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Carbon dot-protoporphyrin IX conjugates for improved drug delivery and bioimaging.

Aguilar Cosme JR, Bryant HE, Claeyssens F.

PLoS One. 2019 Jul 25;14(7):e0220210. doi: 10.1371/journal.pone.0220210. eCollection 2019.


Heteronuclear d-d and d-f Ru(ii)/M complexes [M = Gd(iii), Yb(iii), Nd(iii), Zn(ii) or Mn(ii)] of ligands combining phenanthroline and aminocarboxylate binding sites: combined relaxivity, cell imaging and photophysical studies.

Crowston BJ, Shipp JD, Chekulaev D, McKenzie LK, Jones C, Weinstein JA, Meijer AJH, Bryant HE, Natrajan L, Woodward A, Ward MD.

Dalton Trans. 2019 May 7;48(18):6132-6152. doi: 10.1039/c9dt00954j.


ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage.

Willan J, Cleasby AJ, Flores-Rodriguez N, Stefani F, Rinaldo C, Pisciottani A, Grant E, Woodman P, Bryant HE, Ciani B.

Oncogenesis. 2019 Apr 15;8(5):29. doi: 10.1038/s41389-019-0136-0.


Synthesis and Aggregation of a Porphyrin-Cored Hyperbranched Polyglycidol and Its Application as a Macromolecular Photosensitizer for Photodynamic Therapy.

Kadhim A, McKenzie LK, Bryant HE, Twyman LJ.

Mol Pharm. 2019 Mar 4;16(3):1132-1139. doi: 10.1021/acs.molpharmaceut.8b01119. Epub 2019 Feb 12.


Photophysical and Cellular Imaging Studies of Brightly Luminescent Osmium(II) Pyridyltriazole Complexes.

Omar SAE, Scattergood PA, McKenzie LK, Jones C, Patmore NJ, Meijer AJHM, Weinstein JA, Rice CR, Bryant HE, Elliott PIP.

Inorg Chem. 2018 Nov 5;57(21):13201-13212. doi: 10.1021/acs.inorgchem.8b01627. Epub 2018 Oct 16.


Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib.

Gravells P, Neale J, Grant E, Nathubhai A, Smith KM, James DI, Bryant HE.

DNA Repair (Amst). 2018 Jan;61:25-36. doi: 10.1016/j.dnarep.2017.11.004. Epub 2017 Nov 22.


Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase.

Gravells P, Grant E, Smith KM, James DI, Bryant HE.

DNA Repair (Amst). 2017 Apr;52:81-91. doi: 10.1016/j.dnarep.2017.02.010. Epub 2017 Feb 17.


DNA damage repair in breast cancer and its therapeutic implications.

Ali R, Rakha EA, Madhusudan S, Bryant HE.

Pathology. 2017 Feb;49(2):156-165. doi: 10.1016/j.pathol.2016.11.002. Epub 2016 Dec 26. Review.


Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light.

McKenzie LK, Sazanovich IV, Baggaley E, Bonneau M, Guerchais V, Williams JA, Weinstein JA, Bryant HE.

Chemistry. 2017 Jan 5;23(2):234-238. doi: 10.1002/chem.201604792. Epub 2016 Nov 2.


DNA Repair in Prostate Cancer: Biology and Clinical Implications.

Mateo J, Boysen G, Barbieri CE, Bryant HE, Castro E, Nelson PS, Olmos D, Pritchard CC, Rubin MA, de Bono JS.

Eur Urol. 2017 Mar;71(3):417-425. doi: 10.1016/j.eururo.2016.08.037. Epub 2016 Aug 31. Review.


Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy.

Patterson K, Arya L, Bottomley S, Morgan S, Cox A, Catto J, Bryant HE.

Oncotarget. 2016 Nov 15;7(46):76140-76150. doi: 10.18632/oncotarget.12683.


Towards Water Soluble Mitochondria-Targeting Theranostic Osmium(II) Triazole-Based Complexes.

Omar SA, Scattergood PA, McKenzie LK, Bryant HE, Weinstein JA, Elliott PI.

