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Items: 1 to 50 of 198

1.

Structural and functional characterization of an electron transfer flavoprotein involved in toluene degradation in strictly anaerobic bacteria.

Vogt MS, Schühle K, Kölzer S, Peschke P, Chowdhury NP, Kleinsorge D, Buckel W, Essen LO, Heider J.

J Bacteriol. 2019 Aug 12. pii: JB.00326-19. doi: 10.1128/JB.00326-19. [Epub ahead of print]

PMID:
31405915
2.

Formation of 3-hydroxyglutaric acid in glutaric aciduria type I: in vitro participation of medium chain acyl-CoA dehydrogenase.

Peters V, Morath M, Mack M, Liesert M, Buckel W, Hoffmann GF, Vockley J, Ghisla S, Zschocke J.

JIMD Rep. 2019 Mar 26;47(1):30-34. doi: 10.1002/jmd2.12026. eCollection 2019 May.

3.

Antibiotic Use and Outcomes After Implementation of the Drug Resistance in Pneumonia Score in ED Patients With Community-Onset Pneumonia.

Webb BJ, Sorensen J, Mecham I, Buckel W, Ooi L, Jephson A, Dean NC.

Chest. 2019 May 8. pii: S0012-3692(19)31012-8. doi: 10.1016/j.chest.2019.04.093. [Epub ahead of print]

PMID:
31077649
4.

Enzymatic Reactions Involving Ketyls: From a Chemical Curiosity to a General Biochemical Mechanism.

Buckel W.

Biochemistry. 2019 Apr 23. doi: 10.1021/acs.biochem.9b00171. [Epub ahead of print]

PMID:
30995029
5.

Antimicrobial Stewardship in Community Hospitals.

Buckel WR, Veillette JJ, Vento TJ, Stenehjem E.

Med Clin North Am. 2018 Sep;102(5):913-928. doi: 10.1016/j.mcna.2018.05.005. Review.

PMID:
30126580
6.

Impact of Implementing Antibiotic Stewardship Programs in 15 Small Hospitals: A Cluster-Randomized Intervention.

Stenehjem E, Hersh AL, Buckel WR, Jones P, Sheng X, Evans RS, Burke JP, Lopansri BK, Srivastava R, Greene T, Pavia AT.

Clin Infect Dis. 2018 Aug 1;67(4):525-532. doi: 10.1093/cid/ciy155.

PMID:
29790913
7.
8.

Flavin-Based Electron Bifurcation, A New Mechanism of Biological Energy Coupling.

Buckel W, Thauer RK.

Chem Rev. 2018 Apr 11;118(7):3862-3886. doi: 10.1021/acs.chemrev.7b00707. Epub 2018 Mar 21. Review.

9.

The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile.

Demmer JK, Pal Chowdhury N, Selmer T, Ermler U, Buckel W.

Nat Commun. 2017 Nov 17;8(1):1577. doi: 10.1038/s41467-017-01746-3.

10.

Risk Factors for Non-Therapeutic Initial Steady-State Vancomycin Trough Concentrations in Children and Adolescents Receiving High Empiric Doses of Intravenous Vancomycin.

Buckel WR, Ghobrial S, Tamma PD, Milstone AM, Zhao Y, Hsu AJ.

Paediatr Drugs. 2017 Feb;19(1):43-51. doi: 10.1007/s40272-016-0202-4.

PMID:
27873214
11.

Antibiotic Use in Small Community Hospitals.

Stenehjem E, Hersh AL, Sheng X, Jones P, Buckel WR, Lloyd JF, Howe S, Evans RS, Greene T, Pavia AT.

Clin Infect Dis. 2016 Nov 15;63(10):1273-1280. Epub 2016 Sep 30.

PMID:
27694483
12.

Broad- versus Narrow-Spectrum Oral Antibiotic Transition and Outcomes in Health Care-associated Pneumonia.

Buckel WR, Stenehjem E, Sorensen J, Dean N, Webb B.

Ann Am Thorac Soc. 2017 Feb;14(2):200-205. doi: 10.1513/AnnalsATS.201606-486BC.

PMID:
27690519
13.

Elucidating the Stereochemistry of Enzymatic Benzylsuccinate Synthesis with Chirally Labeled Toluene.

Seyhan D, Friedrich P, Szaleniec M, Hilberg M, Buckel W, Golding BT, Heider J.

Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11664-7. doi: 10.1002/anie.201605197. Epub 2016 Aug 9.

PMID:
27503670
14.

Complete Genome Sequence of the Amino Acid-Fermenting Clostridium propionicum X2 (DSM 1682).

Poehlein A, Schlien K, Chowdhury NP, Gottschalk G, Buckel W, Daniel R.

