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Items: 36

1.

The blood proteomic signature of early-onset pediatric atopic dermatitis shows systemic inflammation and is distinct from adult, longstanding disease.

Brunner PM, He H, Pavel AB, Czarnowicki T, Lefferdink R, Erickson T, Canter T, Puar N, Rangel S, Malik K, Estrada Y, Krueger JG, Guttman-Yassky E, Paller AS.

J Am Acad Dermatol. 2019 Apr 19. pii: S0190-9622(19)30628-0. doi: 10.1016/j.jaad.2019.04.036. [Epub ahead of print]

PMID:
31009665
2.

Early immunologic changes during the onset of atopic dermatitis.

Brunner PM.

Ann Allergy Asthma Immunol. 2019 Apr 4. pii: S1081-1206(19)30255-8. doi: 10.1016/j.anai.2019.03.033. [Epub ahead of print] Review.

PMID:
30953783
3.

Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients.

Brunner PM, Israel A, Leonard A, Pavel AB, Kim HJ, Zhang N, Czarnowicki T, Patel K, Murphrey M, Ramsey K, Rangel S, Zebda R, Soundararajan V, Zheng X, Estrada YD, Xu H, Krueger JG, Paller AS, Guttman-Yassky E.

Ann Allergy Asthma Immunol. 2019 Mar;122(3):318-330.e3. doi: 10.1016/j.anai.2018.11.025. Epub 2018 Dec 1.

PMID:
30508584
4.

Racial differences in atopic dermatitis.

Brunner PM, Guttman-Yassky E.

Ann Allergy Asthma Immunol. 2019 May;122(5):449-455. doi: 10.1016/j.anai.2018.11.015. Epub 2018 Nov 20. Review.

PMID:
30465859
5.

Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab.

Brunner PM, Pavel AB, Khattri S, Leonard A, Malik K, Rose S, Jim On S, Vekaria AS, Traidl-Hoffmann C, Singer GK, Baum D, Gilleaudeau P, Sullivan-Whalen M, Fuentes-Duculan J, Li X, Zheng X, Estrada Y, Garcet S, Wen HC, Gonzalez J, Coats I, Cueto I, Neumann AU, Lebwohl MG, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2019 Jan;143(1):142-154. doi: 10.1016/j.jaci.2018.07.028. Epub 2018 Aug 17.

PMID:
30121291
6.

Author Correction: The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins.

Brunner PM, Suárez-Fariñas M, He H, Malik K, Wen HC, Gonzalez J, Chan TC, Estrada Y, Zheng X, Khattri S, Dattola A, Krueger JG, Guttman-Yassky E.

Sci Rep. 2018 May 29;8(1):8439. doi: 10.1038/s41598-018-26378-5.

7.

Early-onset pediatric atopic dermatitis is characterized by TH2/TH17/TH22-centered inflammation and lipid alterations.

Brunner PM, Israel A, Zhang N, Leonard A, Wen HC, Huynh T, Tran G, Lyon S, Rodriguez G, Immaneni S, Wagner A, Zheng X, Estrada YD, Xu H, Krueger JG, Paller AS, Guttman-Yassky E.

J Allergy Clin Immunol. 2018 Jun;141(6):2094-2106. doi: 10.1016/j.jaci.2018.02.040. Epub 2018 May 3.

PMID:
29731129
8.

Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double-blind, phase 2a trial.

Guttman-Yassky E, Brunner PM, Neumann AU, Khattri S, Pavel AB, Malik K, Singer GK, Baum D, Gilleaudeau P, Sullivan-Whalen M, Rose S, Jim On S, Li X, Fuentes-Duculan J, Estrada Y, Garcet S, Traidl-Hoffmann C, Krueger JG, Lebwohl MG.

J Am Acad Dermatol. 2018 May;78(5):872-881.e6. doi: 10.1016/j.jaad.2018.01.016. Epub 2018 Jan 17.

9.

Moderate-to-severe atopic dermatitis patients show increases in serum C-reactive protein levels, correlating with skin disease activity.

Vekaria AS, Brunner PM, Aleisa AI, Bonomo L, Lebwohl MG, Israel A, Guttman-Yassky E.

Version 2. F1000Res. 2017 Sep 20 [revised 2017 Jan 1];6:1712. doi: 10.12688/f1000research.12422.2. eCollection 2017.

10.

Interleukin-17 alters the biology of many cell types involved in the genesis of psoriasis, systemic inflammation and associated comorbidities.

Krueger JG, Brunner PM.

Exp Dermatol. 2018 Feb;27(2):115-123. doi: 10.1111/exd.13467. Epub 2017 Dec 29. Review.

PMID:
29152791
11.

Analysis of anti-tumour necrosis factor-induced skin lesions reveals strong T helper 1 activation with some distinct immunological characteristics.

Stoffel E, Maier H, Riedl E, Brüggen MC, Reininger B, Schaschinger M, Bangert C, Guenova E, Stingl G, Brunner PM.

Br J Dermatol. 2018 May;178(5):1151-1162. doi: 10.1111/bjd.16126. Epub 2018 Mar 6.

12.

Immunologic, microbial, and epithelial interactions in atopic dermatitis.

