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Invited Commentary: Focus on Quantitative Imaging-Real Progress Is Being Made, but Much Is Left to Do.

Buckler AJ.

Radiographics. 2019 Jul-Aug;39(4):977-980. doi: 10.1148/rg.2019190063. Epub 2019 Jun 14. No abstract available.


Automated plaque analysis for the prognostication of major adverse cardiac events.

van Assen M, Varga-Szemes A, Schoepf UJ, Duguay TM, Hudson HT, Egorova S, Johnson K, St Pierre S, Zaki B, Oudkerk M, Vliegenthart R, Buckler AJ.

Eur J Radiol. 2019 Jul;116:76-83. doi: 10.1016/j.ejrad.2019.04.013. Epub 2019 Apr 27.


Statistical Considerations for Planning Clinical Trials with Quantitative Imaging Biomarkers.

Obuchowski NA, Mozley PD, Matthews D, Buckler A, Bullen J, Jackson E.

J Natl Cancer Inst. 2019 Jan 1;111(1):19-26. doi: 10.1093/jnci/djy194.


Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapy.

Long KK, O'Shea KM, Khairallah RJ, Howell K, Paushkin S, Chen KS, Cote SM, Webster MT, Stains JP, Treece E, Buckler A, Donovan A.

Hum Mol Genet. 2019 Apr 1;28(7):1076-1089. doi: 10.1093/hmg/ddy382.


Evaluation of Simulated Lesions as Surrogates to Clinical Lesions for Thoracic CT Volumetry: The Results of an International Challenge.

Robins M, Kalpathy-Cramer J, Obuchowski NA, Buckler A, Athelogou M, Jarecha R, Petrick N, Pezeshk A, Sahiner B, Samei E.

Acad Radiol. 2019 Jul;26(7):e161-e173. doi: 10.1016/j.acra.2018.07.022. Epub 2018 Sep 12.


CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling.

Henry KL, Kellner D, Bajrami B, Anderson JE, Beyna M, Bhisetti G, Cameron T, Capacci AG, Bertolotti-Ciarlet A, Feng J, Gao B, Hopkins B, Jenkins T, Li K, May-Dracka T, Murugan P, Wei R, Zeng W, Allaire N, Buckler A, Loh C, Juhasz P, Lucas B, Ennis KA, Vollman E, Cahir-McFarland E, Hett EC, Ols ML.

Sci Signal. 2018 Jul 31;11(541). pii: eaam8216. doi: 10.1126/scisignal.aam8216.


Atherosclerotic Plaque Tissue: Noninvasive Quantitative Assessment of Characteristics with Software-aided Measurements from Conventional CT Angiography.

Sheahan M, Ma X, Paik D, Obuchowski NA, St Pierre S, Newman WP 3rd, Rae G, Perlman ES, Rosol M, Keith JC Jr, Buckler AJ.

Radiology. 2018 Feb;286(2):622-631. doi: 10.1148/radiol.2017170127. Epub 2017 Aug 31.


Measurement Accuracy of Atherosclerotic Plaque Structure on CT Using Phantoms to Establish Ground Truth.

St Pierre S, Siegelman J, Obuchowski NA, Ma X, Paik D, Buckler AJ.

Acad Radiol. 2017 Oct;24(10):1203-1215. doi: 10.1016/j.acra.2017.04.007. Epub 2017 May 24.


Volumes Learned: It Takes More Than Size to "Size Up" Pulmonary Lesions.

Ma X, Siegelman J, Paik DS, Mulshine JL, St Pierre S, Buckler AJ.

Acad Radiol. 2016 Sep;23(9):1190-8. doi: 10.1016/j.acra.2016.04.003. Epub 2016 Jun 7. Review.


Algorithm Variability in the Estimation of Lung Nodule Volume From Phantom CT Scans: Results of the QIBA 3A Public Challenge.

Athelogou M, Kim HJ, Dima A, Obuchowski N, Peskin A, Gavrielides MA, Petrick N, Saiprasad G, Colditz Colditz D, Beaumont H, Oubel E, Tan Y, Zhao B, Kuhnigk JM, Moltz JH, Orieux G, Gillies RJ, Gu Y, Mantri N, Goldmacher G, Zhang L, Vega E, Bloom M, Jarecha R, Soza G, Tietjen C, Takeguchi T, Yamagata H, Peterson S, Masoud O, Buckler AJ.

