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The efficiency of murine MLL-ENL-driven leukemia initiation changes with age and peaks during neonatal development.

Okeyo-Owuor T, Li Y, Patel RM, Yang W, Casey EB, Cluster AS, Porter SN, Bryder D, Magee JA.

Blood Adv. 2019 Aug 13;3(15):2388-2399. doi: 10.1182/bloodadvances.2019000554.


Loss of MafA and MafB expression promotes islet inflammation.

Singh T, Colberg JK, Sarmiento L, Chaves P, Hansen L, Bsharat S, Cataldo LR, Dudenhöffer-Pfeifer M, Fex M, Bryder D, Holmberg D, Sitnicka E, Cilio C, Prasad RB, Artner I.

Sci Rep. 2019 Jun 24;9(1):9074. doi: 10.1038/s41598-019-45528-x.


Hif-1α Deletion May Lead to Adverse Treatment Effect in a Mouse Model of MLL-AF9-Driven AML.

Velasco-Hernandez T, Soneji S, Hidalgo I, Erlandsson E, Cammenga J, Bryder D.

Stem Cell Reports. 2019 Jan 8;12(1):112-121. doi: 10.1016/j.stemcr.2018.11.023. Epub 2018 Dec 27.


Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging.

Säwen P, Eldeeb M, Erlandsson E, Kristiansen TA, Laterza C, Kokaia Z, Karlsson G, Yuan J, Soneji S, Mandal PK, Rossi DJ, Bryder D.

Elife. 2018 Dec 18;7. pii: e41258. doi: 10.7554/eLife.41258.


Author Correction: Rapid and efficient induction of functional astrocytes from human pluripotent stem cells.

Canals I, Ginisty A, Quist E, Timmerman R, Fritze J, Miskinyte G, Monni E, Hansen MG, Hidalgo I, Bryder D, Bengzon J, Ahlenius H.

Nat Methods. 2019 Jan;16(1):134. doi: 10.1038/s41592-018-0264-z.


Immunoediting is not a primary transformation event in a murine model of MLL-ENL AML.

Dudenhöffer-Pfeifer M, Bryder D.

Life Sci Alliance. 2018 Jul 10;1(4):e201800079. doi: 10.26508/lsa.201800079. eCollection 2018 Aug.


Rapid and efficient induction of functional astrocytes from human pluripotent stem cells.

Canals I, Ginisty A, Quist E, Timmerman R, Fritze J, Miskinyte G, Monni E, Hansen MG, Hidalgo I, Bryder D, Bengzon J, Ahlenius H.

Nat Methods. 2018 Sep;15(9):693-696. doi: 10.1038/s41592-018-0103-2. Epub 2018 Aug 20. Erratum in: Nat Methods. 2019 Jan;16(1):134.


Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.

Jensen CT, Åhsberg J, Sommarin MNE, Strid T, Somasundaram R, Okuyama K, Ungerbäck J, Kupari J, Airaksinen MS, Lang S, Bryder D, Soneji S, Karlsson G, Sigvardsson M.

J Exp Med. 2018 Jul 2;215(7):1947-1963. doi: 10.1084/jem.20171384. Epub 2018 Jun 13.


SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies.

Davidsson J, Puschmann A, Tedgård U, Bryder D, Nilsson L, Cammenga J.

Leukemia. 2018 May;32(5):1106-1115. doi: 10.1038/s41375-018-0074-4. Epub 2018 Feb 25. Review.


Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration.

Komorowska K, Doyle A, Wahlestedt M, Subramaniam A, Debnath S, Chen J, Soneji S, Van Handel B, Mikkola HKA, Miharada K, Bryder D, Larsson J, Magnusson M.

Cell Rep. 2017 Dec 19;21(12):3514-3523. doi: 10.1016/j.celrep.2017.11.084.


Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor.

Wahlestedt M, Ladopoulos V, Hidalgo I, Sanchez Castillo M, Hannah R, Säwén P, Wan H, Dudenhöffer-Pfeifer M, Magnusson M, Norddahl GL, Göttgens B, Bryder D.

