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Items: 1 to 50 of 146

1.

Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif.

Chen X, Riley BT, de Veer SJ, Hoke DE, Van Haeften J, Leahy D, Swedberg JE, Brattsand M, Hartfield PJ, Buckle AM, Harris JM.

PLoS One. 2019 Jan 22;14(1):e0210842. doi: 10.1371/journal.pone.0210842. eCollection 2019.

2.

Integrating Experiment and Theory to Understand TCR-pMHC Dynamics.

Buckle AM, Borg NA.

Front Immunol. 2018 Dec 7;9:2898. doi: 10.3389/fimmu.2018.02898. eCollection 2018. Review.

3.

Prostate Cancer Risk-Associated Single-Nucleotide Polymorphism Affects Prostate-Specific Antigen Glycosylation and Its Function.

Srinivasan S, Stephens C, Wilson E, Panchadsaram J, DeVoss K, Koistinen H, Stenman UH, Brook MN, Buckle AM, Klein RJ, Lilja H, Clements J, Batra J; Practical Consortium.

Clin Chem. 2019 Jan;65(1):e1-e9. doi: 10.1373/clinchem.2018.295790. Epub 2018 Dec 11.

PMID:
30538125
4.

Thyroid Peroxidase as an Autoantigen in Hashimoto's Disease: Structure, Function, and Antigenicity.

Williams DE, Le SN, Godlewska M, Hoke DE, Buckle AM.

Horm Metab Res. 2018 Dec;50(12):908-921. doi: 10.1055/a-0717-5514. Epub 2018 Oct 25.

PMID:
30360003
5.

Mapping the Pathway and Dynamics of Bestatin Inhibition of the Plasmodium falciparum M1 Aminopeptidase PfA-M1.

Yang W, Riley BT, Lei X, Porebski BT, Kass I, Buckle AM, McGowan S.

ChemMedChem. 2018 Dec 6;13(23):2504-2513. doi: 10.1002/cmdc.201800563. Epub 2018 Nov 9.

PMID:
30318749
6.

Catalytic diversity and cell wall binding repeats in the phage-encoded endolysins.

Broendum SS, Buckle AM, McGowan S.

Mol Microbiol. 2018 Dec;110(6):879-896. doi: 10.1111/mmi.14134. Epub 2018 Nov 13. Review.

PMID:
30230642
7.

Structural Capacitance in Protein Evolution and Human Diseases.

Li C, Clark LVT, Zhang R, Porebski BT, McCoey JM, Borg NA, Webb GI, Kass I, Buckle M, Song J, Woolfson A, Buckle AM.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3200-3217. doi: 10.1016/j.jmb.2018.06.051. Epub 2018 Jul 3.

PMID:
30111491
8.

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target.

Atkinson SC, Dogovski C, Wood K, Griffin MDW, Gorman MA, Hor L, Reboul CF, Buckle AM, Wuttke J, Parker MW, Dobson RCJ, Perugini MA.

Structure. 2018 Jul 3;26(7):948-959.e5. doi: 10.1016/j.str.2018.04.014. Epub 2018 May 24.

PMID:
29804823
9.

Previously Hidden Dynamics at the TCR-Peptide-MHC Interface Revealed.

Fodor J, Riley BT, Borg NA, Buckle AM.

J Immunol. 2018 Jun 15;200(12):4134-4145. doi: 10.4049/jimmunol.1800315. Epub 2018 May 4.

PMID:
29728507
10.

Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus V.

Atkinson SC, Audsley MD, Lieu KG, Marsh GA, Thomas DR, Heaton SM, Paxman JJ, Wagstaff KM, Buckle AM, Moseley GW, Jans DA, Borg NA.

Sci Rep. 2018 Jan 10;8(1):358. doi: 10.1038/s41598-017-18742-8.

11.

Laboratory evolution of protein conformational dynamics.

Campbell EC, Correy GJ, Mabbitt PD, Buckle AM, Tokuriki N, Jackson CJ.

Curr Opin Struct Biol. 2018 Jun;50:49-57. doi: 10.1016/j.sbi.2017.09.005. Epub 2017 Nov 8. Review.

PMID:
29120734
12.

Generation of AMBER force field parameters for zinc centres of M1 and M17 family aminopeptidases.

Yang W, Riley BT, Lei X, Porebski BT, Kass I, Buckle AM, McGowan S.

J Biomol Struct Dyn. 2018 Aug;36(10):2595-2604. doi: 10.1080/07391102.2017.1364669. Epub 2017 Aug 28.