Acad Radiol. 2016 Aug;23(8):940-52. doi: 10.1016/j.acra.2016.02.018. Epub 2016 May 20.


Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.

Bernasconi-Elias P, Hu T, Jenkins D, Firestone B, Gans S, Kurth E, Capodieci P, Deplazes-Lauber J, Petropoulos K, Thiel P, Ponsel D, Hee Choi S, LeMotte P, London A, Goetcshkes M, Nolin E, Jones MD, Slocum K, Kluk MJ, Weinstock DM, Christodoulou A, Weinberg O, Jaehrling J, Ettenberg SA, Buckler A, Blacklow SC, Aster JC, Fryer CJ.

Oncogene. 2016 Nov 24;35(47):6077-6086. doi: 10.1038/onc.2016.133. Epub 2016 May 9.


Statistical Issues in Testing Conformance with the Quantitative Imaging Biomarker Alliance (QIBA) Profile Claims.

Obuchowski NA, Buckler A, Kinahan P, Chen-Mayer H, Petrick N, Barboriak DP, Bullen J, Barnhart H, Sullivan DC.

Acad Radiol. 2016 Apr;23(4):496-506. doi: 10.1016/j.acra.2015.12.020. Epub 2016 Feb 18. Review.


Hepatitis E Virus Does Not Contribute to Hepatic Decompensation Among Patients With Advanced Chronic Hepatitis C.

Samala N, Wright EC, Buckler AG, Vargas V, Shetty K, Reddy KR, Lucey MR, Alter HJ, Hoofnagle JH, Ghany MG.

Clin Gastroenterol Hepatol. 2016 Jun;14(6):896-902. doi: 10.1016/j.cgh.2015.12.048. Epub 2016 Jan 25.


Inter-Method Performance Study of Tumor Volumetry Assessment on Computed Tomography Test-Retest Data.

Buckler AJ, Danagoulian J, Johnson K, Peskin A, Gavrielides MA, Petrick N, Obuchowski NA, Beaumont H, Hadjiiski L, Jarecha R, Kuhnigk JM, Mantri N, McNitt-Gray M, Moltz JH, Nyiri G, Peterson S, Tervé P, Tietjen C, von Lavante E, Ma X, St Pierre S, Athelogou M.

Acad Radiol. 2015 Nov;22(11):1393-408. doi: 10.1016/j.acra.2015.08.007. Epub 2015 Sep 14.


Metabolic Enzyme Sulfotransferase 1A1 Is the Trigger for N-Benzyl Indole Carbinol Tumor Growth Suppression.

Rothman DM, Gao X, George E, Rasmusson T, Bhatia D, Alimov I, Wang L, Kamel A, Hatsis P, Feng Y, Tutter A, Michaud G, McDonald E 3rd, Venkatesan K, Farley D, Digan ME, Ni Y, Harbinski F, Gunduz M, Wilson CJ, Buckler A, Labow M, Tallarico J, Myer VE, Porter JA, Wang S.

Chem Biol. 2015 Sep 17;22(9):1228-37. doi: 10.1016/j.chembiol.2015.06.025. Epub 2015 Sep 10.


Role of the Quantitative Imaging Biomarker Alliance in optimizing CT for the evaluation of lung cancer screen-detected nodules.

Mulshine JL, Gierada DS, Armato SG 3rd, Avila RS, Yankelevitz DF, Kazerooni EA, McNitt-Gray MF, Buckler AJ, Sullivan DC.

J Am Coll Radiol. 2015 Apr;12(4):390-5. doi: 10.1016/j.jacr.2014.12.003.


Determining the Variability of Lesion Size Measurements from CT Patient Data Sets Acquired under "No Change" Conditions.

McNitt-Gray MF, Kim GH, Zhao B, Schwartz LH, Clunie D, Cohen K, Petrick N, Fenimore C, Lu ZQ, Buckler AJ.

Transl Oncol. 2015 Feb;8(1):55-64. doi: 10.1016/j.tranon.2015.01.001.


