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Items: 1 to 50 of 53

1.

Comparative finite element modelling of aneurysm formation and physiologic inflation in the descending aorta.

de Gelidi S, Bucchi A.

Comput Methods Biomech Biomed Engin. 2019 Nov;22(15):1197-1208. doi: 10.1080/10255842.2019.1650036. Epub 2019 Aug 21.

PMID:
31432696
2.

Insights into the micromechanics of stress-relaxation and creep behaviours in the aortic valve.

Anssari-Benam A, Screen HRC, Bucchi A.

J Mech Behav Biomed Mater. 2019 May;93:230-245. doi: 10.1016/j.jmbbm.2019.02.011. Epub 2019 Feb 12.

PMID:
30844614
3.

Rate-dependency of the mechanical behaviour of semilunar heart valves under biaxial deformation.

Anssari-Benam A, Tseng YT, Holzapfel GA, Bucchi A.

Acta Biomater. 2019 Apr 1;88:120-130. doi: 10.1016/j.actbio.2019.02.008. Epub 2019 Feb 10.

PMID:
30753940
4.

A Loss-of-Function HCN4 Mutation Associated With Familial Benign Myoclonic Epilepsy in Infancy Causes Increased Neuronal Excitability.

Campostrini G, DiFrancesco JC, Castellotti B, Milanesi R, Gnecchi-Ruscone T, Bonzanni M, Bucchi A, Baruscotti M, Ferrarese C, Franceschetti S, Canafoglia L, Ragona F, Freri E, Labate A, Gambardella A, Costa C, Gellera C, Granata T, Barbuti A, DiFrancesco D.

Front Mol Neurosci. 2018 Aug 6;11:269. doi: 10.3389/fnmol.2018.00269. eCollection 2018.

5.

A novel de novo HCN1 loss-of-function mutation in genetic generalized epilepsy causing increased neuronal excitability.

Bonzanni M, DiFrancesco JC, Milanesi R, Campostrini G, Castellotti B, Bucchi A, Baruscotti M, Ferrarese C, Franceschetti S, Canafoglia L, Ragona F, Freri E, Labate A, Gambardella A, Costa C, Rivolta I, Gellera C, Granata T, Barbuti A, DiFrancesco D.

Neurobiol Dis. 2018 Oct;118:55-63. doi: 10.1016/j.nbd.2018.06.012. Epub 2018 Jun 21.

6.

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

Saponaro A, Cantini F, Porro A, Bucchi A, DiFrancesco D, Maione V, Donadoni C, Introini B, Mesirca P, Mangoni ME, Thiel G, Banci L, Santoro B, Moroni A.

Elife. 2018 Jun 20;7. pii: e35753. doi: 10.7554/eLife.35753.

7.

A transverse isotropic constitutive model for the aortic valve tissue incorporating rate-dependency and fibre dispersion: Application to biaxial deformation.

Anssari-Benam A, Tseng YT, Bucchi A.

J Mech Behav Biomed Mater. 2018 Sep;85:80-93. doi: 10.1016/j.jmbbm.2018.05.035. Epub 2018 May 26.

PMID:
29859418
8.

Mammalian γ2 AMPK regulates intrinsic heart rate.

Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG, Tarasova YS, Baban D, Sahgal N, Lockstone H, Puliyadi R, de Bono J, Siggs OM, Gomes J, Muskett H, Maguire ML, Beglov Y, Kelly M, Dos Santos PPN, Bright NJ, Woods A, Gehmlich K, Isackson H, Douglas G, Ferguson DJP, Schneider JE, Tinker A, Wolkenhauer O, Channon KM, Cornall RJ, Sternick EB, Paterson DJ, Redwood CS, Carling D, Proenza C, David R, Baruscotti M, DiFrancesco D, Lakatta EG, Watkins H, Ashrafian H.

Nat Commun. 2017 Nov 2;8(1):1258. doi: 10.1038/s41467-017-01342-5.

9.

Modeling the Deformation of the Elastin Network in the Aortic Valve.

Anssari-Benam A, Bucchi A.

J Biomech Eng. 2018 Jan 1;140(1). doi: 10.1115/1.4037916.

PMID:
28916836
10.