Molecules. 2016 Oct 18;21(10). pii: E1382.


Heteronuclear Ir(III)-Ln(III) Luminescent Complexes: Small-Molecule Probes for Dual Modal Imaging and Oxygen Sensing.

Jana A, Crowston BJ, Shewring JR, McKenzie LK, Bryant HE, Botchway SW, Ward AD, Amoroso AJ, Baggaley E, Ward MD.

Inorg Chem. 2016 Jun 6;55(11):5623-33. doi: 10.1021/acs.inorgchem.6b00702. Epub 2016 May 24.


Photodynamic killing of cancer cells by a Platinum(II) complex with cyclometallating ligand.

Doherty RE, Sazanovich IV, McKenzie LK, Stasheuski AS, Coyle R, Baggaley E, Bottomley S, Weinstein JA, Bryant HE.

Sci Rep. 2016 Mar 4;6:22668. doi: 10.1038/srep22668.


The Clinical Impact of BRCA2 Loss in Prostate Cancer.

Bryant HE.

Eur Urol. 2016 Jun;69(6):996-7. doi: 10.1016/j.eururo.2015.12.009. Epub 2015 Dec 18. No abstract available.


Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers.

Arora A, Abdel-Fatah TM, Agarwal D, Doherty R, Croteau DL, Moseley PM, Hameed K, Green A, Aleskandarany MA, Rakha EA, Patterson K, Ball G, Chan SY, Ellis IO, Bohr VA, Bryant HE, Madhusudan S.

Carcinogenesis. 2016 Jan;37(1):63-71. doi: 10.1093/carcin/bgv163. Epub 2015 Nov 19.


PI3King the lock: targeting the PI3K/Akt/mTOR pathway as a novel therapeutic strategy in neuroblastoma.

King D, Yeomanson D, Bryant HE.

J Pediatr Hematol Oncol. 2015 May;37(4):245-51. doi: 10.1097/MPH.0000000000000329. Review.


Identification and diagnostic performance of a small RNA within the PCA3 and BMCC1 gene locus that potentially targets mRNA.

Drayton RM, Rehman I, Clarke R, Zhao Z, Pang K, Miah S, Stoehr R, Hartmann A, Blizard S, Lavin M, Bryant HE, Martens-Uzunova ES, Jenster G, Hamdy FC, Gardiner RA, Catto JW.

Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):268-75. doi: 10.1158/1055-9965.EPI-14-0377. Epub 2014 Nov 12.


'Sex' in the cancer cell.

Lafta IJ, Bryant HE, Goldman AS.

Oncotarget. 2014 Sep 30;5(18):7984-5. No abstract available.


Intrapersonal and social environment correlates of leisure-time physical activity for cancer prevention: a cross-sectional study among Canadian adults.

Aparicio-Ting FE, Friedenreich CM, Kopciuk KA, Plotnikoff RC, Bryant HE.

J Phys Act Health. 2014 May;11(4):790-800. doi: 10.1123/jpah.2012-0110.


MicroRNA-99a and 100 mediated upregulation of FOXA1 in bladder cancer.

Drayton RM, Peter S, Myers K, Miah S, Dudziec E, Bryant HE, Catto JW.

Oncotarget. 2014 Aug 15;5(15):6375-86.


The Sedentary Time and Activity Reporting Questionnaire (STAR-Q): reliability and validity against doubly labeled water and 7-day activity diaries.

Csizmadi I, Neilson HK, Kopciuk KA, Khandwala F, Liu A, Friedenreich CM, Yasui Y, Rabasa-Lhoret R, Bryant HE, Lau DC, Robson PJ.

Am J Epidemiol. 2014 Aug 15;180(4):424-35. doi: 10.1093/aje/kwu150. Epub 2014 Jul 19.


Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11.

Drayton RM, Dudziec E, Peter S, Bertz S, Hartmann A, Bryant HE, Catto JW.

Clin Cancer Res. 2014 Apr 1;20(7):1990-2000. doi: 10.1158/1078-0432.CCR-13-2805. Epub 2014 Feb 10.


