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Items: 1 to 50 of 60

1.

An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.

Futch HS, McFarland KN, Moore BD, Kuhn MZ, Giasson BI, Ladd TB, Scott KA, Shapiro MR, Nosacka RL, Goodwin MS, Ran Y, Cruz PE, Ryu DH, Croft CL, Levites Y, Janus C, Chakrabarty P, Judge AR, Brusko TM, de Kloet AD, Krause EG, Golde TE.

J Exp Med. 2019 Aug 29. pii: jem.20190430. doi: 10.1084/jem.20190430. [Epub ahead of print]

PMID:
31467037
2.

Islet-immune interactions in type 1 diabetes: the nexus of beta cell destruction.

Peters L, Posgai A, Brusko TM.

Clin Exp Immunol. 2019 Jul 15. doi: 10.1111/cei.13349. [Epub ahead of print] Review.

PMID:
31309537
3.

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances.

Ahmed S, Cerosaletti K, James E, Long SA, Mannering S, Speake C, Nakayama M, Tree T, Roep BO, Herold KC, Brusko TM.

Diabetes. 2019 Jul;68(7):1366-1379. doi: 10.2337/db19-0119.

PMID:
31221801
4.

Metformin Inhibits the Type 1 IFN Response in Human CD4+ T Cells.

Titov AA, Baker HV, Brusko TM, Sobel ES, Morel L.

J Immunol. 2019 Jul 15;203(2):338-348. doi: 10.4049/jimmunol.1801651. Epub 2019 Jun 3.

PMID:
31160534
5.

Pleiotropic roles of the insulin-like growth factor axis in type 1 diabetes.

Shapiro MR, Atkinson MA, Brusko TM.

Curr Opin Endocrinol Diabetes Obes. 2019 Aug;26(4):188-194. doi: 10.1097/MED.0000000000000484.

PMID:
31145130
6.

Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model.

Lewis JS, Stewart JM, Marshall GP, Carstens MR, Zhang Y, Dolgova NV, Xia C, Brusko TM, Wasserfall CH, Clare-Salzler MJ, Atkinson MA, Keselowsky BG.

ACS Biomater Sci Eng. 2019 May 13;5(5):2631-2646. doi: 10.1021/acsbiomaterials.9b00332. Epub 2019 Mar 26.

7.

Crossreactive public TCR sequences undergo positive selection in the human thymic repertoire.

Khosravi-Maharlooei M, Obradovic A, Misra A, Motwani K, Holzl M, Seay HR, DeWolf S, Nauman G, Danzl N, Li H, Ho SH, Winchester R, Shen Y, Brusko TM, Sykes M.

J Clin Invest. 2019 Mar 28;129(6):2446-2462. doi: 10.1172/JCI124358.

8.

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.

Van Gool F, Nguyen MLT, Mumbach MR, Satpathy AT, Rosenthal WL, Giacometti S, Le DT, Liu W, Brusko TM, Anderson MS, Rudensky AY, Marson A, Chang HY, Bluestone JA.

Immunity. 2019 Feb 19;50(2):362-377.e6. doi: 10.1016/j.immuni.2018.12.016. Epub 2019 Jan 29.

PMID:
30709738
9.

A checkpoint on innate myeloid cells in pulmonary arterial hypertension.

Bryant AJ, Fu C, Lu Y, Brantly ML, Mehrad B, Moldawer LL, Brusko TM, Brittain EL, West JD, Austin ED, Hamid R.

Pulm Circ. 2019 Jan-Mar;9(1):2045894018823528. doi: 10.1177/2045894018823528. Epub 2018 Dec 18. No abstract available.

10.

Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells.

Choi SC, Titov AA, Abboud G, Seay HR, Brusko TM, Roopenian DC, Salek-Ardakani S, Morel L.

Nat Commun. 2018 Oct 22;9(1):4369. doi: 10.1038/s41467-018-06686-0.

11.

Immune Mechanisms and Pathways Targeted in Type 1 Diabetes.

Jacobsen LM, Newby BN, Perry DJ, Posgai AL, Haller MJ, Brusko TM.

Curr Diab Rep. 2018 Aug 30;18(10):90. doi: 10.1007/s11892-018-1066-5. Review.

PMID:
30168021
12.

Myeloid-Derived Suppressor Cells and Pulmonary Hypertension.

Bryant AJ, Mehrad B, Brusko TM, West JD, Moldawer LL.

Int J Mol Sci. 2018 Aug 3;19(8). pii: E2277. doi: 10.3390/ijms19082277. Review.

13.

Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.

