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Items: 1 to 50 of 73

1.

Feasibility Study of Mesoporous Silica Particles for Pulmonary Drug Delivery: Therapeutic Treatment with Dexamethasone in a Mouse Model of Airway Inflammation.

Gulin-Sarfraz T, Jonasson S, Wigenstam E, von Haartman E, Bucht A, Rosenholm JM.

Pharmaceutics. 2019 Apr 1;11(4). pii: E149. doi: 10.3390/pharmaceutics11040149.

2.

Cytotoxic lymphocytes in COPD airways: increased NK cells associated with disease, iNKT and NKT-like cells with current smoking.

Eriksson Ström J, Pourazar J, Linder R, Blomberg A, Lindberg A, Bucht A, Behndig AF.

Respir Res. 2018 Dec 7;19(1):244. doi: 10.1186/s12931-018-0940-7.

3.

Anti-inflammatory and anti-fibrotic treatment in a rodent model of acute lung injury induced by sulfur dioxide.

Wigenstam E, Elfsmark L, Ågren L, Akfur C, Bucht A, Jonasson S.

Clin Toxicol (Phila). 2018 Dec;56(12):1185-1194. doi: 10.1080/15563650.2018.1479527. Epub 2018 Jun 20.

PMID:
29923422
4.

Contact (kallikrein/kinin) system activation in whole human blood induced by low concentrations of α-Fe2O3 nanoparticles.

Ekdahl KN, Davoodpour P, Ekstrand-Hammarström B, Fromell K, Hamad OA, Hong J, Bucht A, Mohlin C, Seisenbaeva GA, Kessler VG, Nilsson B.

Nanomedicine. 2018 Apr;14(3):735-744. doi: 10.1016/j.nano.2017.12.008. Epub 2017 Dec 24.

PMID:
29277639
5.

8-Isoprostane is an early biomarker for oxidative stress in chlorine-induced acute lung injury.

Elfsmark L, Ågren L, Akfur C, Bucht A, Jonasson S.

Toxicol Lett. 2018 Jan 5;282:1-7. doi: 10.1016/j.toxlet.2017.10.007. Epub 2017 Oct 7.

PMID:
29017959
6.

Comparison of skin decontamination efficacy of commercial decontamination products following exposure to VX on human skin.

Thors L, Koch M, Wigenstam E, Koch B, Hägglund L, Bucht A.

Chem Biol Interact. 2017 Aug 1;273:82-89. doi: 10.1016/j.cbi.2017.06.002. Epub 2017 Jun 7.

PMID:
28601555
7.

RSDL decontamination of human skin contaminated with the nerve agent VX.

Thors L, Lindberg S, Johansson S, Koch B, Koch M, Hägglund L, Bucht A.

Toxicol Lett. 2017 Mar 5;269:47-54. doi: 10.1016/j.toxlet.2017.02.001. Epub 2017 Feb 6.

PMID:
28179194
8.

Inhaled sulfur dioxide causes pulmonary and systemic inflammation leading to fibrotic respiratory disease in a rat model of chemical-induced lung injury.

Wigenstam E, Elfsmark L, Bucht A, Jonasson S.

Toxicology. 2016 Aug 10;368-369:28-36. doi: 10.1016/j.tox.2016.08.018. Epub 2016 Aug 23.

PMID:
27565714
9.

Acute respiratory changes and pulmonary inflammation involving a pathway of TGF-β1 induction in a rat model of chlorine-induced lung injury.

Wigenstam E, Elfsmark L, Koch B, Bucht A, Jonasson S.

Toxicol Appl Pharmacol. 2016 Oct 15;309:44-54. doi: 10.1016/j.taap.2016.08.027. Epub 2016 Aug 30.

PMID:
27586366
10.

In vitro human skin penetration model for organophosphorus compounds with different physicochemical properties.

Thors L, Koch B, Koch M, Hägglund L, Bucht A.

Toxicol In Vitro. 2016 Apr;32:198-204. doi: 10.1016/j.tiv.2016.01.003. Epub 2016 Jan 9.

PMID:
26778740
11.

Differential cellular responses in healthy mice and in mice with established airway inflammation when exposed to hematite nanoparticles.

Gustafsson Å, Bergström U, Ågren L, Österlund L, Sandström T, Bucht A.

Toxicol Appl Pharmacol. 2015 Oct 1;288(1):1-11. doi: 10.1016/j.taap.2015.07.001. Epub 2015 Jul 7.

PMID:
26163175
12.

