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Items: 29

1.

Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.

Ling T, Lang WH, Craig J, Potts MB, Budhraja A, Opferman J, Bollinger J, Maier J, Marsico TD, Rivas F.

J Nat Prod. 2019 May 24;82(5):1301-1311. doi: 10.1021/acs.jnatprod.8b01087. Epub 2019 May 14.

PMID:
31084028
2.

Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer.

Lee T, Christov PP, Shaw S, Tarr JC, Zhao B, Veerasamy N, Jeon KO, Mills JJ, Bian Z, Sensintaffar JL, Arnold AL, Fogarty SA, Perry E, Ramsey HE, Cook RS, Hollingshead M, Davis Millin M, Lee KM, Koss B, Budhraja A, Opferman JT, Kim K, Arteaga CL, Moore WJ, Olejniczak ET, Savona MR, Fesik SW.

J Med Chem. 2019 Apr 25;62(8):3971-3988. doi: 10.1021/acs.jmedchem.8b01991. Epub 2019 Apr 16.

PMID:
30929420
3.

Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents.

Ling T, Maier J, Das S, Budhraja A, Bassett R, Potts MB, Shelat A, Rankovic Z, Opferman JT, Rivas F.

Eur J Med Chem. 2019 Feb 15;164:391-398. doi: 10.1016/j.ejmech.2018.12.059. Epub 2018 Dec 24.

4.

Modulation of Navitoclax Sensitivity by Dihydroartemisinin-Mediated MCL-1 Repression in BCR-ABL+ B-Lineage Acute Lymphoblastic Leukemia.

Budhraja A, Turnis ME, Churchman ML, Kothari A, Yang X, Xu H, Kaminska E, Panetta JC, Finkelstein D, Mullighan CG, Opferman JT.

Clin Cancer Res. 2017 Dec 15;23(24):7558-7568. doi: 10.1158/1078-0432.CCR-17-1231. Epub 2017 Oct 3.

5.

Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.

Lee T, Bian Z, Zhao B, Hogdal LJ, Sensintaffar JL, Goodwin CM, Belmar J, Shaw S, Tarr JC, Veerasamy N, Matulis SM, Koss B, Fischer MA, Arnold AL, Camper DV, Browning CF, Rossanese OW, Budhraja A, Opferman J, Boise LH, Savona MR, Letai A, Olejniczak ET, Fesik SW.

FEBS Lett. 2017 Jan;591(1):240-251. doi: 10.1002/1873-3468.12497. Epub 2016 Dec 19.

6.

Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines.

Koss B, Ryan J, Budhraja A, Szarama K, Yang X, Bathina M, Cardone MH, Nikolovska-Coleska Z, Letai A, Opferman JT.

Oncotarget. 2016 Mar 8;7(10):11500-11. doi: 10.18632/oncotarget.7204.

7.

Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis.

Li G, Zhou J, Budhraja A, Hu X, Chen Y, Cheng Q, Liu L, Zhou T, Li P, Liu E, Gao N.

Oncotarget. 2015 Jan 30;6(3):1834-49.

8.

Role of reactive oxygen species in arsenic-induced transformation of human lung bronchial epithelial (BEAS-2B) cells.

Zhang Z, Pratheeshkumar P, Budhraja A, Son YO, Kim D, Shi X.

Biochem Biophys Res Commun. 2015 Jan 9;456(2):643-8. doi: 10.1016/j.bbrc.2014.12.010. Epub 2014 Dec 10.

9.

RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo.

Li G, Liu L, Shan C, Cheng Q, Budhraja A, Zhou T, Cui H, Gao N.

Cell Death Dis. 2014 Jan 16;5:e998. doi: 10.1038/cddis.2013.519.

10.

Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells.

Yang YX, Li XL, Wang L, Han SY, Zhang YR, Pratheeshkumar P, Wang X, Lu J, Yin YQ, Sun LJ, Budhraja A, Hitron AJ, Ding SZ.

Int J Oncol. 2013 Sep;43(3):936-46. doi: 10.3892/ijo.2013.2004. Epub 2013 Jul 3.

11.

Apigenin suppresses migration and invasion of transformed cells through down-regulation of C-X-C chemokine receptor 4 expression.

Wang L, Kuang L, Hitron JA, Son YO, Wang X, Budhraja A, Lee JC, Pratheeshkumar P, Chen G, Zhang Z, Luo J, Shi X.

Toxicol Appl Pharmacol. 2013 Oct 1;272(1):108-16. doi: 10.1016/j.taap.2013.05.028. Epub 2013 Jun 4.

12.

Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells.

Ding SZ, Yang YX, Li XL, Michelli-Rivera A, Han SY, Wang L, Pratheeshkumar P, Wang X, Lu J, Yin YQ, Budhraja A, Hitron AJ.

Toxicol Appl Pharmacol. 2013 May 15;269(1):61-71. doi: 10.1016/j.taap.2013.03.006. Epub 2013 Mar 19.

13.

Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis.

Pratheeshkumar P, Son YO, Budhraja A, Wang X, Ding S, Wang L, Hitron A, Lee JC, Kim D, Divya SP, Chen G, Zhang Z, Luo J, Shi X.

PLoS One. 2012;7(12):e52279. doi: 10.1371/journal.pone.0052279. Epub 2012 Dec 31.

14.

Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways.

Pratheeshkumar P, Budhraja A, Son YO, Wang X, Zhang Z, Ding S, Wang L, Hitron A, Lee JC, Xu M, Chen G, Luo J, Shi X.