Perry DJ, Wasserfall CH, Oram RA, Williams MD, Posgai A, Muir AB, Haller MJ, Schatz DA, Wallet MA, Mathews CE, Atkinson MA, Brusko TM.

Sci Rep. 2018 Mar 14;8(1):4529. doi: 10.1038/s41598-018-22574-5.

14.

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.

Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P.

Front Immunol. 2018 Jan 15;8:1844. doi: 10.3389/fimmu.2017.01844. eCollection 2017.

15.

Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes.

Yeh WI, Seay HR, Newby B, Posgai AL, Moniz FB, Michels A, Mathews CE, Bluestone JA, Brusko TM.

Front Immunol. 2017 Oct 26;8:1313. doi: 10.3389/fimmu.2017.01313. eCollection 2017.

16.

Isogenic Cellular Systems Model the Impact of Genetic Risk Variants in the Pathogenesis of Type 1 Diabetes.

Wallet MA, Santostefano KE, Terada N, Brusko TM.

Front Endocrinol (Lausanne). 2017 Oct 18;8:276. doi: 10.3389/fendo.2017.00276. eCollection 2017. Review.

17.

T Cell Receptor Profiling in Type 1 Diabetes.

Jacobsen LM, Posgai A, Seay HR, Haller MJ, Brusko TM.

Curr Diab Rep. 2017 Oct 11;17(11):118. doi: 10.1007/s11892-017-0946-4. Review.

18.

T cells display mitochondria hyperpolarization in human type 1 diabetes.

Chen J, Chernatynskaya AV, Li JW, Kimbrell MR, Cassidy RJ, Perry DJ, Muir AB, Atkinson MA, Brusko TM, Mathews CE.

Sci Rep. 2017 Sep 7;7(1):10835. doi: 10.1038/s41598-017-11056-9.

19.

Type 1 Interferons Potentiate Human CD8+ T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway.

Newby BN, Brusko TM, Zou B, Atkinson MA, Clare-Salzler M, Mathews CE.

Diabetes. 2017 Dec;66(12):3061-3071. doi: 10.2337/db17-0106. Epub 2017 Sep 6.

20.

Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression.

Sebastiani G, Ventriglia G, Stabilini A, Socci C, Morsiani C, Laurenzi A, Nigi L, Formichi C, Mfarrej B, Petrelli A, Fousteri G, Brusko TM, Dotta F, Battaglia M.

Sci Rep. 2017 Jul 31;7(1):6897. doi: 10.1038/s41598-017-07172-1.

21.

Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults.

Marcial GE, Ford AL, Haller MJ, Gezan SA, Harrison NA, Cai D, Meyer JL, Perry DJ, Atkinson MA, Wasserfall CH, Garrett T, Gonzalez CF, Brusko TM, Dahl WJ, Lorca GL.

Front Immunol. 2017 Jun 12;8:655. doi: 10.3389/fimmu.2017.00655. eCollection 2017.

22.

Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy.

Seay HR, Putnam AL, Cserny J, Posgai AL, Rosenau EH, Wingard JR, Girard KF, Kraus M, Lares AP, Brown HL, Brown KS, Balavage KT, Peters LD, Bushdorf AN, Atkinson MA, Bluestone JA, Haller MJ, Brusko TM.

Mol Ther Methods Clin Dev. 2016 Dec 24;4:178-191. doi: 10.1016/j.omtm.2016.12.003. eCollection 2017 Mar 17.

23.

Serum Trypsinogen Levels in Type 1 Diabetes.

Li X, Campbell-Thompson M, Wasserfall CH, McGrail K, Posgai A, Schultz AR, Brusko TM, Shuster J, Liang F, Muir A, Schatz D, Haller MJ, Atkinson MA.

Diabetes Care. 2017 Apr;40(4):577-582. doi: 10.2337/dc16-1774. Epub 2017 Jan 23.

24.

Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes.

Seay HR, Yusko E, Rothweiler SJ, Zhang L, Posgai AL, Campbell-Thompson M, Vignali M, Emerson RO, Kaddis JS, Ko D, Nakayama M, Smith MJ, Cambier JC, Pugliese A, Atkinson MA, Robins HS, Brusko TM.

JCI Insight. 2016 Dec 8;1(20):e88242. doi: 10.1172/jci.insight.88242.

25.

Interferon-γ Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes.

Driver JP, Racine JJ, Ye C, Lamont DJ, Newby BN, Leeth CM, Chapman HD, Brusko TM, Chen YG, Mathews CE, Serreze DV.

Diabetes. 2017 Mar;66(3):710-721. doi: 10.2337/db16-0846. Epub 2016 Dec 5.

