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Evolution of the rodent Trim5 cluster is marked by divergent paralogous expansions and independent acquisitions of TrimCyp fusions.

Boso G, Shaffer E, Liu Q, Cavanna K, Buckler-White A, Kozak CA.

Sci Rep. 2019 Aug 2;9(1):11263. doi: 10.1038/s41598-019-47720-5.


Xenotropic Mouse Gammaretroviruses Isolated from Pre-Leukemic Tissues Include a Recombinant.

Bamunusinghe D, Skorski M, Buckler-White A, Kozak CA.

Viruses. 2018 Aug 9;10(8). pii: E418. doi: 10.3390/v10080418.


Ancient Evolutionary Origin and Positive Selection of the Retroviral Restriction Factor Fv1 in Muroid Rodents.

Boso G, Buckler-White A, Kozak CA.

J Virol. 2018 Aug 29;92(18). pii: e00850-18. doi: 10.1128/JVI.00850-18. Print 2018 Sep 15.


A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection.

Gautam R, Nishimura Y, Gaughan N, Gazumyan A, Schoofs T, Buckler-White A, Seaman MS, Swihart BJ, Follmann DA, Nussenzweig MC, Martin MA.

Nat Med. 2018 May;24(5):610-616. doi: 10.1038/s41591-018-0001-2. Epub 2018 Apr 16.


Recombinant Origins of Pathogenic and Nonpathogenic Mouse Gammaretroviruses with Polytropic Host Range.

Bamunusinghe D, Liu Q, Plishka R, Dolan MA, Skorski M, Oler AJ, Yedavalli VRK, Buckler-White A, Hartley JW, Kozak CA.

J Virol. 2017 Oct 13;91(21). pii: e00855-17. doi: 10.1128/JVI.00855-17. Print 2017 Nov 1.


Early antibody therapy can induce long-lasting immunity to SHIV.

Nishimura Y, Gautam R, Chun TW, Sadjadpour R, Foulds KE, Shingai M, Klein F, Gazumyan A, Golijanin J, Donaldson M, Donau OK, Plishka RJ, Buckler-White A, Seaman MS, Lifson JD, Koup RA, Fauci AS, Nussenzweig MC, Martin MA.

Nature. 2017 Mar 23;543(7646):559-563. doi: 10.1038/nature21435. Epub 2017 Mar 13.


Long-term passage of Vif-null HIV-1 in CD4+ T cells expressing sub-lethal levels of APOBEC proteins fails to develop APOBEC resistance.

Miyagi E, Kao S, Fumitaka M, Buckler-White A, Plishka R, Strebel K.

Virology. 2017 Apr;504:1-11. doi: 10.1016/j.virol.2017.01.016. Epub 2017 Jan 25.


TRIM5α Resistance Escape Mutations in the Capsid Are Transferable between Simian Immunodeficiency Virus Strains.

Wu F, Kirmaier A, White E, Ourmanov I, Whitted S, Matsuda K, Riddick N, Hall LR, Morgan JS, Plishka RJ, Buckler-White A, Johnson WE, Hirsch VM.

J Virol. 2016 Nov 28;90(24):11087-11095. Print 2016 Dec 15.


Enhanced antagonism of BST-2 by a neurovirulent SIV envelope.

Matsuda K, Chen CY, Whitted S, Chertova E, Roser DJ, Wu F, Plishka RJ, Ourmanov I, Buckler-White A, Lifson JD, Strebel K, Hirsch VM.

J Clin Invest. 2016 Jun 1;126(6):2295-307. doi: 10.1172/JCI83725. Epub 2016 May 9.


A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges.

Gautam R, Nishimura Y, Pegu A, Nason MC, Klein F, Gazumyan A, Golijanin J, Buckler-White A, Sadjadpour R, Wang K, Mankoff Z, Schmidt SD, Lifson JD, Mascola JR, Nussenzweig MC, Martin MA.

Nature. 2016 May 5;533(7601):105-109. doi: 10.1038/nature17677. Epub 2016 Apr 27.


