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Items: 1 to 50 of 76

1.

Type I IFN ineffectively activates neonatal dendritic cells limiting respiratory antiviral T-cell responses.

Lau-Kilby AW, Turfkruyer M, Kehl M, Yang L, Buchholz UJ, Hickey K, Malloy AMW.

Mucosal Immunol. 2019 Dec 4. doi: 10.1038/s41385-019-0234-5. [Epub ahead of print]

PMID:
31797910
2.

Optimization of the Codon Pair Usage of Human Respiratory Syncytial Virus Paradoxically Resulted in Reduced Viral Replication In Vivo and Reduced Immunogenicity.

Le Nouën C, Luongo CL, Yang L, Mueller S, Wimmer E, DiNapoli JM, Collins PL, Buchholz UJ.

J Virol. 2020 Jan 6;94(2). pii: e01296-19. doi: 10.1128/JVI.01296-19. Print 2020 Jan 6.

3.

Safety and Immunogenicity of the Respiratory Syncytial Virus Vaccine RSV/ΔNS2/Δ1313/I1314L in RSV-Seronegative Children.

Karron RA, Luongo C, Mateo JS, Wanionek K, Collins PL, Buchholz UJ.

J Infect Dis. 2019 Oct 12. pii: jiz408. doi: 10.1093/infdis/jiz408. [Epub ahead of print]

PMID:
31605113
4.

Lack of Activation Marker Induction and Chemokine Receptor Switch in Human Neonatal Myeloid Dendritic Cells in Response to Human Respiratory Syncytial Virus.

Le Nouën C, Hillyer P, Levenson E, Martens C, Rabin RL, Collins PL, Buchholz UJ.

J Virol. 2019 Oct 29;93(22). pii: e01216-19. doi: 10.1128/JVI.01216-19. Print 2019 Nov 15.

5.

The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells.

Lingemann M, McCarty T, Liu X, Buchholz UJ, Surman S, Martin SE, Collins PL, Munir S.

PLoS Pathog. 2019 Aug 5;15(8):e1007963. doi: 10.1371/journal.ppat.1007963. eCollection 2019 Aug.

6.

Attenuation of Human Respiratory Viruses by Synonymous Genome Recoding.

Le Nouën C, Collins PL, Buchholz UJ.

Front Immunol. 2019 Jun 4;10:1250. doi: 10.3389/fimmu.2019.01250. eCollection 2019. Review.

7.

Taxonomy of the order Mononegavirales: update 2019.

Amarasinghe GK, Ayllón MA, Bào Y, Basler CF, Bavari S, Blasdell KR, Briese T, Brown PA, Bukreyev A, Balkema-Buschmann A, Buchholz UJ, Chabi-Jesus C, Chandran K, Chiapponi C, Crozier I, de Swart RL, Dietzgen RG, Dolnik O, Drexler JF, Dürrwald R, Dundon WG, Duprex WP, Dye JM, Easton AJ, Fooks AR, Formenty PBH, Fouchier RAM, Freitas-Astúa J, Griffiths A, Hewson R, Horie M, Hyndman TH, Jiāng D, Kitajima EW, Kobinger GP, Kondō H, Kurath G, Kuzmin IV, Lamb RA, Lavazza A, Lee B, Lelli D, Leroy EM, Lǐ J, Maes P, Marzano SL, Moreno A, Mühlberger E, Netesov SV, Nowotny N, Nylund A, Økland AL, Palacios G, Pályi B, Pawęska JT, Payne SL, Prosperi A, Ramos-González PL, Rima BK, Rota P, Rubbenstroth D, Shī M, Simmonds P, Smither SJ, Sozzi E, Spann K, Stenglein MD, Stone DM, Takada A, Tesh RB, Tomonaga K, Tordo N, Towner JS, van den Hoogen B, Vasilakis N, Wahl V, Walker PJ, Wang LF, Whitfield AE, Williams JV, Zerbini FM, Zhāng T, Zhang YZ, Kuhn JH.

