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Items: 29


Single-molecule kinetics of pore assembly by the membrane attack complex.

Parsons ES, Stanley GJ, Pyne ALB, Hodel AW, Nievergelt AP, Menny A, Yon AR, Rowley A, Richter RP, Fantner GE, Bubeck D, Hoogenboom BW.

Nat Commun. 2019 May 6;10(1):2066. doi: 10.1038/s41467-019-10058-7.


CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.

Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D.

Nat Commun. 2018 Dec 14;9(1):5316. doi: 10.1038/s41467-018-07653-5.


Advances in cryoEM and its impact on β-pore forming proteins.

Boyd CM, Bubeck D.

Curr Opin Struct Biol. 2018 Oct;52:41-49. doi: 10.1016/ Epub 2018 Aug 17. Review.


Molecular cell biology of complement membrane attack.

Morgan BP, Boyd C, Bubeck D.

Semin Cell Dev Biol. 2017 Dec;72:124-132. doi: 10.1016/j.semcdb.2017.06.009. Epub 2017 Jun 21. Review.


Weekly Time Course of Neuro-Muscular Adaptation to Intensive Strength Training.

Brown N, Bubeck D, Haeufle DFB, Weickenmeier J, Kuhl E, Alt W, Schmitt S.

Front Physiol. 2017 Jun 8;8:329. doi: 10.3389/fphys.2017.00329. eCollection 2017.


The mystery behind membrane insertion: a review of the complement membrane attack complex.

Bayly-Jones C, Bubeck D, Dunstone MA.

Philos Trans R Soc Lond B Biol Sci. 2017 Aug 5;372(1726). pii: 20160221. doi: 10.1098/rstb.2016.0221. Review.


Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation.

Boyd CM, Parsons ES, Smith RA, Seddon JM, Ces O, Bubeck D.

Sci Rep. 2016 Dec 2;6:38446. doi: 10.1038/srep38446.


Terminal complexes of the complement system: new structural insights and their relevance to function.

Morgan BP, Walters D, Serna M, Bubeck D.

Immunol Rev. 2016 Nov;274(1):141-151. doi: 10.1111/imr.12461. Review.


Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones.

Taylor JD, Hawthorne WJ, Lo J, Dear A, Jain N, Meisl G, Andreasen M, Fletcher C, Koch M, Darvill N, Scull N, Escalera-Maurer A, Sefer L, Wenman R, Lambert S, Jean J, Xu Y, Turner B, Kazarian SG, Chapman MR, Bubeck D, de Simone A, Knowles TP, Matthews SJ.

Sci Rep. 2016 Apr 21;6:24656. doi: 10.1038/srep24656.


Structural basis of complement membrane attack complex formation.

Serna M, Giles JL, Morgan BP, Bubeck D.

Nat Commun. 2016 Feb 4;7:10587. doi: 10.1038/ncomms10587.


Relationship between muscle volume and contractile properties of the human knee extensors.

Behrens M, Brown N, Bollinger R, Bubeck D, Mau-Moeller A, Weippert M, Zschorlich V, Bruhn S, Alt W.

Appl Physiol Nutr Metab. 2016 Jan;41(1):110-3. doi: 10.1139/apnm-2015-0378. Epub 2015 Oct 7.


Unraveling structural polymorphism of amyloid fibers.

Bubeck D.

Structure. 2015 Jan 6;23(1):10-11. doi: 10.1016/j.str.2014.12.005.


Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.

Günther C, Kind B, Reijns MA, Berndt N, Martinez-Bueno M, Wolf C, Tüngler V, Chara O, Lee YA, Hübner N, Bicknell L, Blum S, Krug C, Schmidt F, Kretschmer S, Koss S, Astell KR, Ramantani G, Bauerfeind A, Morris DL, Cunninghame Graham DS, Bubeck D, Leitch A, Ralston SH, Blackburn EA, Gahr M, Witte T, Vyse TJ, Melchers I, Mangold E, Nöthen MM, Aringer M, Kuhn A, Lüthke K, Unger L, Bley A, Lorenzi A, Isaacs JD, Alexopoulou D, Conrad K, Dahl A, Roers A, Alarcon-Riquelme ME, Jackson AP, Lee-Kirsch MA.