PMID:
28782419
13.

REFOLDdb: a new and sustainable gateway to experimental protocols for protein refolding.

Mizutani H, Sugawara H, Buckle AM, Sangawa T, Miyazono KI, Ohtsuka J, Nagata K, Shojima T, Nosaki S, Xu Y, Wang D, Hu X, Tanokura M, Yura K.

BMC Struct Biol. 2017 Apr 24;17(1):4. doi: 10.1186/s12900-017-0074-z.

14.

The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger.

Keightley MC, Carradice DP, Layton JE, Pase L, Bertrand JY, Wittig JG, Dakic A, Badrock AP, Cole NJ, Traver D, Nutt SL, McCoey J, Buckle AM, Heath JK, Lieschke GJ.

Nat Commun. 2017 Apr 6;8:14911. doi: 10.1038/ncomms14911.

15.

Structural reconstruction of protein ancestry.

Rouet R, Langley DB, Schofield P, Christie M, Roome B, Porebski BT, Buckle AM, Clifton BE, Jackson CJ, Stock D, Christ D.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3897-3902. doi: 10.1073/pnas.1613477114. Epub 2017 Mar 29.

16.

Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics.

Riley BT, Ilyichova O, Costa MG, Porebski BT, de Veer SJ, Swedberg JE, Kass I, Harris JM, Hoke DE, Buckle AM.

Sci Rep. 2016 Oct 21;6:35385. doi: 10.1038/srep35385.

17.

The role of protein dynamics in the evolution of new enzyme function.

Campbell E, Kaltenbach M, Correy GJ, Carr PD, Porebski BT, Livingstone EK, Afriat-Jurnou L, Buckle AM, Weik M, Hollfelder F, Tokuriki N, Jackson CJ.

Nat Chem Biol. 2016 Nov;12(11):944-950. doi: 10.1038/nchembio.2175. Epub 2016 Sep 12.

PMID:
27618189
18.

Smoothing a rugged protein folding landscape by sequence-based redesign.

Porebski BT, Keleher S, Hollins JJ, Nickson AA, Marijanovic EM, Borg NA, Costa MG, Pearce MA, Dai W, Zhu L, Irving JA, Hoke DE, Kass I, Whisstock JC, Bottomley SP, Webb GI, McGowan S, Buckle AM.

Sci Rep. 2016 Sep 26;6:33958. doi: 10.1038/srep33958.

19.

Circumventing the stability-function trade-off in an engineered FN3 domain.

Porebski BT, Conroy PJ, Drinkwater N, Schofield P, Vazquez-Lombardi R, Hunter MR, Hoke DE, Christ D, McGowan S, Buckle AM.

Protein Eng Des Sel. 2016 Aug 29. [Epub ahead of print]

20.

Consensus protein design.

Porebski BT, Buckle AM.

Protein Eng Des Sel. 2016 Jul;29(7):245-51. doi: 10.1093/protein/gzw015. Epub 2016 Jun 5. Review.

21.

PolyQ 2.0: an improved version of PolyQ, a database of human polyglutamine proteins.

Li C, Nagel J, Androulakis S, Lupton CJ, Song J, Buckle AM.

Database (Oxford). 2016 May 17;2016. pii: baw050. doi: 10.1093/database/baw050. Print 2016. No abstract available.

22.

KinetochoreDB: a comprehensive online resource for the kinetochore and its related proteins.

Li C, Androulakis S, Buckle AM, Song J.

Database (Oxford). 2016 Mar 17;2016. pii: baw019. doi: 10.1093/database/baw019. Print 2016.

23.

PolyQ 2.0: an improved version of PolyQ, a database of human polyglutamine proteins.

Li C, Nagel J, Androulakis S, Song J, Buckle AM.

Database (Oxford). 2016 Mar 15;2016. pii: baw021. doi: 10.1093/database/baw021. Print 2016. Erratum in: Database (Oxford). 2016;2016. pii: baw050. doi: 10.1093/database/baw050.

24.

A colostrum trypsin inhibitor gene expressed in the Cape fur seal mammary gland during lactation.

Pharo EA, Cane KN, McCoey J, Buckle AM, Oosthuizen WH, Guinet C, Arnould JP.

Gene. 2016 Mar 1;578(1):7-16. doi: 10.1016/j.gene.2015.11.042. Epub 2015 Nov 27.

PMID:
26639991
25.

Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity.

Le SN, Porebski BT, McCoey J, Fodor J, Riley B, Godlewska M, Góra M, Czarnocka B, Banga JP, Hoke DE, Kass I, Buckle AM.

