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Items: 1 to 50 of 89

1.

Serine-47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase-3 activity.

Kalpage HA, Vaishnav A, Liu J, Varughese A, Wan J, Turner AA, Ji Q, Zurek MP, Kapralov AA, Kagan VE, Brunzelle JS, Recanati MA, Grossman LI, Sanderson TH, Lee I, Salomon AR, Edwards BFP, Hüttemann M.

FASEB J. 2019 Sep 28:fj201901120R. doi: 10.1096/fj.201901120R. [Epub ahead of print]

PMID:
31570002
2.

Structural and Antiviral Studies of the Human Norovirus GII.4 Protease.

Muzzarelli KM, Kuiper B, Spellmon N, Brunzelle J, Hackett J, Amblard F, Zhou S, Liu P, Kovari IA, Yang Z, Schinazi RF, Kovari LC.

Biochemistry. 2019 Feb 19;58(7):900-907. doi: 10.1021/acs.biochem.8b01063. Epub 2019 Jan 16.

PMID:
30605321
3.

A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity.

Cornett EM, Dickson BM, Krajewski K, Spellmon N, Umstead A, Vaughan RM, Shaw KM, Versluis PP, Cowles MW, Brunzelle J, Yang Z, Vega IE, Sun ZW, Rothbart SB.

Sci Adv. 2018 Nov 28;4(11):eaav2623. doi: 10.1126/sciadv.aav2623. eCollection 2018 Nov.

4.

Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.

Yan Y, Zhou XE, Novick SJ, Shaw SJ, Li Y, Brunzelle JS, Hitoshi Y, Griffin PR, Xu HE, Melcher K.

J Biol Chem. 2019 Jan 18;294(3):953-967. doi: 10.1074/jbc.RA118.004883. Epub 2018 Nov 26.

PMID:
30478170
5.

Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation.

Haddad JF, Yang Y, Takahashi YH, Joshi M, Chaudhary N, Woodfin AR, Benyoucef A, Yeung S, Brunzelle JS, Skiniotis G, Brand M, Shilatifard A, Couture JF.

Structure. 2018 Dec 4;26(12):1594-1603.e4. doi: 10.1016/j.str.2018.08.004. Epub 2018 Sep 27.

PMID:
30270175
6.

Structural Determinants of the Stereoinverting Activity of Pseudomonas stutzeri d-Phenylglycine Aminotransferase.

Walton CJW, Thiebaut F, Brunzelle JS, Couture JF, Chica RA.

Biochemistry. 2018 Sep 18;57(37):5437-5446. doi: 10.1021/acs.biochem.8b00767. Epub 2018 Sep 7.

PMID:
30153007
7.

Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.

Qu Q, Takahashi YH, Yang Y, Hu H, Zhang Y, Brunzelle JS, Couture JF, Shilatifard A, Skiniotis G.

Cell. 2018 Aug 23;174(5):1117-1126.e12. doi: 10.1016/j.cell.2018.07.020. Epub 2018 Aug 9.

8.

Crystal structure of Campylobacter jejuni peroxide regulator.

Sarvan S, Charih F, Butcher J, Brunzelle JS, Stintzi A, Couture JF.

FEBS Lett. 2018 Jul;592(13):2351-2360. doi: 10.1002/1873-3468.13120. Epub 2018 Jun 14.

9.

Functional insights into the interplay between DNA interaction and metal coordination in ferric uptake regulators.

Sarvan S, Charih F, Askoura M, Butcher J, Brunzelle JS, Stintzi A, Couture JF.

Sci Rep. 2018 May 8;8(1):7140. doi: 10.1038/s41598-018-25157-6.

10.

A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.

Ma H, Duan J, Ke J, He Y, Gu X, Xu TH, Yu H, Wang Y, Brunzelle JS, Jiang Y, Rothbart SB, Xu HE, Li J, Melcher K.

Sci Adv. 2017 Jun 2;3(6):e1601217. doi: 10.1126/sciadv.1601217. eCollection 2017 Jun.

11.

Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.

Pal K, Bandyopadhyay A, Zhou XE, Xu Q, Marciano DP, Brunzelle JS, Yerrum S, Griffin PR, Vande Woude G, Melcher K, Xu HE.

Structure. 2017 Jun 6;25(6):867-877.e3. doi: 10.1016/j.str.2017.04.015. Epub 2017 May 18.

12.

Molecular basis for the methylation specificity of ATXR5 for histone H3.

Bergamin E, Sarvan S, Malette J, Eram MS, Yeung S, Mongeon V, Joshi M, Brunzelle JS, Michaels SD, Blais A, Vedadi M, Couture JF.

Nucleic Acids Res. 2017 Jun 20;45(11):6375-6387. doi: 10.1093/nar/gkx224.

13.