PLoS One. 2012;7(10):e47516. doi: 10.1371/journal.pone.0047516. Epub 2012 Oct 18.

15.

Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signaling.

Son YO, Wang L, Poyil P, Budhraja A, Hitron JA, Zhang Z, Lee JC, Shi X.

Toxicol Appl Pharmacol. 2012 Oct 15;264(2):153-60. doi: 10.1016/j.taap.2012.07.028. Epub 2012 Aug 3.

16.

Ethanol enhances tumor angiogenesis in vitro induced by low-dose arsenic in colon cancer cells through hypoxia-inducible factor 1 alpha pathway.

Wang L, Son YO, Ding S, Wang X, Hitron JA, Budhraja A, Lee JC, Lin Q, Poyil P, Zhang Z, Luo J, Shi X.

Toxicol Sci. 2012 Dec;130(2):269-80. doi: 10.1093/toxsci/kfs242. Epub 2012 Aug 7.

17.

Cancer prevention with promising natural products: mechanisms of action and molecular targets.

Pratheeshkumar P, Sreekala C, Zhang Z, Budhraja A, Ding S, Son YO, Wang X, Hitron A, Hyun-Jung K, Wang L, Lee JC, Shi X.

Anticancer Agents Med Chem. 2012 Dec;12(10):1159-84. Review.

18.

3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process.

Gao N, Cheng S, Budhraja A, Liu EH, Chen J, Chen D, Yang Z, Luo J, Shi X, Zhang Z.

PLoS One. 2012;7(2):e31783. doi: 10.1371/journal.pone.0031783. Epub 2012 Feb 21.

19.

Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo.

Budhraja A, Gao N, Zhang Z, Son YO, Cheng S, Wang X, Ding S, Hitron A, Chen G, Luo J, Shi X.

Mol Cancer Ther. 2012 Jan;11(1):132-42. doi: 10.1158/1535-7163.MCT-11-0343. Epub 2011 Nov 14.

20.

Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway.

Gao N, Cheng S, Budhraja A, Gao Z, Chen J, Liu EH, Huang C, Chen D, Yang Z, Liu Q, Li P, Shi X, Zhang Z.

Br J Pharmacol. 2012 Mar;165(6):1813-1826. doi: 10.1111/j.1476-5381.2011.01684.x.

21.

Reactive oxygen species mediate arsenic induced cell transformation and tumorigenesis through Wnt/β-catenin pathway in human colorectal adenocarcinoma DLD1 cells.

Zhang Z, Wang X, Cheng S, Sun L, Son YO, Yao H, Li W, Budhraja A, Li L, Shelton BJ, Tucker T, Arnold SM, Shi X.

Toxicol Appl Pharmacol. 2011 Oct 15;256(2):114-21. doi: 10.1016/j.taap.2011.07.016. Epub 2011 Aug 11.

PMID:
21854796
22.

Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells.

Son YO, Wang X, Hitron JA, Zhang Z, Cheng S, Budhraja A, Ding S, Lee JC, Shi X.

Toxicol Appl Pharmacol. 2011 Sep 15;255(3):287-96. doi: 10.1016/j.taap.2011.06.024. Epub 2011 Jul 13.

23.

NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium.

Wang X, Son YO, Chang Q, Sun L, Hitron JA, Budhraja A, Zhang Z, Ke Z, Chen F, Luo J, Shi X.

Toxicol Sci. 2011 Oct;123(2):399-410. doi: 10.1093/toxsci/kfr180. Epub 2011 Jul 8.

24.

Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways.

Gao N, Budhraja A, Cheng S, Liu EH, Chen J, Yang Z, Chen D, Zhang Z, Shi X.

Cell Death Dis. 2011 Apr 7;2:e140. doi: 10.1038/cddis.2011.22.

25.

Interruption of the MEK/ERK signaling cascade promotes dihydroartemisinin-induced apoptosis in vitro and in vivo.

Gao N, Budhraja A, Cheng S, Liu EH, Huang C, Chen J, Yang Z, Chen D, Zhang Z, Shi X.

Apoptosis. 2011 May;16(5):511-23. doi: 10.1007/s10495-011-0580-6.

PMID:
21336837
26.

Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.

Cheng S, Gao N, Zhang Z, Chen G, Budhraja A, Ke Z, Son YO, Wang X, Luo J, Shi X.

Clin Cancer Res. 2010 Dec 1;16(23):5679-91. doi: 10.1158/1078-0432.CCR-10-1565.

27.

The dual roles of c-Jun NH2-terminal kinase signaling in Cr(VI)-induced apoptosis in JB6 cells.

Son YO, Hitron JA, Cheng S, Budhraja A, Zhang Z, Lan Guo N, Lee JC, Shi X.

Toxicol Sci. 2011 Feb;119(2):335-45. doi: 10.1093/toxsci/kfq335. Epub 2010 Nov 3.

28.

Induction of apoptosis in human leukemia cells by grape seed extract occurs via activation of c-Jun NH2-terminal kinase.

Gao N, Budhraja A, Cheng S, Yao H, Zhang Z, Shi X.

Clin Cancer Res. 2009 Jan 1;15(1):140-9. doi: 10.1158/1078-0432.CCR-08-1447.

29.

Inherited factor X deficiency in two brothers.

Barik S, Budhraja A, Bhalla M, Diwan S.

Indian J Pathol Microbiol. 1997 Jan;40(1):63-5.

PMID:
9145616

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