Arch Virol. 2019 Jul;164(7):1967-1980. doi: 10.1007/s00705-019-04247-4.

PMID:
31089958
8.

Taxonomy of the order Mononegavirales: second update 2018.

Maes P, Amarasinghe GK, Ayllón MA, Basler CF, Bavari S, Blasdell KR, Briese T, Brown PA, Bukreyev A, Balkema-Buschmann A, Buchholz UJ, Chandran K, Crozier I, de Swart RL, Dietzgen RG, Dolnik O, Domier LL, Drexler JF, Dürrwald R, Dundon WG, Duprex WP, Dye JM, Easton AJ, Fooks AR, Formenty PBH, Fouchier RAM, Freitas-Astúa J, Ghedin E, Griffiths A, Hewson R, Horie M, Hurwitz JL, Hyndman TH, Jiāng D, Kobinger GP, Kondō H, Kurath G, Kuzmin IV, Lamb RA, Lee B, Leroy EM, Lǐ J, Marzano SL, Mühlberger E, Netesov SV, Nowotny N, Palacios G, Pályi B, Pawęska JT, Payne SL, Rima BK, Rota P, Rubbenstroth D, Simmonds P, Smither SJ, Song Q, Song T, Spann K, Stenglein MD, Stone DM, Takada A, Tesh RB, Tomonaga K, Tordo N, Towner JS, van den Hoogen B, Vasilakis N, Wahl V, Walker PJ, Wang D, Wang LF, Whitfield AE, Williams JV, Yè G, Zerbini FM, Zhang YZ, Kuhn JH.

Arch Virol. 2019 Apr;164(4):1233-1244. doi: 10.1007/s00705-018-04126-4.

PMID:
30663023
9.

Effects of Alterations to the CX3C Motif and Secreted Form of Human Respiratory Syncytial Virus (RSV) G Protein on Immune Responses to a Parainfluenza Virus Vector Expressing the RSV G Protein.

Liang B, Kabatova B, Kabat J, Dorward DW, Liu X, Surman S, Liu X, Moseman AP, Buchholz UJ, Collins PL, Munir S.

J Virol. 2019 Mar 21;93(7). pii: e02043-18. doi: 10.1128/JVI.02043-18. Print 2019 Apr 1.

10.

Murine Pneumonia Virus Expressing the Fusion Glycoprotein of Human Respiratory Syncytial Virus from an Added Gene Is Highly Attenuated and Immunogenic in Rhesus Macaques.

Brock LG, Liu X, Liang B, Lingemann M, Liu X, Herbert R, Hackenberg AD, Buchholz UJ, Collins PL, Munir S.

J Virol. 2018 Aug 16;92(17). pii: e00723-18. doi: 10.1128/JVI.00723-18. Print 2018 Sep 1.

11.

The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates.

Mazur NI, Higgins D, Nunes MC, Melero JA, Langedijk AC, Horsley N, Buchholz UJ, Openshaw PJ, McLellan JS, Englund JA, Mejias A, Karron RA, Simões EA, Knezevic I, Ramilo O, Piedra PA, Chu HY, Falsey AR, Nair H, Kragten-Tabatabaie L, Greenough A, Baraldi E, Papadopoulos NG, Vekemans J, Polack FP, Powell M, Satav A, Walsh EE, Stein RT, Graham BS, Bont LJ; Respiratory Syncytial Virus Network (ReSViNET) Foundation.

Lancet Infect Dis. 2018 Oct;18(10):e295-e311. doi: 10.1016/S1473-3099(18)30292-5. Epub 2018 Jun 18. Review. Erratum in: Lancet Infect Dis. 2018 Jul 25;:.

12.

Differential Responses by Human Respiratory Epithelial Cell Lines to Respiratory Syncytial Virus Reflect Distinct Patterns of Infection Control.

Hillyer P, Shepard R, Uehling M, Krenz M, Sheikh F, Thayer KR, Huang L, Yan L, Panda D, Luongo C, Buchholz UJ, Collins PL, Donnelly RP, Rabin RL.