Quantitative imaging biomarkers: a review of statistical methods for computer algorithm comparisons.

Obuchowski NA, Reeves AP, Huang EP, Wang XF, Buckler AJ, Kim HJ, Barnhart HX, Jackson EF, Giger ML, Pennello G, Toledano AY, Kalpathy-Cramer J, Apanasovich TV, Kinahan PE, Myers KJ, Goldgof DB, Barboriak DP, Gillies RJ, Schwartz LH, Sullivan DC; Algorithm Comparison Working Group.

Stat Methods Med Res. 2015 Feb;24(1):68-106. doi: 10.1177/0962280214537390. Epub 2014 Jun 11. Review.


Statistical issues in the comparison of quantitative imaging biomarker algorithms using pulmonary nodule volume as an example.

Obuchowski NA, Barnhart HX, Buckler AJ, Pennello G, Wang XF, Kalpathy-Cramer J, Kim HJ, Reeves AP; Case Example Working Group.

Stat Methods Med Res. 2015 Feb;24(1):107-40. doi: 10.1177/0962280214537392. Epub 2014 Jun 11.


The emerging science of quantitative imaging biomarkers terminology and definitions for scientific studies and regulatory submissions.

Kessler LG, Barnhart HX, Buckler AJ, Choudhury KR, Kondratovich MV, Toledano A, Guimaraes AR, Filice R, Zhang Z, Sullivan DC; QIBA Terminology Working Group.

Stat Methods Med Res. 2015 Feb;24(1):9-26. doi: 10.1177/0962280214537333. Epub 2014 Jun 11.


Meta-analysis of the technical performance of an imaging procedure: guidelines and statistical methodology.

Huang EP, Wang XF, Choudhury KR, McShane LM, Gönen M, Ye J, Buckler AJ, Kinahan PE, Reeves AP, Jackson EF, Guimaraes AR, Zahlmann G; Meta-Analysis Working Group.

Stat Methods Med Res. 2015 Feb;24(1):141-74. doi: 10.1177/0962280214537394. Epub 2014 May 28. Review.


Spatio-temporal texture (SpTeT) for distinguishing vulnerable from stable atherosclerotic plaque on dynamic contrast enhancement (DCE) MRI in a rabbit model.

Wan T, Madabhushi A, Phinikaridou A, Hamilton JA, Hua N, Pham T, Danagoulian J, Kleiman R, Buckler AJ.

Med Phys. 2014 Apr;41(4):042303. doi: 10.1118/1.4867861.


Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer.

Jaeger S, Min J, Nigsch F, Camargo M, Hutz J, Cornett A, Cleaver S, Buckler A, Jenkins JL.

J Biomol Screen. 2014 Jun;19(5):791-802. doi: 10.1177/1087057114522690. Epub 2014 Feb 11.


Comparison of 1D, 2D, and 3D nodule sizing methods by radiologists for spherical and complex nodules on thoracic CT phantom images.

Petrick N, Kim HJ, Clunie D, Borradaile K, Ford R, Zeng R, Gavrielides MA, McNitt-Gray MF, Lu ZQ, Fenimore C, Zhao B, Buckler AJ.

Acad Radiol. 2014 Jan;21(1):30-40. doi: 10.1016/j.acra.2013.09.020.


Behavioral counseling interventions to promote a healthful diet and physical activity for cardiovascular disease prevention in adults.

Buckler A, Servies T; U.S. Preventive Services Task Force.

Am Fam Physician. 2013 Jun 15;87(12):869-70. No abstract available.


Screening for ovarian cancer.

Buckler A, Luu P.

Am Fam Physician. 2013 May 15;87(10):709-10. No abstract available.


Screening for intimate partner violence and abuse of elderly and vulnerable adults.

Buckler A, Bernhard J.

Am Fam Physician. 2013 Apr 15;87(8):577-8. No abstract available.


Quantitative imaging biomarker ontology (QIBO) for knowledge representation of biomedical imaging biomarkers.

Buckler AJ, Liu TT, Savig E, Suzek BE, Rubin DL, Paik D.

