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Items: 1 to 50 of 173

1.

CRISPR/Cas9 as a tool to dissect cancer mutations.

Sayed S, Paszkowski-Rogacz M, Schmitt LT, Buchholz F.

Methods. 2019 May 10. pii: S1046-2023(19)30047-7. doi: 10.1016/j.ymeth.2019.05.007. [Epub ahead of print]

2.

Comparative RNAi Screens in Isogenic Human Stem Cells Reveal SMARCA4 as a Differential Regulator.

Güneş C, Paszkowski-Rogacz M, Rahmig S, Khattak S, Camgöz A, Wermke M, Dahl A, Bornhäuser M, Waskow C, Buchholz F.

Stem Cell Reports. 2019 May 14;12(5):1084-1098. doi: 10.1016/j.stemcr.2019.03.012. Epub 2019 Apr 25.

3.

Repeat FMISO-PET imaging weakly correlates with hypoxia-associated gene expressions for locally advanced HNSCC treated by primary radiochemotherapy.

Löck S, Linge A, Seidlitz A, Bandurska-Luque A, Nowak A, Gudziol V, Buchholz F, Aust DE, Baretton GB, Zöphel K, Steinbach J, Kotzerke J, Overgaard J, Zips D, Krause M, Baumann M, Troost EGC.

Radiother Oncol. 2019 Jun;135:43-50. doi: 10.1016/j.radonc.2019.02.020. Epub 2019 Mar 9.

PMID:
31015169
4.

Independent validation of tumour volume, cancer stem cell markers and hypoxia-associated gene expressions for HNSCC after primary radiochemotherapy.

Linge A, Schmidt S, Lohaus F, Krenn C, Bandurska-Luque A, Platzek I, von Neubeck C, Appold S, Nowak A, Gudziol V, Buchholz F, Baretton GB, Baumann M, Löck S, Krause M.

Clin Transl Radiat Oncol. 2019 Mar 18;16:40-47. doi: 10.1016/j.ctro.2019.03.002. eCollection 2019 May.

5.

Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis.

Noack F, Pataskar A, Schneider M, Buchholz F, Tiwari VK, Calegari F.

Life Sci Alliance. 2019 Feb 27;2(2). pii: e201900331. doi: 10.26508/lsa.201900331. Print 2019 Apr.

6.

A single reporter mouse line for Vika, Flp, Dre, and Cre-recombination.

Karimova M, Baker O, Camgoz A, Naumann R, Buchholz F, Anastassiadis K.

Sci Rep. 2018 Sep 27;8(1):14453. doi: 10.1038/s41598-018-32802-7.

7.

Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach.

Senserrich J, Batsivari A, Rybtsov S, Gordon-Keylock S, Souilhol C, Buchholz F, Hills D, Zhao S, Medvinsky A.

Stem Cell Reports. 2018 Sep 11;11(3):784-794. doi: 10.1016/j.stemcr.2018.08.004.

8.

Downregulation of PIK3CA via antibody-esiRNA-complexes suppresses human xenograft tumor growth.

Bäumer N, Rehkämper J, Appel N, Terheyden L, Hartmann W, Wardelmann E, Buchholz F, Müller-Tidow C, Berdel WE, Bäumer S.

PLoS One. 2018 Jul 12;13(7):e0200163. doi: 10.1371/journal.pone.0200163. eCollection 2018.

9.

Kinetic-Energy Density-Functional Theory on a Lattice.

Theophilou I, Buchholz F, Eich FG, Ruggenthaler M, Rubio A.

J Chem Theory Comput. 2018 Aug 14;14(8):4072-4087. doi: 10.1021/acs.jctc.8b00292. Epub 2018 Jul 19.

10.

STK3 is a therapeutic target for a subset of acute myeloid leukemias.

Camgoz A, Paszkowski-Rogacz M, Satpathy S, Wermke M, Hamann MV, von Bonin M, Choudhary C, Knapp S, Buchholz F.

