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Items: 1 to 50 of 54

1.

Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α1β3γ2 GABAAR Transmembrane Domain.

Jayakar SS, Zhou X, Chiara DC, Jarava-Barrera C, Savechenkov PY, Bruzik KS, Tortosa M, Miller KW, Cohen JB.

Mol Pharmacol. 2019 Jun;95(6):615-628. doi: 10.1124/mol.118.114975. Epub 2019 Apr 5.

PMID:
30952799
2.

A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor.

Yu Z, Chiara DC, Savechenkov PY, Bruzik KS, Cohen JB.

J Biol Chem. 2019 May 10;294(19):7892-7903. doi: 10.1074/jbc.RA118.007172. Epub 2019 Mar 28.

PMID:
30923128
3.

Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors.

Wu B, Jayakar SS, Zhou X, Titterton K, Chiara DC, Szabo AL, Savechenkov PY, Kent DE, Cohen JB, Forman SA, Miller KW, Bruzik KS.

Eur J Med Chem. 2019 Jan 15;162:810-824. doi: 10.1016/j.ejmech.2018.11.019. Epub 2018 Nov 19.

PMID:
30544077
4.

Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands.

Savechenkov PY, Chiara DC, Desai R, Stern AT, Zhou X, Ziemba AM, Szabo AL, Zhang Y, Cohen JB, Forman SA, Miller KW, Bruzik KS.

Eur J Med Chem. 2017 Aug 18;136:334-347. doi: 10.1016/j.ejmech.2017.04.043. Epub 2017 Apr 21.

5.

General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type A Receptors (GABAARs).

Chiara DC, Jounaidi Y, Zhou X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB.

J Biol Chem. 2016 Dec 16;291(51):26529-26539. Epub 2016 Nov 7.

6.

Synthesis of Biotinylated Inositol Hexakisphosphate To Study DNA Double-Strand Break Repair and Affinity Capture of IP6-Binding Proteins.

Jiao C, Summerlin M, Bruzik KS, Hanakahi L.

Biochemistry. 2015 Oct 20;54(41):6312-22. doi: 10.1021/acs.biochem.5b00642. Epub 2015 Oct 7.

PMID:
26397942
7.

Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.

Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW.

J Physiol. 2015 Nov 15;593(22):4943-61. doi: 10.1113/JP270971.

8.

Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface.

Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB.

J Biol Chem. 2015 Sep 18;290(38):23432-46. doi: 10.1074/jbc.M115.672006. Epub 2015 Jul 30.

9.

Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.

Jayakar SS, Zhou X, Chiara DC, Dostalova Z, Savechenkov PY, Bruzik KS, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB.

J Biol Chem. 2014 Oct 3;289(40):27456-68. doi: 10.1074/jbc.M114.581728. Epub 2014 Aug 1.

10.

Identifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H]allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate.

Hamouda AK, Stewart DS, Chiara DC, Savechenkov PY, Bruzik KS, Cohen JB.

Mol Pharmacol. 2014 May;85(5):735-46. doi: 10.1124/mol.113.090985. Epub 2014 Feb 21.

11.

Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.

Chiara DC, Jayakar SS, Zhou X, Zhang X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB.

J Biol Chem. 2013 Jul 5;288(27):19343-57. doi: 10.1074/jbc.M113.479725. Epub 2013 May 15.

12.

Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cδ*.

Shanmugasundararaj S, Das J, Sandberg WS, Zhou X, Wang D, Messing RO, Bruzik KS, Stehle T, Miller KW.

Biophys J. 2012 Dec 5;103(11):2331-40. doi: 10.1016/j.bpj.2012.10.034.

13.

Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue.

Yue L, Pawlowski M, Dellal SS, Xie A, Feng F, Otis TS, Bruzik KS, Qian H, Pepperberg DR.

Nat Commun. 2012;3:1095. doi: 10.1038/ncomms2094.

14.

Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.

Savechenkov PY, Zhang X, Chiara DC, Stewart DS, Ge R, Zhou X, Raines DE, Cohen JB, Forman SA, Miller KW, Bruzik KS.

J Med Chem. 2012 Jul 26;55(14):6554-65. doi: 10.1021/jm300631e. Epub 2012 Jul 17.