Genome Announc. 2016 Apr 14;4(2). pii: e00294-16. doi: 10.1128/genomeA.00294-16.

15.

Reduction of Flavodoxin by Electron Bifurcation and Sodium Ion-dependent Reoxidation by NAD+ Catalyzed by Ferredoxin-NAD+ Reductase (Rnf).

Chowdhury NP, Klomann K, Seubert A, Buckel W.

J Biol Chem. 2016 Jun 3;291(23):11993-2002. doi: 10.1074/jbc.M116.726299. Epub 2016 Apr 5.

16.

Anaerobic Microbial Degradation of Hydrocarbons: From Enzymatic Reactions to the Environment.

Rabus R, Boll M, Heider J, Meckenstock RU, Buckel W, Einsle O, Ermler U, Golding BT, Gunsalus RP, Kroneck PM, Krüger M, Lueders T, Martins BM, Musat F, Richnow HH, Schink B, Seifert J, Szaleniec M, Treude T, Ullmann GM, Vogt C, von Bergen M, Wilkes H.

J Mol Microbiol Biotechnol. 2016;26(1-3):5-28. doi: 10.1159/000443997. Epub 2016 Mar 10. Review.

17.

Structure and Function of 4-Hydroxyphenylacetate Decarboxylase and Its Cognate Activating Enzyme.

Selvaraj B, Buckel W, Golding BT, Ullmann GM, Martins BM.

J Mol Microbiol Biotechnol. 2016;26(1-3):76-91. doi: 10.1159/000440882. Epub 2016 Mar 10. Review.

PMID:
26959876
18.

Fermentative Cyclohexane Carboxylate Formation in Syntrophus aciditrophicus.

Boll M, Kung JW, Ermler U, Martins BM, Buckel W.

J Mol Microbiol Biotechnol. 2016;26(1-3):165-79. doi: 10.1159/000440881. Epub 2016 Mar 10. Review.

PMID:
26959729
19.

Metabolism of Hydrocarbons in n-Alkane-Utilizing Anaerobic Bacteria.

Wilkes H, Buckel W, Golding BT, Rabus R.

J Mol Microbiol Biotechnol. 2016;26(1-3):138-51. doi: 10.1159/000442160. Epub 2016 Mar 10. Review.

PMID:
26959725
20.

Structure and Function of Benzylsuccinate Synthase and Related Fumarate-Adding Glycyl Radical Enzymes.

Heider J, Szaleniec M, Martins BM, Seyhan D, Buckel W, Golding BT.

J Mol Microbiol Biotechnol. 2016;26(1-3):29-44. doi: 10.1159/000441656. Epub 2016 Mar 10. Review.

PMID:
26959246
21.

Risk of Resistant Organisms and Clostridium difficile with Prolonged Systemic Antibiotic Prophylaxis for Central Nervous System Devices.

Chauv S, Fontaine GV, Hoang QP, McKinney CB, Baldwin M, Buckel WR, Collingridge DS, Majercik S, Wohlt PD.

Neurocrit Care. 2016 Aug;25(1):128-32. doi: 10.1007/s12028-016-0254-x.

PMID:
26920907
22.

Chain Elongation with Reactor Microbiomes: Open-Culture Biotechnology To Produce Biochemicals.

Angenent LT, Richter H, Buckel W, Spirito CM, Steinbusch KJ, Plugge CM, Strik DP, Grootscholten TI, Buisman CJ, Hamelers HV.

Environ Sci Technol. 2016 Mar 15;50(6):2796-810. doi: 10.1021/acs.est.5b04847. Epub 2016 Feb 25. Review.

PMID:
26854969
23.

Ustilago maydis produces itaconic acid via the unusual intermediate trans-aconitate.

Geiser E, Przybilla SK, Friedrich A, Buckel W, Wierckx N, Blank LM, Bölker M.

Microb Biotechnol. 2016 Jan;9(1):116-26. doi: 10.1111/1751-7915.12329. Epub 2015 Dec 7.

24.

On the Origin of Heterotrophy.

Schönheit P, Buckel W, Martin WF.

Trends Microbiol. 2016 Jan;24(1):12-25. doi: 10.1016/j.tim.2015.10.003. Epub 2015 Nov 12. Review.

PMID:
26578093
25.

Two pathways for glutamate biosynthesis in the syntrophic bacterium Syntrophus aciditrophicus.

Kim M, Le HM, Xie X, Feng X, Tang YJ, Mouttaki H, McInerney MJ, Buckel W.

Appl Environ Microbiol. 2015 Dec;81(24):8434-44. doi: 10.1128/AEM.02323-15. Epub 2015 Oct 2.

26.

Reduction of ferredoxin or oxygen by flavin-based electron bifurcation in Megasphaera elsdenii.