J Clin Invest. 2015 Jan;125(1):413-24. doi: 10.1172/JCI78001. Epub 2014 Dec 15.


The making of a macromolecular machine: assembly of the membrane attack complex.

Bubeck D.

Biochemistry. 2014 Apr 1;53(12):1908-15. doi: 10.1021/bi500157z. Epub 2014 Mar 18. Review.


The influence of sex, stroke and distance on the lactate characteristics in high performance swimming.

Holfelder B, Brown N, Bubeck D.

PLoS One. 2013 Oct 22;8(10):e77185. doi: 10.1371/journal.pone.0077185. eCollection 2013.


Structural basis for recognition of the pore-forming toxin intermedilysin by human complement receptor CD59.

Johnson S, Brooks NJ, Smith RA, Lea SM, Bubeck D.

Cell Rep. 2013 May 30;3(5):1369-77. doi: 10.1016/j.celrep.2013.04.029. Epub 2013 May 9.


Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

Hadders MA, Bubeck D, Roversi P, Hakobyan S, Forneris F, Morgan BP, Pangburn MK, Llorca O, Lea SM, Gros P.

Cell Rep. 2012 Mar 29;1(3):200-7. doi: 10.1016/j.celrep.2012.02.003. Epub 2012 Feb 23.


Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling.

Chen S, Bubeck D, MacDonald BT, Liang WX, Mao JH, Malinauskas T, Llorca O, Aricescu AR, Siebold C, He X, Jones EY.

Dev Cell. 2011 Nov 15;21(5):848-61. doi: 10.1016/j.devcel.2011.09.007. Epub 2011 Oct 13.


PCNA directs type 2 RNase H activity on DNA replication and repair substrates.

Bubeck D, Reijns MA, Graham SC, Astell KR, Jones EY, Jackson AP.

Nucleic Acids Res. 2011 May;39(9):3652-66. doi: 10.1093/nar/gkq980. Epub 2011 Jan 17.


The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease.

Reijns MA, Bubeck D, Gibson LC, Graham SC, Baillie GS, Jones EY, Jackson AP.

J Biol Chem. 2011 Mar 25;286(12):10530-9. doi: 10.1074/jbc.M110.177394. Epub 2010 Dec 22.


Structure of human complement C8, a precursor to membrane attack.

Bubeck D, Roversi P, Donev R, Morgan BP, Llorca O, Lea SM.

J Mol Biol. 2011 Jan 14;405(2):325-30. doi: 10.1016/j.jmb.2010.10.031. Epub 2010 Nov 10.


Use of selection with recurrent backcrossing and QTL mapping to identify loci contributing to southern leaf blight resistance in a highly resistant maize line.

Zwonitzer JC, Bubeck DM, Bhattramakki D, Goodman MM, Arellano C, Balint-Kurti PJ.

Theor Appl Genet. 2009 Mar;118(5):911-25. doi: 10.1007/s00122-008-0949-2. Epub 2009 Jan 8.


Post-imaging fiducial markers aid in the orientation determination of complexes with mixed or unknown symmetry.

Bubeck D, Filman DJ, Kuzmin M, Fuller SD, Hogle JM.

J Struct Biol. 2008 Jun;162(3):480-90. doi: 10.1016/j.jsb.2008.03.006. Epub 2008 Mar 25.


Single particle cryoelectron tomography characterization of the structure and structural variability of poliovirus-receptor-membrane complex at 30 A resolution.

Bostina M, Bubeck D, Schwartz C, Nicastro D, Filman DJ, Hogle JM.

J Struct Biol. 2007 Nov;160(2):200-10. Epub 2007 Aug 24.


Structure of the bacteriophage phi6 nucleocapsid suggests a mechanism for sequential RNA packaging.

Huiskonen JT, de Haas F, Bubeck D, Bamford DH, Fuller SD, Butcher SJ.

Structure. 2006 Jun;14(6):1039-48.


Cryo-electron microscopy reconstruction of a poliovirus-receptor-membrane complex.

Bubeck D, Filman DJ, Hogle JM.

Nat Struct Mol Biol. 2005 Jul;12(7):615-8. Epub 2005 Jun 19.


Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex.

Beckmann R, Bubeck D, Grassucci R, Penczek P, Verschoor A, Blobel G, Frank J.

Science. 1997 Dec 19;278(5346):2123-6.

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