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Association of Plasma Levels of Nitric Oxide Oxidative Metabolites with Acute Stroke in Patients Presenting to the Emergency Department of a Low-Middle Income Country.

Waheed S, Kalsekar AG, Kamal AK, Bryan NS, Mian AI.

Emerg Med Int. 2019 Jun 2;2019:9206948. doi: 10.1155/2019/9206948. eCollection 2019.


Update on Gaseous Signaling Molecules Nitric Oxide and Hydrogen Sulfide: Strategies to Capture their Functional Activity for Human Therapeutics.

Bryan NS, Lefer DJ.

Mol Pharmacol. 2019 Jul;96(1):109-114. doi: 10.1124/mol.118.113910. Epub 2019 May 6. Erratum in: Mol Pharmacol. 2019 Aug;96(2):127.


Frequency of Tongue Cleaning Impacts the Human Tongue Microbiome Composition and Enterosalivary Circulation of Nitrate.

Tribble GD, Angelov N, Weltman R, Wang BY, Eswaran SV, Gay IC, Parthasarathy K, Dao DV, Richardson KN, Ismail NM, Sharina IG, Hyde ER, Ajami NJ, Petrosino JF, Bryan NS.

Front Cell Infect Microbiol. 2019 Mar 1;9:39. doi: 10.3389/fcimb.2019.00039. eCollection 2019.


Enhancement of gemcitabine cytotoxicity in pancreatic adenocarcinoma through controlled release of nitric oxide.

Araujo-Gutierrez R, Van Eps JL, Kirui D, Bryan NS, Kang Y, Fleming JB, Fernandez-Moure JS.

Biomed Microdevices. 2019 Feb 21;21(1):23. doi: 10.1007/s10544-019-0375-z.


Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension.

Kho J, Tian X, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BH.

Am J Hum Genet. 2018 Aug 2;103(2):276-287. doi: 10.1016/j.ajhg.2018.07.008.


Functional Nitric Oxide Nutrition to Combat Cardiovascular Disease.

Bryan NS.

Curr Atheroscler Rep. 2018 Mar 17;20(5):21. doi: 10.1007/s11883-018-0723-0. Review.


Biomarkers in Pulmonary Vascular Disease: Gauging Response to Therapy.

McMahon TJ, Bryan NS.

Am J Cardiol. 2017 Oct 15;120(8S):S89-S95. doi: 10.1016/j.amjcard.2017.06.014. Review.


Inorganic nitrate supplementation attenuates peripheral chemoreflex sensitivity but does not improve cardiovagal baroreflex sensitivity in older adults.

Bock JM, Ueda K, Schneider AC, Hughes WE, Limberg JK, Bryan NS, Casey DP.

Am J Physiol Heart Circ Physiol. 2018 Jan 1;314(1):H45-H51. doi: 10.1152/ajpheart.00389.2017. Epub 2017 Sep 29.


Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions.

Raizada MK, Joe B, Bryan NS, Chang EB, Dewhirst FE, Borisy GG, Galis ZS, Henderson W, Jose PA, Ketchum CJ, Lampe JW, Pepine CJ, Pluznick JL, Raj D, Seals DR, Gioscia-Ryan RA, Tang WHW, Oh YS.

Hypertension. 2017 Jul 31. pii: HYPERTENSIONAHA.117.09699. doi: 10.1161/HYPERTENSIONAHA.117.09699. [Epub ahead of print] Review. No abstract available.


Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure.

Bryan NS, Tribble G, Angelov N.

Curr Hypertens Rep. 2017 Apr;19(4):33. doi: 10.1007/s11906-017-0725-2. Review.


Nebivolol Acts as a S-Nitrosoglutathione Reductase Inhibitor: A New Mechanism of Action.

Jiang H, Polhemus DJ, Islam KN, Torregrossa AC, Li Z, Potts A, Lefer DJ, Bryan NS.

J Cardiovasc Pharmacol Ther. 2016 Sep;21(5):478-85. doi: 10.1177/1074248415626300. Epub 2016 Jan 8.


Improved motor and cognitive performance with sodium nitrite supplementation is related to small metabolite signatures: a pilot trial in middle-aged and older adults.

Justice JN, Johnson LC, DeVan AE, Cruickshank-Quinn C, Reisdorph N, Bassett CJ, Evans TD, Brooks FA, Bryan NS, Chonchol MB, Giordano T, McQueen MB, Seals DR.