Chowdhury NP, Kahnt J, Buckel W.

FEBS J. 2015 Aug;282(16):3149-60. doi: 10.1111/febs.13308. Epub 2015 May 18.

27.

Use of computer decision support in an antimicrobial stewardship program (ASP).

Evans RS, Olson JA, Stenehjem E, Buckel WR, Thorell EA, Howe S, Wu X, Jones PS, Lloyd JF.

Appl Clin Inform. 2015 Mar 3;6(1):120-35. doi: 10.4338/ACI-2014-11-RA-0102. eCollection 2015.

28.

Ceftaroline in Combination With Trimethoprim-Sulfamethoxazole for Salvage Therapy of Methicillin-Resistant Staphylococcus aureus Bacteremia and Endocarditis.

Fabre V, Ferrada M, Buckel WR, Avdic E, Cosgrove SE.

Open Forum Infect Dis. 2014 Jul 8;1(2):ofu046. doi: 10.1093/ofid/ofu046. eCollection 2014 Sep. Erratum in: Open Forum Infect Dis. 2015 Apr;2(2):ofv058.

29.

Gut check: Clostridium difficile testing and treatment in the molecular testing era.

Buckel WR, Avdic E, Carroll KC, Gunaseelan V, Hadhazy E, Cosgrove SE.

Infect Control Hosp Epidemiol. 2015 Feb;36(2):217-21. doi: 10.1017/ice.2014.19.

PMID:
25633006
30.

Substrate-induced radical formation in 4-hydroxybutyryl coenzyme A dehydratase from Clostridium aminobutyricum.

Zhang J, Friedrich P, Pierik AJ, Martins BM, Buckel W.

Appl Environ Microbiol. 2015 Feb;81(3):1071-84. doi: 10.1128/AEM.03099-14. Epub 2014 Dec 1.

31.

The benzoyl-coenzyme a reductase and 2-hydroxyacyl-coenzyme a dehydratase radical enzyme family.

Buckel W, Kung JW, Boll M.

Chembiochem. 2014 Oct 13;15(15):2188-94. doi: 10.1002/cbic.201402270. Epub 2014 Sep 9. Review. No abstract available.

PMID:
25204868
32.

High resolution crystal structure of Clostridium propionicum β-alanyl-CoA:ammonia lyase, a new member of the "hot dog fold" protein superfamily.

Heine A, Herrmann G, Selmer T, Terwesten F, Buckel W, Reuter K.

Proteins. 2014 Sep;82(9):2041-53. doi: 10.1002/prot.24557. Epub 2014 Apr 16.

PMID:
24623648
33.

Sir John Warcup Cornforth (1917-2013).

Golding BT, Buckel W.

Angew Chem Int Ed Engl. 2014 Apr 1;53(14):3546. doi: 10.1002/anie.201401077. Epub 2014 Mar 5. No abstract available.

PMID:
24599877
34.

Studies on the mechanism of electron bifurcation catalyzed by electron transferring flavoprotein (Etf) and butyryl-CoA dehydrogenase (Bcd) of Acidaminococcus fermentans.

Chowdhury NP, Mowafy AM, Demmer JK, Upadhyay V, Koelzer S, Jayamani E, Kahnt J, Hornung M, Demmer U, Ermler U, Buckel W.

J Biol Chem. 2014 Feb 21;289(8):5145-57. doi: 10.1074/jbc.M113.521013. Epub 2013 Dec 30.

35.

Molecular dynamics simulations and structure-guided mutagenesis provide insight into the architecture of the catalytic core of the ectoine hydroxylase.

Widderich N, Pittelkow M, Höppner A, Mulnaes D, Buckel W, Gohlke H, Smits SH, Bremer E.

J Mol Biol. 2014 Feb 6;426(3):586-600. doi: 10.1016/j.jmb.2013.10.028. Epub 2013 Oct 30.

PMID:
24184278
36.

Phenylalanine catabolism in Archaeoglobus fulgidus VC-16.

Parthasarathy A, Kahnt J, Chowdhury NP, Buckel W.

Arch Microbiol. 2013 Dec;195(12):781-97. doi: 10.1007/s00203-013-0925-3. Epub 2013 Oct 6.

PMID:
24096454
37.

Bacterial methanogenesis proceeds by a radical mechanism.

Buckel W.

Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8507-9. doi: 10.1002/anie.201304593. Epub 2013 Jul 12. No abstract available.

PMID:
23852991
38.

Effect of an oxygen-tolerant bifurcating butyryl coenzyme A dehydrogenase/electron-transferring flavoprotein complex from Clostridium difficile on butyrate production in Escherichia coli.

Aboulnaga el-H, Pinkenburg O, Schiffels J, El-Refai A, Buckel W, Selmer T.

