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Items: 1 to 50 of 52

1.

Another Score for the Pore: S. aureus Leukocidins Take a Shot on the Endothelium.

Alfano DN, Bubeck Wardenburg J.

Cell Host Microbe. 2019 Mar 13;25(3):351-353. doi: 10.1016/j.chom.2019.02.011.

PMID:
30870619
2.

Staphylococcus aureus alpha toxin activates Notch in vascular cells.

Hernandez SL, Nelson M, Sampedro GR, Bagrodia N, Defnet AM, Lec B, Emolo J, Kirschner R, Wu L, Biermann H, Shen S, Bubeck Wardenburg J, Kandel JJ.

Angiogenesis. 2019 Feb;22(1):197-209. doi: 10.1007/s10456-018-9650-5. Epub 2018 Oct 15.

PMID:
30324336
3.

Comprehensive modeling reveals proximity, seasonality, and hygiene practices as key determinants of MRSA colonization in exposed households.

Mork RL, Hogan PG, Muenks CE, Boyle MG, Thompson RM, Morelli JJ, Sullivan ML, Gehlert SJ, Ross DG, Yn A, Bubeck Wardenburg J, Rzhetsky A, Burnham CD, Fritz SA.

Pediatr Res. 2018 Nov;84(5):668-676. doi: 10.1038/s41390-018-0113-x. Epub 2018 Jul 19.

4.

α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis.

Surewaard BGJ, Thanabalasuriar A, Zeng Z, Tkaczyk C, Cohen TS, Bardoel BW, Jorch SK, Deppermann C, Bubeck Wardenburg J, Davis RP, Jenne CN, Stover KC, Sellman BR, Kubes P.

Cell Host Microbe. 2018 Aug 8;24(2):271-284.e3. doi: 10.1016/j.chom.2018.06.017. Epub 2018 Jul 19.

5.

Vancomycin Monotherapy May Be Insufficient to Treat Methicillin-resistant Staphylococcus aureus Coinfection in Children With Influenza-related Critical Illness.

Randolph AG, Xu R, Novak T, Newhams MM, Bubeck Wardenburg J, Weiss SL, Sanders RC, Thomas NJ, Hall MW, Tarquinio KM, Cvijanovich N, Gedeit RG, Truemper EJ, Markovitz B, Hartman ME, Ackerman KG, Giuliano JS Jr, Shein SL, Moffitt KL; Pediatric Intensive Care Influenza Investigators from the Pediatric Acute Lung Injury and Sepsis Investigator’s Network .

Clin Infect Dis. 2019 Jan 18;68(3):365-372. doi: 10.1093/cid/ciy495.

6.

A common approach to toxin specificity.

Lee B, Bubeck Wardenburg J.

Nat Microbiol. 2018 Jun;3(6):644-645. doi: 10.1038/s41564-018-0173-z. No abstract available.

PMID:
29795538
7.

A Two-Component System Regulates Bacteroides fragilis Toxin to Maintain Intestinal Homeostasis and Prevent Lethal Disease.

Hecht AL, Casterline BW, Choi VM, Bubeck Wardenburg J.

Cell Host Microbe. 2017 Oct 11;22(4):443-448.e5. doi: 10.1016/j.chom.2017.08.007. Epub 2017 Sep 21.

8.

The Bacteroides fragilis pathogenicity island links virulence and strain competition.

Casterline BW, Hecht AL, Choi VM, Bubeck Wardenburg J.

Gut Microbes. 2017 Jul 4;8(4):374-383. doi: 10.1080/19490976.2017.1290758. Epub 2017 Feb 23.

9.

Staphylococcus aureus pore-forming toxins: The interface of pathogen and host complexity.

Seilie ES, Bubeck Wardenburg J.

Semin Cell Dev Biol. 2017 Dec;72:101-116. doi: 10.1016/j.semcdb.2017.04.003. Epub 2017 Apr 23. Review.

10.

Pediatric Multiple Organ Dysfunction Syndrome: Promising Therapies.

Doctor A, Zimmerman J, Agus M, Rajasekaran S, Bubeck Wardenburg J, Fortenberry J, Zajicek A, Mairson E, Typpo K.

Pediatr Crit Care Med. 2017 Mar;18(3_suppl Suppl 1):S67-S82. doi: 10.1097/PCC.0000000000001053. Review.