Aging (Albany NY). 2015 Nov;7(11):1004-21.


Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults.

DeVan AE, Johnson LC, Brooks FA, Evans TD, Justice JN, Cruickshank-Quinn C, Reisdorph N, Bryan NS, McQueen MB, Santos-Parker JR, Chonchol MB, Bassett CJ, Sindler AL, Giordano T, Seals DR.

J Appl Physiol (1985). 2016 Feb 15;120(4):416-25. doi: 10.1152/japplphysiol.00879.2015. Epub 2015 Nov 25.


Nitric oxide enhancement strategies.

Bryan NS.

Future Sci OA. 2015 Aug 1;1(1):FSO48. doi: 10.4155/FSO.15.48. eCollection 2015 Aug. Review.


Inorganic nitrite and nitrate: evidence to support consideration as dietary nutrients.

Bryan NS, Ivy JL.

Nutr Res. 2015 Aug;35(8):643-54. doi: 10.1016/j.nutres.2015.06.001. Epub 2015 Jun 11. Review.


A survey of nitrate and nitrite concentrations in conventional and organic-labeled raw vegetables at retail.

Nuñez de González MT, Osburn WN, Hardin MD, Longnecker M, Garg HK, Bryan NS, Keeton JT.

J Food Sci. 2015 May;80(5):C942-9. doi: 10.1111/1750-3841.12858. Epub 2015 Apr 7.


Oral nitrite therapy improves vascular function in diabetic mice.

Sindler AL, Cox-York K, Reese L, Bryan NS, Seals DR, Gentile CL.

Diab Vasc Dis Res. 2015 May;12(3):221-4. doi: 10.1177/1479164114565628. Epub 2015 Feb 12.


The potential use of salivary nitrite as a marker of NO status in humans.

Bryan NS.

Nitric Oxide. 2015 Feb 15;45:4-6. doi: 10.1016/j.niox.2014.12.011. Epub 2014 Dec 24. No abstract available.


Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice.

Justice JN, Gioscia-Ryan RA, Johnson LC, Battson ML, de Picciotto NE, Beck HJ, Jiang H, Sindler AL, Bryan NS, Enoka RM, Seals DR.

J Appl Physiol (1985). 2015 Jan 15;118(2):163-9. doi: 10.1152/japplphysiol.00608.2014. Epub 2014 Nov 6.


Nitric oxide availability as a marker of oxidative stress.

Pierini D, Bryan NS.

Methods Mol Biol. 2015;1208:63-71. doi: 10.1007/978-1-4939-1441-8_5.


Characterization of the rat oral microbiome and the effects of dietary nitrate.

Hyde ER, Luk B, Cron S, Kusic L, McCue T, Bauch T, Kaplan H, Tribble G, Petrosino JF, Bryan NS.

Free Radic Biol Med. 2014 Dec;77:249-57. doi: 10.1016/j.freeradbiomed.2014.09.017. Epub 2014 Oct 12.


Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis.

Premkumar MH, Sule G, Nagamani SC, Chakkalakal S, Nordin A, Jain M, Ruan MZ, Bertin T, Dawson B, Zhang J, Schady D, Bryan NS, Campeau PM, Erez A, Lee B.

Am J Physiol Gastrointest Liver Physiol. 2014 Aug 1;307(3):G347-54. doi: 10.1152/ajpgi.00403.2013. Epub 2014 Jun 5.


The role of red and processed meat in colorectal cancer development: a perspective.

Oostindjer M, Alexander J, Amdam GV, Andersen G, Bryan NS, Chen D, Corpet DE, De Smet S, Dragsted LO, Haug A, Karlsson AH, Kleter G, de Kok TM, Kulseng B, Milkowski AL, Martin RJ, Pajari AM, Paulsen JE, Pickova J, Rudi K, Sødring M, Weed DL, Egelandsdal B.

Meat Sci. 2014 Aug;97(4):583-96. doi: 10.1016/j.meatsci.2014.02.011. Epub 2014 Feb 24.


Metagenomic analysis of nitrate-reducing bacteria in the oral cavity: implications for nitric oxide homeostasis.

Hyde ER, Andrade F, Vaksman Z, Parthasarathy K, Jiang H, Parthasarathy DK, Torregrossa AC, Tribble G, Kaplan HB, Petrosino JF, Bryan NS.