Cell Rep. 2017 Nov 21;21(8):2251-2263. doi: 10.1016/j.celrep.2017.10.112.


Immunophenotypic Identification of Early Myeloerythroid Development.

Pronk CJH, Bryder D.

Methods Mol Biol. 2018;1678:301-319. doi: 10.1007/978-1-4939-7346-0_13.


The slippery slope of hematopoietic stem cell aging.

Wahlestedt M, Bryder D.

Exp Hematol. 2017 Dec;56:1-6. doi: 10.1016/j.exphem.2017.09.008. Epub 2017 Sep 21. Review.


ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells.

Garrison BS, Rybak AP, Beerman I, Heesters B, Mercier FE, Scadden DT, Bryder D, Baron R, Rossi DJ.

Blood. 2017 Aug 3;130(5):619-624. doi: 10.1182/blood-2016-09-738591. Epub 2017 Jun 14.


Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate.

Wahlestedt M, Erlandsson E, Kristiansen T, Lu R, Brakebusch C, Weissman IL, Yuan J, Martin-Gonzalez J, Bryder D.

Nat Commun. 2017 Feb 22;8:14533. doi: 10.1038/ncomms14533.


Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms.

Tesi B, Davidsson J, Voss M, Rahikkala E, Holmes TD, Chiang SCC, Komulainen-Ebrahim J, Gorcenco S, Rundberg Nilsson A, Ripperger T, Kokkonen H, Bryder D, Fioretos T, Henter JI, Möttönen M, Niinimäki R, Nilsson L, Pronk CJ, Puschmann A, Qian H, Uusimaa J, Moilanen J, Tedgård U, Cammenga J, Bryceson YT.

Blood. 2017 Apr 20;129(16):2266-2279. doi: 10.1182/blood-2016-10-743302. Epub 2017 Feb 15.


Molecular mechanisms underlying lineage bias in aging hematopoiesis.

Elias HK, Bryder D, Park CY.

Semin Hematol. 2017 Jan;54(1):4-11. doi: 10.1053/j.seminhematol.2016.11.002. Epub 2016 Nov 20. Review.


MLL-ENL-mediated leukemia initiation at the interface of lymphoid commitment.

Ugale A, Säwén P, Dudenhöffer-Pfeifer M, Wahlestedt M, Norddahl GL, Bryder D.

Oncogene. 2017 Jun 1;36(22):3207-3212. doi: 10.1038/onc.2016.470. Epub 2017 Jan 9.


Hematopoiesis at single-cell resolution.

Bryder D.

Blood. 2016 Aug 25;128(8):1025-6. doi: 10.1182/blood-2016-07-726497. No abstract available.


Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level.

Kristiansen TA, Jaensson Gyllenbäck E, Zriwil A, Björklund T, Daniel JA, Sitnicka E, Soneji S, Bryder D, Yuan J.

Immunity. 2016 Aug 16;45(2):346-57. doi: 10.1016/j.immuni.2016.07.014.


Potential Pitfalls of the Mx1-Cre System: Implications for Experimental Modeling of Normal and Malignant Hematopoiesis.

Velasco-Hernandez T, Säwén P, Bryder D, Cammenga J.

Stem Cell Reports. 2016 Jul 12;7(1):11-8. doi: 10.1016/j.stemcr.2016.06.002. Epub 2016 Jun 30.


Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias.

Rundberg Nilsson A, Soneji S, Adolfsson S, Bryder D, Pronk CJ.

PLoS One. 2016 Jul 1;11(7):e0158369. doi: 10.1371/journal.pone.0158369. eCollection 2016.


Induction of the 5S RNP-Mdm2-p53 ribosomal stress pathway delays the initiation but fails to eradicate established murine acute myeloid leukemia.

Jaako P, Ugale A, Wahlestedt M, Velasco-Hernandez T, Cammenga J, Lindström MS, Bryder D.

Leukemia. 2017 Jan;31(1):213-221. doi: 10.1038/leu.2016.159. Epub 2016 Jun 3.


Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis.

