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Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.

Shi L, Westwood S, Baird AL, Winchester L, Dobricic V, Kilpert F, Hong S, Franke A, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Buckley NJ, Kate MT, Scheltens P, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lleó A, Alcolea D, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Teunissen CE, Freund-Levi Y, Frölich L, Legido-Quigley C, Barkhof F, Blennow K, Zetterberg H, Baker S, Morgan BP, Streffer J, Visser PJ, Bertram L, Lovestone S, Nevado-Holgado AJ.

Alzheimers Dement. 2019 Sep 5. pii: S1552-5260(19)35118-0. doi: 10.1016/j.jalz.2019.06.4951. [Epub ahead of print]


Repressor element 1-silencing transcription factor drives the development of chronic pain states.

Zhang F, Gigout S, Liu Y, Wang Y, Hao H, Buckley NJ, Zhang H, Wood IC, Gamper N.

Pain. 2019 Oct;160(10):2398-2408. doi: 10.1097/j.pain.0000000000001633.


Clusterin in Alzheimer's Disease: Mechanisms, Genetics, and Lessons From Other Pathologies.

Foster EM, Dangla-Valls A, Lovestone S, Ribe EM, Buckley NJ.

Front Neurosci. 2019 Feb 28;13:164. doi: 10.3389/fnins.2019.00164. eCollection 2019. Review.


Transcriptional and epigenetic mechanisms underlying astrocyte identity.

Pavlou MAS, Grandbarbe L, Buckley NJ, Niclou SP, Michelucci A.

Prog Neurobiol. 2019 Mar;174:36-52. doi: 10.1016/j.pneurobio.2018.12.007. Epub 2018 Dec 29. Review.


Convergent molecular defects underpin diverse neurodegenerative diseases.

Tofaris GK, Buckley NJ.

J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):962-969. doi: 10.1136/jnnp-2017-316988. Epub 2018 Feb 19. Review.


Prediction of Chromatin Accessibility in Gene-Regulatory Regions from Transcriptomics Data.

Jung S, Angarica VE, Andrade-Navarro MA, Buckley NJ, Del Sol A.

Sci Rep. 2017 Jul 5;7(1):4660. doi: 10.1038/s41598-017-04929-6.


A Role for RE-1-Silencing Transcription Factor in Embryonic Stem Cells Cardiac Lineage Specification.

Aksoy I, Marcy G, Chen J, Divakar U, Kumar V, John-Sanchez D, Rahmani M, Buckley NJ, Stanton LW.

Stem Cells. 2016 Apr;34(4):860-72. doi: 10.1002/stem.2304. Epub 2016 Feb 22.


MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration.

Bhinge A, Namboori SC, Bithell A, Soldati C, Buckley NJ, Stanton LW.

Stem Cells. 2016 Jan;34(1):124-34. doi: 10.1002/stem.2233. Epub 2015 Nov 20.


Quantifying barcodes of dendritic spines using entropy-based metrics.

Viggiano D, Srivastava DP, Speranza L, Perrone-Capano C, Bellenchi GC, di Porzio U, Buckley NJ.

Sci Rep. 2015 Sep 30;5:14622. doi: 10.1038/srep14622.


The Neurogenic Potential of Astrocytes Is Regulated by Inflammatory Signals.

Michelucci A, Bithell A, Burney MJ, Johnston CE, Wong KY, Teng SW, Desai J, Gumbleton N, Anderson G, Stanton LW, Williams BP, Buckley NJ.

Mol Neurobiol. 2016 Aug;53(6):3724-3739. doi: 10.1007/s12035-015-9296-x. Epub 2015 Jul 4.


Ascl1 Coordinately Regulates Gene Expression and the Chromatin Landscape during Neurogenesis.

Raposo AASF, Vasconcelos FF, Drechsel D, Marie C, Johnston C, Dolle D, Bithell A, Gillotin S, van den Berg DLC, Ettwiller L, Flicek P, Crawford GE, Parras CM, Berninger B, Buckley NJ, Guillemot F, Castro DS.

Cell Rep. 2015 Mar 10;10(9):1544-1556. doi: 10.1016/j.celrep.2015.02.025. Epub 2015 Mar 5.


RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro.

Soldati C, Caramanica P, Burney MJ, Toselli C, Bithell A, Augusti-Tocco G, Stanton LW, Biagioni S, Buckley NJ, Cacci E.

J Neurosci Res. 2015 Aug;93(8):1203-14. doi: 10.1002/jnr.23572. Epub 2015 Feb 17.


Concise review: a population shift view of cellular reprogramming.

Del Sol A, Buckley NJ.

Stem Cells. 2014 Jun;32(6):1367-72. doi: 10.1002/stem.1627. Review.


Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models.

Conforti P, Zuccato C, Gaudenzi G, Ieraci A, Camnasio S, Buckley NJ, Mutti C, Cotelli F, Contini A, Cattaneo E.

