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Items: 26

1.

Engineered Reader Proteins for Enhanced Detection of Methylated Lysine on Histones.

Albanese KI, Krone MW, Petell CJ, Parker MM, Strahl BD, Brustad EM, Waters ML.

ACS Chem Biol. 2019 Oct 21. doi: 10.1021/acschembio.9b00651. [Epub ahead of print]

PMID:
31634430
2.

Active Targeting of Cancer Cells by Nanobody Decorated Polypeptide Micelle with Bio-orthogonally Conjugated Drug.

Costa SA, Mozhdehi D, Dzuricky MJ, Isaacs FJ, Brustad EM, Chilkoti A.

Nano Lett. 2019 Jan 9;19(1):247-254. doi: 10.1021/acs.nanolett.8b03837. Epub 2018 Dec 14.

PMID:
30540482
3.

Osmolytes and Protein-Protein Interactions.

Rydeen AE, Brustad EM, Pielak GJ.

J Am Chem Soc. 2018 Jun 20;140(24):7441-7444. doi: 10.1021/jacs.8b03903. Epub 2018 Jun 11.

PMID:
29842777
4.

Enhancing cytochrome P450-mediated non-natural cyclopropanation by mutation of a conserved second-shell residue.

Gober JG, Rydeen AE, Schwochert TD, Gibson-O'Grady EJ, Brustad EM.

Biotechnol Bioeng. 2018 Jun;115(6):1416-1426. doi: 10.1002/bit.26571. Epub 2018 Mar 6.

PMID:
29460311
5.

Photo-Crosslinkable Unnatural Amino Acids Enable Facile Synthesis of Thermoresponsive Nano- to Microgels of Intrinsically Disordered Polypeptides.

Costa SA, Simon JR, Amiram M, Tang L, Zauscher S, Brustad EM, Isaacs FJ, Chilkoti A.

Adv Mater. 2018 Feb;30(5). doi: 10.1002/adma.201704878. Epub 2017 Dec 11.

6.

Investigation of Trimethyllysine Binding by the HP1 Chromodomain via Unnatural Amino Acid Mutagenesis.

Baril SA, Koenig AL, Krone MW, Albanese KI, He CQ, Lee GY, Houk KN, Waters ML, Brustad EM.

J Am Chem Soc. 2017 Dec 6;139(48):17253-17256. doi: 10.1021/jacs.7b09223. Epub 2017 Nov 20.

7.

Orthogonal Expression of an Artificial Metalloenzyme for Abiotic Catalysis.

Reynolds EW, Schwochert TD, McHenry MW, Watters JW, Brustad EM.

Chembiochem. 2017 Dec 14;18(24):2380-2384. doi: 10.1002/cbic.201700397. Epub 2017 Nov 9.

8.

P450-Mediated Non-natural Cyclopropanation of Dehydroalanine-Containing Thiopeptides.

Gober JG, Ghodge SV, Bogart JW, Wever WJ, Watkins RR, Brustad EM, Bowers AA.

ACS Chem Biol. 2017 Jul 21;12(7):1726-1731. doi: 10.1021/acschembio.7b00358. Epub 2017 Jun 1.

PMID:
28535034
9.

Corrigendum: Mutating a Highly Conserved Residue in Diverse Cytochrome P450s Facilitates Diastereoselective Olefin Cyclopropanation.

Gober JG, Rydeen AE, Gibson-O'Grady EJ, Leuthaeuser JB, Fetrow JS, Brustad EM.

Chembiochem. 2016 Nov 3;17(21):2099. doi: 10.1002/cbic.201600528. Epub 2016 Oct 12. No abstract available.

PMID:
27805325
10.

Correction to "An Evolved Orthogonal Enzyme/Cofactor Pair".

Reynolds EW, McHenry MW, Cannac F, Gober JG, Snow CD, Brustad EM.

J Am Chem Soc. 2016 Nov 2;138(43):14506. Epub 2016 Oct 19. No abstract available.

PMID:
27759385
11.

Non-natural carbenoid and nitrenoid insertion reactions catalyzed by heme proteins.

Gober JG, Brustad EM.

Curr Opin Chem Biol. 2016 Dec;35:124-132. doi: 10.1016/j.cbpa.2016.09.004. Epub 2016 Sep 30. Review.

PMID:
27697701
12.

An Evolved Orthogonal Enzyme/Cofactor Pair.

Reynolds EW, McHenry MW, Cannac F, Gober JG, Snow CD, Brustad EM.

J Am Chem Soc. 2016 Sep 28;138(38):12451-8. doi: 10.1021/jacs.6b05847. Epub 2016 Sep 16. Erratum in: J Am Chem Soc. 2016 Nov 2;138(43):14506.

