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Items: 1 to 50 of 126

1.

Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice.

Carratt SA, Morin D, Buckpitt AR, Edwards PC, Van Winkle LS.

Toxicol Lett. 2016 Mar 30;246:35-41. doi: 10.1016/j.toxlet.2016.01.019. Epub 2016 Feb 1.

2.

Simultaneous quantification of multiple urinary naphthalene metabolites by liquid chromatography tandem mass spectrometry.

Ayala DC, Morin D, Buckpitt AR.

PLoS One. 2015 Apr 8;10(4):e0121937. doi: 10.1371/journal.pone.0121937. eCollection 2015.

3.

Alterations in the proteome of the respiratory tract in response to single and multiple exposures to naphthalene.

K├╝ltz D, Li J, Sacchi R, Morin D, Buckpitt A, Van Winkle L.

Proteomics. 2015 Aug;15(15):2655-68. doi: 10.1002/pmic.201400445. Epub 2015 May 13.

4.

Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts.

Schebb NH, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH.

Drug Metab Dispos. 2014 Jul;42(7):1098-102. doi: 10.1124/dmd.114.058206. Epub 2014 Apr 14.

5.

Sex differences in the acute nasal antioxidant/antielectrophilic response of the rat to inhaled naphthalene.

Cichocki JA, Smith GJ, Mendoza R, Buckpitt AR, Van Winkle LS, Morris JB.

Toxicol Sci. 2014 May;139(1):234-44. doi: 10.1093/toxsci/kfu031. Epub 2014 Feb 22.

PMID:
24563378
6.

Kinetics of naphthalene metabolism in target and non-target tissues of rodents and in nasal and airway microsomes from the Rhesus monkey.

Buckpitt A, Morin D, Murphy S, Edwards P, Van Winkle L.

Toxicol Appl Pharmacol. 2013 Jul 15;270(2):97-105. doi: 10.1016/j.taap.2013.04.006. Epub 2013 Apr 19.

PMID:
23602890
7.

Characterization of model peptide adducts with reactive metabolites of naphthalene by mass spectrometry.

Pham NT, Jewell WT, Morin D, Jones AD, Buckpitt AR.

PLoS One. 2012;7(8):e42053. doi: 10.1371/journal.pone.0042053. Epub 2012 Aug 3.

8.

Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma.

Plopper CG, Joad JP, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Lasley WL, Buckpitt AR, Pinkerton KE, Tarkington BK, Davis S, Nishio SJ, Gershwin LJ, Wu R, Hyde DM.

Clin Exp Allergy. 2012 Jul;42(7):1104-18. doi: 10.1111/j.1365-2222.2012.04005.x.

9.

Analysis of naphthalene adduct binding sites in model proteins by tandem mass spectrometry.

Pham NT, Jewell WT, Morin D, Buckpitt AR.

Chem Biol Interact. 2012 Aug 30;199(2):120-8. doi: 10.1016/j.cbi.2012.05.009. Epub 2012 May 31.

10.

Free flow electrophoresis separation and AMS quantitation of C-naphthalene-protein adducts.

Buchholz BA, Haack KW, Sporty JL, Buckpitt AR, Morin D.

Nucl Instrum Methods Phys Res B. 2010 Apr 1;268(7-8):1324-1327.

11.

Formation of covalently bound protein adducts from the cytotoxicant naphthalene in nasal epithelium: species comparisons.

DeStefano-Shields C, Morin D, Buckpitt A.

Environ Health Perspect. 2010 May;118(5):647-52. doi: 10.1289/ehp.0901333.

12.

Protein thiol oxidation in murine airway epithelial cells in response to naphthalene or diethyl maleate.

Spiess PC, Morin D, Williams CR, Buckpitt AR.

Am J Respir Cell Mol Biol. 2010 Sep;43(3):316-25. doi: 10.1165/rcmb.2009-0135OC. Epub 2009 Oct 20.

13.

Upper respiratory tract uptake of naphthalene.

Morris JB, Buckpitt AR.

Toxicol Sci. 2009 Oct;111(2):383-91. doi: 10.1093/toxsci/kfp138. Epub 2009 Jul 31.

PMID:
19648534
14.

Toxicity and metabolism of methylnaphthalenes: comparison with naphthalene and 1-nitronaphthalene.

Lin CY, Wheelock AM, Morin D, Baldwin RM, Lee MG, Taff A, Plopper C, Buckpitt A, Rohde A.

Toxicology. 2009 Jun 16;260(1-3):16-27. doi: 10.1016/j.tox.2009.03.002. Epub 2009 Mar 18. Review.

15.

Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization.

DiMaio Knych HK, DeStefano Shields C, Buckpitt AR, Stanley SD.

Arch Biochem Biophys. 2009 May 1;485(1):49-55. doi: 10.1016/j.abb.2009.02.009. Epub 2009 Feb 24.

PMID:
19245785
16.

Measurement of protein sulfhydryls in response to cellular oxidative stress using gel electrophoresis and multiplexed fluorescent imaging analysis.

Spiess PC, Morin D, Jewell WT, Buckpitt AR.