The expression of the rare caveolin-3 variant T78M alters cardiac ion channels function and membrane excitability.

Campostrini G, Bonzanni M, Lissoni A, Bazzini C, Milanesi R, Vezzoli E, Francolini M, Baruscotti M, Bucchi A, Rivolta I, Fantini M, Severi S, Cappato R, Crotti L, J Schwartz P, DiFrancesco D, Barbuti A.

Cardiovasc Res. 2017 Aug 1;113(10):1256-1265. doi: 10.1093/cvr/cvx122.

11.

The effect of thickness measurement on numerical arterial models.

de Gelidi S, Tozzi G, Bucchi A.

Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:1205-1215. doi: 10.1016/j.msec.2017.02.123. Epub 2017 Feb 28.

PMID:
28482487
12.

A transverse isotropic viscoelastic constitutive model for aortic valve tissue.

Anssari-Benam A, Bucchi A, Screen HR, Evans SL.

R Soc Open Sci. 2017 Jan 11;4(1):160585. doi: 10.1098/rsos.160585. eCollection 2017 Jan.

13.

A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia.

Baruscotti M, Bucchi A, Milanesi R, Paina M, Barbuti A, Gnecchi-Ruscone T, Bianco E, Vitali-Serdoz L, Cappato R, DiFrancesco D.

Eur Heart J. 2017 Jan 21;38(4):280-288. doi: 10.1093/eurheartj/ehv582. No abstract available.

PMID:
28182231
14.

INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model.

Benedetti L, Ghilardi A, Rottoli E, De Maglie M, Prosperi L, Perego C, Baruscotti M, Bucchi A, Del Giacco L, Francolini M.

Sci Rep. 2016 Apr 15;6:24515. doi: 10.1038/srep24515.

15.

Current understanding of the pathophysiological mechanisms responsible for inappropriate sinus tachycardia: role of the If "funny" current.

Baruscotti M, Bianco E, Bucchi A, DiFrancesco D.

J Interv Card Electrophysiol. 2016 Jun;46(1):19-28. doi: 10.1007/s10840-015-0097-y. Epub 2016 Jan 18. Review.

PMID:
26781742
16.

Cell-specific Dynamic Clamp analysis of the role of funny If current in cardiac pacemaking.

Ravagli E, Bucchi A, Bartolucci C, Paina M, Baruscotti M, DiFrancesco D, Severi S.

Prog Biophys Mol Biol. 2016 Jan;120(1-3):50-66. doi: 10.1016/j.pbiomolbio.2015.12.004. Epub 2015 Dec 21.

PMID:
26718599
17.

Evaluation of bioprosthetic heart valve failure using a matrix-fibril shear stress transfer approach.

Anssari-Benam A, Barber AH, Bucchi A.

J Mater Sci Mater Med. 2016 Feb;27(2):42. doi: 10.1007/s10856-015-5657-2. Epub 2015 Dec 29.

PMID:
26715134
18.

Unified viscoelasticity: Applying discrete element models to soft tissues with two characteristic times.

Anssari-Benam A, Bucchi A, Bader DL.

J Biomech. 2015 Sep 18;48(12):3128-34. doi: 10.1016/j.jbiomech.2015.07.015. Epub 2015 Jul 21.

PMID:
26232814
19.

The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction.

Milanesi R, Bucchi A, Baruscotti M.

J Interv Card Electrophysiol. 2015 Aug;43(2):121-34. doi: 10.1007/s10840-015-9998-z. Epub 2015 Apr 12. Review.

20.

Exercise training reduces resting heart rate via downregulation of the funny channel HCN4.

D'Souza A, Bucchi A, Johnsen AB, Logantha SJ, Monfredi O, Yanni J, Prehar S, Hart G, Cartwright E, Wisloff U, Dobryznski H, DiFrancesco D, Morris GM, Boyett MR.

Nat Commun. 2014 May 13;5:3775. doi: 10.1038/ncomms4775.

21.

Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.

Lolicato M, Bucchi A, Arrigoni C, Zucca S, Nardini M, Schroeder I, Simmons K, Aquila M, DiFrancesco D, Bolognesi M, Schwede F, Kashin D, Fishwick CW, Johnson AP, Thiel G, Moroni A.

