doi: 10.1164/rccm.201806-1037ED. No abstract available.

PMID:
29966099
5.

Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome.

Mutlu EA, Comba IY, Cho T, Engen PA, Yazıcı C, Soberanes S, Hamanaka RB, Niğdelioğlu R, Meliton AY, Ghio AJ, Budinger GRS, Mutlu GM.

Environ Pollut. 2018 Sep;240:817-830. doi: 10.1016/j.envpol.2018.04.130. Epub 2018 May 18.

PMID:
29783199
6.

Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1β.

Hsiao HM, Fernandez R, Tanaka S, Li W, Spahn JH, Chiu S, Akbarpour M, Ruiz-Perez D, Wu Q, Turam C, Scozzi D, Takahashi T, Luehmann HP, Puri V, Budinger GRS, Krupnick AS, Misharin AV, Lavine KJ, Liu Y, Gelman AE, Bharat A, Kreisel D.

J Clin Invest. 2018 Jul 2;128(7):2833-2847. doi: 10.1172/JCI98436. Epub 2018 May 21.

7.

Letter by Mutlu and Budinger Regarding Article, "Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification".

Mutlu GM, Budinger GRS.

Circulation. 2018 Mar 13;137(11):1203-1204. doi: 10.1161/CIRCULATIONAHA.117.031206. No abstract available.

PMID:
29530899
8.

Inflammatory Monocytes Drive Influenza A Virus-Mediated Lung Injury in Juvenile Mice.

Coates BM, Staricha KL, Koch CM, Cheng Y, Shumaker DK, Budinger GRS, Perlman H, Misharin AV, Ridge KM.

J Immunol. 2018 Apr 1;200(7):2391-2404. doi: 10.4049/jimmunol.1701543. Epub 2018 Feb 14.

PMID:
29445006
9.

A role for heat shock factor 1 in hypercapnia-induced inhibition of inflammatory cytokine expression.

Lu Z, Casalino-Matsuda SM, Nair A, Buchbinder A, Budinger GRS, Sporn PHS, Gates KL.

FASEB J. 2018 Jul;32(7):3614-3622. doi: 10.1096/fj.201701164R. Epub 2018 Feb 5.

PMID:
29405096
10.

Non-classical monocytes in tissue injury and cancer.

Bharat A, McQuattie-Pimentel AC, Budinger GRS.

Oncotarget. 2017 Nov 21;8(63):106171-106172. doi: 10.18632/oncotarget.22584. eCollection 2017 Dec 5. No abstract available.

11.

Monocyte-derived Alveolar Macrophages: The Dark Side of Lung Repair?

McQuattie-Pimentel AC, Budinger GRS, Ballinger MN.

Am J Respir Cell Mol Biol. 2018 Jan;58(1):5-6. doi: 10.1165/rcmb.2017-0328ED. No abstract available.

PMID:
29286855
12.

Association of body mass index with lung transplantation survival in the United States following implementation of the lung allocation score.

Fernandez R, Safaeinili N, Kurihara C, Odell DD, Jain M, DeCamp MM, Budinger GRS, Bharat A.

J Thorac Cardiovasc Surg. 2018 Apr;155(4):1871-1879.e3. doi: 10.1016/j.jtcvs.2017.11.031. Epub 2017 Nov 20.

PMID:
29249487
13.

JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension.

Sala MA, Chen C, Zhang Q, Do-Umehara HC, Wu W, Misharin AV, Waypa GB, Fang D, Budinger GRS, Liu S, Chandel NS, Schumacker PT, Sznajder JI, Liu J.

J Biol Chem. 2018 Jan 5;293(1):271-284. doi: 10.1074/jbc.RA117.000440. Epub 2017 Nov 8.

PMID:
29118187
14.

Bim suppresses the development of SLE by limiting myeloid inflammatory responses.

Tsai F, Homan PJ, Agrawal H, Misharin AV, Abdala-Valencia H, Haines GK 3rd, Dominguez S, Bloomfield CL, Saber R, Chang A, Mohan C, Hutcheson J, Davidson A, Budinger GRS, Bouillet P, Dorfleutner A, Stehlik C, Winter DR, Cuda CM, Perlman H.

J Exp Med. 2017 Dec 4;214(12):3753-3773. doi: 10.1084/jem.20170479. Epub 2017 Nov 7.

15.

HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.