TiO2 nanoparticles tested in a novel screening whole human blood model of toxicity trigger adverse activation of the kallikrein system at low concentrations.

Ekstrand-Hammarström B, Hong J, Davoodpour P, Sandholm K, Ekdahl KN, Bucht A, Nilsson B.

Biomaterials. 2015 May;51:58-68. doi: 10.1016/j.biomaterials.2015.01.031. Epub 2015 Feb 17.

PMID:
25770998
13.

N-acetyl cysteine improves the effects of corticosteroids in a mouse model of chlorine-induced acute lung injury.

Wigenstam E, Koch B, Bucht A, Jonasson S.

Toxicology. 2015 Feb 3;328:40-7. doi: 10.1016/j.tox.2014.12.008. Epub 2014 Dec 11.

PMID:
25497111
14.

Genetic variation influences immune responses in sensitive rats following exposure to TiO2 nanoparticles.

Gustafsson A, Jonasson S, Sandström T, Lorentzen JC, Bucht A.

Toxicology. 2014 Dec 4;326:74-85. doi: 10.1016/j.tox.2014.10.004. Epub 2014 Oct 14.

PMID:
25456268
15.

The gallium(III)-salicylidene acylhydrazide complex shows synergistic anti-biofilm effect and inhibits toxin production by Pseudomonas aeruginosa.

Rzhepishevska O, Hakobyan S, Ekstrand-Hammarström B, Nygren Y, Karlsson T, Bucht A, Elofsson M, Boily JF, Ramstedt M.

J Inorg Biochem. 2014 Sep;138:1-8. doi: 10.1016/j.jinorgbio.2014.04.009. Epub 2014 Apr 23.

16.

Assessment of the capacity of vehicle cabin air inlet filters to reduce diesel exhaust-induced symptoms in human volunteers.

Muala A, Sehlstedt M, Bion A, Osterlund C, Bosson JA, Behndig AF, Pourazar J, Bucht A, Boman C, Mudway IS, Langrish JP, Couderc S, Blomberg A, Sandström T.

Environ Health. 2014 Mar 13;13(1):16. doi: 10.1186/1476-069X-13-16.

17.

Early treatment of chlorine-induced airway hyperresponsiveness and inflammation with corticosteroids.

Jonasson S, Wigenstam E, Koch B, Bucht A.

Toxicol Appl Pharmacol. 2013 Sep 1;271(2):168-74. doi: 10.1016/j.taap.2013.04.037. Epub 2013 May 22.

PMID:
23707766
18.

Strain differences influence timing and magnitude of both acute and late inflammatory reactions after intratracheal instillation of an alkylating agent in rats.

Gustafsson A, Svensson-Elfsmark L, Lorentzen JC, Bucht A.

J Appl Toxicol. 2014 Mar;34(3):272-80. doi: 10.1002/jat.2878. Epub 2013 Apr 29.

PMID:
23625772
19.

Inhalation exposure of nano-scaled titanium dioxide (TiO2) particles alters the inflammatory responses in asthmatic mice.

Jonasson S, Gustafsson A, Koch B, Bucht A.

Inhal Toxicol. 2013 Mar;25(4):179-91. doi: 10.3109/08958378.2013.770939.

PMID:
23480194
20.

Oxidative stress and cytokine expression in respiratory epithelial cells exposed to well-characterized aerosols from Kabul, Afghanistan.

Ekstrand-Hammarström B, Magnusson R, Osterlund C, Andersson BM, Bucht A, Wingfors H.

Toxicol In Vitro. 2013 Mar;27(2):825-33. doi: 10.1016/j.tiv.2012.12.022. Epub 2012 Dec 29.

PMID:
23276820
21.

Inhalation of chlorine causes long-standing lung inflammation and airway hyperresponsiveness in a murine model of chemical-induced lung injury.

Jonasson S, Koch B, Bucht A.

Toxicology. 2013 Jan 7;303:34-42. doi: 10.1016/j.tox.2012.10.022. Epub 2012 Nov 9.

PMID:
23146759
22.

Corticosteroid treatment inhibits airway hyperresponsiveness and lung injury in a murine model of chemical-induced airway inflammation.

Wigenstam E, Jonasson S, Koch B, Bucht A.

Toxicology. 2012 Nov 15;301(1-3):66-71. doi: 10.1016/j.tox.2012.06.020. Epub 2012 Jul 6.

PMID:
22776411
23.

The antibacterial activity of Ga3+ is influenced by ligand complexation as well as the bacterial carbon source.