PLoS One. 2015 Dec 1;10(12):e0142615. doi: 10.1371/journal.pone.0142615. eCollection 2015.

26.

Dynamic Motion and Communication in the Streptococcal C1 Phage Lysin, PlyC.

Riley BT, Broendum SS, Reboul CF, Cowieson NP, Costa MG, Kass I, Jackson C, Perahia D, Buckle AM, McGowan S.

PLoS One. 2015 Oct 15;10(10):e0140219. doi: 10.1371/journal.pone.0140219. eCollection 2015.

27.

Critical evaluation of in silico methods for prediction of coiled-coil domains in proteins.

Li C, Ching Han Chang C, Nagel J, Porebski BT, Hayashida M, Akutsu T, Song J, Buckle AM.

Brief Bioinform. 2016 Mar;17(2):270-82. doi: 10.1093/bib/bbv047. Epub 2015 Jul 15. Review.

28.

Solution structure of a soluble fragment derived from a membrane protein by shotgun proteolysis.

Allen MD, Christie M, Jones P, Porebski BT, Roome B, Freund SM, Buckle AM, Bycroft M, Christ D.

Protein Eng Des Sel. 2015 Oct;28(10):445-50. doi: 10.1093/protein/gzv021. Epub 2015 Apr 15.

29.

Potential role of Notch signalling in CD34+ chronic myeloid leukaemia cells: cross-talk between Notch and BCR-ABL.

Aljedai A, Buckle AM, Hiwarkar P, Syed F.

PLoS One. 2015 Apr 7;10(4):e0123016. doi: 10.1371/journal.pone.0123016. eCollection 2015.

30.

Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain.

Porebski BT, Nickson AA, Hoke DE, Hunter MR, Zhu L, McGowan S, Webb GI, Buckle AM.

Protein Eng Des Sel. 2015 Mar;28(3):67-78. doi: 10.1093/protein/gzv002.

31.

How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.

Giardina G, Brunotti P, Fiascarelli A, Cicalini A, Costa MG, Buckle AM, di Salvo ML, Giorgi A, Marani M, Paone A, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F.

FEBS J. 2015 Apr;282(7):1225-41. doi: 10.1111/febs.13211. Epub 2015 Feb 13.

32.

Understanding the structural dynamics of TCR-pMHC complex interactions.

Kass I, Buckle AM, Borg NA.

Trends Immunol. 2014 Dec;35(12):604-612. doi: 10.1016/j.it.2014.10.005. Epub 2014 Nov 11. Review.

PMID:
25466310
33.

Operation of the Australian Store.Synchrotron for macromolecular crystallography.

Meyer GR, Aragão D, Mudie NJ, Caradoc-Davies TT, McGowan S, Bertling PJ, Groenewegen D, Quenette SM, Bond CS, Buckle AM, Androulakis S.

Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2510-9. doi: 10.1107/S1399004714016174. Epub 2014 Sep 30.

34.

Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase.

Samson AL, Knaupp AS, Kass I, Kleifeld O, Marijanovic EM, Hughes VA, Lupton CJ, Buckle AM, Bottomley SP, Medcalf RL.

J Biol Chem. 2014 Sep 26;289(39):26922-36. doi: 10.1074/jbc.M114.570275. Epub 2014 Aug 1.

35.

Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis.

Kass I, Hoke DE, Costa MG, Reboul CF, Porebski BT, Cowieson NP, Leh H, Pennacchietti E, McCoey J, Kleifeld O, Borri Voltattorni C, Langley D, Roome B, Mackay IR, Christ D, Perahia D, Buckle M, Paiardini A, De Biase D, Buckle AM.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2524-9. doi: 10.1073/pnas.1403182111. Epub 2014 Jun 9.

36.

The α-importome of mammalian germ cell maturation provides novel insights for importin biology.

Arjomand A, Baker MA, Li C, Buckle AM, Jans DA, Loveland KL, Miyamoto Y.

FASEB J. 2014 Aug;28(8):3480-93. doi: 10.1096/fj.13-244913. Epub 2014 Apr 30.

PMID:
24790034
37.

PLP-dependent enzymes.

Paiardini A, Contestabile R, Buckle AM, Cellini B.

Biomed Res Int. 2014;2014:856076. doi: 10.1155/2014/856076. Epub 2014 Jan 15. No abstract available.

38.