Structural basis of PDZ-mediated chemokine receptor CXCR2 scaffolding by guanine nucleotide exchange factor PDZ-RhoGEF.

Spellmon N, Holcomb J, Niu A, Choudhary V, Sun X, Zhang Y, Wan J, Doughan M, Hayden S, Hachem F, Brunzelle J, Li C, Yang Z.

Biochem Biophys Res Commun. 2017 Apr 1;485(2):529-534. doi: 10.1016/j.bbrc.2017.02.010. Epub 2017 Feb 6.

14.

Novel Aldo-Keto Reductases for the Biocatalytic Conversion of 3-Hydroxybutanal to 1,3-Butanediol: Structural and Biochemical Studies.

Kim T, Flick R, Brunzelle J, Singer A, Evdokimova E, Brown G, Joo JC, Minasov GA, Anderson WF, Mahadevan R, Savchenko A, Yakunin AF.

Appl Environ Microbiol. 2017 Mar 17;83(7). pii: e03172-16. doi: 10.1128/AEM.03172-16. Print 2017 Apr 1.

15.

Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination.

Billon P, Li J, Lambert JP, Chen Y, Tremblay V, Brunzelle JS, Gingras AC, Verreault A, Sugiyama T, Couture JF, Côté J.

Mol Cell. 2017 Jan 5;65(1):78-90. doi: 10.1016/j.molcel.2016.10.033. Epub 2016 Dec 1.

16.

Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: IMPLICATIONS FOR AMP KINASE.

Mahapatra G, Varughese A, Ji Q, Lee I, Liu J, Vaishnav A, Sinkler C, Kapralov AA, Moraes CT, Sanderson TH, Stemmler TL, Grossman LI, Kagan VE, Brunzelle JS, Salomon AR, Edwards BF, Hüttemann M.

J Biol Chem. 2017 Jan 6;292(1):64-79. doi: 10.1074/jbc.M116.744664. Epub 2016 Oct 7.

17.

Ligand Binding Enhances Millisecond Conformational Exchange in Xylanase B2 from Streptomyces lividans.

Gagné D, Narayanan C, Nguyen-Thi N, Roux LD, Bernard DN, Brunzelle JS, Couture JF, Agarwal PK, Doucet N.

Biochemistry. 2016 Aug 2;55(30):4184-96. doi: 10.1021/acs.biochem.6b00130. Epub 2016 Jul 21.

18.

Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors.

Ke J, Ma H, Gu X, Thelen A, Brunzelle JS, Li J, Xu HE, Melcher K.

Sci Adv. 2015 Jul 24;1(6):e1500107. doi: 10.1126/sciadv.1500107. eCollection 2015 Jul.

19.

The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.

Wan B, Tang T, Upton H, Shuai J, Zhou Y, Li S, Chen J, Brunzelle JS, Zeng Z, Collins K, Wu J, Lei M.

Nat Struct Mol Biol. 2015 Dec;22(12):1023-6. doi: 10.1038/nsmb.3126. Epub 2015 Nov 9.

20.

Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.

Zhang F, Yao J, Ke J, Zhang L, Lam VQ, Xin XF, Zhou XE, Chen J, Brunzelle J, Griffin PR, Zhou M, Xu HE, Melcher K, He SY.

Nature. 2015 Sep 10;525(7568):269-73. doi: 10.1038/nature14661. Epub 2015 Aug 10.

21.

The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops.

Kuiper BD, Keusch BJ, Dewdney TG, Chordia P, Ross K, Brunzelle JS, Kovari IA, MacArthur R, Salimnia H, Kovari LC.

Biochem Biophys Rep. 2015 Jun 12;2:160-165. doi: 10.1016/j.bbrep.2015.06.003. eCollection 2015 Jul.

22.

A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.

Zhang P, Chaturvedi CP, Tremblay V, Cramet M, Brunzelle JS, Skiniotis G, Brand M, Shilatifard A, Couture JF.

Genes Dev. 2015 Jan 15;29(2):123-8. doi: 10.1101/gad.254870.114.

23.

Structural and functional study of D-glucuronyl C5-epimerase.

Qin Y, Ke J, Gu X, Fang J, Wang W, Cong Q, Li J, Tan J, Brunzelle JS, Zhang C, Jiang Y, Melcher K, Li JP, Xu HE, Ding K.

J Biol Chem. 2015 Feb 20;290(8):4620-30. doi: 10.1074/jbc.M114.602201. Epub 2015 Jan 7.

24.

Molecular basis for DPY-30 association to COMPASS-like and NURF complexes.

Tremblay V, Zhang P, Chaturvedi CP, Thornton J, Brunzelle JS, Skiniotis G, Shilatifard A, Brand M, Couture JF.

Structure. 2014 Dec 2;22(12):1821-1830. doi: 10.1016/j.str.2014.10.002. Epub 2014 Nov 20.

25.