Sequence Diversity, Intersubgroup Relationships, and Origins of the Mouse Leukemia Gammaretroviruses of Laboratory and Wild Mice.

Bamunusinghe D, Naghashfar Z, Buckler-White A, Plishka R, Baliji S, Liu Q, Kassner J, Oler AJ, Hartley J, Kozak CA.

J Virol. 2016 Mar 28;90(8):4186-98. doi: 10.1128/JVI.03186-15. Print 2016 Apr.


Simian Immunodeficiency Virus SIVagm Efficiently Utilizes Non-CCR5 Entry Pathways in African Green Monkey Lymphocytes: Potential Role for GPR15 and CXCR6 as Viral Coreceptors.

Riddick NE, Wu F, Matsuda K, Whitted S, Ourmanov I, Goldstein S, Goeken RM, Plishka RJ, Buckler-White A, Brenchley JM, Hirsch VM.

J Virol. 2015 Dec 9;90(5):2316-31. doi: 10.1128/JVI.02529-15.


The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.

Shingai M, Welbourn S, Brenchley JM, Acharya P, Miyagi E, Plishka RJ, Buckler-White A, Kwong PD, Nishimura Y, Strebel K, Martin MA.

PLoS Pathog. 2015 May 21;11(5):e1004928. doi: 10.1371/journal.ppat.1004928. eCollection 2015 May.


TRIM5α restriction affects clinical outcome and disease progression in simian immunodeficiency virus-infected rhesus macaques.

Wu F, Ourmanov I, Riddick N, Matsuda K, Whitted S, Plishka RJ, Buckler-White A, Starost MF, Hirsch VM.

J Virol. 2015 Feb;89(4):2233-40. doi: 10.1128/JVI.02978-14. Epub 2014 Dec 3.


Characterization of simian immunodeficiency virus (SIV) that induces SIV encephalitis in rhesus macaques with high frequency: role of TRIM5 and major histocompatibility complex genotypes and early entry to the brain.

Matsuda K, Dang Q, Brown CR, Keele BF, Wu F, Ourmanov I, Goeken R, Whitted S, Riddick NE, Buckler-White A, Hirsch VM.

J Virol. 2014 Nov;88(22):13201-11. doi: 10.1128/JVI.01996-14. Epub 2014 Sep 3.


Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques.

Shingai M, Donau OK, Plishka RJ, Buckler-White A, Mascola JR, Nabel GJ, Nason MC, Montefiori D, Moldt B, Poignard P, Diskin R, Bjorkman PJ, Eckhaus MA, Klein F, Mouquet H, Cetrulo Lorenzi JC, Gazumyan A, Burton DR, Nussenzweig MC, Martin MA, Nishimura Y.

J Exp Med. 2014 Sep 22;211(10):2061-74. doi: 10.1084/jem.20132494. Epub 2014 Aug 25.


Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia.

Shingai M, Nishimura Y, Klein F, Mouquet H, Donau OK, Plishka R, Buckler-White A, Seaman M, Piatak M Jr, Lifson JD, Dimitrov DS, Nussenzweig MC, Martin MA.

Nature. 2013 Nov 14;503(7475):277-80. doi: 10.1038/nature12746. Epub 2013 Oct 30.


TRIM5 alpha drives SIVsmm evolution in rhesus macaques.

Wu F, Kirmaier A, Goeken R, Ourmanov I, Hall L, Morgan JS, Matsuda K, Buckler-White A, Tomioka K, Plishka R, Whitted S, Johnson W, Hirsch VM.

PLoS Pathog. 2013;9(8):e1003577. doi: 10.1371/journal.ppat.1003577. Epub 2013 Aug 22.


The avian XPR1 gammaretrovirus receptor is under positive selection and is disabled in bird species in contact with virus-infected wild mice.

Martin C, Buckler-White A, Wollenberg K, Kozak CA.

J Virol. 2013 Sep;87(18):10094-104. doi: 10.1128/JVI.01327-13. Epub 2013 Jul 10.


Laser capture microdissection assessment of virus compartmentalization in the central nervous systems of macaques infected with neurovirulent simian immunodeficiency virus.