J Neurochem. 2013 Oct;127(1):22-35. doi: 10.1111/jnc.12348. Epub 2013 Jul 19.


An epigenetic signature of developmental potential in neural stem cells and early neurons.

Burney MJ, Johnston C, Wong KY, Teng SW, Beglopoulos V, Stanton LW, Williams BP, Bithell A, Buckley NJ.

Stem Cells. 2013 Sep;31(9):1868-80. doi: 10.1002/stem.1431.


HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain.

Denk F, Huang W, Sidders B, Bithell A, Crow M, Grist J, Sharma S, Ziemek D, Rice AS, Buckley NJ, McMahon SB.

Pain. 2013 Sep;154(9):1668-79. doi: 10.1016/j.pain.2013.05.021. Epub 2013 May 18.


In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD mice.

Conforti P, Mas Monteys A, Zuccato C, Buckley NJ, Davidson B, Cattaneo E.

Gene Ther. 2013 Jun;20(6):678-85. doi: 10.1038/gt.2012.84. Epub 2012 Nov 15.


Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease.

Soldati C, Bithell A, Johnston C, Wong KY, Stanton LW, Buckley NJ.

J Neurochem. 2013 Feb;124(3):418-30. doi: 10.1111/jnc.12090.


Neurodegeneration as an RNA disorder.

Johnson R, Noble W, Tartaglia GG, Buckley NJ.

Prog Neurobiol. 2012 Dec;99(3):293-315. doi: 10.1016/j.pneurobio.2012.09.006. Epub 2012 Oct 10. Review.


Repressor element 1 silencing transcription factor couples loss of pluripotency with neural induction and neural differentiation.

Soldati C, Bithell A, Johnston C, Wong KY, Teng SW, Beglopoulos V, Stanton LW, Buckley NJ.

Stem Cells. 2012 Mar;30(3):425-34. doi: 10.1002/stem.1004.


Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis.

Raj B, O'Hanlon D, Vessey JP, Pan Q, Ray D, Buckley NJ, Miller FD, Blencowe BJ.

Mol Cell. 2011 Sep 2;43(5):843-50. doi: 10.1016/j.molcel.2011.08.014.


New insights into non-coding RNA networks in Huntington's disease.

Buckley NJ, Johnson R.

Exp Neurol. 2011 Oct;231(2):191-4. doi: 10.1016/j.expneurol.2011.07.005. Epub 2011 Jul 30. No abstract available.


Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's disease.

Soldati C, Bithell A, Conforti P, Cattaneo E, Buckley NJ.

J Neurochem. 2011 Feb;116(3):415-25. doi: 10.1111/j.1471-4159.2010.07122.x. Epub 2010 Dec 13.


The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease.

Buckley NJ, Johnson R, Zuccato C, Bithell A, Cattaneo E.

Neurobiol Dis. 2010 Jul;39(1):28-39. doi: 10.1016/j.nbd.2010.02.003. Epub 2010 Feb 17. Review.


Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease.

Bithell A, Johnson R, Buckley NJ.

Biochem Soc Trans. 2009 Dec;37(Pt 6):1270-5. doi: 10.1042/BST0371270. Review.


Gene dysregulation in Huntington's disease: REST, microRNAs and beyond.

Johnson R, Buckley NJ.

Neuromolecular Med. 2009;11(3):183-99. doi: 10.1007/s12017-009-8063-4. Epub 2009 May 21.


Is REST a regulator of pluripotency?

Buckley NJ, Johnson R, Sun YM, Stanton LW.

Nature. 2009 Feb 26;457(7233):E5-6; discussion E7. doi: 10.1038/nature07784.


Regulation of neural macroRNAs by the transcriptional repressor REST.

Johnson R, Teh CH, Jia H, Vanisri RR, Pandey T, Lu ZH, Buckley NJ, Stanton LW, Lipovich L.

RNA. 2009 Jan;15(1):85-96. doi: 10.1261/rna.1127009. Epub 2008 Dec 2.


Rest-mediated regulation of extracellular matrix is crucial for neural development.

Sun YM, Cooper M, Finch S, Lin HH, Chen ZF, Williams BP, Buckley NJ.

PLoS One. 2008;3(11):e3656. doi: 10.1371/journal.pone.0003656. Epub 2008 Nov 6.


REST regulates distinct transcriptional networks in embryonic and neural stem cells.

Johnson R, Teh CH, Kunarso G, Wong KY, Srinivasan G, Cooper ML, Volta M, Chan SS, Lipovich L, Pollard SM, Karuturi RK, Wei CL, Buckley NJ, Stanton LW.

PLoS Biol. 2008 Oct 28;6(10):e256. doi: 10.1371/journal.pbio.0060256.


Grassland songbird survival and recruitment in agricultural landscapes: implications for source-sink demography.

Perlut NG, Strong AM, Donovan TM, Buckley NJ.