J Bacteriol. 2013 Aug;195(16):3704-13. doi: 10.1128/JB.00321-13. Epub 2013 Jun 14.

39.

An electron-bifurcating caffeyl-CoA reductase.

Bertsch J, Parthasarathy A, Buckel W, Müller V.

J Biol Chem. 2013 Apr 19;288(16):11304-11. doi: 10.1074/jbc.M112.444919. Epub 2013 Mar 11.

40.

Identification and characterization of re-citrate synthase in Syntrophus aciditrophicus.

Kim M, Le H, McInerney MJ, Buckel W.

J Bacteriol. 2013 Apr;195(8):1689-96. doi: 10.1128/JB.02185-12. Epub 2013 Feb 1.

41.

Caffeate respiration in the acetogenic bacterium Acetobacterium woodii: a coenzyme A loop saves energy for caffeate activation.

Hess V, González JM, Parthasarathy A, Buckel W, Müller V.

Appl Environ Microbiol. 2013 Mar;79(6):1942-7. doi: 10.1128/AEM.03604-12. Epub 2013 Jan 11.

42.

Enzymatic assay for quantitative analysis of (D)-2-hydroxyglutarate.

Balss J, Pusch S, Beck AC, Herold-Mende C, Krämer A, Thiede C, Buckel W, Langhans CD, Okun JG, von Deimling A.

Acta Neuropathol. 2012 Dec;124(6):883-91. doi: 10.1007/s00401-012-1060-y. Epub 2012 Nov 2.

PMID:
23117877
43.

Experimental study of hydrogen bonding potentially stabilizing the 5'-deoxyadenosyl radical from coenzyme B12.

Friedrich P, Baisch U, Harrington RW, Lyatuu F, Zhou K, Zelder F, McFarlane W, Buckel W, Golding BT.

Chemistry. 2012 Dec 7;18(50):16114-22. doi: 10.1002/chem.201201840. Epub 2012 Oct 18.

PMID:
23080006
44.

Development of a satisfactory and general continuous assay for aminotransferases by coupling with (R)-2-hydroxyglutarate dehydrogenase.

Yu X, Bresser J, Schall I, Djurdjevic I, Buckel W, Wang X, Engel PC.

Anal Biochem. 2012 Dec 15;431(2):127-31. doi: 10.1016/j.ab.2012.09.009. Epub 2012 Sep 19.

PMID:
23000002
45.

Hydrogen bonds guide the short-lived 5'-deoxyadenosyl radical to the place of action.

Buckel W, Friedrich P, Golding BT.

Angew Chem Int Ed Engl. 2012 Oct 1;51(40):9974-6. doi: 10.1002/anie.201205299. Epub 2012 Sep 3. No abstract available.

PMID:
22945861
46.

Chemistry and bioactivity of an artificial adenosylpeptide B(12) cofactor.

Zhou K, Oetterli RM, Brandl H, Lyatuu FE, Buckel W, Zelder F.

Chembiochem. 2012 Sep 24;13(14):2052-5. doi: 10.1002/cbic.201200429. Epub 2012 Aug 24.

PMID:
22927110
47.

On the ATP-dependent activation of the radical enzyme (R)-2-hydroxyisocaproyl-CoA dehydratase.

Knauer SH, Buckel W, Dobbek H.

Biochemistry. 2012 Aug 21;51(33):6609-22. doi: 10.1021/bi300571z. Epub 2012 Aug 8.

PMID:
22827463
48.

Engineering Escherichia coli with acrylate pathway genes for propionic acid synthesis and its impact on mixed-acid fermentation.

Kandasamy V, Vaidyanathan H, Djurdjevic I, Jayamani E, Ramachandran KB, Buckel W, Jayaraman G, Ramalingam S.

Appl Microbiol Biotechnol. 2013 Feb;97(3):1191-200. doi: 10.1007/s00253-012-4274-y. Epub 2012 Jul 19.

PMID:
22810300
49.

Energy conservation via electron bifurcating ferredoxin reduction and proton/Na(+) translocating ferredoxin oxidation.

Buckel W, Thauer RK.

Biochim Biophys Acta. 2013 Feb;1827(2):94-113. doi: 10.1016/j.bbabio.2012.07.002. Epub 2012 Jul 16. Review.

50.

The single NqrB and NqrC subunits in the Na(+)-translocating NADH: quinone oxidoreductase (Na(+)-NQR) from Vibrio cholerae each carry one covalently attached FMN.

Casutt MS, Schlosser A, Buckel W, Steuber J.

Biochim Biophys Acta. 2012 Oct;1817(10):1817-22. doi: 10.1016/j.bbabio.2012.02.012. Epub 2012 Feb 16.

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