Magnani ND, Dada LA, Queisser MA, Brazee PL, Welch LC, Anekalla KR, Zhou G, Vagin O, Misharin AV, Budinger GRS, Iwai K, Ciechanover AJ, Sznajder JI.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10178-E10186. doi: 10.1073/pnas.1713563114. Epub 2017 Nov 6.

16.

Reactive oxygen species as signaling molecules in the development of lung fibrosis.

Gonzalez-Gonzalez FJ, Chandel NS, Jain M, Budinger GRS.

Transl Res. 2017 Dec;190:61-68. doi: 10.1016/j.trsl.2017.09.005. Epub 2017 Oct 10. Review.

PMID:
29080401
17.

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H.

J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10.

18.

The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.

Budinger GRS, Kohanski RA, Gan W, Kobor MS, Amaral LA, Armanios M, Kelsey KT, Pardo A, Tuder R, Macian F, Chandel N, Vaughan D, Rojas M, Mora AL, Kovacs E, Duncan SR, Finkel T, Choi A, Eickelberg O, Chen D, Agusti A, Selman M, Balch WE, Busse P, Lin A, Morimoto R, Sznajder JI, Thannickal VJ.

J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1492-1500. doi: 10.1093/gerona/glx090. Review.

19.

Klotho, an antiaging molecule, attenuates oxidant-induced alveolar epithelial cell mtDNA damage and apoptosis.

Kim SJ, Cheresh P, Eren M, Jablonski RP, Yeldandi A, Ridge KM, Budinger GRS, Kim DH, Wolf M, Vaughan DE, Kamp DW.

Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L16-L26. doi: 10.1152/ajplung.00063.2017. Epub 2017 Apr 20.

20.

SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis.

Jablonski RP, Kim SJ, Cheresh P, Williams DB, Morales-Nebreda L, Cheng Y, Yeldandi A, Bhorade S, Pardo A, Selman M, Ridge K, Gius D, Budinger GRS, Kamp DW.

FASEB J. 2017 Jun;31(6):2520-2532. doi: 10.1096/fj.201601077R. Epub 2017 Mar 3.

21.

Sequelae of Donor-derived Mollicutes Transmission in Lung Recipients.

Fernandez R, Chi M, Ison MG, Waites KB, Crabb DM, Ratliff AE, Cajigas H, DeCamp MM, Odell D, Budinger GR, Bharat A.

Am J Respir Crit Care Med. 2017 Mar 1;195(5):687-689. doi: 10.1164/rccm.201607-1377LE. No abstract available.

22.

Lrp5/β-Catenin Signaling Controls Lung Macrophage Differentiation and Inhibits Resolution of Fibrosis.

Sennello JA, Misharin AV, Flozak AS, Berdnikovs S, Cheresh P, Varga J, Kamp DW, Budinger GR, Gottardi CJ, Lam AP.

Am J Respir Cell Mol Biol. 2017 Feb;56(2):191-201. doi: 10.1165/rcmb.2016-0147OC.

23.

Spontaneous Cerebral Hemorrhage and Sudden Biventricular Failure After Lung Transplantation.

Bharat A, Cajigas H, Budinger GR.

JAMA Cardiol. 2016 Nov 1;1(8):963-964. doi: 10.1001/jamacardio.2016.2568. No abstract available.

PMID:
27654933
24.

Tenascin-C drives persistence of organ fibrosis.

Bhattacharyya S, Wang W, Morales-Nebreda L, Feng G, Wu M, Zhou X, Lafyatis R, Lee J, Hinchcliff M, Feghali-Bostwick C, Lakota K, Budinger GR, Raparia K, Tamaki Z, Varga J.

Nat Commun. 2016 Jun 3;7:11703. doi: 10.1038/ncomms11703.

25.

Lung Injury Combined with Loss of Regulatory T Cells Leads to De Novo Lung-Restricted Autoimmunity.

Chiu S, Fernandez R, Subramanian V, Sun H, DeCamp MM, Kreisel D, Perlman H, Budinger GR, Mohanakumar T, Bharat A.

J Immunol. 2016 Jul 1;197(1):51-7. doi: 10.4049/jimmunol.1502539. Epub 2016 May 18.

26.

Lung-Restricted Antibodies Mediate Primary Graft Dysfunction and Prevent Allotolerance after Murine Lung Transplantation.

Bharat A, Chiu S, Zheng Z, Sun H, Yeldandi A, DeCamp MM, Perlman H, Budinger GR, Mohanakumar T.

Am J Respir Cell Mol Biol. 2016 Oct;55(4):532-541.

