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A new era for treatment of drug-resistant tuberculosis.

Gandhi NR, Brust JCM, Shah NS.

Eur Respir J. 2018 Oct 4;52(4). pii: 1801350. doi: 10.1183/13993003.01350-2018. Print 2018 Oct. No abstract available.


Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis.

Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–2017, Ahmad N, Ahuja SD, Akkerman OW, Alffenaar JC, Anderson LF, Baghaei P, Bang D, Barry PM, Bastos ML, Behera D, Benedetti A, Bisson GP, Boeree MJ, Bonnet M, Brode SK, Brust JCM, Cai Y, Caumes E, Cegielski JP, Centis R, Chan PC, Chan ED, Chang KC, Charles M, Cirule A, Dalcolmo MP, D'Ambrosio L, de Vries G, Dheda K, Esmail A, Flood J, Fox GJ, Fréchet-Jachym M, Fregona G, Gayoso R, Gegia M, Gler MT, Gu S, Guglielmetti L, Holtz TH, Hughes J, Isaakidis P, Jarlsberg L, Kempker RR, Keshavjee S, Khan FA, Kipiani M, Koenig SP, Koh WJ, Kritski A, Kuksa L, Kvasnovsky CL, Kwak N, Lan Z, Lange C, Laniado-Laborín R, Lee M, Leimane V, Leung CC, Leung EC, Li PZ, Lowenthal P, Maciel EL, Marks SM, Mase S, Mbuagbaw L, Migliori GB, Milanov V, Miller AC, Mitnick CD, Modongo C, Mohr E, Monedero I, Nahid P, Ndjeka N, O'Donnell MR, Padayatchi N, Palmero D, Pape JW, Podewils LJ, Reynolds I, Riekstina V, Robert J, Rodriguez M, Seaworth B, Seung KJ, Schnippel K, Shim TS, Singla R, Smith SE, Sotgiu G, Sukhbaatar G, Tabarsi P, Tiberi S, Trajman A, Trieu L, Udwadia ZF, van der Werf TS, Veziris N, Viiklepp P, Vilbrun SC, Walsh K, Westenhouse J, Yew WW, Yim JJ, Zetola NM, Zignol M, Menzies D.

Lancet. 2018 Sep 8;392(10150):821-834. doi: 10.1016/S0140-6736(18)31644-1. Review.


Extensively drug-resistant tuberculosis in South Africa: genomic evidence supporting transmission in communities.

Auld SC, Shah NS, Mathema B, Brown TS, Ismail N, Omar SV, Brust JCM, Nelson KN, Allana S, Campbell A, Mlisana K, Moodley P, Gandhi NR.

Eur Respir J. 2018 Oct 18;52(4). pii: 1800246. doi: 10.1183/13993003.00246-2018. Print 2018 Oct.


Spatial Patterns of Extensively Drug-Resistant Tuberculosis Transmission in KwaZulu-Natal, South Africa.

Nelson KN, Shah NS, Mathema B, Ismail N, Brust JCM, Brown TS, Auld SC, Omar SV, Morris N, Campbell A, Allana S, Moodley P, Mlisana K, Gandhi NR.

J Infect Dis. 2018 Nov 5;218(12):1964-1973. doi: 10.1093/infdis/jiy394.


MDR-TB patients in KwaZulu-Natal, South Africa: Cost-effectiveness of 5 models of care.

Loveday M, Wallengren K, Reddy T, Besada D, Brust JCM, Voce A, Desai H, Ngozo J, Radebe Z, Master I, Padayatchi N, Daviaud E.

PLoS One. 2018 Apr 18;13(4):e0196003. doi: 10.1371/journal.pone.0196003. eCollection 2018.


Improved Survival and Cure Rates With Concurrent Treatment for Multidrug-Resistant Tuberculosis-Human Immunodeficiency Virus Coinfection in South Africa.

Brust JCM, Shah NS, Mlisana K, Moodley P, Allana S, Campbell A, Johnson BA, Master I, Mthiyane T, Lachman S, Larkan LM, Ning Y, Malik A, Smith JP, Gandhi NR.

Clin Infect Dis. 2018 Apr 3;66(8):1246-1253. doi: 10.1093/cid/cix1125.


Spatial distribution of extensively drug-resistant tuberculosis (XDR TB) patients in KwaZulu-Natal, South Africa.

Kapwata T, Morris N, Campbell A, Mthiyane T, Mpangase P, Nelson KN, Allana S, Brust JCM, Moodley P, Mlisana K, Gandhi NR, Shah NS.