Matsuda K, Brown CR, Foley B, Goeken R, Whitted S, Dang Q, Wu F, Plishka R, Buckler-White A, Hirsch VM.

J Virol. 2013 Aug;87(16):8896-908. doi: 10.1128/JVI.00874-13. Epub 2013 May 29.


Emergence of gp120 V3 variants confers neutralization resistance in an R5 simian-human immunodeficiency virus-infected macaque elite neutralizer that targets the N332 glycan of the human immunodeficiency virus type 1 envelope glycoprotein.

Sadjadpour R, Donau OK, Shingai M, Buckler-White A, Kao S, Strebel K, Nishimura Y, Martin MA.

J Virol. 2013 Aug;87(15):8798-804. doi: 10.1128/JVI.00878-13. Epub 2013 May 29.


Most rhesus macaques infected with the CCR5-tropic SHIV(AD8) generate cross-reactive antibodies that neutralize multiple HIV-1 strains.

Shingai M, Donau OK, Schmidt SD, Gautam R, Plishka RJ, Buckler-White A, Sadjadpour R, Lee WR, LaBranche CC, Montefiori DC, Mascola JR, Nishimura Y, Martin MA.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19769-74. doi: 10.1073/pnas.1217443109. Epub 2012 Nov 5.


Degenerate recognition of MHC class I molecules with Bw4 and Bw6 motifs by a killer cell Ig-like receptor 3DL expressed by macaque NK cells.

Maloveste SM, Chen D, Gostick E, Vivian JP, Plishka RJ, Iyengar R, Kruthers RL, Buckler-White A, Brooks AG, Rossjohn J, Price DA, Lafont BA.

J Immunol. 2012 Nov 1;189(9):4338-48. doi: 10.4049/jimmunol.1201360. Epub 2012 Oct 5.


Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaques.

Dang Q, Whitted S, Goeken RM, Brenchley JM, Matsuda K, Brown CR, Lafont BA, Starost MF, Iyengar R, Plishka RJ, Buckler-White A, Hirsch VM.

J Virol. 2012 Dec;86(24):13795-9. doi: 10.1128/JVI.02174-12. Epub 2012 Oct 3.


Sequential evolution and escape from neutralization of simian immunodeficiency virus SIVsmE660 clones in rhesus macaques.

Wu F, Ourmanov I, Kuwata T, Goeken R, Brown CR, Buckler-White A, Iyengar R, Plishka R, Aoki ST, Hirsch VM.

J Virol. 2012 Aug;86(16):8835-47. doi: 10.1128/JVI.00923-12. Epub 2012 Jun 13.


Pathogenicity and mucosal transmissibility of the R5-tropic simian/human immunodeficiency virus SHIV(AD8) in rhesus macaques: implications for use in vaccine studies.

Gautam R, Nishimura Y, Lee WR, Donau O, Buckler-White A, Shingai M, Sadjadpour R, Schmidt SD, LaBranche CC, Keele BF, Montefiori D, Mascola JR, Martin MA.

J Virol. 2012 Aug;86(16):8516-26. doi: 10.1128/JVI.00644-12. Epub 2012 May 30.


Recombination-mediated changes in coreceptor usage confer an augmented pathogenic phenotype in a nonhuman primate model of HIV-1-induced AIDS.

Nishimura Y, Shingai M, Lee WR, Sadjadpour R, Donau OK, Willey R, Brenchley JM, Iyengar R, Buckler-White A, Igarashi T, Martin MA.

J Virol. 2011 Oct;85(20):10617-26. doi: 10.1128/JVI.05010-11. Epub 2011 Aug 3.


Evolution of functional and sequence variants of the mammalian XPR1 receptor for mouse xenotropic gammaretroviruses and the human-derived retrovirus XMRV.

Yan Y, Liu Q, Wollenberg K, Martin C, Buckler-White A, Kozak CA.

J Virol. 2010 Nov;84(22):11970-80. doi: 10.1128/JVI.01549-10. Epub 2010 Sep 15.


TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species.

