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A Potent CD1d-binding Glycolipid for iNKT-Cell-based Therapy Against Human Breast Cancer.

Seki T, Liu J, Brutkiewicz RR, Tsuji M.

Anticancer Res. 2019 Feb;39(2):549-555. doi: 10.21873/anticanres.13147.


JNK2 modulates the CD1d-dependent and -independent activation of iNKT cells.

Liu J, Gallo RM, Khan MA, Iyer AK, Kratzke IM, Brutkiewicz RR.

Eur J Immunol. 2019 Feb;49(2):255-265. doi: 10.1002/eji.201847755. Epub 2018 Dec 3.


Immune evasion of the CD1d/NKT cell axis.

Brutkiewicz RR, Yunes-Medina L, Liu J.

Curr Opin Immunol. 2018 Jun;52:87-92. doi: 10.1016/j.coi.2018.04.021. Epub 2018 May 4. Review.


Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T-Cell Lymphoma.

Liu J, Gallo RM, Khan MA, Renukaradhya GJ, Brutkiewicz RR.

Front Immunol. 2018 Jan 5;8:1901. doi: 10.3389/fimmu.2017.01901. eCollection 2017.


The Toll-like receptor 9 signalling pathway regulates MR1-mediated bacterial antigen presentation in B cells.

Liu J, Brutkiewicz RR.

Immunology. 2017 Oct;152(2):232-242. doi: 10.1111/imm.12759. Epub 2017 Jun 29.


Cell Signaling Pathways That Regulate Antigen Presentation.

Brutkiewicz RR.

J Immunol. 2016 Oct 15;197(8):2971-2979. Review.


A VP22-Null HSV-1 Is Impaired in Inhibiting CD1d-Mediated Antigen Presentation.

Liu J, Gallo RM, Duffy C, Brutkiewicz RR.

Viral Immunol. 2016 Sep;29(7):409-16. doi: 10.1089/vim.2015.0145. Epub 2016 Jun 21.


Alterations in cellular metabolism modulate CD1d-mediated NKT-cell responses.

Webb TJ, Carey GB, East JE, Sun W, Bollino DR, Kimball AS, Brutkiewicz RR.

Pathog Dis. 2016 Aug;74(6). pii: ftw055. doi: 10.1093/femspd/ftw055. Epub 2016 Jun 12.


STAT3 promotes CD1d-mediated lipid antigen presentation by regulating a critical gene in glycosphingolipid biosynthesis.

Iyer AK, Liu J, Gallo RM, Kaplan MH, Brutkiewicz RR.

Immunology. 2015 Nov;146(3):444-55. doi: 10.1111/imm.12521. Epub 2015 Sep 21.


Critical role of NKT cells in posttransplant alloantibody production.

Zimmerer JM, Swamy P, Sanghavi PB, Wright CL, Abdel-Rasoul M, Elzein SM, Brutkiewicz RR, Bumgardner GL.

Am J Transplant. 2014 Nov;14(11):2491-9. doi: 10.1111/ajt.12922. Epub 2014 Sep 12.


Inhibition of CD1d-mediated antigen presentation by the transforming growth factor-β/Smad signalling pathway.

Bailey JC, Iyer AK, Renukaradhya GJ, Lin Y, Nguyen H, Brutkiewicz RR.

Immunology. 2014 Dec;143(4):679-91. doi: 10.1111/imm.12353.


Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.

Walline CC, Deffit SN, Wang N, Guindon LM, Crotzer VL, Liu J, Hollister K, Eisenlohr LC, Brutkiewicz RR, Kaplan MH, Blum JS.

Immunology. 2014 Apr;141(4):531-9. doi: 10.1111/imm.12210.


Forming a complex with MHC class I molecules interferes with mouse CD1d functional expression.

Gourapura RJ, Khan MA, Gallo RM, Shaji D, Liu J, Brutkiewicz RR.

PLoS One. 2013 Aug 29;8(8):e72867. doi: 10.1371/journal.pone.0072867. eCollection 2013.


Allergic airway disease in mice alters T and B cell responses during an acute respiratory poxvirus infection.

Walline CC, Sehra S, Fisher AJ, Guindon LM, Kratzke IM, Montgomery JB, Lipking KP, Glosson NL, Benson HL, Sandusky GE, Wilkes DS, Brutkiewicz RR, Kaplan MH, Blum JS.

PLoS One. 2013 Apr 19;8(4):e62222. doi: 10.1371/journal.pone.0062222. Print 2013.


An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD.

Zeng MY, Pham D, Bagaitkar J, Liu J, Otero K, Shan M, Wynn TA, Brombacher F, Brutkiewicz RR, Kaplan MH, Dinauer MC.

Blood. 2013 Apr 25;121(17):3473-83. doi: 10.1182/blood-2012-10-461913. Epub 2013 Feb 20.


Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.

Gallo RM, Khan MA, Shi J, Kapur R, Wei L, Bailey JC, Liu J, Brutkiewicz RR.

J Immunol. 2012 Aug 15;189(4):1689-98. doi: 10.4049/jimmunol.1101484. Epub 2012 Jul 13.