11.

Staphylococcus aureus in the Intensive Care Unit: Are These Golden Grapes Ripe for a New Approach?

Sampedro GR, Bubeck Wardenburg J.

J Infect Dis. 2017 Feb 15;215(suppl_1):S64-S70. doi: 10.1093/infdis/jiw581. Review.

12.

Staphylococcus aureus α-Toxin Response Distinguishes Respiratory Virus-Methicillin-Resistant S. aureus Coinfection in Children.

Yu KO, Randolph AG, Agan AA, Yip WK, Truemper EJ, Weiss SL, Ackerman KG, Schwarz AJ, Giuliano JS Jr, Hall MW, Bubeck Wardenburg J; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) PICFlu Study Group; PALISI PICFlu Study Group.

J Infect Dis. 2016 Dec 1;214(11):1638-1646. Epub 2016 Sep 20.

13.

Strain competition restricts colonization of an enteric pathogen and prevents colitis.

Hecht AL, Casterline BW, Earley ZM, Goo YA, Goodlett DR, Bubeck Wardenburg J.

EMBO Rep. 2016 Sep;17(9):1281-91. doi: 10.15252/embr.201642282. Epub 2016 Jul 18.

14.

Activation Mechanism of the Bacteroides fragilis Cysteine Peptidase, Fragipain.

Herrou J, Choi VM, Bubeck Wardenburg J, Crosson S.

Biochemistry. 2016 Jul 26;55(29):4077-84. doi: 10.1021/acs.biochem.6b00546. Epub 2016 Jul 12.

15.

Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice.

Choi VM, Herrou J, Hecht AL, Teoh WP, Turner JR, Crosson S, Bubeck Wardenburg J.

Nat Med. 2016 May;22(5):563-7. doi: 10.1038/nm.4077. Epub 2016 Apr 18.

16.

Auto-Assembling Detoxified Staphylococcus aureus Alpha-Hemolysin Mimicking the Wild-Type Cytolytic Toxin.

Fiaschi L, Di Palo B, Scarselli M, Pozzi C, Tomaszewski K, Galletti B, Nardi-Dei V, Arcidiacono L, Mishra RP, Mori E, Pallaoro M, Falugi F, Torre A, Fontana MR, Soriani M, Bubeck Wardenburg J, Grandi G, Rappuoli R, Ferlenghi I, Bagnoli F.

Clin Vaccine Immunol. 2016 Jun 6;23(6):442-50. doi: 10.1128/CVI.00091-16. Print 2016 Jun.

17.

Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus.

Uchiyama S, Döhrmann S, Timmer AM, Dixit N, Ghochani M, Bhandari T, Timmer JC, Sprague K, Bubeck-Wardenburg J, Simon SI, Nizet V.

Front Immunol. 2015 Nov 16;6:581. doi: 10.3389/fimmu.2015.00581. eCollection 2015.

18.

Staphylococcus aureus and the skin: a longstanding and complex interaction.

Becker RE, Bubeck Wardenburg J.

Skinmed. 2015 Mar-Apr;13(2):111-9; quiz 120. Review.

PMID:
26137737
19.

Synergistic Action of Staphylococcus aureus α-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis.

Powers ME, Becker RE, Sailer A, Turner JR, Bubeck Wardenburg J.

Cell Host Microbe. 2015 Jun 10;17(6):775-87. doi: 10.1016/j.chom.2015.05.011.

20.

Host autophagy combating S. aureus: α-toxin will be tolerated.

Powers ME, Bubeck Wardenburg J.

Cell Host Microbe. 2015 Apr 8;17(4):419-20. doi: 10.1016/j.chom.2015.03.010.

21.

Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus.

Bagnoli F, Fontana MR, Soldaini E, Mishra RP, Fiaschi L, Cartocci E, Nardi-Dei V, Ruggiero P, Nosari S, De Falco MG, Lofano G, Marchi S, Galletti B, Mariotti P, Bacconi M, Torre A, Maccari S, Scarselli M, Rinaudo CD, Inoshima N, Savino S, Mori E, Rossi-Paccani S, Baudner B, Pallaoro M, Swennen E, Petracca R, Brettoni C, Liberatori S, Norais N, Monaci E, Bubeck Wardenburg J, Schneewind O, O'Hagan DT, Valiante NM, Bensi G, Bertholet S, De Gregorio E, Rappuoli R, Grandi G.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3680-5. doi: 10.1073/pnas.1424924112. Epub 2015 Mar 9.

