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Chronic Obstructive Pulmonary Disease In Aboriginal Patients Of The Northern Territory Of Australia: A Landscape Perspective.

Heraganahally SS, Wasgewatta SL, McNamara K, Eisemberg CC, Budd RC, Mehra S, Sajkov D.

Int J Chron Obstruct Pulmon Dis. 2019 Sep 26;14:2205-2217. doi: 10.2147/COPD.S213947. eCollection 2019.


Detection of Cell Surface Ligands for Human Synovial γδ T Cells.

Collins C, Lui Y, Santos AM, Ballif BA, Gogerly-Moragoda AM, Brouwer H, Ross R, Balagurunathan K, Sharma S, Wright GJ, Davis S, Budd RC.

J Immunol. 2019 Nov 1;203(9):2369-2376. doi: 10.4049/jimmunol.1900451. Epub 2019 Sep 23.


Glycolysis Induces MCJ Expression That Links T Cell Proliferation With Caspase-3 Activity and Death.

Secinaro MA, Fortner KA, Collins C, Rincón M, Budd RC.

Front Cell Dev Biol. 2019 Mar 11;7:28. doi: 10.3389/fcell.2019.00028. eCollection 2019.


Reducing protein oxidation reverses lung fibrosis.

Anathy V, Lahue KG, Chapman DG, Chia SB, Casey DT, Aboushousha R, van der Velden JLJ, Elko E, Hoffman SM, McMillan DH, Jones JT, Nolin JD, Abdalla S, Schneider R, Seward DJ, Roberson EC, Liptak MD, Cousins ME, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, Ho YS, Hakem R, Brown KK, Matsui R, Bachschmid MM, Gomez JL, Kaminski N, van der Vliet A, Janssen-Heininger YMW.

Nat Med. 2018 Aug;24(8):1128-1135. doi: 10.1038/s41591-018-0090-y. Epub 2018 Jul 9.


Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists.

Bewley MA, Budd RC, Ryan E, Cole J, Collini P, Marshall J, Kolsum U, Beech G, Emes RD, Tcherniaeva I, Berbers GAM, Walmsley SR, Donaldson G, Wedzicha JA, Kilty I, Rumsey W, Sanchez Y, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Whyte MKB, Dockrell DH; COPDMAP.

Am J Respir Crit Care Med. 2018 Sep 15;198(6):739-750. doi: 10.1164/rccm.201705-0903OC.


Glycolysis promotes caspase-3 activation in lipid rafts in T cells.

Secinaro MA, Fortner KA, Dienz O, Logan A, Murphy MP, Anathy V, Boyson JE, Budd RC.

Cell Death Dis. 2018 Jan 19;9(2):62. doi: 10.1038/s41419-017-0099-z.


Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages.

Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Shapiro SD, Whyte MKB, Dockrell DH.

Am J Respir Crit Care Med. 2017 Oct 1;196(7):845-855. doi: 10.1164/rccm.201608-1714OC.


The molecular signature of murine T cell homeostatic proliferation reveals both inflammatory and immune inhibition patterns.

Fortner KA, Bond JP, Austin JW, Boss JM, Budd RC.

J Autoimmun. 2017 Aug;82:47-61. doi: 10.1016/j.jaut.2017.05.003. Epub 2017 May 24.


Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus.

Buskiewicz IA, Montgomery T, Yasewicz EC, Huber SA, Murphy MP, Hartley RC, Kelly R, Crow MK, Perl A, Budd RC, Koenig A.

Sci Signal. 2016 Nov 29;9(456):ra115. Erratum in: Sci Signal. 2017 May 16;10 (479):.


Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.

Bewley MA, Belchamber KB, Chana KK, Budd RC, Donaldson G, Wedzicha JA, Brightling CE, Kilty I, Donnelly LE, Barnes PJ, Singh D, Whyte MK, Dockrell DH; COPDMAP.

PLoS One. 2016 Sep 28;11(9):e0163139. doi: 10.1371/journal.pone.0163139. eCollection 2016.


Necroptosis of Dendritic Cells Promotes Activation of γδ T Cells.

Collins CC, Bashant K, Erikson C, Thwe PM, Fortner KA, Wang H, Morita CT, Budd RC.

J Innate Immun. 2016;8(5):479-92. doi: 10.1159/000446498. Epub 2016 Jul 19.


Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

McMillan DH, van der Velden JL, Lahue KG, Qian X, Schneider RW, Iberg MS, Nolin JD, Abdalla S, Casey DT, Tew KD, Townsend DM, Henderson CJ, Wolf CR, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, van der Vliet A, Flemer S, Anathy V, Janssen-Heininger YM.

JCI Insight. 2016 Jun 2;1(8). pii: 85717. doi: 10.1172/jci.insight.85717.


J. Donald Capra, M.D. (1937-2015).

James JA, Thompson LF, Budd RC.

J Immunol. 2015 Jun 15;194(12):5575-6. doi: 10.4049/jimmunol.1590010. No abstract available.


γδ T Cells and dendritic cells in refractory Lyme arthritis.