CD1d expression on and regulation of murine hematopoietic stem and progenitor cells.

Broxmeyer HE, Christopherson K, Hangoc G, Cooper S, Mantel C, Renukaradhya GJ, Brutkiewicz RR.

Blood. 2012 Jun 14;119(24):5731-41. doi: 10.1182/blood-2012-01-404012. Epub 2012 Apr 25.


Lipids-Я-Us: peroxisome generation of iNKT ligands.

Brutkiewicz RR, Dent AL.

Nat Immunol. 2012 Apr 18;13(5):435-6. doi: 10.1038/ni.2288. No abstract available.


Donor lung derived myeloid and plasmacytoid dendritic cells differentially regulate T cell proliferation and cytokine production.

Benson HL, Suzuki H, Lott J, Fisher AJ, Walline C, Heidler KM, Brutkiewicz R, Blum JS, Wilkes DS.

Respir Res. 2012 Mar 20;13:25. doi: 10.1186/1465-9921-13-25.


CD1d-expressing breast cancer cells modulate NKT cell-mediated antitumor immunity in a murine model of breast cancer metastasis.

Hix LM, Shi YH, Brutkiewicz RR, Stein PL, Wang CR, Zhang M.

PLoS One. 2011;6(6):e20702. doi: 10.1371/journal.pone.0020702. Epub 2011 Jun 13.


STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis.

Kaplan MH, Glosson NL, Stritesky GL, Yeh N, Kinzfogl J, Rohrabaugh SL, Goswami R, Pham D, Levy DE, Brutkiewicz RR, Blum JS, Cooper S, Hangoc G, Broxmeyer HE.

Blood. 2011 Jun 9;117(23):6198-201. doi: 10.1182/blood-2011-02-334367. Epub 2011 Apr 19.


Research faculty development: an historical perspective and ideas for a successful future.

Brutkiewicz RR.

Adv Health Sci Educ Theory Pract. 2012 May;17(2):259-68. doi: 10.1007/s10459-010-9261-4. Epub 2010 Nov 20.


Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype.

Yeh N, Glosson NL, Wang N, Guindon L, McKinley C, Hamada H, Li Q, Dutton RW, Shrikant P, Zhou B, Brutkiewicz RR, Blum JS, Kaplan MH.

J Immunol. 2010 Aug 15;185(4):2089-98. doi: 10.4049/jimmunol.1000818. Epub 2010 Jul 12.


A threonine-based targeting signal in the human CD1d cytoplasmic tail controls its functional expression.

Liu J, Shaji D, Cho S, Du W, Gervay-Hague J, Brutkiewicz RR.

J Immunol. 2010 May 1;184(9):4973-81. doi: 10.4049/jimmunol.0901448. Epub 2010 Apr 5.


Anthrax lethal toxin impairs CD1d-mediated antigen presentation by targeting the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway.

Khan MA, Gallo RM, Brutkiewicz RR.

Infect Immun. 2010 May;78(5):1859-63. doi: 10.1128/IAI.01307-09. Epub 2010 Mar 1.


Diversifying Biomedical Training: A Synergistic Intervention.

Gibau GS, Foertsch J, Blum J, Brutkiewicz R, Queener S, Roman A, Rhodes S, Sturek M, Wilkes D, Broxmeyer H.

J Women Minor Sci Eng. 2010;16(3):215-235.


Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation.

Khan MA, Gallo RM, Renukaradhya GJ, Du W, Gervay-Hague J, Brutkiewicz RR.

J Immunol. 2009 Apr 15;182(8):4744-50. doi: 10.4049/jimmunol.0804311.


MHC class II-expressing thymocytes suppress invariant NKT cell development.

Li W, Sofi MH, Wei DG, Du W, Gervay-Hague J, Renukaradhya GJ, Brutkiewicz RR, Chang CH.

Immunol Cell Biol. 2009 Feb;87(2):186-9. doi: 10.1038/icb.2008.78. Epub 2008 Nov 4.


Vesicular stomatitis virus matrix protein impairs CD1d-mediated antigen presentation through activation of the p38 MAPK pathway.

Renukaradhya GJ, Khan MA, Shaji D, Brutkiewicz RR.

J Virol. 2008 Dec;82(24):12535-42. doi: 10.1128/JVI.00881-08. Epub 2008 Sep 24.


Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons.

Mann BA, Huang JH, Li P, Chang HC, Slee RB, O'Sullivan A, Anita M, Yeh N, Klemsz MJ, Brutkiewicz RR, Blum JS, Kaplan MH.

J Interferon Cytokine Res. 2008 Jun;28(6):367-80. doi: 10.1089/jir.2007.0113.


Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma.

Renukaradhya GJ, Khan MA, Vieira M, Du W, Gervay-Hague J, Brutkiewicz RR.

Blood. 2008 Jun 15;111(12):5637-45. doi: 10.1182/blood-2007-05-092866. Epub 2008 Apr 16.


Apoptosis-induced inhibition of CD1d-mediated antigen presentation: different roles for caspases and signal transduction pathways.