Säwén P, Lang S, Mandal P, Rossi DJ, Soneji S, Bryder D.

Cell Rep. 2016 Mar 29;14(12):2809-18. doi: 10.1016/j.celrep.2016.02.073. Epub 2016 Mar 17.


SCExV: a webtool for the analysis and visualisation of single cell qRT-PCR data.

Lang S, Ugale A, Erlandsson E, Karlsson G, Bryder D, Soneji S.

BMC Bioinformatics. 2015 Oct 5;16:320. doi: 10.1186/s12859-015-0757-z.


Probing hematopoietic stem cell function using serial transplantation: Seeding characteristics and the impact of stem cell purification.

Rundberg Nilsson A, Pronk CJ, Bryder D.

Exp Hematol. 2015 Sep;43(9):812-7.e1. doi: 10.1016/j.exphem.2015.05.003. Epub 2015 May 29.


Disruption of the 5S RNP-Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia.

Jaako P, Debnath S, Olsson K, Zhang Y, Flygare J, Lindström MS, Bryder D, Karlsson S.

Leukemia. 2015 Nov;29(11):2221-9. doi: 10.1038/leu.2015.128. Epub 2015 May 19.


Concise review: hematopoietic stem cell aging and the prospects for rejuvenation.

Wahlestedt M, Pronk CJ, Bryder D.

Stem Cells Transl Med. 2015 Feb;4(2):186-94. doi: 10.5966/sctm.2014-0132. Epub 2014 Dec 29. Review.


Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9.

Mandal PK, Ferreira LM, Collins R, Meissner TB, Boutwell CL, Friesen M, Vrbanac V, Garrison BS, Stortchevoi A, Bryder D, Musunuru K, Brand H, Tager AM, Allen TM, Talkowski ME, Rossi DJ, Cowan CA.

Cell Stem Cell. 2014 Nov 6;15(5):643-52. doi: 10.1016/j.stem.2014.10.004. Epub 2014 Nov 6.


Hematopoietic stem cells are intrinsically protected against MLL-ENL-mediated transformation.

Ugale A, Norddahl GL, Wahlestedt M, Säwén P, Jaako P, Pronk CJ, Soneji S, Cammenga J, Bryder D.

Cell Rep. 2014 Nov 20;9(4):1246-55. doi: 10.1016/j.celrep.2014.10.036. Epub 2014 Nov 13.


HIF-1α can act as a tumor suppressor gene in murine acute myeloid leukemia.

Velasco-Hernandez T, Hyrenius-Wittsten A, Rehn M, Bryder D, Cammenga J.

Blood. 2014 Dec 4;124(24):3597-607. doi: 10.1182/blood-2014-04-567065. Epub 2014 Sep 29.


Induced hematopoietic stem cells: unlocking restrictions in lineage potential and self-renewal.

Wahlestedt M, Bryder D.

Cell Stem Cell. 2014 May 1;14(5):555-6. doi: 10.1016/j.stem.2014.04.008.


Somatic cells with a heavy mitochondrial DNA mutational load render induced pluripotent stem cells with distinct differentiation defects.

Wahlestedt M, Ameur A, Moraghebi R, Norddahl GL, Sten G, Woods NB, Bryder D.

Stem Cells. 2014 May;32(5):1173-82. doi: 10.1002/stem.1630.


Frequency determination of rare populations by flow cytometry: a hematopoietic stem cell perspective.

Rundberg Nilsson A, Bryder D, Pronk CJ.

Cytometry A. 2013 Aug;83(8):721-7. doi: 10.1002/cyto.a.22324. Epub 2013 Jul 9. Review.


An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.

Wahlestedt M, Norddahl GL, Sten G, Ugale A, Frisk MA, Mattsson R, Deierborg T, Sigvardsson M, Bryder D.

Blood. 2013 May 23;121(21):4257-64. doi: 10.1182/blood-2012-11-469080. Epub 2013 Mar 8.


Dynamical modelling of haematopoiesis: an integrated view over the system in homeostasis and under perturbation.

Manesso E, Teles J, Bryder D, Peterson C.