Agonist ligands mediate the transcriptional response of nuclear receptor heterodimers through distinct stoichiometric assemblies with coactivators.

Pavlin MR, Brunzelle JS, Fernandez EJ.

J Biol Chem. 2014 Sep 5;289(36):24771-8. doi: 10.1074/jbc.M114.575423. Epub 2014 Jul 22.

26.

Crystal structure of the NHERF1 PDZ2 domain in complex with the chemokine receptor CXCR2 reveals probable modes of PDZ2 dimerization.

Holcomb J, Jiang Y, Guan X, Trescott L, Lu G, Hou Y, Wang S, Brunzelle J, Sirinupong N, Li C, Yang Z.

Biochem Biophys Res Commun. 2014 May 30;448(2):169-74. doi: 10.1016/j.bbrc.2014.04.085. Epub 2014 Apr 24.

PMID:
24768637
27.

Crystallographic analysis of NHERF1-PLCβ3 interaction provides structural basis for CXCR2 signaling in pancreatic cancer.

Jiang Y, Wang S, Holcomb J, Trescott L, Guan X, Hou Y, Brunzelle J, Sirinupong N, Li C, Yang Z.

Biochem Biophys Res Commun. 2014 Apr 4;446(2):638-43. doi: 10.1016/j.bbrc.2014.03.028. Epub 2014 Mar 15.

PMID:
24642259
28.

Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication.

Jacob Y, Bergamin E, Donoghue MT, Mongeon V, LeBlanc C, Voigt P, Underwood CJ, Brunzelle JS, Michaels SD, Reinberg D, Couture JF, Martienssen RA.

Science. 2014 Mar 14;343(6176):1249-53. doi: 10.1126/science.1248357.

29.

Structural insights into PDZ-mediated interaction of NHERF2 and LPA(2), a cellular event implicated in CFTR channel regulation.

Holcomb J, Jiang Y, Lu G, Trescott L, Brunzelle J, Sirinupong N, Li C, Naren AP, Yang Z.

Biochem Biophys Res Commun. 2014 Mar 28;446(1):399-403. doi: 10.1016/j.bbrc.2014.02.128. Epub 2014 Mar 12.

30.

Structural insights into estrogen receptor α methylation by histone methyltransferase SMYD2, a cellular event implicated in estrogen signaling regulation.

Jiang Y, Trescott L, Holcomb J, Zhang X, Brunzelle J, Sirinupong N, Shi X, Yang Z.

J Mol Biol. 2014 Oct 9;426(20):3413-25. doi: 10.1016/j.jmb.2014.02.019. Epub 2014 Mar 1.

PMID:
24594358
31.

Intersubunit communication in the dihydroorotase-aspartate transcarbamoylase complex of Aquifex aeolicus.

Evans HG, Fernando R, Vaishnav A, Kotichukkala M, Heyl D, Hachem F, Brunzelle JS, Edwards BF, Evans DR.

Protein Sci. 2014 Jan;23(1):100-9. doi: 10.1002/pro.2396.

32.

New conformational state of NHERF1-CXCR2 signaling complex captured by crystal lattice trapping.

Jiang Y, Lu G, Trescott LR, Hou Y, Guan X, Wang S, Stamenkovich A, Brunzelle J, Sirinupong N, Li C, Yang Z.

PLoS One. 2013 Dec 10;8(12):e81904. doi: 10.1371/journal.pone.0081904. eCollection 2013.

33.

The mononuclear metal center of type-I dihydroorotase from Aquifex aeolicus.

Edwards BF, Fernando R, Martin PD, Grimley E, Cordes M, Vaishnav A, Brunzelle JS, Evans HG, Evans DR.

BMC Biochem. 2013 Dec 9;14:36. doi: 10.1186/1471-2091-14-36.

34.

Structural basis for RNA recognition by a dimeric PPR-protein complex.

Ke J, Chen RZ, Ban T, Zhou XE, Gu X, Tan MH, Chen C, Kang Y, Brunzelle JS, Zhu JK, Melcher K, Xu HE.

Nat Struct Mol Biol. 2013 Dec;20(12):1377-82. doi: 10.1038/nsmb.2710. Epub 2013 Nov 3.

PMID:
24186060
35.

X-ray solution structure of the native neuronal porosome-synaptic vesicle complex: Implication in neurotransmitter release.

Kovari LC, Brunzelle JS, Lewis KT, Cho WJ, Lee JS, Taatjes DJ, Jena BP.

Micron. 2014 Jan;56:37-43. doi: 10.1016/j.micron.2013.10.002. Epub 2013 Oct 16.

PMID:
24176623
36.

Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease.

Dewdney TG, Wang Y, Liu Z, Sharma SK, Reiter SJ, Brunzelle JS, Kovari IA, Woster PM, Kovari LC.