PLoS One. 2014 Mar 26;9(3):e88645. doi: 10.1371/journal.pone.0088645. eCollection 2014.


Dietary nitrite improves insulin signaling through GLUT4 translocation.

Jiang H, Torregrossa AC, Potts A, Pierini D, Aranke M, Garg HK, Bryan NS.

Free Radic Biol Med. 2014 Feb;67:51-7. doi: 10.1016/j.freeradbiomed.2013.10.809. Epub 2013 Oct 21.


Coronary microvascular pericytes are the cellular target of sunitinib malate-induced cardiotoxicity.

Chintalgattu V, Rees ML, Culver JC, Goel A, Jiffar T, Zhang J, Dunner K Jr, Pati S, Bankson JA, Pasqualini R, Arap W, Bryan NS, Taegtmeyer H, Langley RR, Yao H, Kupferman ME, Entman ML, Dickinson ME, Khakoo AY.

Sci Transl Med. 2013 May 29;5(187):187ra69. doi: 10.1126/scitranslmed.3005066.


Nitric oxide and its metabolites in the critical phase of illness: rapid biomarkers in the making.

Mian AI, Aranke M, Bryan NS.

Open Biochem J. 2013;7:24-32. doi: 10.2174/1874091X01307010024. Epub 2013 Mar 8.


Acute effects of hemodialysis on nitrite and nitrate: potential cardiovascular implications in dialysis patients.

Bryan NS, Torregrossa AC, Mian AI, Berkson DL, Westby CM, Moncrief JW.

Free Radic Biol Med. 2013 May;58:46-51. doi: 10.1016/j.freeradbiomed.2013.01.020. Epub 2013 Jan 29.


Pharmacological therapies, lifestyle choices and nitric oxide deficiency: a perfect storm.

Bryan NS.

Pharmacol Res. 2012 Dec;66(6):448-56. doi: 10.1016/j.phrs.2012.09.009. Epub 2012 Oct 5. Review.


Ingested nitrate and nitrite and stomach cancer risk: an updated review.

Bryan NS, Alexander DD, Coughlin JR, Milkowski AL, Boffetta P.

Food Chem Toxicol. 2012 Oct;50(10):3646-65. doi: 10.1016/j.fct.2012.07.062. Epub 2012 Aug 4. Review.


Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly.

Torregrossa AC, Aranke M, Bryan NS.

J Geriatr Cardiol. 2011 Dec;8(4):230-42. doi: 10.3724/SP.J.1263.2011.00230.


Curcumin induces differentiation of embryonic stem cells through possible modulation of nitric oxide-cyclic GMP pathway.

Mujoo K, Nikonoff LE, Sharin VG, Bryan NS, Kots AY, Murad F.

Protein Cell. 2012 Jul;3(7):535-44. doi: 10.1007/s13238-012-2053-2. Epub 2012 Jul 10.


Analytical techniques for assaying nitric oxide bioactivity.

Jiang H, Parthasarathy D, Torregrossa AC, Mian A, Bryan NS.

J Vis Exp. 2012 Jun 18;(64):e3722. doi: 10.3791/3722.


Application of nitric oxide in drug discovery and development.

Bryan NS.

Expert Opin Drug Discov. 2011 Nov;6(11):1139-54. doi: 10.1517/17460441.2011.613933. Epub 2011 Aug 25.


Natural product nitric oxide chemistry: new activity of old medicines.

Jiang H, Torregrossa AC, Parthasarathy DK, Bryan NS.

Evid Based Complement Alternat Med. 2012;2012:873210. doi: 10.1155/2012/873210. Epub 2012 Apr 2.


Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria.

Nagamani SC, Campeau PM, Shchelochkov OA, Premkumar MH, Guse K, Brunetti-Pierri N, Chen Y, Sun Q, Tang Y, Palmer D, Reddy AK, Li L, Slesnick TC, Feig DI, Caudle S, Harrison D, Salviati L, Marini JC, Bryan NS, Erez A, Lee B.

Am J Hum Genet. 2012 May 4;90(5):836-46. doi: 10.1016/j.ajhg.2012.03.018. Epub 2012 Apr 26.


Concentration- and stage-specific effects of nitrite on colon cancer cell lines.