26.

Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.

Delitto D, Delitto AE, DiVita BB, Pham K, Han S, Hartlage ER, Newby BN, Gerber MH, Behrns KE, Moldawer LL, Thomas RM, George TJ Jr, Brusko TM, Mathews CE, Liu C, Trevino JG, Hughes SJ, Wallet SM.

Cancer Res. 2017 Feb 1;77(3):672-683. doi: 10.1158/0008-5472.CAN-16-1765. Epub 2016 Nov 18.

27.

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.

Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Perry DJ, Schultz AR, Hulme MA, Shuster JJ, Zou B, Wasserfall CH, Posgai AL, Mathews CE, Brusko TM, Atkinson MA, Schatz DA.

Diabetes. 2016 Dec;65(12):3765-3775. Epub 2016 Sep 26.

28.

The Lupus Susceptibility Gene Pbx1 Regulates the Balance between Follicular Helper T Cell and Regulatory T Cell Differentiation.

Choi SC, Hutchinson TE, Titov AA, Seay HR, Li S, Brusko TM, Croker BP, Salek-Ardakani S, Morel L.

J Immunol. 2016 Jul 15;197(2):458-69. doi: 10.4049/jimmunol.1502283. Epub 2016 Jun 13.

29.

Mobilization without immune depletion fails to restore immunological tolerance or preserve beta cell function in recent onset type 1 diabetes.

Haller MJ, Atkinson MA, Wasserfall CH, Brusko TM, Mathews CE, Hulme M, Cintron M, Shuster J, McGrail K, Posgai A, Schatz D.

Clin Exp Immunol. 2016 Mar;183(3):350-7. doi: 10.1111/cei.12731. Epub 2015 Dec 7.

30.

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.

Fuhrman CA, Yeh WI, Seay HR, Saikumar Lakshmi P, Chopra G, Zhang L, Perry DJ, McClymont SA, Yadav M, Lopez MC, Baker HV, Zhang Y, Li Y, Whitley M, von Schack D, Atkinson MA, Bluestone JA, Brusko TM.

J Immunol. 2015 Jul 1;195(1):145-55. doi: 10.4049/jimmunol.1402381. Epub 2015 May 20.

31.

Normalization of CD4+ T cell metabolism reverses lupus.

Yin Y, Choi SC, Xu Z, Perry DJ, Seay H, Croker BP, Sobel ES, Brusko TM, Morel L.

Sci Transl Med. 2015 Feb 11;7(274):274ra18. doi: 10.1126/scitranslmed.aaa0835.

32.

Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes.

Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Rosenthal SM, Shuster JJ, Zou B, Brusko TM, Hulme MA, Wasserfall CH, Mathews CE, Atkinson MA, Schatz DA.

J Clin Invest. 2015 Jan;125(1):448-55. doi: 10.1172/JCI78492. Epub 2014 Dec 15.

33.

Ex Vivo Expanded Autologous Polyclonal Regulatory T Cells Suppress Inhibitor Formation in Hemophilia.

Sarkar D, Biswas M, Liao G, Seay HR, Perrin GQ, Markusic DM, Hoffman BE, Brusko TM, Terhorst C, Herzog RW.

Mol Ther Methods Clin Dev. 2014 Jul 30;1. pii: 14030.

34.

Combinatorial delivery of immunosuppressive factors to dendritic cells using dual-sized microspheres.

Lewis JS, Roche C, Zhang Y, Brusko TM, Wasserfall CH, Atkinson M, Clare-Salzler MJ, Keselowsky BG.

J Mater Chem B. 2014 May 7;2(17):2562-2574.

35.

Influence of host immunoregulatory genes, ER stress and gut microbiota on the shared pathogenesis of inflammatory bowel disease and Type 1 diabetes.

Gjymishka A, Coman RM, Brusko TM, Glover SC.

Immunotherapy. 2013 Dec;5(12):1357-66. doi: 10.2217/imt.13.130. Review.

36.

Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression.

Mueller C, Chulay JD, Trapnell BC, Humphries M, Carey B, Sandhaus RA, McElvaney NG, Messina L, Tang Q, Rouhani FN, Campbell-Thompson M, Fu AD, Yachnis A, Knop DR, Ye GJ, Brantly M, Calcedo R, Somanathan S, Richman LP, Vonderheide RH, Hulme MA, Brusko TM, Wilson JM, Flotte TR.

J Clin Invest. 2013 Dec;123(12):5310-8. doi: 10.1172/JCI70314. Epub 2013 Nov 15.