Mechanism-based selection of a potent kallikrein-related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI-1.

de Veer SJ, Ukolova SS, Munro CA, Swedberg JE, Buckle AM, Harris JM.

Biopolymers. 2013 Sep;100(5):510-8. doi: 10.1002/bip.22231.

PMID:
24078181
39.

Interactive visualization tools for the structural biologist.

Porebski BT, Ho BK, Buckle AM.

J Appl Crystallogr. 2013 Oct 1;46(Pt 5):1518-1520. Epub 2013 Aug 3.

40.

Cell-surface Notch1 expression identifies a primitive phenotype within CD34+ CD38- haematopoietic cells.

Portillo V, Chadwick N, Lloyd R, Jackson D, Buckle AM.

Eur J Haematol. 2014 Jan;92(1):26-34. doi: 10.1111/ejh.12200. Epub 2013 Oct 29.

PMID:
24010734
41.

A redundant role of human thyroid peroxidase propeptide for cellular, enzymatic, and immunological activity.

Godlewska M, Góra M, Buckle AM, Porebski BT, Kemp EH, Sutton BJ, Czarnocka B, Banga JP.

Thyroid. 2014 Feb;24(2):371-82. doi: 10.1089/thy.2013.0127. Epub 2013 Sep 26.

42.

Yersinia enterocolitica provides the link between thyroid-stimulating antibodies and their germline counterparts in Graves' disease.

Hargreaves CE, Grasso M, Hampe CS, Stenkova A, Atkinson S, Joshua GW, Wren BW, Buckle AM, Dunn-Walters D, Banga JP.

J Immunol. 2013 Jun 1;190(11):5373-81. doi: 10.4049/jimmunol.1203412. Epub 2013 Apr 29.

43.

Molecular determinants of the substrate specificity of the complement-initiating protease, C1r.

Wijeyewickrema LC, Yongqing T, Tran TP, Thompson PE, Viljoen JE, Coetzer TH, Duncan RC, Kass I, Buckle AM, Pike RN.

J Biol Chem. 2013 May 31;288(22):15571-80. doi: 10.1074/jbc.M113.451757. Epub 2013 Apr 15.

44.

Mechanism-based selection of a potent kallikrein-related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI-1.

de Veer SJ, Ukolova SS, Munro CA, Swedberg JE, Buckle AM, Harris JM.

Biopolymers. 2013 Mar 11. doi: 10.1002/peps.22231. [Epub ahead of print]

PMID:
23494567
45.

Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates.

Langendorf CG, Tuck KL, Key TL, Fenalti G, Pike RN, Rosado CJ, Wong AS, Buckle AM, Law RH, Whisstock JC.

Biosci Rep. 2013 Jan 11;33(1):137-44. doi: 10.1042/BSR20120111.

46.

X-ray crystal structure of the streptococcal specific phage lysin PlyC.

McGowan S, Buckle AM, Mitchell MS, Hoopes JT, Gallagher DT, Heselpoth RD, Shen Y, Reboul CF, Law RH, Fischetti VA, Whisstock JC, Nelson DC.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12752-7. doi: 10.1073/pnas.1208424109. Epub 2012 Jul 17.

47.

Crystal, solution and in silico structural studies of dihydrodipicolinate synthase from the common grapevine.

Atkinson SC, Dogovski C, Downton MT, Pearce FG, Reboul CF, Buckle AM, Gerrard JA, Dobson RC, Wagner J, Perugini MA.

PLoS One. 2012;7(6):e38318. doi: 10.1371/journal.pone.0038318. Epub 2012 Jun 25.

48.

Conformational properties of the disease-causing Z variant of α1-antitrypsin revealed by theory and experiment.

Kass I, Knaupp AS, Bottomley SP, Buckle AM.

Biophys J. 2012 Jun 20;102(12):2856-65. doi: 10.1016/j.bpj.2012.05.023. Epub 2012 Jun 19.

49.

Structural and dynamic requirements for optimal activity of the essential bacterial enzyme dihydrodipicolinate synthase.

Reboul CF, Porebski BT, Griffin MD, Dobson RC, Perugini MA, Gerrard JA, Buckle AM.

PLoS Comput Biol. 2012;8(6):e1002537. doi: 10.1371/journal.pcbi.1002537. Epub 2012 Jun 7.

50.

Hybrid approaches to molecular simulation.

Ho BK, Perahia D, Buckle AM.

Curr Opin Struct Biol. 2012 Jun;22(3):386-93. doi: 10.1016/j.sbi.2012.05.005. Epub 2012 May 25. Review.

PMID:
22633678

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