J Digit Imaging. 2013 Aug;26(4):630-41. doi: 10.1007/s10278-013-9599-2. Review. Erratum in: J Digit Imaging. 2013 Aug;26(4):642. Ouellette, M [removed]; Danagoulian, J [removed]; Wernsing, G [removed].


Menopausal hormone therapy for the primary prevention of chronic conditions.

Buckler A, Voss J.

Am Fam Physician. 2013 Mar 15;87(6):437-8. No abstract available.


A novel knowledge representation framework for the statistical validation of quantitative imaging biomarkers.

Buckler AJ, Paik D, Ouellette M, Danagoulian J, Wernsing G, Suzek BE.

J Digit Imaging. 2013 Aug;26(4):614-29. doi: 10.1007/s10278-013-9598-3. Review.


Identification of cardiac glycoside molecules as inhibitors of c-Myc IRES-mediated translation.

Didiot MC, Hewett J, Varin T, Freuler F, Selinger D, Nick H, Reinhardt J, Buckler A, Myer V, Schuffenhauer A, Guy CT, Parker CN.

J Biomol Screen. 2013 Apr;18(4):407-19. doi: 10.1177/1087057112466698. Epub 2012 Nov 13.


Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth.

Harbinski F, Craig VJ, Sanghavi S, Jeffery D, Liu L, Sheppard KA, Wagner S, Stamm C, Buness A, Chatenay-Rivauday C, Yao Y, He F, Lu CX, Guagnano V, Metz T, Finan PM, Hofmann F, Sellers WR, Porter JA, Myer VE, Graus-Porta D, Wilson CJ, Buckler A, Tiedt R.

Cancer Discov. 2012 Oct;2(10):948-59. doi: 10.1158/2159-8290.CD-12-0237. Epub 2012 Aug 8.


Life sciences domain analysis model.

Freimuth RR, Freund ET, Schick L, Sharma MK, Stafford GA, Suzek BE, Hernandez J, Hipp J, Kelley JM, Rokicki K, Pan S, Buckler A, Stokes TH, Fernandez A, Fore I, Buetow KH, Klemm JD.

J Am Med Inform Assoc. 2012 Nov-Dec;19(6):1095-102. doi: 10.1136/amiajnl-2011-000763. Epub 2012 Jun 28.


Measurement of tumor volumes improves RECIST-based response assessments in advanced lung cancer.

Mozley PD, Bendtsen C, Zhao B, Schwartz LH, Thorn M, Rong Y, Zhang L, Perrone A, Korn R, Buckler AJ.

Transl Oncol. 2012 Feb;5(1):19-25. Epub 2012 Feb 1.


The Military Health System and TRICARE: breastfeeding promotion.

Buckler AG.

Breastfeed Med. 2011 Oct;6:295-7. doi: 10.1089/bfm.2011.0065. No abstract available.


A collaborative enterprise for multi-stakeholder participation in the advancement of quantitative imaging.

Buckler AJ, Bresolin L, Dunnick NR, Sullivan DC; Group.

Radiology. 2011 Mar;258(3):906-14. doi: 10.1148/radiol.10100799.


Quantitative imaging test approval and biomarker qualification: interrelated but distinct activities.

Buckler AJ, Bresolin L, Dunnick NR, Sullivan DC, Aerts HJ, Bendriem B, Bendtsen C, Boellaard R, Boone JM, Cole PE, Conklin JJ, Dorfman GS, Douglas PS, Eidsaunet W, Elsinger C, Frank RA, Gatsonis C, Giger ML, Gupta SN, Gustafson D, Hoekstra OS, Jackson EF, Karam L, Kelloff GJ, Kinahan PE, McLennan G, Miller CG, Mozley PD, Muller KE, Patt R, Raunig D, Rosen M, Rupani H, Schwartz LH, Siegel BA, Sorensen AG, Wahl RL, Waterton JC, Wolf W, Zahlmann G, Zimmerman B.

Radiology. 2011 Jun;259(3):875-84. doi: 10.1148/radiol.10100800. Epub 2011 Feb 15.


Standardization of quantitative imaging: the time is right, and 18F-FDG PET/CT is a good place to start.

Buckler AJ, Boellaard R.

J Nucl Med. 2011 Feb;52(2):171-2. doi: 10.2967/jnumed.110.081224. Epub 2011 Jan 13. No abstract available.