Brunner PM, Leung DYM, Guttman-Yassky E.

Ann Allergy Asthma Immunol. 2018 Jan;120(1):34-41. doi: 10.1016/j.anai.2017.09.055. Epub 2017 Nov 7. Review.

PMID:
29126710
13.

The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins.

Brunner PM, Suárez-Fariñas M, He H, Malik K, Wen HC, Gonzalez J, Chan TC, Estrada Y, Zheng X, Khattri S, Dattola A, Krueger JG, Guttman-Yassky E.

Sci Rep. 2017 Aug 18;7(1):8707. doi: 10.1038/s41598-017-09207-z. Erratum in: Sci Rep. 2018 May 29;8(1):8439.

14.

Nonlesional atopic dermatitis skin shares similar T-cell clones with lesional tissues.

Brunner PM, Emerson RO, Tipton C, Garcet S, Khattri S, Coats I, Krueger JG, Guttman-Yassky E.

Allergy. 2017 Dec;72(12):2017-2025. doi: 10.1111/all.13223. Epub 2017 Jun 28.

PMID:
28599078
15.

The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies.

Brunner PM, Guttman-Yassky E, Leung DY.

J Allergy Clin Immunol. 2017 Apr;139(4S):S65-S76. doi: 10.1016/j.jaci.2017.01.011. Review.

16.

Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder.

Brunner PM, Silverberg JI, Guttman-Yassky E, Paller AS, Kabashima K, Amagai M, Luger TA, Deleuran M, Werfel T, Eyerich K, Stingl G; Councilors of the International Eczema Council.

J Invest Dermatol. 2017 Jan;137(1):18-25. doi: 10.1016/j.jid.2016.08.022. Epub 2016 Oct 20. Review.

17.

Human skin dendritic cell fate is differentially regulated by the monocyte identity factor Kruppel-like factor 4 during steady state and inflammation.

Jurkin J, Krump C, Köffel R, Fieber C, Schuster C, Brunner PM, Borek I, Eisenwort G, Lim C, Mages J, Lang R, Bauer W, Mechtcheriakova D, Meshcheryakova A, Elbe-Bürger A, Stingl G, Strobl H.

J Allergy Clin Immunol. 2017 Jun;139(6):1873-1884.e10. doi: 10.1016/j.jaci.2016.09.018. Epub 2016 Oct 11.

18.

Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin.

Esaki H, Brunner PM, Renert-Yuval Y, Czarnowicki T, Huynh T, Tran G, Lyon S, Rodriguez G, Immaneni S, Johnson DB, Bauer B, Fuentes-Duculan J, Zheng X, Peng X, Estrada YD, Xu H, de Guzman Strong C, Suárez-Fariñas M, Krueger JG, Paller AS, Guttman-Yassky E.

J Allergy Clin Immunol. 2016 Dec;138(6):1639-1651. doi: 10.1016/j.jaci.2016.07.013. Epub 2016 Sep 23.

PMID:
27671162
19.

In Situ Mapping of Innate Lymphoid Cells in Human Skin: Evidence for Remarkable Differences between Normal and Inflamed Skin.

Brüggen MC, Bauer WM, Reininger B, Clim E, Captarencu C, Steiner GE, Brunner PM, Meier B, French LE, Stingl G.

J Invest Dermatol. 2016 Dec;136(12):2396-2405. doi: 10.1016/j.jid.2016.07.017. Epub 2016 Jul 22.

20.

Efficacy and safety of ustekinumab treatment in adults with moderate-to-severe atopic dermatitis.

Khattri S, Brunner PM, Garcet S, Finney R, Cohen SR, Oliva M, Dutt R, Fuentes-Duculan J, Zheng X, Li X, Bonifacio KM, Kunjravia N, Coats I, Cueto I, Gilleaudeau P, Sullivan-Whalen M, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E.

Exp Dermatol. 2017 Jan;26(1):28-35. doi: 10.1111/exd.13112. Epub 2016 Aug 9.

21.

Proteome analysis identifies L1CAM/CD171 and DPP4/CD26 as novel markers of human skin mast cells.

Gschwandtner M, Paulitschke V, Mildner M, Brunner PM, Hacker S, Eisenwort G, Sperr WR, Valent P, Gerner C, Tschachler E.

Allergy. 2017 Jan;72(1):85-97. doi: 10.1111/all.12919. Epub 2016 May 25.

PMID:
27091730
22.

A mild topical steroid leads to progressive anti-inflammatory effects in the skin of patients with moderate-to-severe atopic dermatitis.

Brunner PM, Khattri S, Garcet S, Finney R, Oliva M, Dutt R, Fuentes-Duculan J, Zheng X, Li X, Bonifacio KM, Kunjravia N, Coats I, Cueto I, Gilleaudeau P, Sullivan-Whalen M, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2016 Jul;138(1):169-78. doi: 10.1016/j.jaci.2015.12.1323. Epub 2016 Mar 2.

PMID:
26948076
23.

The single-chain anti-TNF-α antibody DLX105 induces clinical and biomarker responses upon local administration in patients with chronic plaque-type psoriasis.