Oncotarget. 2018 May 22;9(39):25458-25473. doi: 10.18632/oncotarget.25238. eCollection 2018 May 22.

11.

The potential of plant microbiota in reducing postharvest food loss.

Buchholz F, Kostić T, Sessitsch A, Mitter B.

Microb Biotechnol. 2018 Nov;11(6):971-975. doi: 10.1111/1751-7915.13252. Epub 2018 Mar 26.

12.

Protein Dynamics in Complex DNA Lesions.

Aleksandrov R, Dotchev A, Poser I, Krastev D, Georgiev G, Panova G, Babukov Y, Danovski G, Dyankova T, Hubatsch L, Ivanova A, Atemin A, Nedelcheva-Veleva MN, Hasse S, Sarov M, Buchholz F, Hyman AA, Grill SW, Stoynov SS.

Mol Cell. 2018 Mar 15;69(6):1046-1061.e5. doi: 10.1016/j.molcel.2018.02.016.

13.

The long noncoding RNA lncR492 inhibits neural differentiation of murine embryonic stem cells.

Winzi M, Casas Vila N, Paszkowski-Rogacz M, Ding L, Noack S, Theis M, Butter F, Buchholz F.

PLoS One. 2018 Jan 24;13(1):e0191682. doi: 10.1371/journal.pone.0191682. eCollection 2018.

14.

Transcription factor Runx1 is pro-neurogenic in adult hippocampal precursor cells.

Fukui H, Rünker A, Fabel K, Buchholz F, Kempermann G.

PLoS One. 2018 Jan 11;13(1):e0190789. doi: 10.1371/journal.pone.0190789. eCollection 2018.

15.

Development and Validation of a Gene Signature for Patients with Head and Neck Carcinomas Treated by Postoperative Radio(chemo)therapy.

Schmidt S, Linge A, Zwanenburg A, Leger S, Lohaus F, Krenn C, Appold S, Gudziol V, Nowak A, von Neubeck C, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Bunea H, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, Baretton GB, Buchholz F, Baumann M, Krause M, Löck S; DKTK-ROG.

Clin Cancer Res. 2018 Mar 15;24(6):1364-1374. doi: 10.1158/1078-0432.CCR-17-2345. Epub 2018 Jan 3.

16.

Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC.

Linge A, Schötz U, Löck S, Lohaus F, von Neubeck C, Gudziol V, Nowak A, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Bunea H, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Lauber K, Pigorsch S, Combs SE, Mönnich D, Zips D, Baretton GB, Buchholz F, Krause M, Belka C, Baumann M; DKTK-ROG.

Radiother Oncol. 2018 Apr;127(1):27-35. doi: 10.1016/j.radonc.2017.12.007. Epub 2017 Dec 30.

PMID:
29295747
17.

lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1.

Chakraborty D, Paszkowski-Rogacz M, Berger N, Ding L, Mircetic J, Fu J, Iesmantavicius V, Choudhary C, Anastassiadis K, Stewart AF, Buchholz F.

Cell Rep. 2017 Dec 12;21(11):3012-3021. doi: 10.1016/j.celrep.2017.11.045.

18.

MS Western, a Method of Multiplexed Absolute Protein Quantification is a Practical Alternative to Western Blotting.

Kumar M, Joseph SR, Augsburg M, Bogdanova A, Drechsel D, Vastenhouw NL, Buchholz F, Gentzel M, Shevchenko A.

Mol Cell Proteomics. 2018 Feb;17(2):384-396. doi: 10.1074/mcp.O117.067082. Epub 2017 Nov 30.

19.

Development of a genetic sensor that eliminates p53 deficient cells.

Mircetic J, Dietrich A, Paszkowski-Rogacz M, Krause M, Buchholz F.

Nat Commun. 2017 Nov 13;8(1):1463. doi: 10.1038/s41467-017-01688-w.

20.

Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding.

Toyoda Y, Cattin CJ, Stewart MP, Poser I, Theis M, Kurzchalia TV, Buchholz F, Hyman AA, Müller DJ.