J Virol. 2018 Jul 17;92(15). pii: e02202-17. doi: 10.1128/JVI.02202-17. Print 2018 Aug 1.

13.

Live Respiratory Syncytial Virus (RSV) Vaccine Candidate Containing Stabilized Temperature-Sensitivity Mutations Is Highly Attenuated in RSV-Seronegative Infants and Children.

Buchholz UJ, Cunningham CK, Muresan P, Gnanashanmugam D, Sato P, Siberry GK, Rexroad V, Valentine M, Perlowski C, Schappell E, Thumar B, Luongo C, Barr E, Aziz M, Yogev R, Spector SA, Collins PL, McFarland EJ, Karron RA; International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1114 Study Team.

J Infect Dis. 2018 Apr 11;217(9):1338-1346. doi: 10.1093/infdis/jiy066.

14.

Live-Attenuated Respiratory Syncytial Virus Vaccine Candidate With Deletion of RNA Synthesis Regulatory Protein M2-2 is Highly Immunogenic in Children.

McFarland EJ, Karron RA, Muresan P, Cunningham CK, Valentine ME, Perlowski C, Thumar B, Gnanashanmugam D, Siberry GK, Schappell E, Barr E, Rexroad V, Yogev R, Spector SA, Aziz M, Patel N, Cielo M, Luongo C, Collins PL, Buchholz UJ; International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) 2000 Study Team.

J Infect Dis. 2018 Apr 11;217(9):1347-1355. doi: 10.1093/infdis/jiy040.

15.

Multicolor Stimulated Emission Depletion (STED) Microscopy to Generate High-resolution Images of Respiratory Syncytial Virus Particles and Infected Cells.

Mehedi M, Smelkinson M, Kabat J, Ganesan S, Collins PL, Buchholz UJ.

Bio Protoc. 2017 Sep 5;7(17). pii: e2543. doi: 10.21769/BioProtoc.2543.

16.

A novel host factor for human respiratory syncytial virus.

Mehedi M, Collins PL, Buchholz UJ.

Commun Integr Biol. 2017 May 8;10(3):e1319025. doi: 10.1080/19420889.2017.1319025. eCollection 2017.

17.

Evaluation of a Live Attenuated Human Metapneumovirus Vaccine in Adults and Children.

Karron RA, San Mateo J, Wanionek K, Collins PL, Buchholz UJ.

J Pediatric Infect Dis Soc. 2018 Feb 19;7(1):86-89. doi: 10.1093/jpids/pix006.

18.

Attenuated Human Parainfluenza Virus Type 1 Expressing Ebola Virus Glycoprotein GP Administered Intranasally Is Immunogenic in African Green Monkeys.

Lingemann M, Liu X, Surman S, Liang B, Herbert R, Hackenberg AD, Buchholz UJ, Collins PL, Munir S.

J Virol. 2017 Apr 28;91(10). pii: e02469-16. doi: 10.1128/JVI.02469-16. Print 2017 May 15.

19.

Respiratory syncytial virus infection induces a subset of types I and III interferons in human dendritic cells.

Hillyer P, Mane VP, Chen A, Dos Santos MB, Schramm LM, Shepard RE, Luongo C, Le Nouën C, Huang L, Yan L, Buchholz UJ, Jubin RG, Collins PL, Rabin RL.

Virology. 2017 Apr;504:63-72. doi: 10.1016/j.virol.2017.01.017. Epub 2017 Jan 31.

20.

Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure.

Le Nouën C, McCarty T, Brown M, Smith ML, Lleras R, Dolan MA, Mehedi M, Yang L, Luongo C, Liang B, Munir S, DiNapoli JM, Mueller S, Wimmer E, Collins PL, Buchholz UJ.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E386-E395. doi: 10.1073/pnas.1619242114. Epub 2017 Jan 3.

21.

Actin-Related Protein 2 (ARP2) and Virus-Induced Filopodia Facilitate Human Respiratory Syncytial Virus Spread.