Rzhepishevska O, Ekstrand-Hammarström B, Popp M, Björn E, Bucht A, Sjöstedt A, Antti H, Ramstedt M.

Antimicrob Agents Chemother. 2011 Dec;55(12):5568-80. doi: 10.1128/AAC.00386-11. Epub 2011 Sep 26.

24.

Human primary bronchial epithelial cells respond differently to titanium dioxide nanoparticles than the lung epithelial cell lines A549 and BEAS-2B.

Ekstrand-Hammarström B, Akfur CM, Andersson PO, Lejon C, Osterlund L, Bucht A.

Nanotoxicology. 2012 Sep;6(6):623-34. doi: 10.3109/17435390.2011.598245. Epub 2011 Jul 25.

PMID:
21781018
25.

Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD.

Roos-Engstrand E, Pourazar J, Behndig AF, Bucht A, Blomberg A.

Respir Res. 2011 Jun 8;12:74. doi: 10.1186/1465-9921-12-74.

26.

Lung exposure of titanium dioxide nanoparticles induces innate immune activation and long-lasting lymphocyte response in the Dark Agouti rat.

Gustafsson Å, Lindstedt E, Elfsmark LS, Bucht A.

J Immunotoxicol. 2011 Jun;8(2):111-21. doi: 10.3109/1547691X.2010.546382. Epub 2011 Feb 10.

27.

Polymorph- and size-dependent uptake and toxicity of TiO₂ nanoparticles in living lung epithelial cells.

Andersson PO, Lejon C, Ekstrand-Hammarström B, Akfur C, Ahlinder L, Bucht A, Osterlund L.

Small. 2011 Feb 18;7(4):514-23. doi: 10.1002/smll.201001832. Epub 2011 Jan 24.

PMID:
21265017
28.

Non-proteolytic aeroallergens from mites, cat and dog exert adjuvant-like activation of bronchial epithelial cells.

Osterlund C, Grönlund H, Gafvelin G, Bucht A.

Int Arch Allergy Immunol. 2011;155(2):111-8. doi: 10.1159/000318743. Epub 2010 Dec 22.

29.

Inhalation of alkylating mustard causes long-term T cell-dependent inflammation in airways and growth of connective tissue.

Ekstrand-Hammarström B, Wigenstam E, Bucht A.

Toxicology. 2011 Feb 27;280(3):88-97. doi: 10.1016/j.tox.2010.11.012. Epub 2010 Dec 1.

PMID:
21129433
30.

Cytotoxic T cells expressing the co-stimulatory receptor NKG2 D are increased in cigarette smoking and COPD.

Roos-Engstrand E, Pourazar J, Behndig AF, Blomberg A, Bucht A.

Respir Res. 2010 Sep 24;11:128. doi: 10.1186/1465-9921-11-128.

31.

Mouse mast cell protease 4 is the major chymase in murine airways and has a protective role in allergic airway inflammation.

Waern I, Jonasson S, Hjoberg J, Bucht A, Abrink M, Pejler G, Wernersson S.

J Immunol. 2009 Nov 15;183(10):6369-76. doi: 10.4049/jimmunol.0900180. Epub 2009 Oct 19.

32.

Treatment with dexamethasone or liposome-encapsuled vitamin E provides beneficial effects after chemical-induced lung injury.

Wigenstam E, Rocksén D, Ekstrand-Hammarström B, Bucht A.

Inhal Toxicol. 2009 Sep;21(11):958-64. doi: 10.1080/08958370802596298.

PMID:
19572781
33.

Rats repeatedly exposed to toluene diisocyanate exhibit immune reactivity against methyl isocyanate-protein conjugates.

Svensson-Elfsmark L, Koch BL, Gustafsson A, Bucht A.

Int Arch Allergy Immunol. 2009;150(3):229-36. doi: 10.1159/000222675. Epub 2009 Jun 3.

PMID:
19494520
34.

The non-proteolytic house dust mite allergen Der p 2 induce NF-kappaB and MAPK dependent activation of bronchial epithelial cells.

Osterlund C, Grönlund H, Polovic N, Sundström S, Gafvelin G, Bucht A.

Clin Exp Allergy. 2009 Aug;39(8):1199-208. doi: 10.1111/j.1365-2222.2009.03284.x. Epub 2009 May 26.

PMID:
19486032
35.

Influence of smoking cessation on airway T lymphocyte subsets in COPD.

Roos-Engstrand E, Ekstrand-Hammarström B, Pourazar J, Behndig AF, Bucht A, Blomberg A.