Investigation of heparin-related hypotensive adverse events during photopheresis: utility of a patient care database.

McPherson RA, Buckler AG, Sanford KW, Roseff SD.

Transfusion. 2011 Jun;51(6):1314-20. doi: 10.1111/j.1537-2995.2010.02968.x. Epub 2010 Dec 6.


Data sets for the qualification of volumetric CT as a quantitative imaging biomarker in lung cancer.

Buckler AJ, Schwartz LH, Petrick N, McNitt-Gray M, Zhao B, Fenimore C, Reeves AP, Mozley PD, Avila RS.

Opt Express. 2010 Jul 5;18(14):15267-82. doi: 10.1364/OE.18.015267.


Change in lung tumor volume as a biomarker of treatment response: a critical review of the evidence.

Mozley PD, Schwartz LH, Bendtsen C, Zhao B, Petrick N, Buckler AJ.

Ann Oncol. 2010 Sep;21(9):1751-5. doi: 10.1093/annonc/mdq051. Epub 2010 Mar 23. Review.


Volumetric CT in lung cancer: an example for the qualification of imaging as a biomarker.

Buckler AJ, Mozley PD, Schwartz L, Petrick N, McNitt-Gray M, Fenimore C, O'Donnell K, Hayes W, Kim HJ, Clarke L, Sullivan D.

Acad Radiol. 2010 Jan;17(1):107-15. doi: 10.1016/j.acra.2009.06.019.


The use of volumetric CT as an imaging biomarker in lung cancer.

Buckler AJ, Mulshine JL, Gottlieb R, Zhao B, Mozley PD, Schwartz L.

Acad Radiol. 2010 Jan;17(1):100-6. doi: 10.1016/j.acra.2009.07.030. Review.


NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models.

Jensen MR, Schoepfer J, Radimerski T, Massey A, Guy CT, Brueggen J, Quadt C, Buckler A, Cozens R, Drysdale MJ, Garcia-Echeverria C, Chène P.

Breast Cancer Res. 2008;10(2):R33. doi: 10.1186/bcr1996. Epub 2008 Apr 22.


"Product ion monitoring" assay for prostate-specific antigen in serum using a linear ion-trap.

Kulasingam V, Smith CR, Batruch I, Buckler A, Jeffery DA, Diamandis EP.

J Proteome Res. 2008 Feb;7(2):640-7. doi: 10.1021/pr7005999. Epub 2008 Jan 11.


Identification and characterization of novel human transcripts embedded within HMGA2 in t(12;14)(q15;q24.1) uterine leiomyoma.

Ingraham SE, Lynch RA, Surti U, Rutter JL, Buckler AJ, Khan SA, Menon AG, Lepont P.

Mutat Res. 2006 Dec 1;602(1-2):43-53. Epub 2006 Oct 12.


Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations.

Walker SA, Kupzig S, Bouyoucef D, Davies LC, Tsuboi T, Bivona TG, Cozier GE, Lockyer PJ, Buckler A, Rutter GA, Allen MJ, Philips MR, Cullen PJ.

EMBO J. 2004 Apr 21;23(8):1749-60. Epub 2004 Apr 1.


The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades.

Tugores A, Le J, Sorokina I, Snijders AJ, Duyao M, Reddy PS, Carlee L, Ronshaugen M, Mushegian A, Watanaskul T, Chu S, Buckler A, Emtage S, McCormick MK.

J Biol Chem. 2001 Jun 8;276(23):20397-406. Epub 2001 Mar 19.


High prevalence of the very rare Wilson disease gene mutation Leu708Pro in the Island of Gran Canaria (Canary Islands, Spain): a genetic and clinical study.

García-Villarreal L, Daniels S, Shaw SH, Cotton D, Galvin M, Geskes J, Bauer P, Sierra-Hernández A, Buckler A, Tugores A.

Hepatology. 2000 Dec;32(6):1329-36.


Genomic organization of the UGT2b gene cluster on human chromosome 4q13.

Riedy M, Wang JY, Miller AP, Buckler A, Hall J, Guida M.

Pharmacogenetics. 2000 Apr;10(3):251-60.


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