Nat Chem Biol. 2014 Jun;10(6):457-62. doi: 10.1038/nchembio.1521. Epub 2014 Apr 28. Erratum in: Nat Chem Biol. 2014 Aug;10(8):692.

22.

Embryonic stem cell-derived CD166+ precursors develop into fully functional sinoatrial-like cells.

Scavone A, Capilupo D, Mazzocchi N, Crespi A, Zoia S, Campostrini G, Bucchi A, Milanesi R, Baruscotti M, Benedetti S, Antonini S, Messina G, DiFrancesco D, Barbuti A.

Circ Res. 2013 Aug 2;113(4):389-98. doi: 10.1161/CIRCRESAHA.113.301283. Epub 2013 Jun 10.

23.

Identification of the molecular site of ivabradine binding to HCN4 channels.

Bucchi A, Baruscotti M, Nardini M, Barbuti A, Micheloni S, Bolognesi M, DiFrancesco D.

PLoS One. 2013;8(1):e53132. doi: 10.1371/journal.pone.0053132. Epub 2013 Jan 4.

24.

Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models.

Bucchi A, Barbuti A, Difrancesco D, Baruscotti M.

Front Physiol. 2012 Jul 2;3:240. doi: 10.3389/fphys.2012.00240. eCollection 2012.

25.

Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.

DiFrancesco JC, Barbuti A, Milanesi R, Coco S, Bucchi A, Bottelli G, Ferrarese C, Franceschetti S, Terragni B, Baruscotti M, DiFrancesco D.

J Neurosci. 2011 Nov 30;31(48):17327-37. doi: 10.1523/JNEUROSCI.3727-11.2011.

26.

Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4.

Baruscotti M, Bucchi A, Viscomi C, Mandelli G, Consalez G, Gnecchi-Rusconi T, Montano N, Casali KR, Micheloni S, Barbuti A, DiFrancesco D.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1705-10. doi: 10.1073/pnas.1010122108. Epub 2011 Jan 10.

27.

Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific.

Wu J, Meng Z, Jiang M, Zhang E, Trippler M, Broering R, Bucchi A, Krux F, Dittmer U, Yang D, Roggendorf M, Gerken G, Lu M, Schlaak JF.

Immunology. 2010 Mar;129(3):363-74. doi: 10.1111/j.1365-2567.2009.03179.x. Epub 2009 Nov 16.

28.

The cardiac pacemaker current.

Baruscotti M, Barbuti A, Bucchi A.

J Mol Cell Cardiol. 2010 Jan;48(1):55-64. doi: 10.1016/j.yjmcc.2009.06.019. Epub 2009 Jul 8. Review.

PMID:
19591835
29.

In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality.

Zhao X, Bucchi A, Oren RV, Kryukova Y, Dun W, Clancy CE, Robinson RB.

J Physiol. 2009 Apr 1;587(Pt 7):1513-25. doi: 10.1113/jphysiol.2008.163444. Epub 2009 Jan 26.

30.

Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells.

Wu J, Meng Z, Jiang M, Pei R, Trippler M, Broering R, Bucchi A, Sowa JP, Dittmer U, Yang D, Roggendorf M, Gerken G, Lu M, Schlaak JF.

Hepatology. 2009 Apr;49(4):1132-40. doi: 10.1002/hep.22751.

PMID:
19140219
31.

Extent of liver resection modulates the activation of transcription factors and the production of cytokines involved in liver regeneration.

Sowa JP, Best J, Benko T, Bockhorn M, Gu Y, Niehues EM, Bucchi A, Benedetto-Castro EM, Gerken G, Rauen U, Schlaak JF.

World J Gastroenterol. 2008 Dec 14;14(46):7093-100.

32.

Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium.

Protas L, Dun W, Jia Z, Lu J, Bucchi A, Kumari S, Chen M, Cohen IS, Rosen MR, Entcheva E, Robinson RB.

Cardiovasc Res. 2009 Feb 15;81(3):528-35. doi: 10.1093/cvr/cvn290. Epub 2008 Oct 31.

33.

HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with I(f) blockade.

Plotnikov AN, Bucchi A, Shlapakova I, Danilo P Jr, Brink PR, Robinson RB, Cohen IS, Rosen MR.