PLoS One. 2017 Oct 13;12(10):e0181797. doi: 10.1371/journal.pone.0181797. eCollection 2017.


Polymorphisms in the vitamin D receptor gene are associated with reduced rate of sputum culture conversion in multidrug-resistant tuberculosis patients in South Africa.

Magee MJ, Sun YV, Brust JCM, Shah NS, Ning Y, Allana S, Campbell A, Hui Q, Mlisana K, Moodley P, Gandhi NR.

PLoS One. 2017 Jul 10;12(7):e0180916. doi: 10.1371/journal.pone.0180916. eCollection 2017.


Drug-resistant tuberculosis in patients with minimal symptoms: favourable outcomes in the absence of treatment.

Loveday M, Ramjee A, Osburn G, Master I, Kabera G, Brust JC, Padayatchi N, Warren R, Theron G.

Int J Tuberc Lung Dis. 2017 May 1;21(5):556-563. doi: 10.5588/ijtld.16.0779.


pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia.

Allana S, Shashkina E, Mathema B, Bablishvili N, Tukvadze N, Shah NS, Kempker RR, Blumberg HM, Moodley P, Mlisana K, Brust JC, Gandhi NR.

Emerg Infect Dis. 2017 Mar;23(3):491-495. doi: 10.3201/eid2303.161034.


Transmission of Extensively Drug-Resistant Tuberculosis in South Africa.

Shah NS, Auld SC, Brust JC, Mathema B, Ismail N, Moodley P, Mlisana K, Allana S, Campbell A, Mthiyane T, Morris N, Mpangase P, van der Meulen H, Omar SV, Brown TS, Narechania A, Shaskina E, Kapwata T, Kreiswirth B, Gandhi NR.

N Engl J Med. 2017 Jan 19;376(3):243-253. doi: 10.1056/NEJMoa1604544.


More on Treatment Outcomes in Multidrug-Resistant Tuberculosis.

Brust JC, Shah NS, Gandhi NR.

N Engl J Med. 2016 Dec 29;375(26):2610. doi: 10.1056/NEJMc1613123. No abstract available.


Dilemma of managing asymptomatic children referred with 'culture-confirmed' drug-resistant tuberculosis.

Loveday M, Sunkari B, Marais BJ, Master I, Brust JC.

Arch Dis Child. 2016 Jul;101(7):608-13. doi: 10.1136/archdischild-2015-310186. Epub 2016 Apr 4.


Re-inventing adherence: toward a patient-centered model of care for drug-resistant tuberculosis and HIV.

O'Donnell MR, Daftary A, Frick M, Hirsch-Moverman Y, Amico KR, Senthilingam M, Wolf A, Metcalfe JZ, Isaakidis P, Davis JL, Zelnick JR, Brust JC, Naidu N, Garretson M, Bangsberg DR, Padayatchi N, Friedland G.

Int J Tuberc Lung Dis. 2016 Apr;20(4):430-4. doi: 10.5588/ijtld.15.0360.


High Prevalence of inhA Promoter Mutations among Patients with Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa.

Niehaus AJ, Mlisana K, Gandhi NR, Mathema B, Brust JC.

PLoS One. 2015 Sep 2;10(9):e0135003. doi: 10.1371/journal.pone.0135003. eCollection 2015.


Incidence and Geographic Distribution of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa.

Lim JR, Gandhi NR, Mthiyane T, Mlisana K, Moodley J, Jaglal P, Ramdin N, Brust JC, Ismail N, Rustomjee R, Shah NS.

PLoS One. 2015 Jul 6;10(7):e0132076. doi: 10.1371/journal.pone.0132076. eCollection 2015.


Comment: Prescription opioids-Misused or misunderstood?

Brust JC.

Neurology. 2015 Aug 18;85(7):650. doi: 10.1212/WNL.0000000000001775. Epub 2015 Jul 2. No abstract available.


Acute withdrawal: diagnosis and treatment.

Brust JC.

Handb Clin Neurol. 2014;125:123-31. doi: 10.1016/B978-0-444-62619-6.00008-2. Review.


Author response.

Brust JC.

Neurology. 2014 Aug 19;83(8):772. No abstract available.


Spice, pot, and stroke.

Barber PA, Anderson NE, Brust JC.

Neurology. 2014 Aug 19;83(8):772. doi: 10.1212/WNL.0000000000000722. No abstract available.


Neurologic complications of illicit drug abuse.