Nat Commun. 2017 Nov 2;8(1):1266. doi: 10.1038/s41467-017-01147-6.

21.

Crystal structure of an engineered, HIV-specific recombinase for removal of integrated proviral DNA.

Meinke G, Karpinski J, Buchholz F, Bohm A.

Nucleic Acids Res. 2017 Sep 19;45(16):9726-9740. doi: 10.1093/nar/gkx603.

22.

ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator.

Jahn A, Rane G, Paszkowski-Rogacz M, Sayols S, Bluhm A, Han CT, Draškovič I, Londoño-Vallejo JA, Kumar AP, Buchholz F, Butter F, Kappei D.

EMBO Rep. 2017 Jun;18(6):929-946. doi: 10.15252/embr.201744095. Epub 2017 May 12.

23.

Phylointeractomics reconstructs functional evolution of protein binding.

Kappei D, Scheibe M, Paszkowski-Rogacz M, Bluhm A, Gossmann TI, Dietz S, Dejung M, Herlyn H, Buchholz F, Mann M, Butter F.

Nat Commun. 2017 Feb 8;8:14334. doi: 10.1038/ncomms14334.

24.

The Apical Domain Is Required and Sufficient for the First Lineage Segregation in the Mouse Embryo.

Korotkevich E, Niwayama R, Courtois A, Friese S, Berger N, Buchholz F, Hiiragi T.

Dev Cell. 2017 Feb 6;40(3):235-247.e7. doi: 10.1016/j.devcel.2017.01.006.

25.

Independent validation of the prognostic value of cancer stem cell marker expression and hypoxia-induced gene expression for patients with locally advanced HNSCC after postoperative radiotherapy.

Linge A, Löck S, Krenn C, Appold S, Lohaus F, Nowak A, Gudziol V, Baretton GB, Buchholz F, Baumann M, Krause M.

Clin Transl Radiat Oncol. 2016 Dec 22;1:19-26. doi: 10.1016/j.ctro.2016.10.002. eCollection 2016 Dec.

26.

HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).

Linge A, Lohaus F, Löck S, Nowak A, Gudziol V, Valentini C, von Neubeck C, Jütz M, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, Buchholz F, Aust DE, Baretton GB, Thames HD, Dubrovska A, Alsner J, Overgaard J, Krause M, Baumann M; DKTK-ROG.

Radiother Oncol. 2016 Dec;121(3):364-373. doi: 10.1016/j.radonc.2016.11.008. Epub 2016 Nov 29.

PMID:
27913065
27.

Responses of the arcto-boreal krill species Thysanoessa inermis to variations in water temperature: coupling Hsp70 isoform expressions with metabolism.

Huenerlage K, Cascella K, Corre E, Toomey L, Lee CY, Buchholz F, Toullec JY.

Cell Stress Chaperones. 2016 Nov;21(6):969-981. Epub 2016 Aug 25.

28.

Antiviral therapy of persistent viral infection using genome editing.

Buchholz F, Hauber J.

Curr Opin Virol. 2016 Oct;20:85-91. doi: 10.1016/j.coviro.2016.09.012. Epub 2016 Oct 7. Review.

PMID:
27723558
29.

Inactivation of Cancer Mutations Utilizing CRISPR/Cas9.

Gebler C, Lohoff T, Paszkowski-Rogacz M, Mircetic J, Chakraborty D, Camgoz A, Hamann MV, Theis M, Thiede C, Buchholz F.

J Natl Cancer Inst. 2016 Aug 30;109(1). doi: 10.1093/jnci/djw183. Print 2017 Jan.

30.

Discovery of Nigri/nox and Panto/pox site-specific recombinase systems facilitates advanced genome engineering.

Karimova M, Splith V, Karpinski J, Pisabarro MT, Buchholz F.

Sci Rep. 2016 Jul 22;6:30130. doi: 10.1038/srep30130.

31.