Mehedi M, McCarty T, Martin SE, Le Nouën C, Buehler E, Chen YC, Smelkinson M, Ganesan S, Fischer ER, Brock LG, Liang B, Munir S, Collins PL, Buchholz UJ.

PLoS Pathog. 2016 Dec 7;12(12):e1006062. doi: 10.1371/journal.ppat.1006062. eCollection 2016 Dec.

22.

Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread.

El Najjar F, Cifuentes-Muñoz N, Chen J, Zhu H, Buchholz UJ, Moncman CL, Dutch RE.

PLoS Pathog. 2016 Sep 28;12(9):e1005922. doi: 10.1371/journal.ppat.1005922. eCollection 2016 Sep.

23.

Evaluation of a Live-Attenuated Human Parainfluenza Type 1 Vaccine in Adults and Children.

Karron RA, San Mateo J, Thumar B, Schaap-Nutt A, Buchholz UJ, Schmidt AC, Bartlett EJ, Murphy BR, Collins PL.

J Pediatric Infect Dis Soc. 2015 Dec;4(4):e143-6. doi: 10.1093/jpids/piu104. Epub 2014 Nov 12.

24.

A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in children.

Karron RA, Luongo C, Thumar B, Loehr KM, Englund JA, Collins PL, Buchholz UJ.

Sci Transl Med. 2015 Nov 4;7(312):312ra175. doi: 10.1126/scitranslmed.aac8463.

25.

TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization.

Caballero MT, Serra ME, Acosta PL, Marzec J, Gibbons L, Salim M, Rodriguez A, Reynaldi A, Garcia A, Bado D, Buchholz UJ, Hijano DR, Coviello S, Newcomb D, Bellabarba M, Ferolla FM, Libster R, Berenstein A, Siniawaski S, Blumetti V, Echavarria M, Pinto L, Lawrence A, Ossorio MF, Grosman A, Mateu CG, Bayle C, Dericco A, Pellegrini M, Igarza I, Repetto HA, Grimaldi LA, Gudapati P, Polack NR, Althabe F, Shi M, Ferrero F, Bergel E, Stein RT, Peebles RS, Boothby M, Kleeberger SR, Polack FP.

J Clin Invest. 2015 Feb;125(2):571-82. doi: 10.1172/JCI75183. Epub 2015 Jan 2.

26.

Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization.

Le Nouën C, Brock LG, Luongo C, McCarty T, Yang L, Mehedi M, Wimmer E, Mueller S, Collins PL, Buchholz UJ, DiNapoli JM.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13169-74. doi: 10.1073/pnas.1411290111. Epub 2014 Aug 25.

27.

A comprehensive proteomic view of responses of A549 type II alveolar epithelial cells to human respiratory syncytial virus infection.

Dave KA, Norris EL, Bukreyev AA, Headlam MJ, Buchholz UJ, Singh T, Collins PL, Gorman JJ.

Mol Cell Proteomics. 2014 Dec;13(12):3250-69. doi: 10.1074/mcp.M114.041129. Epub 2014 Aug 8.

28.

RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction.

Liesman RM, Buchholz UJ, Luongo CL, Yang L, Proia AD, DeVincenzo JP, Collins PL, Pickles RJ.

J Clin Invest. 2014 May;124(5):2219-33. doi: 10.1172/JCI72948. Epub 2014 Apr 8.

29.

Recombinant bovine respiratory syncytial virus with deletion of the SH gene induces increased apoptosis and pro-inflammatory cytokines in vitro, and is attenuated and induces protective immunity in calves.

Taylor G, Wyld S, Valarcher JF, Guzman E, Thom M, Widdison S, Buchholz UJ.

J Gen Virol. 2014 Jun;95(Pt 6):1244-54. doi: 10.1099/vir.0.064931-0. Epub 2014 Apr 3.

30.

Human metapneumovirus SH and G glycoproteins inhibit macropinocytosis-mediated entry into human dendritic cells and reduce CD4+ T cell activation.