15.

The glycerophosphoinositols and their cellular functions.

Corda D, Zizza P, Varone A, Bruzik KS, Mariggiò S.

Biochem Soc Trans. 2012 Feb;40(1):101-7. doi: 10.1042/BST20110679.

PMID:
22260673
16.

p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.

Stewart DS, Savechenkov PY, Dostalova Z, Chiara DC, Ge R, Raines DE, Cohen JB, Forman SA, Bruzik KS, Miller KW.

J Med Chem. 2011 Dec 8;54(23):8124-35. doi: 10.1021/jm200943f. Epub 2011 Nov 10.

17.

Potentiating action of propofol at GABAA receptors of retinal bipolar cells.

Yue L, Xie A, Bruzik KS, Frølund B, Qian H, Pepperberg DR.

Invest Ophthalmol Vis Sci. 2011 Apr 16;52(5):2497-509. doi: 10.1167/iovs.10-5991. Print 2011 Apr.

18.

Unique catalytic mechanism of phosphatidylinositol-specific phospholipase C from Streptomyces antibioticus.

Bai C, Zhao L, Tsai MD, Bruzik KS.

J Am Chem Soc. 2010 Feb 3;132(4):1210-1. doi: 10.1021/ja908285h.

19.

Trans-cyclization of phosphatidylinositol catalyzed by phospholipase C from Streptomyces antibioticus.

Bai C, Zhao L, Rebecchi M, Tsai MD, Bruzik KS.

J Am Chem Soc. 2009 Jun 24;131(24):8362-3. doi: 10.1021/ja902326u.

20.

Phosphorothiolate analogues of phosphatidylinositols as assay substrates for phospholipase C.

Liu Y, Mihai C, Kubiak RJ, Rebecchi M, Bruzik KS.

Chembiochem. 2007 Aug 13;8(12):1430-9.

PMID:
17659518
21.

Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.

Stahelin RV, Karathanassis D, Bruzik KS, Waterfield MD, Bravo J, Williams RL, Cho W.

J Biol Chem. 2006 Dec 22;281(51):39396-406. Epub 2006 Oct 12.

22.

Mechanism of membrane binding of the phospholipase D1 PX domain.

Stahelin RV, Ananthanarayanan B, Blatner NR, Singh S, Bruzik KS, Murray D, Cho W.

J Biol Chem. 2004 Dec 24;279(52):54918-26. Epub 2004 Oct 8.

23.

New aspects of formation of 1,2-cyclic phosphates by phospholipase C-delta1.

Liu Y, Bruzik KS, Ananthanarayanan B, Cho W.

Bioorg Med Chem. 2003 May 29;11(11):2471-5.

PMID:
12735994
24.

Application of Brønsted-type LFER in the study of the phospholipase C mechanism.

Mihai C, Kravchuk AV, Tsai MD, Bruzik KS.

J Am Chem Soc. 2003 Mar 19;125(11):3236-42.

PMID:
12630878
25.
26.
27.

Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox.

Stahelin RV, Burian A, Bruzik KS, Murray D, Cho W.

J Biol Chem. 2003 Apr 18;278(16):14469-79. Epub 2003 Jan 29.

29.

Phosphatidylinositol 3-phosphate induces the membrane penetration of the FYVE domains of Vps27p and Hrs.

Stahelin RV, Long F, Diraviyam K, Bruzik KS, Murray D, Cho W.

J Biol Chem. 2002 Jul 19;277(29):26379-88. Epub 2002 May 10.

30.

Reactivities of inositol and ribonucleoside phosphodiesters toward P--O bond cleavage.

Kubiak RJ, Bruzik KS.

J Am Chem Soc. 2001 Feb 28;123(8):1760-1. No abstract available.

PMID:
11456778
31.

Mechanism of phosphatidylinositol-specific phospholipase C: origin of unusually high nonbridging thio effects.

Kravchuk AV, Zhao L, Kubiak RJ, Bruzik KS, Tsai MD.

Biochemistry. 2001 May 8;40(18):5433-9.

PMID:
11331007
32.

Involvement of the Arg-Asp-His catalytic triad in enzymatic cleavage of the phosphodiester bond.