Jiang H, Tang Y, Garg HK, Parthasarathy DK, Torregrossa AC, Hord NG, Bryan NS.

Nitric Oxide. 2012 May 15;26(4):267-73. doi: 10.1016/j.niox.2012.03.010. Epub 2012 Apr 5.


Sodium nitrite: the "cure" for nitric oxide insufficiency.

Parthasarathy DK, Bryan NS.

Meat Sci. 2012 Nov;92(3):274-9. doi: 10.1016/j.meatsci.2012.03.001. Epub 2012 Mar 10. Review.


Survey of residual nitrite and nitrate in conventional and organic/natural/uncured/indirectly cured meats available at retail in the United States.

Nuñez De González MT, Osburn WN, Hardin MD, Longnecker M, Garg HK, Bryan NS, Keeton JT.

J Agric Food Chem. 2012 Apr 18;60(15):3981-90. doi: 10.1021/jf204611k. Epub 2012 Apr 5.


Translational research in the developing world: molecular medicine goes global.

Mian AI, Bryan NS, Zaidi AK.

Trends Mol Med. 2012 Mar;18(3):135-7. doi: 10.1016/j.molmed.2012.01.002. Epub 2012 Feb 1. No abstract available.


Nitroso-redox status and vascular function in marginal and severe ascorbate deficiency.

Garcia-Saura MF, Saijo F, Bryan NS, Bauer S, Rodriguez J, Feelisch M.

Antioxid Redox Signal. 2012 Oct 1;17(7):937-50. doi: 10.1089/ars.2011.4201. Epub 2012 Mar 8.


Requirement of argininosuccinate lyase for systemic nitric oxide production.

Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B.

Nat Med. 2011 Nov 13;17(12):1619-26. doi: 10.1038/nm.2544.


Towards nitric oxide based diagnostics: call to action.

Aranke M, Bryan NS, Mian AI.

Trends Mol Med. 2011 Nov;17(11):614-6. doi: 10.1016/j.molmed.2011.07.006. Epub 2011 Aug 20. No abstract available.


An integrated approach to assessing nitroso-redox balance in systemic inflammation.

Dyson A, Bryan NS, Fernandez BO, Garcia-Saura MF, Saijo F, Mongardon N, Rodriguez J, Singer M, Feelisch M.

Free Radic Biol Med. 2011 Sep 15;51(6):1137-45. doi: 10.1016/j.freeradbiomed.2011.06.012. Epub 2011 Jun 14.


Urinary nitrate might be an early biomarker for pediatric acute kidney injury in the emergency department.

Mian AI, Du Y, Garg HK, Caviness AC, Goldstein SL, Bryan NS.

Pediatr Res. 2011 Aug;70(2):203-7. doi: 10.1203/PDR.0b013e31822188b4.


All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans.

Zand J, Lanza F, Garg HK, Bryan NS.

Nutr Res. 2011 Apr;31(4):262-9. doi: 10.1016/j.nutres.2011.03.008.


Letter by Bryan regarding article, "red and processed meat consumption and risk of incident coronary heart disease, stroke, and diabetes mellitus: a systematic review and meta-analysis".

Bryan NS.

Circulation. 2011 Jan 25;123(3):e16; author reply e17. doi: 10.1161/CIRCULATIONAHA.110.967604. No abstract available.


Redox-sensitivity and site-specificity of S- and N- denitrosation in proteins.

Jourd'heuil FL, Lowery AM, Melton EM, Mnaimneh S, Bryan NS, Fernandez BO, Park JH, Ha CE, Bhagavan NV, Feelisch M, Jourd'heuil D.

PLoS One. 2010 Dec 21;5(12):e14400. doi: 10.1371/journal.pone.0014400.


Nitrite and nitrate: cardiovascular risk-benefit and metabolic effect.

Tang Y, Jiang H, Bryan NS.

Curr Opin Lipidol. 2011 Feb;22(1):11-5. doi: 10.1097/MOL.0b013e328341942c. Review.


Nitrate and nitrite content of human, formula, bovine, and soy milks: implications for dietary nitrite and nitrate recommendations.

Hord NG, Ghannam JS, Garg HK, Berens PD, Bryan NS.

Breastfeed Med. 2011 Dec;6(6):393-9. doi: 10.1089/bfm.2010.0070. Epub 2010 Oct 19.

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