27.

Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.

Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu GM, Budinger GR, Herold S.

J Clin Invest. 2016 Apr 1;126(4):1566-80. doi: 10.1172/JCI83931. Epub 2016 Mar 21.

28.

The cardiomyocyte protein αT-catenin contributes to asthma through regulating pulmonary vein inflammation.

Folmsbee SS, Budinger GR, Bryce PJ, Gottardi CJ.

J Allergy Clin Immunol. 2016 Jul;138(1):123-129.e2. doi: 10.1016/j.jaci.2015.11.037. Epub 2016 Mar 3.

29.

BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosis.

Banuelos J, Shin S, Cao Y, Bochner BS, Morales-Nebreda L, Budinger GR, Zhou L, Li S, Xin J, Lingen MW, Dong C, Schleimer RP, Lu NZ.

Allergy. 2016 May;71(5):640-50. doi: 10.1111/all.12840. Epub 2016 Feb 4.

30.

Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner.

Cuda CM, Misharin AV, Khare S, Saber R, Tsai F, Archer AM, Homan PJ, Haines GK 3rd, Hutcheson J, Dorfleutner A, Budinger GR, Stehlik C, Perlman H.

Arthritis Res Ther. 2015 Oct 16;17:291. doi: 10.1186/s13075-015-0794-z.

31.

Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect.

Ghio AJ, Soukup JM, Dailey LA, Tong H, Kesic MJ, Budinger GR, Mutlu GM.

Chem Res Toxicol. 2015 Nov 16;28(11):2104-11. doi: 10.1021/acs.chemrestox.5b00270. Epub 2015 Oct 22.

32.

Failure to Improve the Oxygenation Index Is a Useful Predictor of Therapy Failure in Acute Respiratory Distress Syndrome Clinical Trials.

Go L, Budinger GR, Kwasny MJ, Peng J, Forel JM, Papazian L, Jain M.

Crit Care Med. 2016 Jan;44(1):e40-4. doi: 10.1097/CCM.0000000000001295.

33.

Modeling human influenza infection in the laboratory.

Radigan KA, Misharin AV, Chi M, Budinger GS.

Infect Drug Resist. 2015 Aug 31;8:311-20. eCollection 2015. Review.

34.

The heterogeneity of lung macrophages in the susceptibility to disease.

Morales-Nebreda L, Misharin AV, Perlman H, Budinger GR.

Eur Respir Rev. 2015 Sep;24(137):505-9. doi: 10.1183/16000617.0031-2015. Review.

35.

Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and Mice.

Bharat A, Bhorade SM, Morales-Nebreda L, McQuattie-Pimentel AC, Soberanes S, Ridge K, DeCamp MM, Mestan KK, Perlman H, Budinger GR, Misharin AV.

Am J Respir Cell Mol Biol. 2016 Jan;54(1):147-9. doi: 10.1165/rcmb.2015-0147LE. No abstract available.

36.

Influenza virus-induced lung injury: pathogenesis and implications for treatment.

Herold S, Becker C, Ridge KM, Budinger GR.

Eur Respir J. 2015 May;45(5):1463-78. doi: 10.1183/09031936.00186214. Epub 2015 Mar 18. Review.

37.

Muscle dysfunction in patients with lung diseases: a growing epidemic.

Barreiro E, Sznajder JI, Nader GA, Budinger GR.

Am J Respir Crit Care Med. 2015 Mar 15;191(6):616-9. doi: 10.1164/rccm.201412-2189OE. No abstract available.

38.

Vimentin regulates activation of the NLRP3 inflammasome.

dos Santos G, Rogel MR, Baker MA, Troken JR, Urich D, Morales-Nebreda L, Sennello JA, Kutuzov MA, Sitikov A, Davis JM, Lam AP, Cheresh P, Kamp D, Shumaker DK, Budinger GR, Ridge KM.

Nat Commun. 2015 Mar 12;6:6574. doi: 10.1038/ncomms7574.

39.

Nitric oxide prevents alveolar senescence and emphysema in a mouse model.

Boe AE, Eren M, Morales-Nebreda L, Murphy SB, Budinger GR, Mutlu GM, Miyata T, Vaughan DE.

PLoS One. 2015 Mar 10;10(3):e0116504. doi: 10.1371/journal.pone.0116504. eCollection 2015.

40.

Blue journal conference. Aging and susceptibility to lung disease.