Kubiak RJ, Yue X, Hondal RJ, Mihai C, Tsai MD, Bruzik KS.

Biochemistry. 2001 May 8;40(18):5422-32.

PMID:
11331006
33.

Kinetic Isotope Effects and Stereochemical Studies on a Ribonuclease Model: Hydrolysis Reactions of Uridine 3'-Nitrophenyl Phosphate.

Hengge AC, Bruzik KS, Tobin AE, Cleland WW, Tsai MD.

Bioorg Chem. 2000 Jun;28(3):119-133.

PMID:
10915550
34.

Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate.

Yang X, Rudolf M, Carew MA, Yoshida M, Nerreter V, Riley AM, Chung SK, Bruzik KS, Potter BV, Schultz C, Shears SB.

J Biol Chem. 1999 Jul 2;274(27):18973-80.

35.

Regulation of Ca2+-dependent Cl- conductance in a human colonic epithelial cell line (T84): cross-talk between Ins(3,4,5,6)P4 and protein phosphatases.

Xie W, Solomons KR, Freeman S, Kaetzel MA, Bruzik KS, Nelson DJ, Shears SB.

J Physiol. 1998 Aug 1;510 ( Pt 3):661-73.

36.

Mechanism of phosphatidylinositol-specific phospholipase C: a unified view of the mechanism of catalysis.

Hondal RJ, Zhao Z, Kravchuk AV, Liao H, Riddle SR, Yue X, Bruzik KS, Tsai MD.

Biochemistry. 1998 Mar 31;37(13):4568-80.

PMID:
9521777
37.

Inhibition by inositoltetrakisphosphates of calcium- and volume-activated Cl- currents in macrovascular endothelial cells.

Nilius B, Prenen J, Voets T, Eggermont J, Bruzik KS, Shears SB, Droogmans G.

Pflugers Arch. 1998 Apr;435(5):637-44.

PMID:
9479016
38.

Phosphatidylinositol-specific phospholipase C: kinetic and stereochemical evidence for an interaction between arginine-69 and the phosphate group of phosphatidylinositol.

Hondal RJ, Riddle SR, Kravchuk AV, Zhao Z, Liao H, Bruzik KS, Tsai MD.

Biochemistry. 1997 Jun 3;36(22):6633-42.

PMID:
9184143
39.

Ins(3,4,5,6)P4 specifically inhibits a receptor-mediated Ca2+-dependent Cl- current in CFPAC-1 cells.

Ho MW, Shears SB, Bruzik KS, Duszyk M, French AS.

Am J Physiol. 1997 Apr;272(4 Pt 1):C1160-8.

PMID:
9142840
42.
43.

Are D- and L-chiro-phosphoinositides substrates of phosphatidylinositol-specific phospholipase C?

Bruzik KS, Hakeem AA, Tsai MD.

Biochemistry. 1994 Jul 12;33(27):8367-74.

PMID:
8031771
44.

Toward the mechanism of phosphoinositide-specific phospholipases C.

Bruzik KS, Tsai MD.

Bioorg Med Chem. 1994 Feb;2(2):49-72. Review. No abstract available.

PMID:
7922124
45.
46.

Phospholipase stereospecificity at phosphorus.

Bruzik KS, Tsai MD.

Methods Enzymol. 1991;197:258-69. No abstract available.

PMID:
1646930
47.

Nuclear magnetic resonance study of sphingomyelin bilayers.

Bruzik KS, Sobon B, Salamonczyk GM.

Biochemistry. 1990 Apr 24;29(16):4017-21.

PMID:
2354174
48.

13C CP-MAS study of the gel phases of 1,2-dipalmitoylphosphatidylcholine.

Bruzik KS, Salamonczyk GM, Sobon B.

Biochim Biophys Acta. 1990 Mar 30;1023(1):143-6. Erratum in: Biochim Biophys Acta 1990 Apr 30;1023(3):483.

PMID:
2337426
49.
50.

Conformation of the polar headgroup of sphingomyelin and its analogues.

Bruzik KS.

Biochim Biophys Acta. 1988 Apr 7;939(2):315-26.

PMID:
3355820

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