Chem Res Toxicol. 2008 May;21(5):1074-85. doi: 10.1021/tx8000708. Epub 2008 Apr 17.

17.

Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase.

Morisseau C, Newman JW, Wheelock CE, Hill Iii T, Morin D, Buckpitt AR, Hammock BD.

Chem Res Toxicol. 2008 Apr;21(4):951-7. doi: 10.1021/tx700446u. Epub 2008 Mar 25.

PMID:
18363382
18.

TRX-ASK1-JNK signaling regulation of cell density-dependent cytotoxicity in cigarette smoke-exposed human bronchial epithelial cells.

Lee YC, Chuang CY, Lee PK, Lee JS, Harper RW, Buckpitt AB, Wu R, Oslund K.

Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L921-31. doi: 10.1152/ajplung.00250.2007. Epub 2008 Feb 15.

19.

Hemin rescues adrenodoxin, heme a and cytochrome oxidase activity in frataxin-deficient oligodendroglioma cells.

Napoli E, Morin D, Bernhardt R, Buckpitt A, Cortopassi G.

Biochim Biophys Acta. 2007 Jul;1772(7):773-80. Epub 2007 Apr 10.

20.

Asthma/allergic airways disease: does postnatal exposure to environmental toxicants promote airway pathobiology?

Plopper CG, Smiley-Jewell SM, Miller LA, Fanucchi MV, Evans MJ, Buckpitt AR, Avdalovic M, Gershwin LJ, Joad JP, Kajekar R, Larson S, Pinkerton KE, Van Winkle LS, Schelegle ES, Pieczarka EM, Wu R, Hyde DM.

Toxicol Pathol. 2007 Jan;35(1):97-110.

PMID:
17325978
21.

Identification of proteins adducted by reactive metabolites of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques.

Lin CY, Boland BC, Lee YJ, Salemi MR, Morin D, Miller LA, Plopper CG, Buckpitt AR.

Proteomics. 2006 Feb;6(3):972-82.

PMID:
16453347
22.

Use of a fluorescent internal protein standard to achieve quantitative two-dimensional gel electrophoresis.

Wheelock AM, Morin D, Bartosiewicz M, Buckpitt AR.

Proteomics. 2006 Mar;6(5):1385-98.

PMID:
16429456
23.

Software-induced variance in two-dimensional gel electrophoresis image analysis.

Wheelock AM, Buckpitt AR.

Electrophoresis. 2005 Dec;26(23):4508-20.

PMID:
16315176
24.

Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells.

Schoenfeld RA, Napoli E, Wong A, Zhan S, Reutenauer L, Morin D, Buckpitt AR, Taroni F, Lonnerdal B, Ristow M, Puccio H, Cortopassi GA.

Hum Mol Genet. 2005 Dec 15;14(24):3787-99. Epub 2005 Oct 20.

PMID:
16239244
25.

Identification of proteins adducted by reactive naphthalene metabolites in vitro.

Isbell MA, Morin D, Boland B, Buckpitt A, Salemi M, Presley J.

Proteomics. 2005 Nov;5(16):4197-204.

PMID:
16206326
26.

Characterization of a structurally intact in situ lung model and comparison of naphthalene protein adducts generated in this model vs lung microsomes.

Lin CY, Isbell MA, Morin D, Boland BC, Salemi MR, Jewell WT, Weir AJ, Fanucchi MV, Baker GL, Plopper CG, Buckpitt AR.

Chem Res Toxicol. 2005 May;18(5):802-13.

PMID:
15892573
27.

In vivo effects of ozone exposure on protein adduct formation by 1-nitronaphthalene in rat lung.

Wheelock AM, Boland BC, Isbell M, Morin D, Wegesser TC, Plopper CG, Buckpitt AR.

Am J Respir Cell Mol Biol. 2005 Aug;33(2):130-7. Epub 2005 Apr 21.

28.

In situ naphthalene bioactivation and nasal airflow cause region-specific injury patterns in the nasal mucosa of rats exposed to naphthalene by inhalation.

Lee MG, Phimister A, Morin D, Buckpitt A, Plopper C.

J Pharmacol Exp Ther. 2005 Jul;314(1):103-10. Epub 2005 Apr 15.

29.
30.

Bioactivation of the pulmonary toxicants naphthalene and 1-nitronaphthalene by rat CYP2F4.

Baldwin RM, Shultz MA, Buckpitt AR.

J Pharmacol Exp Ther. 2005 Feb;312(2):857-65. Epub 2004 Oct 27.

31.

Glutathione depletion is a major determinant of inhaled naphthalene respiratory toxicity and naphthalene metabolism in mice.

Phimister AJ, Lee MG, Morin D, Buckpitt AR, Plopper CG.

Toxicol Sci. 2004 Nov;82(1):268-78. Epub 2004 Aug 19.

PMID:
15319489
32.

Site-specific metabolism of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques.

Boland B, Lin CY, Morin D, Miller L, Plopper C, Buckpitt A.

J Pharmacol Exp Ther. 2004 Aug;310(2):546-54. Epub 2004 Apr 13.