Tsianakas A, Brunner PM, Ghoreschi K, Berger C, Loser K, Röcken M, Stingl G, Luger T, Jung T.

Exp Dermatol. 2016 Jun;25(6):428-33. doi: 10.1111/exd.12927. Epub 2016 Feb 13.

PMID:
26738450
24.

Bioinformatics approach for choosing the correct reference genes when studying gene expression in human keratinocytes.

Beer L, Mlitz V, Gschwandtner M, Berger T, Narzt MS, Gruber F, Brunner PM, Tschachler E, Mildner M.

Exp Dermatol. 2015 Oct;24(10):742-7. doi: 10.1111/exd.12759. Epub 2015 Jun 4.

PMID:
25980460
25.

CCL7 contributes to the TNF-alpha-dependent inflammation of lesional psoriatic skin.

Brunner PM, Glitzner E, Reininger B, Klein I, Stary G, Mildner M, Uhrin P, Sibilia M, Stingl G.

Exp Dermatol. 2015 Jul;24(7):522-8. doi: 10.1111/exd.12709. Epub 2015 May 4.

PMID:
25828150
26.

Autoantibody Levels and Clinical Disease Severity in Patients with Pemphigus: Comparison of Aggregated Anti-desmoglein ELISA Values and Indirect Immunofluorescence Titres.

Weiss D, Ristl R, Griss J, Bangert C, Foedinger D, Stingl G, Brunner PM.

Acta Derm Venereol. 2015 May;95(5):559-64. doi: 10.2340/00015555-2023.

27.

Specific roles for dendritic cell subsets during initiation and progression of psoriasis.

Glitzner E, Korosec A, Brunner PM, Drobits B, Amberg N, Schonthaler HB, Kopp T, Wagner EF, Stingl G, Holcmann M, Sibilia M.

EMBO Mol Med. 2014 Oct;6(10):1312-27. doi: 10.15252/emmm.201404114.

28.

Infliximab induces downregulation of the IL-12/IL-23 axis in 6-sulfo-LacNac (slan)+ dendritic cells and macrophages.

Brunner PM, Koszik F, Reininger B, Kalb ML, Bauer W, Stingl G.

J Allergy Clin Immunol. 2013 Nov;132(5):1184-1193.e8. doi: 10.1016/j.jaci.2013.05.036. Epub 2013 Jul 26.

PMID:
23890755
29.

Cold induces reactive oxygen species production and activation of the NF-kappa B response in endothelial cells and inflammation in vivo.

Awad EM, Khan SY, Sokolikova B, Brunner PM, Olcaydu D, Wojta J, Breuss JM, Uhrin P.

J Thromb Haemost. 2013 Sep;11(9):1716-26. doi: 10.1111/jth.12357.

30.

Clinical Challenges in the Management of Leishmania/HIV Coinfection in a Nonendemic Area: A Case Report.

Grabmeier-Pfistershammer K, Poeppl W, Brunner PM, Rappersberger K, Rieger A.

Case Rep Infect Dis. 2012;2012:787305. doi: 10.1155/2012/787305. Epub 2012 Dec 17.

31.

Changing views of the role of Langerhans cells.

Romani N, Brunner PM, Stingl G.

J Invest Dermatol. 2012 Mar;132(3 Pt 2):872-81. doi: 10.1038/jid.2011.437. Epub 2012 Jan 5. Review.

32.

Immune functions of the skin.

Bangert C, Brunner PM, Stingl G.

Clin Dermatol. 2011 Jul-Aug;29(4):360-76. doi: 10.1016/j.clindermatol.2011.01.006.

PMID:
21679864
33.

Density enhanced phosphatase-1 down-regulates urokinase receptor surface expression in confluent endothelial cells.

Brunner PM, Heier PC, Mihaly-Bison J, Priglinger U, Binder BR, Prager GW.

Blood. 2011 Apr 14;117(15):4154-61. doi: 10.1182/blood-2010-09-307694. Epub 2011 Feb 8.

34.

Host defense mechanisms in secondary syphilitic lesions: a role for IFN-gamma-/IL-17-producing CD8+ T cells?

Stary G, Klein I, Brüggen MC, Kohlhofer S, Brunner PM, Spazierer D, Müllauer L, Petzelbauer P, Stingl G.

Am J Pathol. 2010 Nov;177(5):2421-32. doi: 10.2353/ajpath.2010.100277. Epub 2010 Oct 1.

35.

Urokinase mediates endothelial cell survival via induction of the X-linked inhibitor of apoptosis protein.

Prager GW, Mihaly J, Brunner PM, Koshelnick Y, Hoyer-Hansen G, Binder BR.

Blood. 2009 Feb 5;113(6):1383-90. doi: 10.1182/blood-2008-06-164210. Epub 2008 Oct 23.

36.

Vascular endothelial growth factor receptor-2-induced initial endothelial cell migration depends on the presence of the urokinase receptor.

Prager GW, Breuss JM, Steurer S, Olcaydu D, Mihaly J, Brunner PM, Stockinger H, Binder BR.

Circ Res. 2004 Jun 25;94(12):1562-70. Epub 2004 May 6.

PMID:
15131009

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