22.

The psmα locus regulates production of Staphylococcus aureus alpha-toxin during infection.

Berube BJ, Sampedro GR, Otto M, Bubeck Wardenburg J.

Infect Immun. 2014 Aug;82(8):3350-8. doi: 10.1128/IAI.00089-14. Epub 2014 May 27.

23.

Tissue-specific patterning of host innate immune responses by Staphylococcus aureus α-toxin.

Becker RE, Berube BJ, Sampedro GR, DeDent AC, Bubeck Wardenburg J.

J Innate Immun. 2014;6(5):619-31. doi: 10.1159/000360006. Epub 2014 May 10.

24.

Targeting Staphylococcus aureus α-toxin as a novel approach to reduce severity of recurrent skin and soft-tissue infections.

Sampedro GR, DeDent AC, Becker RE, Berube BJ, Gebhardt MJ, Cao H, Bubeck Wardenburg J.

J Infect Dis. 2014 Oct 1;210(7):1012-8. doi: 10.1093/infdis/jiu223. Epub 2014 Apr 16.

25.

Igniting the fire: Staphylococcus aureus virulence factors in the pathogenesis of sepsis.

Powers ME, Bubeck Wardenburg J.

PLoS Pathog. 2014 Feb 13;10(2):e1003871. doi: 10.1371/journal.ppat.1003871. eCollection 2014 Feb. Review. No abstract available.

26.

Bacteria activate sensory neurons that modulate pain and inflammation.

Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ.

Nature. 2013 Sep 5;501(7465):52-7. doi: 10.1038/nature12479. Epub 2013 Aug 21.

27.

Staphylococcus aureus α-toxin: nearly a century of intrigue.

Berube BJ, Bubeck Wardenburg J.

Toxins (Basel). 2013 Jun;5(6):1140-66. Review.

28.

A serologic correlate of protective immunity against community-onset Staphylococcus aureus infection.

Fritz SA, Tiemann KM, Hogan PG, Epplin EK, Rodriguez M, Al-Zubeidi DN, Bubeck Wardenburg J, Hunstad DA.

Clin Infect Dis. 2013 Jun;56(11):1554-61. doi: 10.1093/cid/cit123. Epub 2013 Feb 27.

29.

Abscess formation and alpha-hemolysin induced toxicity in a mouse model of Staphylococcus aureus peritoneal infection.

Rauch S, DeDent AC, Kim HK, Bubeck Wardenburg J, Missiakas DM, Schneewind O.

Infect Immun. 2012 Oct;80(10):3721-32. doi: 10.1128/IAI.00442-12. Epub 2012 Jul 16.

30.

Host response signature to Staphylococcus aureus alpha-hemolysin implicates pulmonary Th17 response.

Frank KM, Zhou T, Moreno-Vinasco L, Hollett B, Garcia JG, Bubeck Wardenburg J.

Infect Immun. 2012 Sep;80(9):3161-9. doi: 10.1128/IAI.00191-12. Epub 2012 Jun 25.

31.

ADAM10 mediates vascular injury induced by Staphylococcus aureus α-hemolysin.

Powers ME, Kim HK, Wang Y, Bubeck Wardenburg J.

J Infect Dis. 2012 Aug 1;206(3):352-6. doi: 10.1093/infdis/jis192. Epub 2012 Apr 2.

32.

Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection.

Inoshima N, Wang Y, Bubeck Wardenburg J.

J Invest Dermatol. 2012 May;132(5):1513-6. doi: 10.1038/jid.2011.462. Epub 2012 Mar 1. No abstract available.

33.

Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus.

DeLeo FR, Kennedy AD, Chen L, Bubeck Wardenburg J, Kobayashi SD, Mathema B, Braughton KR, Whitney AR, Villaruz AE, Martens CA, Porcella SF, McGavin MJ, Otto M, Musser JM, Kreiswirth BN.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18091-6. doi: 10.1073/pnas.1111084108. Epub 2011 Oct 24.

34.

A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice.

