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Items: 27


Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways.

Miner K, Labitzke K, Liu B, Wang P, Henckels K, Gaida K, Elliott R, Chen JJ, Liu L, Leith A, Trueblood E, Hensley K, Xia XZ, Homann O, Bennett B, Fiorino M, Whoriskey J, Yu G, Escobar S, Wong M, Born TL, Budelsky A, Comeau M, Smith D, Phillips J, Johnston JA, McGivern JG, Weikl K, Powers D, Kunzelmann K, Mohn D, Hochheimer A, Sullivan JK.

Front Pharmacol. 2019 Feb 14;10:51. doi: 10.3389/fphar.2019.00051. eCollection 2019.


Role of IL-17A in murine models of COPD airway disease.

Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, Ito S, Araya J, Budelsky A, Goodsell A, Baron JL, Nishimura SL.

Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L122-L130. doi: 10.1152/ajplung.00301.2016. Epub 2016 Dec 2.


Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis.

Xue X, Soroosh P, De Leon-Tabaldo A, Luna-Roman R, Sablad M, Rozenkrants N, Yu J, Castro G, Banie H, Fung-Leung WP, Santamaria-Babi L, Schlueter T, Albers M, Leonard K, Budelsky AL, Fourie AM.

Sci Rep. 2016 Dec 1;6:37977. doi: 10.1038/srep37977.


Effect of IL-17 receptor A blockade with brodalumab in inflammatory diseases.

Nirula A, Nilsen J, Klekotka P, Kricorian G, Erondu N, Towne JE, Russell CB, Martin DA, Budelsky AL.

Rheumatology (Oxford). 2016 Dec;55(suppl 2):ii43-ii55. Review.


β-Glucan exacerbates allergic asthma independent of fungal sensitization and promotes steroid-resistant TH2/TH17 responses.

Zhang Z, Biagini Myers JM, Brandt EB, Ryan PH, Lindsey M, Mintz-Cole RA, Reponen T, Vesper SJ, Forde F, Ruff B, Bass SA, LeMasters GK, Bernstein DI, Lockey J, Budelsky AL, Khurana Hershey GK.

J Allergy Clin Immunol. 2017 Jan;139(1):54-65.e8. doi: 10.1016/j.jaci.2016.02.031. Epub 2016 Apr 20.


Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine-driven inflammation and fibrosis.

Vannella KM, Ramalingam TR, Borthwick LA, Barron L, Hart KM, Thompson RW, Kindrachuk KN, Cheever AW, White S, Budelsky AL, Comeau MR, Smith DE, Wynn TA.

Sci Transl Med. 2016 May 4;8(337):337ra65. doi: 10.1126/scitranslmed.aaf1938.


Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation.

Maxwell JR, Zhang Y, Brown WA, Smith CL, Byrne FR, Fiorino M, Stevens E, Bigler J, Davis JA, Rottman JB, Budelsky AL, Symons A, Towne JE.

Immunity. 2015 Oct 20;43(4):739-50. doi: 10.1016/j.immuni.2015.08.019. Epub 2015 Sep 29.


A new mouse strain for the analysis of invariant NKT cell function.

Chandra S, Zhao M, Budelsky A, de Mingo Pulido A, Day J, Fu Z, Siegel L, Smith D, Kronenberg M.

Nat Immunol. 2015 Aug;16(8):799-800. doi: 10.1038/ni.3203. Epub 2015 Jun 15. No abstract available.


IL-17RA Signaling in Airway Inflammation and Bronchial Hyperreactivity in Allergic Asthma.

Willis CR, Siegel L, Leith A, Mohn D, Escobar S, Wannberg S, Misura K, Rickel E, Rottman JB, Comeau MR, Sullivan JK, Metz DP, Tocker J, Budelsky AL.

Am J Respir Cell Mol Biol. 2015 Dec;53(6):810-21. doi: 10.1165/rcmb.2015-0038OC.


The prostaglandin D₂ receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung.

Wojno ED, Monticelli LA, Tran SV, Alenghat T, Osborne LC, Thome JJ, Willis C, Budelsky A, Farber DL, Artis D.

Mucosal Immunol. 2015 Nov;8(6):1313-23. doi: 10.1038/mi.2015.21. Epub 2015 Apr 8.


Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP.

Johnson MG, Liu JJ, Li AR, van Lengerich B, Wang S, Medina JC, Collins TL, Danao J, Seitz L, Willee A, D'Souza W, Budelsky AL, Fan PW, Wong SG.

Bioorg Med Chem Lett. 2014 Jul 1;24(13):2877-80. doi: 10.1016/j.bmcl.2014.04.092. Epub 2014 May 4.


Diesel exhaust particle induction of IL-17A contributes to severe asthma.

Brandt EB, Kovacic MB, Lee GB, Gibson AM, Acciani TH, Le Cras TD, Ryan PH, Budelsky AL, Khurana Hershey GK.

J Allergy Clin Immunol. 2013 Nov;132(5):1194-1204.e2. doi: 10.1016/j.jaci.2013.06.048. Epub 2013 Sep 20.


