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Items: 19

1.

2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach.

Schehr M, Ianes C, Weisner J, Heintze L, Müller MP, Pichlo C, Charl J, Brunstein E, Ewert J, Lehr M, Baumann U, Rauh D, Knippschild U, Peifer C, Herges R.

Photochem Photobiol Sci. 2019 Jun 12;18(6):1398-1407. doi: 10.1039/c9pp00010k.

PMID:
30924488
2.

Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 Inhibitors Modified with Chiral Pyrrolidine Scaffolds.

Luxenburger A, Schmidt D, Ianes C, Pichlo C, Krüger M, von Drathen T, Brunstein E, Gainsford GJ, Baumann U, Knippschild U, Peifer C.

Molecules. 2019 Mar 1;24(5). pii: E873. doi: 10.3390/molecules24050873.

3.

Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.

García-Reyes B, Witt L, Jansen B, Karasu E, Gehring T, Leban J, Henne-Bruns D, Pichlo C, Brunstein E, Baumann U, Wesseler F, Rathmer B, Schade D, Peifer C, Knippschild U.

J Med Chem. 2018 May 10;61(9):4087-4102. doi: 10.1021/acs.jmedchem.8b00095. Epub 2018 May 1.

PMID:
29630366
4.

Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK.

Halekotte J, Witt L, Ianes C, Krüger M, Bührmann M, Rauh D, Pichlo C, Brunstein E, Luxenburger A, Baumann U, Knippschild U, Bischof J, Peifer C.

Molecules. 2017 Mar 24;22(4). pii: E522. doi: 10.3390/molecules22040522.

5.

The first crystal structure of the peptidase domain of the U32 peptidase family.

Schacherl M, Montada AA, Brunstein E, Baumann U.

Acta Crystallogr D Biol Crystallogr. 2015 Dec 1;71(Pt 12):2505-12. doi: 10.1107/S1399004715019549. Epub 2015 Nov 27.

PMID:
26627657
6.

The structure of Aquifex aeolicus FtsH in the ADP-bound state reveals a C2-symmetric hexamer.

Vostrukhina M, Popov A, Brunstein E, Lanz MA, Baumgartner R, Bieniossek C, Schacherl M, Baumann U.

Acta Crystallogr D Biol Crystallogr. 2015 Jun;71(Pt 6):1307-18. doi: 10.1107/S1399004715005945. Epub 2015 May 14.

PMID:
26057670
7.

Structural basis for signaling by exclusive EDS1 heteromeric complexes with SAG101 or PAD4 in plant innate immunity.

Wagner S, Stuttmann J, Rietz S, Guerois R, Brunstein E, Bautor J, Niefind K, Parker JE.

Cell Host Microbe. 2013 Dec 11;14(6):619-30. doi: 10.1016/j.chom.2013.11.006.

8.

Molecular basis for the action of the collagen-specific chaperone Hsp47/SERPINH1 and its structure-specific client recognition.

Widmer C, Gebauer JM, Brunstein E, Rosenbaum S, Zaucke F, Drögemüller C, Leeb T, Baumann U.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13243-7. doi: 10.1073/pnas.1208072109. Epub 2012 Jul 30.

9.

Interaction between CK2α and CK2β, the subunits of protein kinase CK2: thermodynamic contributions of key residues on the CK2α surface.

Raaf J, Bischoff N, Klopffleisch K, Brunstein E, Olsen BB, Vilk G, Litchfield DW, Issinger OG, Niefind K.

Biochemistry. 2011 Feb 1;50(4):512-22. doi: 10.1021/bi1013563. Epub 2010 Dec 31.

PMID:
21142136
10.

The interaction of CK2alpha and CK2beta, the subunits of protein kinase CK2, requires CK2beta in a preformed conformation and is enthalpically driven.

Raaf J, Brunstein E, Issinger OG, Niefind K.

Protein Sci. 2008 Dec;17(12):2180-6. doi: 10.1110/ps.037770.108. Epub 2008 Sep 29.

11.

The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules.

Raaf J, Brunstein E, Issinger OG, Niefind K.

Chem Biol. 2008 Feb;15(2):111-7. doi: 10.1016/j.chembiol.2007.12.012.

12.

Subcutaneous glucose monitoring by means of electrochemical sensors: fiction or reality?

Rebrin K, Fischer U, Hahn von Dorsche H, von Woetke T, Abel P, Brunstein E.

J Biomed Eng. 1992 Jan;14(1):33-40.

PMID:
1569738
13.

Implantable glucose sensors: comparison between in vitro and in vivo kinetics.

von Woedtke T, Fischer U, Brunstein E, Rebrin K, Abel P.

Int J Artif Organs. 1991 Aug;14(8):473-81.

PMID:
1937938
14.

[Continuous intracorporeal glucose measurement using enzyme electrodes].

Brunstein E, Abel P, Rebrin K, Fischer U.

Z Exp Chir Transplant Kunstliche Organe. 1990;23(2):95-8. German.

PMID:
2278163
15.

[Role of and current technical possibilities for intracorporeal determination of blood glucose in the treatment of insulin-dependent diabetes mellitus].

Fischer U, Abel P, Rebrin K, von Woedtke T, Brunstein E.

Journ Annu Diabetol Hotel Dieu. 1990:247-66. Review. French. No abstract available.

PMID:
2195209
16.

Automated feedback control of subcutaneous glucose concentration in diabetic dogs.

Rebrin K, Fischer U, von Woedtke T, Abel P, Brunstein E.

Diabetologia. 1989 Aug;32(8):573-6.

PMID:
2673892
17.

Preparation and validation of implantable electrodes for the measurement of oxygen and glucose.

Brunstein E, Abel P, Gens A, Eich K, Woedtke TV.

Biomed Biochim Acta. 1989;48(11-12):911-7.

PMID:
2636836
18.

The GOD-H2O2-electrode as an approach to implantable glucose sensors.

Abel P, Fischer U, Brunstein E, Ertle R.

Horm Metab Res Suppl. 1988;20:26-9.

PMID:
3248787
19.

Assessment of subcutaneous glucose concentration: validation of the wick technique as a reference for implanted electrochemical sensors in normal and diabetic dogs.

Fischer U, Ertle R, Abel P, Rebrin K, Brunstein E, Hahn von Dorsche H, Freyse EJ.

Diabetologia. 1987 Dec;30(12):940-5.

PMID:
3436490

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