Brust JC.

Continuum (Minneap Minn). 2014 Jun;20(3 Neurology of Systemic Disease):642-56. doi: 10.1212/ Review.


Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology.

Koppel BS, Brust JC, Fife T, Bronstein J, Youssof S, Gronseth G, Gloss D.

Neurology. 2014 Apr 29;82(17):1556-63. doi: 10.1212/WNL.0000000000000363. Review.


Association between health systems performance and treatment outcomes in patients co-infected with MDR-TB and HIV in KwaZulu-Natal, South Africa: implications for TB programmes.

Loveday M, Padayatchi N, Wallengren K, Roberts J, Brust JC, Ngozo J, Master I, Voce A.

PLoS One. 2014 Apr 9;9(4):e94016. doi: 10.1371/journal.pone.0094016. eCollection 2014.


Minimal diversity of drug-resistant Mycobacterium tuberculosis strains, South Africa.

Gandhi NR, Brust JC, Moodley P, Weissman D, Heo M, Ning Y, Moll AP, Friedland GH, Sturm AW, Shah NS.

Emerg Infect Dis. 2014 Mar;20(3):426-33. doi: 10.3201/eid2003.131083.


Spice, pot, and stroke.

Brust JC.

Neurology. 2013 Dec 10;81(24):2064-5. doi: 10.1212/01.wnl.0000437310.96160.fa. Epub 2013 Nov 8.


Chest radiograph findings and time to culture conversion in patients with multidrug-resistant tuberculosis and HIV in Tugela Ferry, South Africa.

Brust JC, Berman AR, Zalta B, Haramati LB, Ning Y, Heo M, van der Merwe TL, Bamber S, Moll AP, Friedland GH, Shah NS, Gandhi NR.

PLoS One. 2013 Sep 6;8(9):e73975. doi: 10.1371/journal.pone.0073975. eCollection 2013.


Natural ventilation reduces high TB transmission risk in traditional homes in rural KwaZulu-Natal, South Africa.

Lygizos M, Shenoi SV, Brooks RP, Bhushan A, Brust JC, Zelterman D, Deng Y, Northrup V, Moll AP, Friedland GH.

BMC Infect Dis. 2013 Jul 1;13:300. doi: 10.1186/1471-2334-13-300.


Adverse events in an integrated home-based treatment program for MDR-TB and HIV in KwaZulu-Natal, South Africa.

Brust JC, Shah NS, van der Merwe TL, Bamber S, Ning Y, Heo M, Moll AP, Loveday M, Lalloo UG, Friedland GH, Gandhi NR.

J Acquir Immune Defic Syndr. 2013 Apr 1;62(4):436-40. doi: 10.1097/QAI.0b013e31828175ed.


Reply to Seddon, Schaaf, and Hesseling.

Dooley KE, Mitnick C, Degroote MA, Obuku E, Hamilton CD, Makhene M, Shah S, Brust JC, Durakovic N, Nuermberger E; Efficacy Subgroup, RESIST-TB.

Clin Infect Dis. 2013 Jan;56(1):168-9. doi: 10.1093/cid/cis820. Epub 2012 Sep 18. No abstract available.


Meningococcal meningitis, dexamethasone, and Class III evidence.

Brust JC.

Neurology. 2012 Oct 9;79(15):1528-9. doi: 10.1212/WNL.0b013e31826e7398. Epub 2012 Sep 12. No abstract available.


Cognition and cannabis: from anecdote to advanced technology.

Brust JC.

Brain. 2012 Jul;135(Pt 7):2004-5. doi: 10.1093/brain/aws165. No abstract available.


Integrated, home-based treatment for MDR-TB and HIV in rural South Africa: an alternate model of care.

Brust JC, Shah NS, Scott M, Chaiyachati K, Lygizos M, van der Merwe TL, Bamber S, Radebe Z, Loveday M, Moll AP, Margot B, Lalloo UG, Friedland GH, Gandhi NR.

Int J Tuberc Lung Dis. 2012 Aug;16(8):998-1004. doi: 10.5588/ijtld.11.0713. Epub 2012 Jun 5.


Old drugs, new purpose: retooling existing drugs for optimized treatment of resistant tuberculosis.

Dooley KE, Mitnick CD, Ann DeGroote M, Obuku E, Belitsky V, Hamilton CD, Makhene M, Shah S, Brust JC, Durakovic N, Nuermberger E; Efficacy Subgroup, RESIST-TB.