Heart Rhythm. 2008 Feb;5(2):282-8. doi: 10.1016/j.hrthm.2007.09.028. Epub 2007 Oct 3.

34.

Modulation of cyclic nucleotide-regulated HCN channels by PIP(2) and receptors coupled to phospholipase C.

Pian P, Bucchi A, Decostanzo A, Robinson RB, Siegelbaum SA.

Pflugers Arch. 2007 Oct;455(1):125-45. Epub 2007 Jun 29.

PMID:
17605039
35.

Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker current.

Bucchi A, Baruscotti M, Robinson RB, DiFrancesco D.

J Mol Cell Cardiol. 2007 Jul;43(1):39-48. Epub 2007 May 6.

PMID:
17543331
36.

Heart rate reduction via selective 'funny' channel blockers.

Bucchi A, Barbuti A, Baruscotti M, DiFrancesco D.

Curr Opin Pharmacol. 2007 Apr;7(2):208-13. Epub 2007 Jan 30. Review.

PMID:
17267284
37.

Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2.

Pian P, Bucchi A, Robinson RB, Siegelbaum SA.

J Gen Physiol. 2006 Nov;128(5):593-604.

38.

Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker.

Bucchi A, Plotnikov AN, Shlapakova I, Danilo P Jr, Kryukova Y, Qu J, Lu Z, Liu H, Pan Z, Potapova I, KenKnight B, Girouard S, Cohen IS, Brink PR, Robinson RB, Rosen MR.

Circulation. 2006 Sep 5;114(10):992-9. Epub 2006 Aug 21.

PMID:
16923750
39.

Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.

Bucchi A, Tognati A, Milanesi R, Baruscotti M, DiFrancesco D.

J Physiol. 2006 Apr 15;572(Pt 2):335-46. Epub 2006 Feb 16.

40.

Physiology and pharmacology of the cardiac pacemaker ("funny") current.

Baruscotti M, Bucchi A, Difrancesco D.

Pharmacol Ther. 2005 Jul;107(1):59-79. Review.

PMID:
15963351
41.

I(f)-dependent modulation of pacemaker rate mediated by cAMP in the presence of ryanodine in rabbit sino-atrial node cells.

Bucchi A, Baruscotti M, Robinson RB, DiFrancesco D.

J Mol Cell Cardiol. 2003 Aug;35(8):905-13.

PMID:
12878477
42.

Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.

Qu J, Altomare C, Bucchi A, DiFrancesco D, Robinson RB.

Pflugers Arch. 2002 Aug;444(5):597-601. Epub 2002 Jun 12.

PMID:
12194012
43.

Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine.

Bucchi A, Baruscotti M, DiFrancesco D.

J Gen Physiol. 2002 Jul;120(1):1-13.

44.

C terminus-mediated control of voltage and cAMP gating of hyperpolarization-activated cyclic nucleotide-gated channels.

Viscomi C, Altomare C, Bucchi A, Camatini E, Baruscotti M, Moroni A, DiFrancesco D.

J Biol Chem. 2001 Aug 10;276(32):29930-4. Epub 2001 Jun 7.

45.

Integrated allosteric model of voltage gating of HCN channels.

Altomare C, Bucchi A, Camatini E, Baruscotti M, Viscomi C, Moroni A, DiFrancesco D.

J Gen Physiol. 2001 Jun;117(6):519-32.

46.

Crude oil spill in sea water: an assessment of the risk for bathers correlated to benzo(a)pyrene exposure.

Attias L, Bucchi AR, Maranghi F, Holt S, Marcello I, Zapponi GA.

Cent Eur J Public Health. 1995 Aug;3(3):142-5.

PMID:
8535372
47.
48.

The environmental behavior of chemicals in soil: atrazine as an example.

Lupi C, Bucchi AR, Piccioni A, Zapponi GA.

Ecotoxicol Environ Saf. 1988 Oct;16(2):133-42.

PMID:
3234287
49.

Dose-response relationships in rodents of promoter carcinogens: a tentative interpretation of some downward trends.

Bucchi AR, Gabriele M, Lupi C, Zapponi GA.

Biomed Environ Sci. 1988 Aug;1(2):184-93.

PMID:
3268115
50.

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