Inoshima I, Inoshima N, Wilke GA, Powers ME, Frank KM, Wang Y, Bubeck Wardenburg J.

Nat Med. 2011 Sep 18;17(10):1310-4. doi: 10.1038/nm.2451.

35.

Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection.

Kobayashi SD, Malachowa N, Whitney AR, Braughton KR, Gardner DJ, Long D, Bubeck Wardenburg J, Schneewind O, Otto M, Deleo FR.

J Infect Dis. 2011 Sep 15;204(6):937-41. doi: 10.1093/infdis/jir441.

36.

Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model.

Kennedy AD, Bubeck Wardenburg J, Gardner DJ, Long D, Whitney AR, Braughton KR, Schneewind O, DeLeo FR.

J Infect Dis. 2010 Oct 1;202(7):1050-8. doi: 10.1086/656043.

37.

Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury.

Wilke GA, Bubeck Wardenburg J.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13473-8. doi: 10.1073/pnas.1001815107. Epub 2010 Jul 12.

38.

Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells.

Craven RR, Gao X, Allen IC, Gris D, Bubeck Wardenburg J, McElvania-Tekippe E, Ting JP, Duncan JA.

PLoS One. 2009 Oct 14;4(10):e7446. doi: 10.1371/journal.pone.0007446.

39.

Prevention and treatment of Staphylococcus aureus pneumonia with a beta-cyclodextrin derivative.

Ragle BE, Karginov VA, Bubeck Wardenburg J.

Antimicrob Agents Chemother. 2010 Jan;54(1):298-304. doi: 10.1128/AAC.00973-09. Epub 2009 Oct 5.

40.

A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation.

Villaruz AE, Bubeck Wardenburg J, Khan BA, Whitney AR, Sturdevant DE, Gardner DJ, DeLeo FR, Otto M.

J Infect Dis. 2009 Sep 1;200(5):724-34. doi: 10.1086/604728.

41.

Anti-alpha-hemolysin monoclonal antibodies mediate protection against Staphylococcus aureus pneumonia.

Ragle BE, Bubeck Wardenburg J.

Infect Immun. 2009 Jul;77(7):2712-8. doi: 10.1128/IAI.00115-09. Epub 2009 Apr 20.

42.

Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease.

Bubeck Wardenburg J, Palazzolo-Ballance AM, Otto M, Schneewind O, DeLeo FR.

J Infect Dis. 2008 Oct 15;198(8):1166-70. doi: 10.1086/592053.

43.

Vaccine protection against Staphylococcus aureus pneumonia.

Bubeck Wardenburg J, Schneewind O.

J Exp Med. 2008 Feb 18;205(2):287-94. doi: 10.1084/jem.20072208. Epub 2008 Feb 11.

44.

Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia.

Bubeck Wardenburg J, Bae T, Otto M, Deleo FR, Schneewind O.

Nat Med. 2007 Dec;13(12):1405-6. No abstract available.

PMID:
18064027
45.

Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia.

Bubeck Wardenburg J, Patel RJ, Schneewind O.

Infect Immun. 2007 Feb;75(2):1040-4. Epub 2006 Nov 13.

46.

Host defenses against Staphylococcus aureus infection require recognition of bacterial lipoproteins.

Bubeck Wardenburg J, Williams WA, Missiakas D.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13831-6. Epub 2006 Sep 5.

47.

Requirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell development.

Gong Q, Jin X, Akk AM, Foger N, White M, Gong G, Bubeck Wardenburg J, Chan AC.

J Exp Med. 2001 Aug 20;194(4):507-18.

48.

Regulation of antigen receptor function by protein tyrosine kinases.

Bubeck-Wardenburg J, Wong J, Fütterer K, Pappu R, Fu C, Waksman G, Chan AC.

Prog Biophys Mol Biol. 1999;71(3-4):373-92. Review. No abstract available.

PMID:
10354705
49.

Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation.

Williams BL, Irvin BJ, Sutor SL, Chini CC, Yacyshyn E, Bubeck Wardenburg J, Dalton M, Chan AC, Abraham RT.

EMBO J. 1999 Apr 1;18(7):1832-44.

50.

Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76.

Bubeck Wardenburg J, Pappu R, Bu JY, Mayer B, Chernoff J, Straus D, Chan AC.

Immunity. 1998 Nov;9(5):607-16.

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