CAGS and ACS evidence based reviews in surgery. 48. What is the effect of screening mammography on breast cancer incidence?

Latosinsky S, Boileau JF, Bryant HE, Newman LA; Evidence-Based Reviews in Surgery Group.

Can J Surg. 2014 Feb;57(1):67-9. No abstract available.


Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Silva Idos S, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O'Connor JP, O'Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM.

Breast Cancer Res. 2013 Oct 1;15(5):R92. doi: 10.1186/bcr3493. Review.


Quality indicators for ductal carcinoma in situ (DCIS) of the breast: development using a multidisciplinary delphi process and its use in monitoring population-based treatment.

Chin-Lenn L, Craighead P, Bryant HE, Mack L, Temple W, Ghali W, Quan ML.

J Surg Oncol. 2013 Nov;108(6):348-51. doi: 10.1002/jso.23401. Epub 2013 Aug 22.


Reduced FANCD2 influences spontaneous SCE and RAD51 foci formation in uveal melanoma and Fanconi anaemia.

Gravells P, Hoh L, Solovieva S, Patil A, Dudziec E, Rennie IG, Sisley K, Bryant HE.

Oncogene. 2013 Nov 14;32(46):5338-46. doi: 10.1038/onc.2012.627. Epub 2013 Jan 14.


A first look at participation rates in cervical cancer screening programs in Canada.

Forte T, Decker K, Lockwood GA, McLachlin CM, Fekete S, Bryant HE; Pan-Canadian Cervical Cancer Screening Initiative: Monitoring Program Performance Working Group.

Curr Oncol. 2012 Oct;19(5):269-71. doi: 10.3747/co.19.1188. No abstract available. Erratum in: Curr Oncol. 2013 Feb;20(1):e56. Decker, K [added]; Pan-Canadian Cervical Cancer Screening Initiative: Monitoring Program Performance Working Group [added].


Prevalence of meeting physical activity guidelines for cancer prevention in Alberta.

Aparicio-Ting FE, Friedenreich CM, Kopciuk KA, Plotnikoff RC, Bryant HE.

Chronic Dis Inj Can. 2012 Sep;32(4):216-26.


DNA double-strand break damage and repair assessed by pulsed-field gel electrophoresis.

Bryant HE.

Methods Mol Biol. 2012;920:315-21. doi: 10.1007/978-1-61779-998-3_22.


Incidence trends in head and neck cancers and human papillomavirus (HPV)-associated oropharyngeal cancer in Canada, 1992-2009.

Forte T, Niu J, Lockwood GA, Bryant HE.

Cancer Causes Control. 2012 Aug;23(8):1343-8. doi: 10.1007/s10552-012-0013-z. Epub 2012 Jun 21.


Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells.

Fathers C, Drayton RM, Solovieva S, Bryant HE.

Cell Cycle. 2012 Mar 1;11(5):990-7. doi: 10.4161/cc.11.5.19482. Epub 2012 Mar 1.


Resistance of uveal melanoma to the interstrand cross-linking agent mitomycin C is associated with reduced expression of CYP450R.

Gravells P, Hoh L, Canovas D, Rennie IG, Sisley K, Bryant HE.

Br J Cancer. 2011 Mar 29;104(7):1098-105. doi: 10.1038/bjc.2011.56. Epub 2011 Mar 8.


Associations of overall and abdominal adiposity with area and volumetric mammographic measures among postmenopausal women.

Woolcott CG, Cook LS, Courneya KS, Boyd NF, Yaffe MJ, Terry T, Brant R, McTiernan A, Bryant HE, Magliocco AM, Friedenreich CM.

Int J Cancer. 2011 Jul 15;129(2):440-8. doi: 10.1002/ijc.25676. Epub 2010 Nov 16.


Human RECQL5 overcomes thymidine-induced replication stress.

Blundred R, Myers K, Helleday T, Goldman AS, Bryant HE.

DNA Repair (Amst). 2010 Sep 4;9(9):964-75. doi: 10.1016/j.dnarep.2010.06.009.


Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.