Thannickal VJ, Murthy M, Balch WE, Chandel NS, Meiners S, Eickelberg O, Selman M, Pardo A, White ES, Levy BD, Busse PJ, Tuder RM, Antony VB, Sznajder JI, Budinger GR.

Am J Respir Crit Care Med. 2015 Feb 1;191(3):261-9. doi: 10.1164/rccm.201410-1876PP. Review.

41.

The cardiac protein αT-catenin contributes to chemical-induced asthma.

Folmsbee SS, Morales-Nebreda L, Van Hengel J, Tyberghein K, Van Roy F, Budinger GR, Bryce PJ, Gottardi CJ.

Am J Physiol Lung Cell Mol Physiol. 2015 Feb 1;308(3):L253-8. doi: 10.1152/ajplung.00331.2014. Epub 2014 Dec 5.

42.

Calcium release-activated calcium (CRAC) channels mediate the β(2)-adrenergic regulation of Na,K-ATPase.

Keller MJ, Lecuona E, Prakriya M, Cheng Y, Soberanes S, Budinger GR, Sznajder JI.

FEBS Lett. 2014 Dec 20;588(24):4686-93. doi: 10.1016/j.febslet.2014.10.041. Epub 2014 Nov 11. Erratum in: FEBS Lett. 2015 Jan 30;589(3):414.

43.

β₂-Agonist therapy may contribute to the air pollution and IL-6-associated risk of developing severe asthma with dual-positive TH2/TH17 cells.

Chiarella SE, Budinger GR, Mutlu GM.

J Allergy Clin Immunol. 2015 Jan;135(1):290-1. doi: 10.1016/j.jaci.2014.09.037. Epub 2014 Nov 11. No abstract available.

44.

Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice.

Misharin AV, Cuda CM, Saber R, Turner JD, Gierut AK, Haines GK 3rd, Berdnikovs S, Filer A, Clark AR, Buckley CD, Mutlu GM, Budinger GR, Perlman H.

Cell Rep. 2014 Oct 23;9(2):591-604. doi: 10.1016/j.celrep.2014.09.032. Epub 2014 Oct 16.

45.

Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury.

Morales-Nebreda L, Chi M, Lecuona E, Chandel NS, Dada LA, Ridge K, Soberanes S, Nigdelioglu R, Sznajder JI, Mutlu GM, Budinger GR, Radigan KA.

J Virol Methods. 2014 Dec;209:116-20. doi: 10.1016/j.jviromet.2014.09.004. Epub 2014 Sep 17.

46.

Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages.

Radigan KA, Morales-Nebreda L, Soberanes S, Nicholson T, Nigdelioglu R, Cho T, Chi M, Hamanaka RB, Misharin AV, Perlman H, Budinger GR, Mutlu GM.

PLoS One. 2014 Sep 18;9(9):e108138. doi: 10.1371/journal.pone.0108138. eCollection 2014.

47.

Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis.

Morales-Nebreda LI, Rogel MR, Eisenberg JL, Hamill KJ, Soberanes S, Nigdelioglu R, Chi M, Cho T, Radigan KA, Ridge KM, Misharin AV, Woychek A, Hopkinson S, Perlman H, Mutlu GM, Pardo A, Selman M, Jones JC, Budinger GR.

Am J Respir Cell Mol Biol. 2015 Apr;52(4):503-12. doi: 10.1165/rcmb.2014-0057OC.

48.

HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth.

Queisser MA, Dada LA, Deiss-Yehiely N, Angulo M, Zhou G, Kouri FM, Knab LM, Liu J, Stegh AH, DeCamp MM, Budinger GR, Chandel NS, Ciechanover A, Iwai K, Sznajder JI.

Am J Respir Crit Care Med. 2014 Sep 15;190(6):688-98. doi: 10.1164/rccm.201403-0463OC.

49.

Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis.

Lam AP, Herazo-Maya JD, Sennello JA, Flozak AS, Russell S, Mutlu GM, Budinger GR, DasGupta R, Varga J, Kaminski N, Gottardi CJ.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):185-95. doi: 10.1164/rccm.201401-0079OC.

50.

Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice.

Cheresh P, Morales-Nebreda L, Kim SJ, Yeldandi A, Williams DB, Cheng Y, Mutlu GM, Budinger GR, Ridge K, Schumacker PT, Bohr VA, Kamp DW.

Am J Respir Cell Mol Biol. 2015 Jan;52(1):25-36. doi: 10.1165/rcmb.2014-0038OC.

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