33.

Comparison of pulmonary/nasal CYP2F expression levels in rodents and rhesus macaque.

Baldwin RM, Jewell WT, Fanucchi MV, Plopper CG, Buckpitt AR.

J Pharmacol Exp Ther. 2004 Apr;309(1):127-36. Epub 2004 Jan 14.

34.

Assessing gene expression in lung subcompartments utilizing in situ RNA preservation.

Baker GL, Shultz MA, Fanucchi MV, Morin DM, Buckpitt AR, Plopper CG.

Toxicol Sci. 2004 Jan;77(1):135-41. Epub 2003 Nov 4.

PMID:
14600286
35.

Isolation of rodent airway epithelial cell proteins facilitates in vivo proteomics studies of lung toxicity.

Wheelock AM, Zhang L, Tran MU, Morin D, Penn S, Buckpitt AR, Plopper CG.

Am J Physiol Lung Cell Mol Physiol. 2004 Feb;286(2):L399-410. Epub 2003 Oct 31.

36.

Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development.

Shultz MA, Zhang L, Gu YZ, Baker GL, Fannuchi MV, Padua AM, Gurske WA, Morin D, Penn SG, Jovanovich SB, Plopper CG, Buckpitt AR.

Am J Respir Cell Mol Biol. 2004 Mar;30(3):296-310. Epub 2003 Aug 28.

PMID:
12947022
37.

Measurement of glutathione conjugates.

Shultz MA, Morin D, Chan KW, Buckpitt AR.

Curr Protoc Toxicol. 2003;Chapter 6:Unit6.8. doi: 10.1002/0471140856.tx0608s14.

PMID:
23045094
38.

Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.

Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.

Drug Metab Rev. 2002 Nov;34(4):791-820. Review.

PMID:
12487150
39.

Pharmacokinetics and metabolism of a novel antifibrotic drug pirfenidone, in mice following intravenous administration.

Giri SN, Wang Q, Xie Y, Lango J, Morin D, Margolin SB, Buckpitt AR.

Biopharm Drug Dispos. 2002 Jul;23(5):203-11.

PMID:
12116052
40.

Induction of tolerance to naphthalene in Clara cells is dependent on a stable phenotypic adaptation favoring maintenance of the glutathione pool.

West JA, Williams KJ, Toskala E, Nishio SJ, Fleschner CA, Forman HJ, Buckpitt AR, Plopper CG.

Am J Pathol. 2002 Mar;160(3):1115-27. Erratum in: Am J Pathol. 2003 Aug;163(2):803.

41.

Urinary naphthalene mercapturates as biomarkers of exposure and stereoselectivity of naphthalene epoxidation.

Pakenham G, Lango J, Buonarati M, Morin D, Buckpitt A.

Drug Metab Dispos. 2002 Mar;30(3):247-53.

42.

Inhaled naphthalene causes dose dependent Clara cell cytotoxicity in mice but not in rats.

West JA, Pakehham G, Morin D, Fleschner CA, Buckpitt AR, Plopper CG.

Toxicol Appl Pharmacol. 2001 Jun 1;173(2):114-9.

PMID:
11384213
43.

Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants.

Bartosiewicz MJ, Jenkins D, Penn S, Emery J, Buckpitt A.

J Pharmacol Exp Ther. 2001 Jun;297(3):895-905.

44.

Factors modulating the epithelial response to toxicants in tracheobronchial airways.

Plopper CG, Buckpitt A, Evans M, Van Winkle L, Fanucchi M, Smiley-Jewell S, Lakritz J, West J, Lawson G, Paige R, Miller L, Hyde D.

Toxicology. 2001 Mar 7;160(1-3):173-80.

PMID:
11246137
45.

Early events in naphthalene-induced acute Clara cell toxicity. II. Comparison of glutathione depletion and histopathology by airway location.

Plopper CG, Van Winkle LS, Fanucchi MV, Malburg SR, Nishio SJ, Chang A, Buckpitt AR.

Am J Respir Cell Mol Biol. 2001 Mar;24(3):272-81.

PMID:
11245626
47.

Metabolic capabilities of CYP2F2 with various pulmonary toxicants and its relative abundance in mouse lung subcompartments.

Shultz MA, Morin D, Chang AM, Buckpitt A.

J Pharmacol Exp Ther. 2001 Feb;296(2):510-9.

48.

Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae).

Schelegle ES, Gershwin LJ, Miller LA, Fanucchi MV, Van Winkle LS, Gerriets JP, Walby WF, Omlor AM, Buckpitt AR, Tarkington BK, Wong VJ, Joad JP, Pinkerton KB, Wu R, Evans MJ, Hyde DM, Plopper CG.

Am J Pathol. 2001 Jan;158(1):333-41.

49.
50.

Development of phase II xenobiotic metabolizing enzymes in differentiating murine clara cells.

Fanucchi MV, Buckpitt AR, Murphy ME, Storms DH, Hammock BD, Plopper CG.

Toxicol Appl Pharmacol. 2000 Nov 1;168(3):253-67.

PMID:
11042098

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