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Items: 24


An application of mass spectrometry for quality control of biologicals: Highly sensitive profiling of plasma residuals in human plasma-derived immunoglobulin.

Limonier F, Van Steendam K, Waeterloos G, Brusselmans K, Sneyers M, Deforce D.

J Proteomics. 2017 Jan 30;152:312-320. doi: 10.1016/j.jprot.2016.11.007. Epub 2016 Nov 26.


Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development.

Willemarck N, Rysman E, Brusselmans K, Van Imschoot G, Vanderhoydonc F, Moerloose K, Lerut E, Verhoeven G, van Roy F, Vleminckx K, Swinnen JV.

Cancer Res. 2010 Nov 15;70(22):9453-62. doi: 10.1158/0008-5472.CAN-10-2324. Epub 2010 Oct 1.


De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation.

Rysman E, Brusselmans K, Scheys K, Timmermans L, Derua R, Munck S, Van Veldhoven PP, Waltregny D, Daniëls VW, Machiels J, Vanderhoydonc F, Smans K, Waelkens E, Verhoeven G, Swinnen JV.

Cancer Res. 2010 Oct 15;70(20):8117-26. doi: 10.1158/0008-5472.CAN-09-3871. Epub 2010 Sep 28.


Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells.

Beckers A, Organe S, Timmermans L, Scheys K, Peeters A, Brusselmans K, Verhoeven G, Swinnen JV.

Cancer Res. 2007 Sep 1;67(17):8180-7.


Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation.

Brusselmans K, Timmermans L, Van de Sande T, Van Veldhoven PP, Guan G, Shechter I, Claessens F, Verhoeven G, Swinnen JV.

J Biol Chem. 2007 Jun 29;282(26):18777-85. Epub 2007 May 5.


Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.

Beckers A, Organe S, Timmermans L, Vanderhoydonc F, Deboel L, Derua R, Waelkens E, Brusselmans K, Verhoeven G, Swinnen JV.

Mol Cancer Ther. 2006 Sep;5(9):2211-7.


Increased lipogenesis in cancer cells: new players, novel targets.

Swinnen JV, Brusselmans K, Verhoeven G.

Curr Opin Clin Nutr Metab Care. 2006 Jul;9(4):358-65. Review.


Genetic evidence for a tumor suppressor role of HIF-2alpha.

Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P.

Cancer Cell. 2005 Aug;8(2):131-41.


Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype.

Swinnen JV, Beckers A, Brusselmans K, Organe S, Segers J, Timmermans L, Vanderhoydonc F, Deboel L, Derua R, Waelkens E, De Schrijver E, Van de Sande T, Noël A, Foufelle F, Verhoeven G.

Cancer Res. 2005 Mar 15;65(6):2441-8.


Androgens, lipogenesis and prostate cancer.

Swinnen JV, Heemers H, van de Sande T, de Schrijver E, Brusselmans K, Heyns W, Verhoeven G.

J Steroid Biochem Mol Biol. 2004 Nov;92(4):273-9. Epub 2004 Dec 19. Review.


A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia.

Brusselmans K, Bono F, Collen D, Herbert JM, Carmeliet P, Dewerchin M.

J Biol Chem. 2005 Feb 4;280(5):3493-9. Epub 2004 Nov 29.


Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity.

Brusselmans K, Vrolix R, Verhoeven G, Swinnen JV.

J Biol Chem. 2005 Feb 18;280(7):5636-45. Epub 2004 Nov 8.


Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha.

Compernolle V, Brusselmans K, Franco D, Moorman A, Dewerchin M, Collen D, Carmeliet P.

Cardiovasc Res. 2003 Dec 1;60(3):569-79.


Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia.

Brusselmans K, Compernolle V, Tjwa M, Wiesener MS, Maxwell PH, Collen D, Carmeliet P.

J Clin Invest. 2003 May;111(10):1519-27.


Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains.

Swinnen JV, Van Veldhoven PP, Timmermans L, De Schrijver E, Brusselmans K, Vanderhoydonc F, Van de Sande T, Heemers H, Heyns W, Verhoeven G.

Biochem Biophys Res Commun. 2003 Mar 21;302(4):898-903.


Loss of placental growth factor protects mice against vascular permeability in pathological conditions.

Luttun A, Brusselmans K, Fukao H, Tjwa M, Ueshima S, Herbert JM, Matsuo O, Collen D, Carmeliet P, Moons L.

Biochem Biophys Res Commun. 2002 Jul 12;295(2):428-34.


Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice.

Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, Nemery B, Dewerchin M, Van Veldhoven P, Plate K, Moons L, Collen D, Carmeliet P.

Nat Med. 2002 Jul;8(7):702-10. Epub 2002 Jun 10. Erratum in: Nat Med 2002 Nov;8(11):1329.


Hypoxia-inducible factor-2alpha (HIF-2alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia.

Brusselmans K, Bono F, Maxwell P, Dor Y, Dewerchin M, Collen D, Herbert JM, Carmeliet P.

J Biol Chem. 2001 Oct 19;276(42):39192-6. Epub 2001 Aug 23.


Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

Oosthuyse B, Moons L, Storkebaum E, Beck H, Nuyens D, Brusselmans K, Van Dorpe J, Hellings P, Gorselink M, Heymans S, Theilmeier G, Dewerchin M, Laudenbach V, Vermylen P, Raat H, Acker T, Vleminckx V, Van Den Bosch L, Cashman N, Fujisawa H, Drost MR, Sciot R, Bruyninckx F, Hicklin DJ, Ince C, Gressens P, Lupu F, Plate KH, Robberecht W, Herbert JM, Collen D, Carmeliet P.

Nat Genet. 2001 Jun;28(2):131-8.


Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188.

Carmeliet P, Ng YS, Nuyens D, Theilmeier G, Brusselmans K, Cornelissen I, Ehler E, Kakkar VV, Stalmans I, Mattot V, Perriard JC, Dewerchin M, Flameng W, Nagy A, Lupu F, Moons L, Collen D, D'Amore PA, Shima DT.

Nat Med. 1999 May;5(5):495-502. No abstract available.


Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.

Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E.

Nature. 1998 Jul 30;394(6692):485-90. Erratum in: Nature 1998 Oct 1;395(6701):525. Keshet E [corrected to Keshert E].


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