COPD. 2009 Apr;6(2):112-20. doi: 10.1080/15412550902755358.

PMID:
19378224
36.

Bacterial and mammalian cell response to poly(3-sulfopropyl methacrylate) brushes loaded with silver halide salts.

Ramstedt M, Ekstrand-Hammarström B, Shchukarev AV, Bucht A, Osterlund L, Welch M, Huck WT.

Biomaterials. 2009 Mar;30(8):1524-31. doi: 10.1016/j.biomaterials.2008.12.008. Epub 2008 Dec 23.

PMID:
19108885
37.

Increased intraepithelial T-cells in stable COPD.

Löfdahl MJ, Roos-Engstrand E, Pourazar J, Bucht A, Dahlen B, Elmberger G, Blomberg A, Sköld CM.

Respir Med. 2008 Dec;102(12):1812-8. doi: 10.1016/j.rmed.2008.06.013. Epub 2008 Aug 15.

38.

Involvement of NADPH oxidase and iNOS in rodent pulmonary cytokine responses to urban air and mineral particles.

Becher R, Bucht A, Øvrevik J, Hongslo JK, Dahlman HJ, Samuelsen JT, Schwarze PE.

Inhal Toxicol. 2007 Jun;19(8):645-55.

PMID:
17510837
39.

Vitamin E down-modulates mitogen-activated protein kinases, nuclear factor-kappaB and inflammatory responses in lung epithelial cells.

Ekstrand-Hammarström B, Osterlund C, Lilliehöök B, Bucht A.

Clin Exp Immunol. 2007 Feb;147(2):359-69.

40.

The nitrogen mustard melphalan activates mitogen-activated phosphorylated kinases (MAPK), nuclear factor-kappaB and inflammatory response in lung epithelial cells.

Osterlund C, Lilliehöök B, Ekstrand-Hammarström B, Sandström T, Bucht A.

J Appl Toxicol. 2005 Jul-Aug;25(4):328-37.

PMID:
16025434
41.

A mouse model for in vivo tracking of the major dust mite allergen Der p 2 after inhalation.

Johansson L, Svensson L, Bergström U, Jacobsson-Ekman G, Arnér ES, van Hage M, Bucht A, Gafvelin G.

FEBS J. 2005 Jul;272(13):3449-60.

42.

Increased expression of p38 MAPK in human bronchial epithelium after lipopolysaccharide exposure.

Roos-Engstrand E, Wallin A, Bucht A, Pourazar J, Sandström T, Blomberg A.

Eur Respir J. 2005 May;25(5):797-803.

43.

Lipopolysaccharide-induced pulmonary inflammation is not accompanied by a release of anandamide into the lavage fluid or a down-regulation of the activity of fatty acid amide hydrolase.

Holt S, Rocksén D, Bucht A, Petersen G, Hansen HS, Valenti M, Di Marzo V, Fowler CJ.

Life Sci. 2004 Dec 10;76(4):461-72.

PMID:
15530507
44.
45.

Adjuvant oil induces waves of arthritogenic lymph node cells prior to arthritis onset.

Holm BC, Lorentzen JC, Bucht A.

Clin Exp Immunol. 2004 Jul;137(1):59-64.

46.

Increased levels of hypoxia-sensitive proteins in allergic airway inflammation.

Fajardo I, Svensson L, Bucht A, Pejler G.

Am J Respir Crit Care Med. 2004 Sep 1;170(5):477-84. Epub 2004 May 19.

PMID:
15151919
47.

Oligodeoxynucleotides containing CpG motifs can induce T cell-dependent arthritis in rats.

Svelander L, Erlandsson Harris H, Lorentzen JC, Trollmo C, Klareskog L, Bucht A.

Arthritis Rheum. 2004 Jan;50(1):297-304.

48.

Ozone-induced bronchial epithelial cytokine expression differs between healthy and asthmatic subjects.

Bosson J, Stenfors N, Bucht A, Helleday R, Pourazar J, Holgate ST, Kelly FJ, Sandström T, Wilson S, Frew AJ, Blomberg A.

Clin Exp Allergy. 2003 Jun;33(6):777-82.

PMID:
12801312
49.

Vitamin E reduces transendothelial migration of neutrophils and prevents lung injury in endotoxin-induced airway inflammation.

Rocksén D, Ekstrand-Hammarström B, Johansson L, Bucht A.

Am J Respir Cell Mol Biol. 2003 Feb;28(2):199-207.

PMID:
12540487
50.

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