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Items: 27


[Sestrins are Gatekeepers in the Way from Stress to Aging and Disease].

Dalina AA, Kovaleva IE, Budanov AV.

Mol Biol (Mosk). 2018 Nov-Dec;52(6):948-962. doi: 10.1134/S0026898418060046. Review. Russian.


Implication of KRT16, FAM129A and HKDC1 genes as ATF4 regulated components of the integrated stress response.

Evstafieva AG, Kovaleva IE, Shoshinova MS, Budanov AV, Chumakov PM.

PLoS One. 2018 Feb 8;13(2):e0191107. doi: 10.1371/journal.pone.0191107. eCollection 2018.


Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma.

Oricchio E, Katanayeva N, Donaldson MC, Sungalee S, Pasion JP, B├ęguelin W, Battistello E, Sanghvi VR, Jiang M, Jiang Y, Teater M, Parmigiani A, Budanov AV, Chan FC, Shah SP, Kridel R, Melnick AM, Ciriello G, Wendel HG.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaak9969. doi: 10.1126/scitranslmed.aak9969.


Sensing the Environment Through Sestrins: Implications for Cellular Metabolism.

Parmigiani A, Budanov AV.

Int Rev Cell Mol Biol. 2016;327:1-42. doi: 10.1016/bs.ircmb.2016.05.003. Epub 2016 Jun 24. Review.


SESTRINs regulate mTORC1 via RRAGs: The riddle of GATOR.

Budanov AV.

Mol Cell Oncol. 2015 Jan 23;2(3):e997113. doi: 10.1080/23723556.2014.997113. eCollection 2015 Jul-Sep.


Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.

Ding B, Parmigiani A, Divakaruni AS, Archer K, Murphy AN, Budanov AV.

Sci Rep. 2016 Mar 2;6:22538. doi: 10.1038/srep22538.


Sestrin-2 is significantly increased in malignant pleural effusions due to lung cancer and is potentially secreted by pleural mesothelial cells.

Tsilioni I, Filippidis AS, Kerenidi T, Budanov AV, Zarogiannis SG, Gourgoulianis KI.

Clin Biochem. 2016 Jun;49(9):726-728. doi: 10.1016/j.clinbiochem.2016.02.002. Epub 2016 Feb 11.


Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation.

Ding B, Parmigiani A, Yang C, Budanov AV.

Cell Cycle. 2015;14(20):3231-41. doi: 10.1080/15384101.2015.1084447.


Sestrins inhibit mTORC1 kinase activation through the GATOR complex.

Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV.

Cell Rep. 2014 Nov 20;9(4):1281-91.


Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.

Zhao B, Shah P, Budanov AV, Qiang L, Ming M, Aplin A, Sims DM, He YY.

J Biol Chem. 2014 Dec 26;289(52):35806-14. doi: 10.1074/jbc.M114.595397. Epub 2014 Nov 6.


The role of tumor suppressor p53 in the antioxidant defense and metabolism.

Budanov AV.

Subcell Biochem. 2014;85:337-58. doi: 10.1007/978-94-017-9211-0_18. Review.


Sestrins orchestrate cellular metabolism to attenuate aging.

Lee JH, Budanov AV, Karin M.

Cell Metab. 2013 Dec 3;18(6):792-801. doi: 10.1016/j.cmet.2013.08.018. Epub 2013 Sep 19. Review.


Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.

Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M.

Cell Metab. 2012 Sep 5;16(3):311-21. doi: 10.1016/j.cmet.2012.08.004.


Stressin' Sestrins take an aging fight.

Budanov AV, Lee JH, Karin M.

EMBO Mol Med. 2010 Oct;2(10):388-400. doi: 10.1002/emmm.201000097. Review.


Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling.

Budanov AV.

Antioxid Redox Signal. 2011 Sep 15;15(6):1679-90. doi: 10.1089/ars.2010.3530. Epub 2011 Feb 18. Review.


Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.

Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M.

Science. 2010 Mar 5;327(5970):1223-8. doi: 10.1126/science.1182228.


p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.

Budanov AV, Karin M.

Cell. 2008 Aug 8;134(3):451-60. doi: 10.1016/j.cell.2008.06.028. Erratum in: Cell. 2009 Jan 23;136(2):378.


[Transcriptional inhibition of human papilloma virus in cervical carcinoma cells reactivates functions of the tumor suppressor p53].

Kochetkov DV, Il'inskaia GV, Komarov PG, Strom E, Agapova LS, Ivanov AV, Budanov AV, Frolova EI, Chumakov PM.

Mol Biol (Mosk). 2007 May-Jun;41(3):515-23. Russian.


The antioxidant function of the p53 tumor suppressor.

Sablina AA, Budanov AV, Ilyinskaya GV, Agapova LS, Kravchenko JE, Chumakov PM.

Nat Med. 2005 Dec;11(12):1306-13. Epub 2005 Nov 13.


[Retroviral reporter systems for the assessment of activity of stress-induced signal transduction pathways controlled by p53, HIF-1 and HSF-1 transcription factors].

Razorenova OV, Agapova LS, Budanov AV, Ivanov AV, Strunina SM, Chumakov PM.

Mol Biol (Mosk). 2005 Mar-Apr;39(2):286-93. Russian.


Virus-based reporter systems for monitoring transcriptional activity of hypoxia-inducible factor 1.

Razorenova OV, Ivanov AV, Budanov AV, Chumakov PM.

Gene. 2005 Apr 25;350(1):89-98.


Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.

Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM.

Science. 2004 Apr 23;304(5670):596-600.


Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells.

Gurova KV, Rokhlin OW, Budanov AV, Burdelya LG, Chumakov PM, Cohen MB, Gudkov AV.

Cancer Res. 2003 Jun 1;63(11):2905-12.


Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.

Budanov AV, Shoshani T, Faerman A, Zelin E, Kamer I, Kalinski H, Gorodin S, Fishman A, Chajut A, Einat P, Skaliter R, Gudkov AV, Chumakov PM, Feinstein E.

Oncogene. 2002 Sep 5;21(39):6017-31.


High constitutive level of NF-kappaB is crucial for viability of adenocarcinoma cells.

Smirnov AS, Ruzov AS, Budanov AV, Prokhortchouk AV, Ivanov AV, Prokhortchouk EB.

Cell Death Differ. 2001 Jun;8(6):621-30.


[A high constitutive level of NF-kappa B is necessary for viability of murine adenocarcinoma cells--possible role of p53].

Smirnov AS, Budanov AV, Ruzov AS, Ivanov AV, Prokhorchuk AV, Gnuchev NV, Prokhorchuk EB.

Mol Biol (Mosk). 2000 Sep-Oct;34(5):775-82. Russian. No abstract available.


[Construction by using retrovirus vector of recombinant with synthetic bradykinin "gene" for investigations of human gene expression in mammalian cells].

Neverova ME, Budanov AV, Adamskaia EI, Prasolov VS, Kalinin ME.

Vestn Ross Akad Med Nauk. 2000;(7):33-5. Russian.


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