Bioorg Med Chem. 2013 Dec 1;21(23):7430-4. doi: 10.1016/j.bmc.2013.09.045. Epub 2013 Sep 27.

PMID:
24128815
37.

Structural insights into neutrophilic migration revealed by the crystal structure of the chemokine receptor CXCR2 in complex with the first PDZ domain of NHERF1.

Lu G, Wu Y, Jiang Y, Wang S, Hou Y, Guan X, Brunzelle J, Sirinupong N, Sheng S, Li C, Yang Z.

PLoS One. 2013 Oct 2;8(10):e76219. doi: 10.1371/journal.pone.0076219. eCollection 2013.

38.

Crystal structure of Saccharomyces cerevisiae Aro8, a putative α-aminoadipate aminotransferase.

Bulfer SL, Brunzelle JS, Trievel RC.

Protein Sci. 2013 Oct;22(10):1417-24. doi: 10.1002/pro.2315. Epub 2013 Aug 28.

39.

Structural basis for molecular recognition of folic acid by folate receptors.

Chen C, Ke J, Zhou XE, Yi W, Brunzelle JS, Li J, Yong EL, Xu HE, Melcher K.

Nature. 2013 Aug 22;500(7463):486-9. doi: 10.1038/nature12327. Epub 2013 Jul 14.

40.

Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: mechanism of drug recognition and resistance.

Liu Z, Yedidi RS, Wang Y, Dewdney TG, Reiter SJ, Brunzelle JS, Kovari IA, Kovari LC.

Biochem Biophys Res Commun. 2013 Jul 26;437(2):199-204. doi: 10.1016/j.bbrc.2013.06.027. Epub 2013 Jun 18.

41.

Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex.

Liu Z, Yedidi RS, Wang Y, Dewdney TG, Reiter SJ, Brunzelle JS, Kovari IA, Kovari LC.

Biochem Biophys Res Commun. 2013 Feb 8;431(2):232-8. doi: 10.1016/j.bbrc.2012.12.127. Epub 2013 Jan 8.

PMID:
23313846
42.

Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes.

Liu Z, Wang Y, Yedidi RS, Dewdney TG, Reiter SJ, Brunzelle JS, Kovari IA, Kovari LC.

Biochem Biophys Res Commun. 2013 Jan 18;430(3):1022-7. doi: 10.1016/j.bbrc.2012.12.045. Epub 2012 Dec 19.

43.

Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium.

Zheng H, Beliavsky A, Tchigvintsev A, Brunzelle JS, Brown G, Flick R, Evdokimova E, Wawrzak Z, Mahadevan R, Anderson WF, Savchenko A, Yakunin AF.

Proteins. 2013 Jun;81(6):1031-41. doi: 10.1002/prot.24227. Epub 2013 Apr 1.

PMID:
23229889
44.

Structure and regulon of Campylobacter jejuni ferric uptake regulator Fur define apo-Fur regulation.

Butcher J, Sarvan S, Brunzelle JS, Couture JF, Stintzi A.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10047-52. doi: 10.1073/pnas.1118321109. Epub 2012 Jun 4.

45.

Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration.

Zou Y, Zhang H, Brunzelle JS, Johannes TW, Woodyer R, Hung JE, Nair N, van der Donk WA, Zhao H, Nair SK.

Biochemistry. 2012 May 29;51(21):4263-70. doi: 10.1021/bi2016926. Epub 2012 May 17.

46.

Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers.

Putcha BD, Wright E, Brunzelle JS, Fernandez EJ.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6084-7. doi: 10.1073/pnas.1119852109. Epub 2012 Apr 2.

47.

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds.

Yedidi RS, Liu Z, Wang Y, Brunzelle JS, Kovari IA, Woster PM, Kovari LC, Gupta D.

Biochem Biophys Res Commun. 2012 May 11;421(3):413-7. doi: 10.1016/j.bbrc.2012.03.096. Epub 2012 Mar 24.

48.

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

Zhang P, Lee H, Brunzelle JS, Couture JF.

Nucleic Acids Res. 2012 May;40(9):4237-46. doi: 10.1093/nar/gkr1235. Epub 2012 Jan 20.

49.

Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease.

Wang Y, Dewdney TG, Liu Z, Reiter SJ, Brunzelle JS, Kovari IA, Kovari LC.

Biology (Basel). 2012 May 31;1(1):81-93. doi: 10.3390/biology1010081.

50.

Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.

Soon FF, Ng LM, Zhou XE, West GM, Kovach A, Tan MH, Suino-Powell KM, He Y, Xu Y, Chalmers MJ, Brunzelle JS, Zhang H, Yang H, Jiang H, Li J, Yong EL, Cutler S, Zhu JK, Griffin PR, Melcher K, Xu HE.

Science. 2012 Jan 6;335(6064):85-8. doi: 10.1126/science.1215106. Epub 2011 Nov 24.

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