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Items: 23


Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4+ T Cell Activation.

Akkaya B, Roesler AS, Miozzo P, Theall BP, Al Souz J, Smelkinson MG, Kabat J, Traba J, Sack MN, Brzostowski JA, Pena M, Dorward DW, Pierce SK, Akkaya M.

J Immunol. 2018 Dec 1;201(11):3294-3306. doi: 10.4049/jimmunol.1800753. Epub 2018 Oct 29.


Imaging Protein-Protein Interactions by Förster Resonance Energy Transfer (FRET) Microscopy in Live Cells.

Manzella-Lapeira J, Brzostowski JA.

Curr Protoc Protein Sci. 2018 Aug;93(1):e58. doi: 10.1002/cpps.58. Epub 2018 Jul 9.


The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake.

Sherling ES, Knuepfer E, Brzostowski JA, Miller LH, Blackman MJ, van Ooij C.

Elife. 2017 Mar 2;6. pii: e23239. doi: 10.7554/eLife.23239.


Arrestins function in cAR1 GPCR-mediated signaling and cAR1 internalization in the development of Dictyostelium discoideum.

Cao X, Yan J, Shu S, Brzostowski JA, Jin T.

Mol Biol Cell. 2014 Oct 15;25(20):3210-21. doi: 10.1091/mbc.E14-03-0834. Epub 2014 Aug 20.


Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay.

Brzostowski JA, Sawai S, Rozov O, Liao XH, Imoto D, Parent CA, Kimmel AR.

J Cell Sci. 2013 Oct 15;126(Pt 20):4614-26. doi: 10.1242/jcs.122952. Epub 2013 Jul 31.


A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis.

Yan J, Mihaylov V, Xu X, Brzostowski JA, Li H, Liu L, Veenstra TD, Parent CA, Jin T.

Dev Cell. 2012 Jan 17;22(1):92-103. doi: 10.1016/j.devcel.2011.11.007.


Cutting edge: NKG2D-dependent cytotoxicity is controlled by ligand distribution in the target cell membrane.

Martinez E, Brzostowski JA, Long EO, Gross CC.

J Immunol. 2011 May 15;186(10):5538-42. doi: 10.4049/jimmunol.1002254. Epub 2011 Apr 4.


Coupling mechanism of a GPCR and a heterotrimeric G protein during chemoattractant gradient sensing in Dictyostelium.

Xu X, Meckel T, Brzostowski JA, Yan J, Meier-Schellersheim M, Jin T.

Sci Signal. 2010 Sep 28;3(141):ra71. doi: 10.1126/scisignal.2000980.


Tethering of intercellular adhesion molecule on target cells is required for LFA-1-dependent NK cell adhesion and granule polarization.

Gross CC, Brzostowski JA, Liu D, Long EO.

J Immunol. 2010 Sep 1;185(5):2918-26. doi: 10.4049/jimmunol.1000761. Epub 2010 Jul 30.


Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites.

Singh S, Alam MM, Pal-Bhowmick I, Brzostowski JA, Chitnis CE.

PLoS Pathog. 2010 Feb 5;6(2):e1000746. doi: 10.1371/journal.ppat.1000746.


Monitoring dynamic GPCR signaling events using fluorescence microscopy, FRET imaging, and single-molecule imaging.

Xu X, Brzostowski JA, Jin T.

Methods Mol Biol. 2009;571:371-83. doi: 10.1007/978-1-60761-198-1_25.


The Elmo family forms an ancient group of actin-regulating proteins.

Brzostowski JA, Fey P, Yan J, Isik N, Jin T.

Commun Integr Biol. 2009 Jul;2(4):337-40.


Imaging protein-protein interactions by Förster resonance energy transfer (FRET) microscopy in live cells.

Brzostowski JA, Meckel T, Hong J, Chen A, Jin T.

Curr Protoc Protein Sci. 2009 Apr;Chapter 19:Unit19.5. doi: 10.1002/0471140864.ps1905s56.


An Elmo-like protein associated with myosin II restricts spurious F-actin events to coordinate phagocytosis and chemotaxis.

Isik N, Brzostowski JA, Jin T.

Dev Cell. 2008 Oct;15(4):590-602. doi: 10.1016/j.devcel.2008.08.006.


How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum.

Jin T, Xu X, Fang J, Isik N, Yan J, Brzostowski JA, Hereld D.

Immunol Res. 2009;43(1-3):118-27. doi: 10.1007/s12026-008-8056-7. Review.


A vesicle surface tyrosine kinase regulates phagosome maturation.

Fang J, Brzostowski JA, Ou S, Isik N, Nair V, Jin T.

J Cell Biol. 2007 Jul 30;178(3):411-23.


Nonadaptive regulation of ERK2 in Dictyostelium: implications for mechanisms of cAMP relay.

Brzostowski JA, Kimmel AR.

Mol Biol Cell. 2006 Oct;17(10):4220-7. Epub 2006 Jul 26.


A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms.

Khurana T, Brzostowski JA, Kimmel AR.

EMBO J. 2005 Jul 6;24(13):2254-64. Epub 2005 Jun 16.


A G alpha-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement.

Brzostowski JA, Parent CA, Kimmel AR.

Genes Dev. 2004 Apr 1;18(7):805-15. Epub 2004 Apr 1.


Galpha-mediated inhibition of developmental signal response.

Brzostowski JA, Johnson C, Kimmel AR.

Curr Biol. 2002 Jul 23;12(14):1199-208.


Signaling at zero G: G-protein-independent functions for 7-TM receptors.

Brzostowski JA, Kimmel AR.

Trends Biochem Sci. 2001 May;26(5):291-7. Review.


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