Rapid αβ T-cell responses orchestrate innate immunity in response to Staphylococcal enterotoxin A.

Kumar S, Colpitts SL, Ménoret A, Budelsky AL, Lefrancois L, Vella AT.

Mucosal Immunol. 2013 Sep;6(5):1006-15. doi: 10.1038/mi.2012.138. Epub 2013 Jan 16.


Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients.

Busse WW, Wenzel SE, Meltzer EO, Kerwin EM, Liu MC, Zhang N, Chon Y, Budelsky AL, Lin J, Lin SL.

J Allergy Clin Immunol. 2013 Feb;131(2):339-45. doi: 10.1016/j.jaci.2012.10.013. Epub 2012 Nov 20.


Dectin-1 and IL-17A suppress murine asthma induced by Aspergillus versicolor but not Cladosporium cladosporioides due to differences in β-glucan surface exposure.

Mintz-Cole RA, Gibson AM, Bass SA, Budelsky AL, Reponen T, Hershey GK.

J Immunol. 2012 Oct 1;189(7):3609-17. Epub 2012 Sep 7.


Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology.

Petersen BC, Budelsky AL, Baptist AP, Schaller MA, Lukacs NW.

Nat Med. 2012 May;18(5):751-8. doi: 10.1038/nm.2735.


Optimization of phenylacetic acid derivatives for balanced CRTH2 and DP dual antagonists.

Liu JJ, Wang Y, Johnson MG, Li AR, Shen W, Wang X, Su Y, Brown M, Van Lengerich B, Rickel E, Martin T, Budelsky A, Seitz L, Danao J, Tang HL, Collins T, Medina JC.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1686-9. doi: 10.1016/j.bmcl.2011.12.107. Epub 2011 Dec 30.


Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism.

Wang Y, Fu Z, Schmitt M, Wang X, Shen W, Rickel E, Martin T, Budelsky A, Marshall D, Collins T, Tang HL, Medina JC, Liu JJ.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):367-70. doi: 10.1016/j.bmcl.2011.10.123. Epub 2011 Nov 9.


Are Th17 cells in the gut pathogenic or protective?

Symons A, Budelsky AL, Towne JE.

Mucosal Immunol. 2012 Jan;5(1):4-6. doi: 10.1038/mi.2011.51. Epub 2011 Nov 9.


Prostaglandin D₂ receptor CRTH2 antagonists for the treatment of inflammatory diseases.

Chen JJ, Budelsky AL.

Prog Med Chem. 2011;50:49-107. doi: 10.1016/B978-0-12-381290-2.00002-1. No abstract available.


Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma.

Lajoie S, Lewkowich IP, Suzuki Y, Clark JR, Sproles AA, Dienger K, Budelsky AL, Wills-Karp M.

Nat Immunol. 2010 Oct;11(10):928-35. doi: 10.1038/ni.1926. Epub 2010 Aug 29.


The role of interleukin-4Ralpha in the induction of glutamic acid decarboxylase in airway epithelium following acute house dust mite exposure.

Hirota JA, Budelsky A, Smith D, Lipsky B, Ellis R, Xiang YY, Lu WY, Inman MD.

Clin Exp Allergy. 2010 May;40(5):820-30. doi: 10.1111/j.1365-2222.2010.03458.x. Epub 2010 Mar 12.


IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses.

Saenz SA, Siracusa MC, Perrigoue JG, Spencer SP, Urban JF Jr, Tocker JE, Budelsky AL, Kleinschek MA, Kastelein RA, Kambayashi T, Bhandoola A, Artis D.

Nature. 2010 Apr 29;464(7293):1362-6. doi: 10.1038/nature08901. Epub 2010 Mar 3.


Pulmonary IL-17E (IL-25) production and IL-17RB+ myeloid cell-derived Th2 cytokine production are dependent upon stem cell factor-induced responses during chronic allergic pulmonary disease.

Dolgachev V, Petersen BC, Budelsky AL, Berlin AA, Lukacs NW.

J Immunol. 2009 Nov 1;183(9):5705-15. doi: 10.4049/jimmunol.0901666. Epub 2009 Oct 14.


Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response.

Jessup HK, Brewer AW, Omori M, Rickel EA, Budelsky AL, Yoon BR, Ziegler SF, Comeau MR.

J Immunol. 2008 Sep 15;181(6):4311-9.


Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities.

Rickel EA, Siegel LA, Yoon BR, Rottman JB, Kugler DG, Swart DA, Anders PM, Tocker JE, Comeau MR, Budelsky AL.

J Immunol. 2008 Sep 15;181(6):4299-310.


BTNL2, a butyrophilin/B7-like molecule, is a negative costimulatory molecule modulated in intestinal inflammation.

Arnett HA, Escobar SS, Gonzalez-Suarez E, Budelsky AL, Steffen LA, Boiani N, Zhang M, Siu G, Brewer AW, Viney JL.

J Immunol. 2007 Feb 1;178(3):1523-33.

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