Gottipati P, Vischioni B, Schultz N, Solomons J, Bryant HE, Djureinovic T, Issaeva N, Sleeth K, Sharma RA, Helleday T.

Cancer Res. 2010 Jul 1;70(13):5389-98. doi: 10.1158/0008-5472.CAN-09-4716. Epub 2010 Jun 15. Erratum in: Cancer Res. 2011 Apr 1;71(7):2803.


Smoking frequency, prevalence and trends, and their socio-demographic associations in Alberta, Canada.

Li FX, Robson PJ, Ashbury FD, Hatcher J, Bryant HE.

Can J Public Health. 2009 Nov-Dec;100(6):453-8.


PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.

Loseva O, Jemth AS, Bryant HE, Schüler H, Lehtiö L, Karlberg T, Helleday T.

J Biol Chem. 2010 Mar 12;285(11):8054-60. doi: 10.1074/jbc.M109.077834. Epub 2010 Jan 11.


Specific targeted gene repair using single-stranded DNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination.

McLachlan J, Fernandez S, Helleday T, Bryant HE.

DNA Repair (Amst). 2009 Dec 3;8(12):1424-33. doi: 10.1016/j.dnarep.2009.09.014. Epub 2009 Oct 24.


The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links.

Al-Minawi AZ, Lee YF, Håkansson D, Johansson F, Lundin C, Saleh-Gohari N, Schultz N, Jenssen D, Bryant HE, Meuth M, Hinz JM, Helleday T.

Nucleic Acids Res. 2009 Oct;37(19):6400-13. doi: 10.1093/nar/gkp705. Epub 2009 Aug 27.


PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

Bryant HE, Petermann E, Schultz N, Jemth AS, Loseva O, Issaeva N, Johansson F, Fernandez S, McGlynn P, Helleday T.

EMBO J. 2009 Sep 2;28(17):2601-15. doi: 10.1038/emboj.2009.206. Epub 2009 Jul 23.


BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells.

Ying S, Myers K, Bottomley S, Helleday T, Bryant HE.

Nucleic Acids Res. 2009 Aug;37(15):5105-13. doi: 10.1093/nar/gkp538. Epub 2009 Jun 23.


Survival of metastatic colorectal cancer patients treated with chemotherapy in Alberta (1995-2004).

Chen Y, Qiu Z, Kamruzzaman A, Snodgrass T, Scarfe A, Bryant HE.

Support Care Cancer. 2010 Feb;18(2):217-24. doi: 10.1007/s00520-009-0647-x. Epub 2009 May 15.


Prevalence, trend, and sociodemographic association of five modifiable lifestyle risk factors for cancer in Alberta and Canada.

Li FX, Robson PJ, Chen Y, Qiu Z, Lo Siou G, Bryant HE.

Cancer Causes Control. 2009 Apr;20(3):395-407. doi: 10.1007/s10552-008-9254-2. Epub 2008 Nov 8.


Sociodemographic, health and lifestyle characteristics reported by discrete groups of adult dietary supplement users in Alberta, Canada: findings from The Tomorrow Project.

Robson PJ, Siou GL, Ullman R, Bryant HE.

Public Health Nutr. 2008 Dec;11(12):1238-47. doi: 10.1017/S136898000800219X. Epub 2008 May 6.


Low uptake of colorectal cancer screening 3 yr after release of national recommendations for screening.

McGregor SE, Hilsden RJ, Li FX, Bryant HE, Murray A.

Am J Gastroenterol. 2007 Aug;102(8):1727-35. Epub 2007 Apr 16.


Homologous recombination is involved in repair of chromium-induced DNA damage in mammalian cells.

Bryant HE, Ying S, Helleday T.

Mutat Res. 2006 Jul 25;599(1-2):116-23. Epub 2006 Mar 27.


An analysis of the effect of selection bias on the association of hormone replacement therapy and breast cancer risk.

Csizmadi I, Friedenreich CM, Bryant HE, Courneya KS.

Chronic Dis Can. 2005 Spring-Summer;26(2-3):73-9.


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