Kirmaier A, Wu F, Newman RM, Hall LR, Morgan JS, O'Connor S, Marx PA, Meythaler M, Goldstein S, Buckler-White A, Kaur A, Hirsch VM, Johnson WE.

PLoS Biol. 2010 Aug 24;8(8). pii: e1000462. doi: 10.1371/journal.pbio.1000462.


Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.

Sanville B, Dolan MA, Wollenberg K, Yan Y, Martin C, Yeung ML, Strebel K, Buckler-White A, Kozak CA.

PLoS Pathog. 2010 Jul 1;6:e1000974. doi: 10.1371/journal.ppat.1000974.


Correction of a carboxyl terminal simian immunodeficiency virus Nef frameshift mutation restores virus replication in macaques.

Zheng Y, Ourmanov I, Goeken RM, Whitted S, Brown CR, Buckler-White A, Iyengar R, Plishka RJ, Hirsch VM.

Virology. 2010 Jun 5;401(2):207-14. doi: 10.1016/j.virol.2010.02.026. Epub 2010 Mar 19.


Generation of the pathogenic R5-tropic simian/human immunodeficiency virus SHIVAD8 by serial passaging in rhesus macaques.

Nishimura Y, Shingai M, Willey R, Sadjadpour R, Lee WR, Brown CR, Brenchley JM, Buckler-White A, Petros R, Eckhaus M, Hoffman V, Igarashi T, Martin MA.

J Virol. 2010 May;84(9):4769-81. doi: 10.1128/JVI.02279-09. Epub 2010 Feb 10.


Initiation of antiretroviral therapy 48 hours after infection with simian immunodeficiency virus potently suppresses acute-phase viremia and blocks the massive loss of memory CD4+ T cells but fails to prevent disease.

Kubo M, Nishimura Y, Shingai M, Lee W, Brenchley J, Lafont B, Buckler-White A, Igarashi T, Martin MA.

J Virol. 2009 Jul;83(14):7099-108. doi: 10.1128/JVI.02522-08. Epub 2009 May 6.


High frequencies of resting CD4+ T cells containing integrated viral DNA are found in rhesus macaques during acute lentivirus infections.

Nishimura Y, Sadjadpour R, Mattapallil JJ, Igarashi T, Lee W, Buckler-White A, Roederer M, Chun TW, Martin MA.

Proc Natl Acad Sci U S A. 2009 May 12;106(19):8015-20. doi: 10.1073/pnas.0903022106. Epub 2009 Apr 27.


Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies.

Kuwata T, Nishimura Y, Whitted S, Ourmanov I, Brown CR, Dang Q, Buckler-White A, Iyengar R, Brenchley JM, Hirsch VM.

PLoS Pathog. 2009 Apr;5(4):e1000372. doi: 10.1371/journal.ppat.1000372. Epub 2009 Apr 10.


Improved survival in rhesus macaques immunized with modified vaccinia virus Ankara recombinants expressing simian immunodeficiency virus envelope correlates with reduction in memory CD4+ T-cell loss and higher titers of neutralizing antibody.

Ourmanov I, Kuwata T, Goeken R, Goldstein S, Iyengar R, Buckler-White A, Lafont B, Hirsch VM.

J Virol. 2009 Jun;83(11):5388-400. doi: 10.1128/JVI.02598-08. Epub 2009 Mar 25.


Origin, antiviral function and evidence for positive selection of the gammaretrovirus restriction gene Fv1 in the genus Mus.

Yan Y, Buckler-White A, Wollenberg K, Kozak CA.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3259-63. doi: 10.1073/pnas.0900181106. Epub 2009 Feb 12. Erratum in: Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6878.


APOBEC3G-independent reduction in virion infectivity during long-term HIV-1 replication in terminally differentiated macrophages.

Miyagi E, Schwartzkopff F, Plishka R, Buckler-White A, Clouse KA, Strebel K.

Virology. 2008 Sep 30;379(2):266-74. doi: 10.1016/j.virol.2008.06.033. Epub 2008 Aug 3.


Adaptive evolution of simian immunodeficiency viruses isolated from 2 conventional-progressor macaques with encephalitis.