Divan A, Budd RC, Tobin RP, Newell-Rogers MK.

J Leukoc Biol. 2015 Apr;97(4):653-63. doi: 10.1189/jlb.2RU0714-343RR. Epub 2015 Jan 20. Review.


c-FLIP-Short reduces type I interferon production and increases viremia with coxsackievirus B3.

Buskiewicz IA, Koenig A, Roberts B, Russell J, Shi C, Lee SH, Jung JU, Huber SA, Budd RC.

PLoS One. 2014 May 9;9(5):e96156. doi: 10.1371/journal.pone.0096156. eCollection 2014.


In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice.

Logan A, Shabalina IG, Prime TA, Rogatti S, Kalinovich AV, Hartley RC, Budd RC, Cannon B, Murphy MP.

Aging Cell. 2014 Aug;13(4):765-8. doi: 10.1111/acel.12212. Epub 2014 Mar 13.


IL-15 maintains T-cell survival via S-nitrosylation-mediated inhibition of caspase-3.

Saligrama PT, Fortner KA, Secinaro MA, Collins CC, Russell JQ, Budd RC.

Cell Death Differ. 2014 Jun;21(6):904-14. doi: 10.1038/cdd.2014.10. Epub 2014 Feb 7.


The role of sex differences in autophagy in the heart during coxsackievirus B3-induced myocarditis.

Koenig A, Sateriale A, Budd RC, Huber SA, Buskiewicz IA.

J Cardiovasc Transl Res. 2014 Mar;7(2):182-91. doi: 10.1007/s12265-013-9525-5. Epub 2013 Dec 10. Review.


The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.

Koenig A, Buskiewicz IA, Fortner KA, Russell JQ, Asaoka T, He YW, Hakem R, Eriksson JE, Budd RC.

J Biol Chem. 2014 Jan 10;289(2):1183-91. doi: 10.1074/jbc.M113.506428. Epub 2013 Nov 25.


Serum amyloid A inhibits dendritic cell apoptosis to induce glucocorticoid resistance in CD4(+) T cells.

Ather JL, Fortner KA, Budd RC, Anathy V, Poynter ME.

Cell Death Dis. 2013 Sep 5;4:e786. doi: 10.1038/cddis.2013.327.


Caspase-8 and FLIP regulate RIG-I/MDA5-induced innate immune host responses to picornaviruses.

Buskiewicz IA, Koenig A, Huber SA, Budd RC.

Future Virol. 2012 Dec;7(12):1221-1236.


Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease.

Martin RA, Ather JL, Lundblad LK, Suratt BT, Boyson JE, Budd RC, Alcorn JF, Flavell RA, Eisenbarth SC, Poynter ME.

Am J Respir Cell Mol Biol. 2013 May;48(5):655-64. doi: 10.1165/rcmb.2012-0423OC.


Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis.

Anathy V, Roberson E, Cunniff B, Nolin JD, Hoffman S, Spiess P, Guala AS, Lahue KG, Goldman D, Flemer S, van der Vliet A, Heintz NH, Budd RC, Tew KD, Janssen-Heininger YM.

Mol Cell Biol. 2012 Sep;32(17):3464-78. doi: 10.1128/MCB.00125-12. Epub 2012 Jul 2.


Proliferating γδ T cells manifest high and spatially confined caspase-3 activity.

Koenig A, Fortner KA, King BR, Madden J, Buskiewicz IA, Budd RC.

Immunology. 2012 Apr;135(4):276-86. doi: 10.1111/j.1365-2567.2011.03540.x.


Increased caspase activity primes human Lyme arthritis synovial γδ T cells for proliferation and death.

Thai PT, Collins CC, Fortner KA, Koenig A, Hayes SM, Budd RC.

Hum Immunol. 2011 Dec;72(12):1168-75. doi: 10.1016/j.humimm.2011.08.019. Epub 2011 Sep 22.


Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death.

Anathy V, Roberson EC, Guala AS, Godburn KE, Budd RC, Janssen-Heininger YM.

Antioxid Redox Signal. 2012 Mar 15;16(6):496-505. doi: 10.1089/ars.2011.4281. Epub 2011 Dec 22. Review.


Reduced immune response to Borrelia burgdorferi in the absence of γδ T cells.

Shi C, Sahay B, Russell JQ, Fortner KA, Hardin N, Sellati TJ, Budd RC.

Infect Immun. 2011 Oct;79(10):3940-6. doi: 10.1128/IAI.00148-11. Epub 2011 Jul 18.


Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts.

Fortner KA, Lees RK, MacDonald HR, Budd RC.

Int Immunol. 2011 Feb;23(2):75-88. doi: 10.1093/intimm/dxq466. Epub 2011 Jan 25.


Apoptosis regulators Fas and Bim synergistically control T-lymphocyte homeostatic proliferation.

Fortner KA, Bouillet P, Strasser A, Budd RC.

Eur J Immunol. 2010 Nov;40(11):3043-53. doi: 10.1002/eji.201040577. Epub 2010 Oct 27.


Regulation of apoptosis through cysteine oxidation: implications for fibrotic lung disease.