Ecology. 2008 Jul;89(7):1941-52.


A microRNA-based gene dysregulation pathway in Huntington's disease.

Johnson R, Zuccato C, Belyaev ND, Guest DJ, Cattaneo E, Buckley NJ.

Neurobiol Dis. 2008 Mar;29(3):438-45. Epub 2007 Nov 13.


Analysis of transcription, chromatin dynamics and epigenetic changes in neural genes.

Buckley NJ.

Prog Neurobiol. 2007 Nov;83(4):195-210. Epub 2007 Aug 1. Review.


Grassland songbirds in a dynamic management landscape: behavioral responses and management strategies.

Perlut NG, Strong AM, Donovan TM, Buckley NJ.

Ecol Appl. 2006 Dec;16(6):2235-47.


RE1 Silencing transcription factor maintains a repressive chromatin environment in embryonic hippocampal neural stem cells.

Greenway DJ, Street M, Jeffries A, Buckley NJ.

Stem Cells. 2007 Feb;25(2):354-63. Epub 2006 Nov 2.


The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype.

Bruce AW, Krejcí A, Ooi L, Deuchars J, Wood IC, Dolezal V, Buckley NJ.

J Neurochem. 2006 Sep;98(6):1828-40.


Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication.

Johnson R, Gamblin RJ, Ooi L, Bruce AW, Donaldson IJ, Westhead DR, Wood IC, Jackson RM, Buckley NJ.

Nucleic Acids Res. 2006;34(14):3862-77. Epub 2006 Aug 9.


Regulation and role of REST and REST4 variants in modulation of gene expression in in vivo and in vitro in epilepsy models.

Spencer EM, Chandler KE, Haddley K, Howard MR, Hughes D, Belyaev ND, Coulson JM, Stewart JP, Buckley NJ, Kipar A, Walker MC, Quinn JP.

Neurobiol Dis. 2006 Oct;24(1):41-52. Epub 2006 Jul 7.


Stimulation of Galphaq-coupled M1 muscarinic receptor causes reversible spectrin redistribution mediated by PLC, PKC and ROCK.

Street M, Marsh SJ, Stabach PR, Morrow JS, Brown DA, Buckley NJ.

J Cell Sci. 2006 Apr 15;119(Pt 8):1528-36. Epub 2006 Mar 21.


Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation.

Cheong A, Bingham AJ, Li J, Kumar B, Sukumar P, Munsch C, Buckley NJ, Neylon CB, Porter KE, Beech DJ, Wood IC.

Mol Cell. 2005 Oct 7;20(1):45-52.


Distinct profiles of REST interactions with its target genes at different stages of neuronal development.

Sun YM, Greenway DJ, Johnson R, Street M, Belyaev ND, Deuchars J, Bee T, Wilde S, Buckley NJ.

Mol Biol Cell. 2005 Dec;16(12):5630-8. Epub 2005 Sep 29. Erratum in: Mol Biol Cell. 2006 Mar;17(3):1494.


Healthy aging at older ages: are income and education important?

Buckley NJ, Denton FT, Robb AL, Spencer BG.

Can J Aging. 2004;23 Suppl 1:S155-69.


Multiple promoters drive tissue-specific expression of the human M muscarinic acetylcholine receptor gene.

Krejci A, Bruce AW, Dolezal V, Tucek S, Buckley NJ.

J Neurochem. 2004 Oct;91(1):88-98.


The transition from good to poor health: an econometric study of the older population.

Buckley NJ, Denton FT, Robb AL, Spencer BG.

J Health Econ. 2004 Sep;23(5):1013-34.


Evidence for inhibition mediated by coassembly of GABAA and GABAC receptor subunits in native central neurons.

Milligan CJ, Buckley NJ, Garret M, Deuchars J, Deuchars SA.

J Neurosci. 2004 Aug 18;24(33):7241-50.


Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes.

Bruce AW, Donaldson IJ, Wood IC, Yerbury SA, Sadowski MI, Chapman M, Göttgens B, Buckley NJ.

Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10458-63. Epub 2004 Jul 6.


Transcription of the M1 muscarinic receptor gene in neurons and neuronal progenitors of the embryonic rat forebrain.

Williams BP, Milligan CJ, Street M, Hornby FM, Deuchars J, Buckley NJ.

J Neurochem. 2004 Jan;88(1):70-7.


Interaction of the repressor element 1-silencing transcription factor (REST) with target genes.

Wood IC, Belyaev ND, Bruce AW, Jones C, Mistry M, Roopra A, Buckley NJ.

J Mol Biol. 2003 Dec 12;334(5):863-74.


Distinct RE-1 silencing transcription factor-containing complexes interact with different target genes.

Belyaev ND, Wood IC, Bruce AW, Street M, Trinh JB, Buckley NJ.

J Biol Chem. 2004 Jan 2;279(1):556-61. Epub 2003 Oct 15.

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