37.

The autoimmune disease-associated SNP rs917997 of IL18RAP controls IFNγ production by PBMC.

Myhr CB, Hulme MA, Wasserfall CH, Hong PJ, Lakshmi PS, Schatz DA, Haller MJ, Brusko TM, Atkinson MA.

J Autoimmun. 2013 Aug;44:8-12. doi: 10.1016/j.jaut.2013.06.001. Epub 2013 Jul 24.

38.

Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes.

Haller MJ, Wasserfall CH, Hulme MA, Cintron M, Brusko TM, McGrail KM, Wingard JR, Theriaque DW, Shuster JJ, Ferguson RJ, Kozuch M, Clare-Salzler M, Atkinson MA, Schatz DA.

Biol Blood Marrow Transplant. 2013 Jul;19(7):1126-9. doi: 10.1016/j.bbmt.2013.04.011. Epub 2013 Apr 20.

39.

Autologous regulatory T cells for the treatment of type 1 diabetes.

Thompson JA, Perry D, Brusko TM.

Curr Diab Rep. 2012 Oct;12(5):623-32. doi: 10.1007/s11892-012-0304-5. Review.

PMID:
22843491
40.

Central role for interleukin-2 in type 1 diabetes.

Hulme MA, Wasserfall CH, Atkinson MA, Brusko TM.

Diabetes. 2012 Jan;61(1):14-22. doi: 10.2337/db11-1213. Review.

41.

Autologous umbilical cord blood transfusion in young children with type 1 diabetes fails to preserve C-peptide.

Haller MJ, Wasserfall CH, Hulme MA, Cintron M, Brusko TM, McGrail KM, Sumrall TM, Wingard JR, Theriaque DW, Shuster JJ, Atkinson MA, Schatz DA.

Diabetes Care. 2011 Dec;34(12):2567-9. doi: 10.2337/dc11-1406. Epub 2011 Oct 19.

42.

Defective response of CD4(+) T cells to retinoic acid and TGFβ in systemic lupus erythematosus.

Sobel ES, Brusko TM, Butfiloski EJ, Hou W, Li S, Cuda CM, Abid AN, Reeves WH, Morel L.

Arthritis Res Ther. 2011 Jun 27;13(3):R106. doi: 10.1186/ar3387.

43.

Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

McClymont SA, Putnam AL, Lee MR, Esensten JH, Liu W, Hulme MA, Hoffmüller U, Baron U, Olek S, Bluestone JA, Brusko TM.

J Immunol. 2011 Apr 1;186(7):3918-26. doi: 10.4049/jimmunol.1003099. Epub 2011 Mar 2.

44.

Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells.

Golovina TN, Mikheeva T, Brusko TM, Blazar BR, Bluestone JA, Riley JL.

PLoS One. 2011 Jan 6;6(1):e15868. doi: 10.1371/journal.pone.0015868.

45.

Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.

Brusko TM, Koya RC, Zhu S, Lee MR, Putnam AL, McClymont SA, Nishimura MI, Han S, Chang LJ, Atkinson MA, Ribas A, Bluestone JA.

PLoS One. 2010 Jul 22;5(7):e11726. doi: 10.1371/journal.pone.0011726.

46.

Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.

Brusko TM, Wasserfall CH, Hulme MA, Cabrera R, Schatz D, Atkinson MA.

PLoS One. 2009 Nov 24;4(11):e7980. doi: 10.1371/journal.pone.0007980.

47.

Regulatory T cells directed to the site of the action.

Brusko TM, Bluestone JA.

Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20553-4. doi: 10.1073/pnas.0911848107. Epub 2009 Dec 1. No abstract available.

48.

Autologous umbilical cord blood transfusion in very young children with type 1 diabetes.

Haller MJ, Wasserfall CH, McGrail KM, Cintron M, Brusko TM, Wingard JR, Kelly SS, Shuster JJ, Atkinson MA, Schatz DA.

Diabetes Care. 2009 Nov;32(11):2041-6. doi: 10.2337/dc09-0967.

49.

Mesenchymal stem cells: a potential border patrol for transplanted islets?

Brusko TM.

Diabetes. 2009 Aug;58(8):1728-9. doi: 10.2337/db09-0749. No abstract available.

50.

Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency.

Xue S, Wasserfall CH, Parker M, Brusko TM, McGrail S, McGrail K, Moore M, Campbell-Thompson M, Schatz DA, Atkinson MA, Haller MJ.

Ann N Y Acad Sci. 2008 Dec;1150:152-6. doi: 10.1196/annals.1447.049.

PMID:
19120286

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