Janssen-Heininger YM, Aesif SW, van der Velden J, Guala AS, Reiss JN, Roberson EC, Budd RC, Reynaert NL, Anathy V.

Ann N Y Acad Sci. 2010 Aug;1203:23-8. doi: 10.1111/j.1749-6632.2010.05553.x. Review.


Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas.

Anathy V, Aesif SW, Guala AS, Havermans M, Reynaert NL, Ho YS, Budd RC, Janssen-Heininger YM.

J Cell Biol. 2009 Jan 26;184(2):241-52. doi: 10.1083/jcb.200807019.


Activation of gamma delta T cells by Borrelia burgdorferi is indirect via a TLR- and caspase-dependent pathway.

Collins C, Shi C, Russell JQ, Fortner KA, Budd RC.

J Immunol. 2008 Aug 15;181(4):2392-8.


Spatial differences in active caspase-8 defines its role in T-cell activation versus cell death.

Koenig A, Russell JQ, Rodgers WA, Budd RC.

Cell Death Differ. 2008 Nov;15(11):1701-11. doi: 10.1038/cdd.2008.100. Epub 2008 Jul 11.


Attenuation of apoptosis and the eye of the beholder.

Sobel BE, Zaman T, Budd RC, Schneider DJ, Taatjes DJ.

Coron Artery Dis. 2008 Feb;19(1):55-8. doi: 10.1097/MCA.0b013e3282f19b14. Review.


Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity.

Hughes PD, Belz GT, Fortner KA, Budd RC, Strasser A, Bouillet P.

Immunity. 2008 Feb;28(2):197-205. doi: 10.1016/j.immuni.2007.12.017.


c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival.

Hinshaw-Makepeace J, Huston G, Fortner KA, Russell JQ, Holoch D, Swain S, Budd RC.

Eur J Immunol. 2008 Jan;38(1):54-63.


Morphological and cytochemical determination of cell death by apoptosis.

Taatjes DJ, Sobel BE, Budd RC.

Histochem Cell Biol. 2008 Jan;129(1):33-43. Epub 2007 Nov 14. Review.


The CD95 receptor: apoptosis revisited.

Peter ME, Budd RC, Desbarats J, Hedrick SM, Hueber AO, Newell MK, Owen LB, Pope RM, Tschopp J, Wajant H, Wallach D, Wiltrout RH, Zörnig M, Lynch DH.

Cell. 2007 May 4;129(3):447-50.


Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.

Misra RS, Russell JQ, Koenig A, Hinshaw-Makepeace JA, Wen R, Wang D, Huo H, Littman DR, Ferch U, Ruland J, Thome M, Budd RC.

J Biol Chem. 2007 Jul 6;282(27):19365-74. Epub 2007 Apr 26.


Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells.

Dienz O, Eaton SM, Krahl TJ, Diehl S, Charland C, Dodge J, Swain SL, Budd RC, Haynes L, Rincon M.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7175-80. Epub 2007 Apr 16.


Reduced myocarditis following Coxsackievirus infection in cellular FLICE inhibitory protein--long form-transgenic mice.

Huber S, Dohrman A, Sartini D, Budd RC.

Immunology. 2006 Dec;119(4):541-50. Epub 2006 Sep 28.


Augmentation of proliferation of vascular smooth muscle cells by plasminogen activator inhibitor type 1.

Chen Y, Budd RC, Kelm RJ Jr, Sobel BE, Schneider DJ.

Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1777-83. Epub 2006 May 18.


cFLIP regulation of lymphocyte activation and development.

Budd RC, Yeh WC, Tschopp J.

Nat Rev Immunol. 2006 Mar;6(3):196-204. Review.


Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3.

Wu W, Misra RS, Russell JQ, Flavell RA, Rincón M, Budd RC.

J Biol Chem. 2006 Apr 21;281(16):10682-90. Epub 2006 Feb 2.


Fas ligand deficiency impairs host inflammatory response against infection with the spirochete Borrelia burgdorferi.

Shi C, Wolfe J, Russell JQ, Fortner K, Hardin N, Anguita J, Budd RC.

Infect Immun. 2006 Feb;74(2):1156-60.


Lyme arthritis synovial gammadelta T cells instruct dendritic cells via fas ligand.

Collins C, Wolfe J, Roessner K, Shi C, Sigal LH, Budd RC.

J Immunol. 2005 Nov 1;175(9):5656-65.


Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8.

Dohrman A, Russell JQ, Cuenin S, Fortner K, Tschopp J, Budd RC.

J Immunol. 2005 Jul 1;175(1):311-8.


Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation.

Dohrman A, Kataoka T, Cuenin S, Russell JQ, Tschopp J, Budd RC.

J Immunol. 2005 May 1;174(9):5270-8.


Effector CD4+ T cells generate intermediate caspase activity and cleavage of caspase-8 substrates.

Misra RS, Jelley-Gibbs DM, Russell JQ, Huston G, Swain SL, Budd RC.

J Immunol. 2005 Apr 1;174(7):3999-4009.

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