Dang Q, Goeken RM, Brown CR, Plishka RJ, Buckler-White A, Byrum R, Foley BT, Hirsch VM.

J Infect Dis. 2008 Jun 15;197(12):1695-700. doi: 10.1086/588671.


Human immunodeficiency virus type 1 derivative with 7% simian immunodeficiency virus genetic content is able to establish infections in pig-tailed macaques.

Igarashi T, Iyengar R, Byrum RA, Buckler-White A, Dewar RL, Buckler CE, Lane HC, Kamada K, Adachi A, Martin MA.

J Virol. 2007 Oct;81(20):11549-52. Epub 2007 Aug 1.


Although macrophage-tropic simian/human immunodeficiency viruses can exhibit a range of pathogenic phenotypes, a majority of isolates induce no clinical disease in immunocompetent macaques.

Igarashi T, Donau OK, Imamichi H, Nishimura Y, Theodore TS, Iyengar R, Erb C, Buckler-White A, Buckler CE, Martin MA.

J Virol. 2007 Oct;81(19):10669-79. Epub 2007 Jul 11.


A rapid progressor-specific variant clone of simian immunodeficiency virus replicates efficiently in vivo only in the absence of immune responses.

Kuwata T, Byrum R, Whitted S, Goeken R, Buckler-White A, Plishka R, Iyengar R, Hirsch VM.

J Virol. 2007 Sep;81(17):8891-904. Epub 2007 Jun 27.


Vif counteracts a cyclophilin A-imposed inhibition of simian immunodeficiency viruses in human cells.

Takeuchi H, Buckler-White A, Goila-Gaur R, Miyagi E, Khan MA, Opi S, Kao S, Sokolskaja E, Pertel T, Luban J, Strebel K.

J Virol. 2007 Aug;81(15):8080-90. Epub 2007 May 23.


The locus encoding an oligomorphic family of MHC-A alleles (Mane-A*06/Mamu-A*05) is present at high frequency in several macaque species.

Lafont BA, McGraw CM, Stukes SA, Buckler-White A, Plishka RJ, Byrum RA, Hirsch VM, Martin MA.

Immunogenetics. 2007 Mar;59(3):211-23. Epub 2007 Jan 26.


Loss of naïve cells accompanies memory CD4+ T-cell depletion during long-term progression to AIDS in Simian immunodeficiency virus-infected macaques.

Nishimura Y, Igarashi T, Buckler-White A, Buckler C, Imamichi H, Goeken RM, Lee WR, Lafont BA, Byrum R, Lane HC, Hirsch VM, Martin MA.

J Virol. 2007 Jan;81(2):893-902. Epub 2006 Nov 8.


Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge.

Mattapallil JJ, Douek DC, Buckler-White A, Montefiori D, Letvin NL, Nabel GJ, Roederer M.

J Exp Med. 2006 Jun 12;203(6):1533-41. Epub 2006 May 30.


Comparison of simian immunodeficiency virus SIVagmVer replication and CD4+ T-cell dynamics in vervet and sabaeus African green monkeys.

Goldstein S, Brown CR, Ourmanov I, Pandrea I, Buckler-White A, Erb C, Nandi JS, Foster GJ, Autissier P, Schmitz JE, Hirsch VM.

J Virol. 2006 May;80(10):4868-77.


Infectious molecular clones from a simian immunodeficiency virus-infected rapid-progressor (RP) macaque: evidence of differential selection of RP-specific envelope mutations in vitro and in vivo.

Kuwata T, Dehghani H, Brown CR, Plishka R, Buckler-White A, Igarashi T, Mattapallil J, Roederer M, Hirsch VM.

J Virol. 2006 Feb;80(3):1463-75.


Immunodeficiency in the absence of high viral load in pig-tailed macaques infected with Simian immunodeficiency virus SIVsun or SIVlhoest.

Beer BE, Brown CR, Whitted S, Goldstein S, Goeken R, Plishka R, Buckler-White A, Hirsch VM.

J Virol. 2005 Nov;79(22):14044-56.

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