J R Soc Interface. 2013 Mar 6;10(80):20120817. doi: 10.1098/rsif.2012.0817. Print 2013 Mar 6.


SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.

Hansen N, Ågerstam H, Wahlestedt M, Landberg N, Askmyr M, Ehinger M, Rissler M, Lilljebjörn H, Johnels P, Ishiko J, Melo JV, Alexander WS, Bryder D, Järås M, Fioretos T.

Leukemia. 2013 Jan;27(1):130-5. doi: 10.1038/leu.2012.169. Epub 2012 Jun 22.


Reduced repression of cytokine signaling ameliorates age-induced decline in hematopoietic stem cell function.

Norddahl GL, Wahlestedt M, Gisler S, Sigvardsson M, Bryder D.

Aging Cell. 2012 Dec;11(6):1128-31. doi: 10.1111/j.1474-9726.2012.00863.x. Epub 2012 Aug 27.


Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia.

Jaako P, Debnath S, Olsson K, Bryder D, Flygare J, Karlsson S.

Blood. 2012 Sep 13;120(11):2225-8. doi: 10.1182/blood-2012-05-431437. Epub 2012 Jul 12.


Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.

Jaako P, Flygare J, Olsson K, Quere R, Ehinger M, Henson A, Ellis S, Schambach A, Baum C, Richter J, Larsson J, Bryder D, Karlsson S.

Blood. 2011 Dec 1;118(23):6087-96. doi: 10.1182/blood-2011-08-371963. Epub 2011 Oct 11.


The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor.

Welinder E, Mansson R, Mercer EM, Bryder D, Sigvardsson M, Murre C.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17402-7. doi: 10.1073/pnas.1111766108. Epub 2011 Oct 4.


Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors.

Pronk CJ, Veiby OP, Bryder D, Jacobsen SE.

J Exp Med. 2011 Aug 1;208(8):1563-70. doi: 10.1084/jem.20110752. Epub 2011 Jul 18.


Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.

Norddahl GL, Pronk CJ, Wahlestedt M, Sten G, Nygren JM, Ugale A, Sigvardsson M, Bryder D.

Cell Stem Cell. 2011 May 6;8(5):499-510. doi: 10.1016/j.stem.2011.03.009.


Flow cytometry-based identification of immature myeloerythroid development.

Pronk CJ, Bryder D.

Methods Mol Biol. 2011;699:275-93. doi: 10.1007/978-1-61737-950-5_13.


Load and lock: the molecular mechanisms of B-lymphocyte commitment.

Zandi S, Bryder D, Sigvardsson M.

Immunol Rev. 2010 Nov;238(1):47-62. doi: 10.1111/j.1600-065X.2010.00950.x. Review.


Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion.

Beerman I, Bhattacharya D, Zandi S, Sigvardsson M, Weissman IL, Bryder D, Rossi DJ.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5465-70. doi: 10.1073/pnas.1000834107. Epub 2010 Mar 18.


Shaping up a lineage--lessons from B lymphopoesis.

Bryder D, Sigvardsson M.

Curr Opin Immunol. 2010 Apr;22(2):148-53. doi: 10.1016/j.coi.2010.02.001. Epub 2010 Mar 6. Review.


Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication.

Zetterblad J, Qian H, Zandi S, Månsson R, Lagergren A, Hansson F, Bryder D, Paulsson N, Sigvardsson M.

BMC Genomics. 2010 Feb 12;11:108. doi: 10.1186/1471-2164-11-108.


Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity.

Mansson R, Zandi S, Welinder E, Tsapogas P, Sakaguchi N, Bryder D, Sigvardsson M.

Blood. 2010 Apr 1;115(13):2601-9. doi: 10.1182/blood-2009-08-236398. Epub 2009 Dec 8.


Niche recycling through division-independent egress of hematopoietic stem cells.

Bhattacharya D, Czechowicz A, Ooi AG, Rossi DJ, Bryder D, Weissman IL.

J Exp Med. 2009 Nov 23;206(12):2837-50. doi: 10.1084/jem.20090778. Epub 2009 Nov 2.

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