Cre Recombinase and Other Tyrosine Recombinases.

Meinke G, Bohm A, Hauber J, Pisabarro MT, Buchholz F.

Chem Rev. 2016 Oct 26;116(20):12785-12820. doi: 10.1021/acs.chemrev.6b00077. Epub 2016 May 10. Review.

PMID:
27163859
32.

Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells.

Ding L, Paszkowski-Rogacz M, Winzi M, Chakraborty D, Theis M, Singh S, Ciotta G, Poser I, Roguev A, Chu WK, Choudhary C, Mann M, Stewart AF, Krogan N, Buchholz F.

Cell Syst. 2015 Aug 26;1(2):141-51. doi: 10.1016/j.cels.2015.08.002. Epub 2015 Aug 26.

33.

Dissecting mechanisms of mouse embryonic stem cells heterogeneity through a model-based analysis of transcription factor dynamics.

Herberg M, Glauche I, Zerjatke T, Winzi M, Buchholz F, Roeder I.

J R Soc Interface. 2016 Apr;13(117). pii: 20160167. doi: 10.1098/rsif.2016.0167.

34.

Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity.

Karpinski J, Hauber I, Chemnitz J, Schäfer C, Paszkowski-Rogacz M, Chakraborty D, Beschorner N, Hofmann-Sieber H, Lange UC, Grundhoff A, Hackmann K, Schrock E, Abi-Ghanem J, Pisabarro MT, Surendranath V, Schambach A, Lindner C, van Lunzen J, Hauber J, Buchholz F.

Nat Biotechnol. 2016 Apr;34(4):401-9. doi: 10.1038/nbt.3467. Epub 2016 Feb 22.

PMID:
26900663
35.

Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG.

Linge A, Löck S, Gudziol V, Nowak A, Lohaus F, von Neubeck C, Jütz M, Abdollahi A, Debus J, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Avlar M, Grosu AL, Bayer C, Belka C, Pigorsch S, Combs SE, Welz S, Zips D, Buchholz F, Aust DE, Baretton GB, Thames HD, Dubrovska A, Alsner J, Overgaard J, Baumann M, Krause M; DKTK-ROG.

Clin Cancer Res. 2016 Jun 1;22(11):2639-49. doi: 10.1158/1078-0432.CCR-15-1990. Epub 2016 Jan 11.

36.

Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown.

Bäumer N, Appel N, Terheyden L, Buchholz F, Rossig C, Müller-Tidow C, Berdel WE, Bäumer S.

Nat Protoc. 2016 Jan;11(1):22-36. doi: 10.1038/nprot.2015.137. Epub 2015 Dec 3.

PMID:
26633129
37.

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M.

Cell. 2015 Oct 22;163(3):712-23. doi: 10.1016/j.cell.2015.09.053. Epub 2015 Oct 22.

38.

Erratum to: Genome sequencing of the Trichoderma reesei QM9136 mutant identifies a truncation of the transcriptional regulator XYR1 as the cause for its cellulase-negative phenotype.

Lichius A, Bidard F, Buchholz F, Le Crom S, Martin J, Schackwitz W, Austerlitz T, Grigoriev IV, Baker SE, Margeot A, Seiboth B, Kubicek CP.

BMC Genomics. 2015 Sep 22;16(1):725. doi: 10.1186/s12864-015-1917-2. No abstract available.

39.

CRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X.

Karimova M, Beschorner N, Dammermann W, Chemnitz J, Indenbirken D, Bockmann JH, Grundhoff A, Lüth S, Buchholz F, Schulze zur Wiesch J, Hauber J.

Sci Rep. 2015 Sep 3;5:13734. doi: 10.1038/srep13734.

40.

RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug.

Wermke M, Camgoz A, Paszkowski-Rogacz M, Thieme S, von Bonin M, Dahl A, Platzbecker U, Theis M, Ehninger G, Brenner S, Bornhäuser M, Buchholz F.