Clin Infect Dis. 2012 Aug;55(4):572-81. Epub 2012 May 21. Review.


Risk factors for mortality among MDR- and XDR-TB patients in a high HIV prevalence setting.

Gandhi NR, Andrews JR, Brust JC, Montreuil R, Weissman D, Heo M, Moll AP, Friedland GH, Shah NS.

Int J Tuberc Lung Dis. 2012 Jan;16(1):90-7. doi: 10.5588/ijtld.11.0153.


Effect of delayed diagnosis on severity of Pott's disease.

Kamara E, Mehta S, Brust JC, Jain AK.

Int Orthop. 2012 Feb;36(2):245-54. doi: 10.1007/s00264-011-1432-2. Epub 2012 Jan 4.


A contemporary reflection on Charcot and vibratory therapeutics.

Brust JC.

J Nerv Ment Dis. 2011 Nov;199(11):830-1. doi: 10.1097/NMD.0b013e3182348e2f. No abstract available.


TB/HIV: an orphan disease?

Brust JC, O'Donnell MR, Metcalfe JZ.

Am J Respir Crit Care Med. 2011 Jun 1;183(11):1441-2. doi: 10.1164/rccm.201010-1753ED. No abstract available.


Culture conversion among HIV co-infected multidrug-resistant tuberculosis patients in Tugela Ferry, South Africa.

Brust JC, Lygizos M, Chaiyachati K, Scott M, van der Merwe TL, Moll AP, Li X, Loveday M, Bamber SA, Lalloo UG, Friedland GH, Shah NS, Gandhi NR.

PLoS One. 2011 Jan 6;6(1):e15841. doi: 10.1371/journal.pone.0015841.


Directly observed antiretroviral therapy in substance abusers receiving methadone maintenance therapy does not cause increased drug resistance.

Brust JC, Litwin AH, Berg KM, Li X, Heo M, Arnsten JH.

AIDS Res Hum Retroviruses. 2011 May;27(5):535-41. doi: 10.1089/aid.2010.0181. Epub 2010 Nov 23.


Substance abuse and movement disorders.

Brust JC.

Mov Disord. 2010 Oct 15;25(13):2010-20. doi: 10.1002/mds.22599. Review.


Ethanol and cognition: indirect effects, neurotoxicity and neuroprotection: a review.

Brust JC.

Int J Environ Res Public Health. 2010 Apr;7(4):1540-57. doi: 10.3390/ijerph7041540. Epub 2010 Apr 4. Review.


High treatment failure and default rates for patients with multidrug-resistant tuberculosis in KwaZulu-Natal, South Africa, 2000-2003.

Brust JC, Gandhi NR, Carrara H, Osburn G, Padayatchi N.

Int J Tuberc Lung Dis. 2010 Apr;14(4):413-9.


Five cases of bacteraemia due to Gordonia species.

Brust JC, Whittier S, Scully BE, McGregor CC, Yin MT.

J Med Microbiol. 2009 Oct;58(Pt 10):1376-8. doi: 10.1099/jmm.0.010272-0. Epub 2009 Jun 15.


Seizures, illicit drugs, and ethanol.

Brust JC.

Curr Neurol Neurosci Rep. 2008 Jul;8(4):333-8. Review.


The association of race and sex with the underuse of stroke prevention measures.

Tuhrim S, Cooperman A, Rojas M, Brust JC, Koppel B, Martin K, Chassin M.

J Stroke Cerebrovasc Dis. 2008 Jul-Aug;17(4):226-34. doi: 10.1016/j.jstrokecerebrovasdis.2008.02.003.


A 74-year-old man with memory loss and neuropathy who enjoys alcoholic beverages.

Brust JC.

JAMA. 2008 Mar 5;299(9):1046-54. doi: 10.1001/jama.299.5.jrr80000. Epub 2008 Feb 5.


Seizures and substance abuse: treatment considerations.

Brust JC.

Neurology. 2006 Dec 26;67(12 Suppl 4):S45-8. Review.


Sudden deafness from stroke.

Boylan LS, Staudinger R, Brust JC.

Neurology. 2006 Sep 12;67(5):919; author reply 919. No abstract available.


Antihypertensive therapy and cognition: more questions than answers.

Brust JC.

Stroke. 2006 May;37(5):1146. Epub 2006 Apr 6. No abstract available.


Vivid visual hallucinations from occipital lobe infarction.

Flint AC, Loh JP, Brust JC.

Neurology. 2005 Sep 13;65(5):756. No abstract available.


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