PMID:
27575374
13.

Mutating a Highly Conserved Residue in Diverse Cytochrome P450s Facilitates Diastereoselective Olefin Cyclopropanation.

Gober JG, Rydeen AE, Gibson-O'Grady EJ, Leuthaeuser JB, Fetrow JS, Brustad EM.

Chembiochem. 2016 Mar 2;17(5):394-7. doi: 10.1002/cbic.201500624. Epub 2016 Feb 4. Erratum in: Chembiochem. 2016 Nov 3;17 (21):2099.

14.

Tissue-specific proteome tagging: an orthogonal approach.

Snyder AL, Brustad EM.

Chembiochem. 2014 Aug 18;15(12):1731-3. doi: 10.1002/cbic.201402210. Epub 2014 Jul 2. Review.

PMID:
24990619
15.

C-H activation: New recipes for biocatalysis.

Brustad EM.

Nat Chem Biol. 2014 Mar;10(3):170-1. doi: 10.1038/nchembio.1457. Epub 2014 Jan 26. No abstract available.

PMID:
24463699
16.

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo.

Coelho PS, Wang ZJ, Ener ME, Baril SA, Kannan A, Arnold FH, Brustad EM.

Nat Chem Biol. 2013 Aug;9(8):485-7. doi: 10.1038/nchembio.1278. Epub 2013 Jun 23. Erratum in: Nat Chem Biol. 2014 Feb;10(2):164.

17.

General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH.

Brinkmann-Chen S, Flock T, Cahn JK, Snow CD, Brustad EM, McIntosh JA, Meinhold P, Zhang L, Arnold FH.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10946-51. doi: 10.1073/pnas.1306073110. Epub 2013 Jun 17.

18.

Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes.

Coelho PS, Brustad EM, Kannan A, Arnold FH.

Science. 2013 Jan 18;339(6117):307-10. doi: 10.1126/science.1231434. Epub 2012 Dec 20.

19.

Chimeragenesis of distantly-related proteins by noncontiguous recombination.

Smith MA, Romero PA, Wu T, Brustad EM, Arnold FH.

Protein Sci. 2013 Feb;22(2):231-8. doi: 10.1002/pro.2202. Epub 2012 Dec 29.

20.

Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol.

Liu X, Bastian S, Snow CD, Brustad EM, Saleski TE, Xu JH, Meinhold P, Arnold FH.

J Biotechnol. 2012 Dec 15;164(2):188-95. doi: 10.1016/j.jbiotec.2012.08.008. Epub 2012 Sep 3.

21.

Structure-guided directed evolution of highly selective p450-based magnetic resonance imaging sensors for dopamine and serotonin.

Brustad EM, Lelyveld VS, Snow CD, Crook N, Jung ST, Martinez FM, Scholl TJ, Jasanoff A, Arnold FH.

J Mol Biol. 2012 Sep 14;422(2):245-62. doi: 10.1016/j.jmb.2012.05.029. Epub 2012 May 30.

22.

Optimizing non-natural protein function with directed evolution.

Brustad EM, Arnold FH.

Curr Opin Chem Biol. 2011 Apr;15(2):201-10. doi: 10.1016/j.cbpa.2010.11.020. Epub 2010 Dec 23. Review.

23.

Site-directed spin labeling of a genetically encoded unnatural amino acid.

Fleissner MR, Brustad EM, Kálai T, Altenbach C, Cascio D, Peters FB, Hideg K, Peuker S, Schultz PG, Hubbell WL.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21637-42. doi: 10.1073/pnas.0912009106. Epub 2009 Dec 7. Erratum in: Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5693. Peuker, Sebastian [added].

24.

Microfluidic device for single-molecule experiments with enhanced photostability.

Lemke EA, Gambin Y, Vandelinder V, Brustad EM, Liu HW, Schultz PG, Groisman A, Deniz AA.

J Am Chem Soc. 2009 Sep 30;131(38):13610-2. doi: 10.1021/ja9027023.

25.

Evolution of proteins with genetically encoded "chemical warheads".

Liu CC, Mack AV, Brustad EM, Mills JH, Groff D, Smider VV, Schultz PG.

J Am Chem Soc. 2009 Jul 22;131(28):9616-7. doi: 10.1021/ja902985e.

26.

A general and efficient method for the site-specific dual-labeling of proteins for single molecule fluorescence resonance energy transfer.

Brustad EM, Lemke EA, Schultz PG, Deniz AA.

J Am Chem Soc. 2008 Dec 31;130(52):17664-5. doi: 10.1021/ja807430h.

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