Blood. 2015 Jun 11;125(24):3760-8. doi: 10.1182/blood-2014-07-590646. Epub 2015 Apr 30.

41.

Targeting Human Long Noncoding Transcripts by Endoribonuclease-Prepared siRNAs.

Theis M, Paszkowski-Rogacz M, Weisswange I, Chakraborty D, Buchholz F.

J Biomol Screen. 2015 Sep;20(8):1018-26. doi: 10.1177/1087057115583448. Epub 2015 Apr 24.

PMID:
25911635
42.

Genome sequencing of the Trichoderma reesei QM9136 mutant identifies a truncation of the transcriptional regulator XYR1 as the cause for its cellulase-negative phenotype.

Lichius A, Bidard F, Buchholz F, Le Crom S, Martin J, Schackwitz W, Austerlitz T, Grigoriev IV, Baker SE, Margeot A, Seiboth B, Kubicek CP.

BMC Genomics. 2015 Apr 20;16:326. doi: 10.1186/s12864-015-1526-0. Erratum in: BMC Genomics. 2015;16(1):725.

43.

Antibody-mediated delivery of anti-KRAS-siRNA in vivo overcomes therapy resistance in colon cancer.

Bäumer S, Bäumer N, Appel N, Terheyden L, Fremerey J, Schelhaas S, Wardelmann E, Buchholz F, Berdel WE, Müller-Tidow C.

Clin Cancer Res. 2015 Mar 15;21(6):1383-94. doi: 10.1158/1078-0432.CCR-13-2017. Epub 2015 Jan 14.

44.

The coilin interactome identifies hundreds of small noncoding RNAs that traffic through Cajal bodies.

Machyna M, Kehr S, Straube K, Kappei D, Buchholz F, Butter F, Ule J, Hertel J, Stadler PF, Neugebauer KM.

Mol Cell. 2014 Nov 6;56(3):389-99. doi: 10.1016/j.molcel.2014.10.004. Epub 2014 Nov 6.

45.

Universal Tre (uTre) recombinase specifically targets the majority of HIV-1 isolates.

Karpinski J, Chemnitz J, Hauber I, Abi-Ghanem J, Paszkowski-Rogacz M, Surendranath V, Chakrabort D, Hackmann K, Schröck E, Pisabarro MT, Hauber J, Buchholz F.

J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19706. doi: 10.7448/IAS.17.4.19706. eCollection 2014.

46.

Stage-specific binding profiles of cohesin in resting and activated B lymphocytes suggest a role for cohesin in immunoglobulin class switching and maturation.

Günal-Sadık G, Paszkowski-Rogacz M, Singaravelu K, Beyer A, Buchholz F, Jessberger R.

PLoS One. 2014 Nov 6;9(11):e111748. doi: 10.1371/journal.pone.0111748. eCollection 2014.

47.

Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this.

Liakhovitskaia A, Rybtsov S, Smith T, Batsivari A, Rybtsova N, Rode C, de Bruijn M, Buchholz F, Gordon-Keylock S, Zhao S, Medvinsky A.

Development. 2014 Sep;141(17):3319-23. doi: 10.1242/dev.110841.

48.

Another brick in the wall: RNAi Screens identify new barriers in iPSC reprogramming.

Winzi M, Paszkowski-Rogacz M, Buchholz F.

Cell Stem Cell. 2014 Aug 7;15(2):116-8. doi: 10.1016/j.stem.2014.07.008.

49.

Chip calorimetry for evaluation of biofilm treatment with biocides, antibiotics, and biological agents.

Morais FM, Buchholz F, Maskow T.

Methods Mol Biol. 2014;1147:267-75. doi: 10.1007/978-1-4939-0467-9_19.

PMID:
24664840
50.

Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1.

Raychaudhuri S, Loew C, Körner R, Pinkert S, Theis M, Hayer-Hartl M, Buchholz F, Hartl FU.

Cell. 2014 Feb 27;156(5):975-85. doi: 10.1016/j.cell.2014.01.055.

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