Le Nouën C, Hillyer P, Brock LG, Winter CC, Rabin RL, Collins PL, Buchholz UJ.

J Virol. 2014 Jun;88(11):6453-69. doi: 10.1128/JVI.03261-13. Epub 2014 Mar 26.

31.

Chimeric bovine/human parainfluenza virus type 3 expressing respiratory syncytial virus (RSV) F glycoprotein: effect of insert position on expression, replication, immunogenicity, stability, and protection against RSV infection.

Liang B, Munir S, Amaro-Carambot E, Surman S, Mackow N, Yang L, Buchholz UJ, Collins PL, Schaap-Nutt A.

J Virol. 2014 Apr;88(8):4237-50. doi: 10.1128/JVI.03481-13. Epub 2014 Jan 29.

32.

Live-attenuated respiratory syncytial virus vaccines.

Karron RA, Buchholz UJ, Collins PL.

Curr Top Microbiol Immunol. 2013;372:259-84. doi: 10.1007/978-3-642-38919-1_13.

33.

Evaluation of the replication, pathogenicity, and immunogenicity of avian paramyxovirus (APMV) serotypes 2, 3, 4, 5, 7, and 9 in rhesus macaques.

Khattar SK, Nayak B, Kim SH, Xiao S, Samal S, Paldurai A, Buchholz UJ, Collins PL, Samal SK.

PLoS One. 2013 Oct 10;8(10):e75456. doi: 10.1371/journal.pone.0075456. eCollection 2013.

34.

Experimental infection of adults with recombinant wild-type human metapneumovirus.

Talaat KR, Karron RA, Thumar B, McMahon BA, Schmidt AC, Collins PL, Buchholz UJ.

J Infect Dis. 2013 Nov 15;208(10):1669-78. doi: 10.1093/infdis/jit356. Epub 2013 Aug 1.

35.

Attenuation of live respiratory syncytial virus vaccines is associated with reductions in levels of nasal cytokines.

Karron RA, Thumar B, Schappell E, Buchholz UJ, Collins PL.

J Infect Dis. 2013 Jun 1;207(11):1773-9. doi: 10.1093/infdis/jit089. Epub 2013 Mar 12.

37.

Increased genetic and phenotypic stability of a promising live-attenuated respiratory syncytial virus vaccine candidate by reverse genetics.

Luongo C, Winter CC, Collins PL, Buchholz UJ.

J Virol. 2012 Oct;86(19):10792-804. doi: 10.1128/JVI.01227-12. Epub 2012 Jul 25.

38.

Potential electrostatic interactions in multiple regions affect human metapneumovirus F-mediated membrane fusion.

Chang A, Hackett BA, Winter CC, Buchholz UJ, Dutch RE.

J Virol. 2012 Sep;86(18):9843-53. doi: 10.1128/JVI.00639-12. Epub 2012 Jul 3.

39.

Evaluation of pneumonia virus of mice as a possible human pathogen.

Brock LG, Karron RA, Krempl CD, Collins PL, Buchholz UJ.

J Virol. 2012 May;86(10):5829-43. doi: 10.1128/JVI.00163-12. Epub 2012 Mar 21.

40.

The human respiratory syncytial virus nonstructural protein 1 regulates type I and type II interferon pathways.

Hastie ML, Headlam MJ, Patel NB, Bukreyev AA, Buchholz UJ, Dave KA, Norris EL, Wright CL, Spann KM, Collins PL, Gorman JJ.

Mol Cell Proteomics. 2012 May;11(5):108-27. doi: 10.1074/mcp.M111.015909. Epub 2012 Feb 8.

41.

Human metapneumovirus (HMPV) binding and infection are mediated by interactions between the HMPV fusion protein and heparan sulfate.

Chang A, Masante C, Buchholz UJ, Dutch RE.

J Virol. 2012 Mar;86(6):3230-43. doi: 10.1128/JVI.06706-11. Epub 2012 Jan 11.