Khan MA, Sriram V, Renukaradhya GJ, Du W, Gervay-Hague J, Brutkiewicz RR.

Immunology. 2008 Sep;125(1):80-90. doi: 10.1111/j.1365-2567.2008.02823.x. Epub 2008 Mar 14.


Importance of N-linked glycosylation in the functional expression of murine CD1d1.

Sriram V, Willard CA, Liu J, Brutkiewicz RR.

Immunology. 2008 Feb;123(2):272-81. Epub 2007 Aug 28. Erratum in: Immunology. 2008 Mar;123(3):457.


Thymic selection pathway regulates the effector function of CD4 T cells.

Li W, Sofi MH, Yeh N, Sehra S, McCarthy BP, Patel DR, Brutkiewicz RR, Kaplan MH, Chang CH.

J Exp Med. 2007 Sep 3;204(9):2145-57. Epub 2007 Aug 27.


Protein kinase C delta is a critical regulator of CD1d-mediated antigen presentation.

Brutkiewicz RR, Willard CA, Gillett-Heacock KK, Pawlak MR, Bailey JC, Khan MA, Nagala M, Du W, Gervay-Hague J, Renukaradhya GJ.

Eur J Immunol. 2007 Sep;37(9):2390-5.


Vaccinia virus infection induces dendritic cell maturation but inhibits antigen presentation by MHC class II.

Yao Y, Li P, Singh P, Thiele AT, Wilkes DS, Renukaradhya GJ, Brutkiewicz RR, Travers JB, Luker GD, Hong SC, Blum JS, Chang CH.

Cell Immunol. 2007 Apr;246(2):92-102. Epub 2007 Aug 2.


A role for natural killer T cells and CD1d molecules in counteracting suppression of hematopoiesis in mice induced by infection with murine cytomegalovirus.

Broxmeyer HE, Dent A, Cooper S, Hangoc G, Wang ZY, Du W, Gervay-Haque J, Sriram V, Renukaradhya GJ, Brutkiewicz RR.

Exp Hematol. 2007 Apr;35(4 Suppl 1):87-93.


Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules.

Webb TJ, Litavecz RA, Khan MA, Du W, Gervay-Hague J, Renukaradhya GJ, Brutkiewicz RR.

Eur J Immunol. 2006 Oct;36(10):2595-600.


Selective identification of Valpha14i T cells using slide-immobilized, CD1d-antigen complexes.

Zullo AJ, Brutkiewicz RR, Taparowsky EJ.

J Immunoassay Immunochem. 2006;27(3):207-12.


CD1d ligands: the good, the bad, and the ugly.

Brutkiewicz RR.

J Immunol. 2006 Jul 15;177(2):769-75. Review.


CD44 differentially activates mouse NK T cells and conventional T cells.

Larkin J, Renukaradhya GJ, Sriram V, Du W, Gervay-Hague J, Brutkiewicz RR.

J Immunol. 2006 Jul 1;177(1):268-79.


Inhibition of antitumor immunity by invariant natural killer T cells in a T-cell lymphoma model in vivo.

Renukaradhya GJ, Sriram V, Du W, Gervay-Hague J, Van Kaer L, Brutkiewicz RR.

Int J Cancer. 2006 Jun 15;118(12):3045-53. Erratum in: Int J Cancer. 2006 Nov 1;119(9):2246.


Regulation of Th2 cytokine expression in NKT cells: unconventional use of Stat6, GATA-3, and NFAT2.

Wang ZY, Kusam S, Munugalavadla V, Kapur R, Brutkiewicz RR, Dent AL.

J Immunol. 2006 Jan 15;176(2):880-8.


Role for IL-4 nonproducing NKT cells in CC-chemokine ligand 2-induced Th2 cell generation.

Fujita K, Kobayashi M, Brutkiewicz RR, Hanafusa T, Herndon DN, Suzuki F.

Immunol Cell Biol. 2006 Feb;84(1):44-50. Epub 2005 Nov 7.


Disruption of MHC class II-restricted antigen presentation by vaccinia virus.

Li P, Wang N, Zhou D, Yee CS, Chang CH, Brutkiewicz RR, Blum JS.

J Immunol. 2005 Nov 15;175(10):6481-8.


Virus-induced inhibition of CD1d1-mediated antigen presentation: reciprocal regulation by p38 and ERK.

Renukaradhya GJ, Webb TJ, Khan MA, Lin YL, Du W, Gervay-Hague J, Brutkiewicz RR.

J Immunol. 2005 Oct 1;175(7):4301-8.


Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex.

Cho S, Knox KS, Kohli LM, He JJ, Exley MA, Wilson SB, Brutkiewicz RR.

Virology. 2005 Jul 5;337(2):242-52.


Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells.

Sriram V, Du W, Gervay-Hague J, Brutkiewicz RR.

Eur J Immunol. 2005 Jun;35(6):1692-701.


Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens.

Zhou D, Li P, Lin Y, Lott JM, Hislop AD, Canaday DH, Brutkiewicz RR, Blum JS.

Immunity. 2005 May;22(5):571-81.

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