42.

Low CCR7-mediated migration of human monocyte derived dendritic cells in response to human respiratory syncytial virus and human metapneumovirus.

Le Nouën C, Hillyer P, Winter CC, McCarty T, Rabin RL, Collins PL, Buchholz UJ.

PLoS Pathog. 2011 Jun;7(6):e1002105. doi: 10.1371/journal.ppat.1002105. Epub 2011 Jun 23.

43.

Respiratory syncytial virus interferon antagonist NS1 protein suppresses and skews the human T lymphocyte response.

Munir S, Hillyer P, Le Nouën C, Buchholz UJ, Rabin RL, Collins PL, Bukreyev A.

PLoS Pathog. 2011 Apr;7(4):e1001336. doi: 10.1371/journal.ppat.1001336. Epub 2011 Apr 21.

44.

Both nonstructural proteins NS1 and NS2 of pneumonia virus of mice are inhibitors of the interferon type I and type III responses in vivo.

Heinze B, Frey S, Mordstein M, Schmitt-Gräff A, Ehl S, Buchholz UJ, Collins PL, Staeheli P, Krempl CD.

J Virol. 2011 May;85(9):4071-84. doi: 10.1128/JVI.01365-10. Epub 2011 Feb 9.

45.

Effects of human respiratory syncytial virus, metapneumovirus, parainfluenza virus 3 and influenza virus on CD4+ T cell activation by dendritic cells.

Le Nouën C, Hillyer P, Munir S, Winter CC, McCarty T, Bukreyev A, Collins PL, Rabin RL, Buchholz UJ.

PLoS One. 2010 Nov 29;5(11):e15017. doi: 10.1371/journal.pone.0015017.

46.

The open reading frame 3a protein of severe acute respiratory syndrome-associated coronavirus promotes membrane rearrangement and cell death.

Freundt EC, Yu L, Goldsmith CS, Welsh S, Cheng A, Yount B, Liu W, Frieman MB, Buchholz UJ, Screaton GR, Lippincott-Schwartz J, Zaki SR, Xu XN, Baric RS, Subbarao K, Lenardo MJ.

J Virol. 2010 Jan;84(2):1097-109. doi: 10.1128/JVI.01662-09. Epub 2009 Nov 4.

47.

Codon stabilization analysis of the "248" temperature sensitive mutation for increased phenotypic stability of respiratory syncytial virus vaccine candidates.

Luongo C, Yang L, Winter CC, Spann KM, Murphy BR, Collins PL, Buchholz UJ.

Vaccine. 2009 Sep 18;27(41):5667-76. doi: 10.1016/j.vaccine.2009.07.022. Epub 2009 Jul 29.

48.

A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction.

Moore ML, Chi MH, Luongo C, Lukacs NW, Polosukhin VV, Huckabee MM, Newcomb DC, Buchholz UJ, Crowe JE Jr, Goleniewska K, Williams JV, Collins PL, Peebles RS Jr.

J Virol. 2009 May;83(9):4185-94. doi: 10.1128/JVI.01853-08. Epub 2009 Feb 11.

49.

Infection and maturation of monocyte-derived human dendritic cells by human respiratory syncytial virus, human metapneumovirus, and human parainfluenza virus type 3.

Le Nouën C, Munir S, Losq S, Winter CC, McCarty T, Stephany DA, Holmes KL, Bukreyev A, Rabin RL, Collins PL, Buchholz UJ.

Virology. 2009 Mar 1;385(1):169-82. doi: 10.1016/j.virol.2008.11.043. Epub 2009 Jan 6.

50.

Deletion of nonstructural proteins NS1 and NS2 from pneumonia virus of mice attenuates viral replication and reduces pulmonary cytokine expression and disease.

Buchholz UJ, Ward JM, Lamirande EW, Heinze B, Krempl CD, Collins PL.

J Virol. 2009 Feb;83(4):1969-80. doi: 10.1128/JVI.02041-08. Epub 2008 Dec 3.

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