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Discordance in the epithelial cell-dendritic cell MHC class II immunoproteome: implications for Chlamydia vaccine development.

Karunakaran KP, Yu H, Jiang X, Chan QWT, Foster LJ, Johnson RM, Brunham RC.

J Infect Dis. 2019 Oct 10. pii: jiz522. doi: 10.1093/infdis/jiz522. [Epub ahead of print]


Bacterial Vaginosis and Desquamative Inflammatory Vaginitis. Reply.

Paavonen J, Brunham RC.

N Engl J Med. 2019 Mar 14;380(11):1089. doi: 10.1056/NEJMc1900134. No abstract available.


Bacterial Vaginosis and Desquamative Inflammatory Vaginitis.

Paavonen J, Brunham RC.

N Engl J Med. 2018 Dec 6;379(23):2246-2254. doi: 10.1056/NEJMra1808418. Review. No abstract available.


The genome, microbiome and evolutionary medicine.

Brunham RC.

CMAJ. 2018 Feb 12;190(6):E162-E166. doi: 10.1503/cmaj.170846. No abstract available.


B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters.

Johnson RM, Yu H, Strank NO, Karunakaran K, Zhu Y, Brunham RC.

Infect Immun. 2018 Jan 22;86(2). pii: e00614-17. doi: 10.1128/IAI.00614-17. Print 2018 Feb.


National Institute of Allergy and Infectious Diseases workshop report: "Chlamydia vaccines: The way forward".

Zhong G, Brunham RC, de la Maza LM, Darville T, Deal C.

Vaccine. 2019 Nov 28;37(50):7346-7354. doi: 10.1016/j.vaccine.2017.10.075. Epub 2017 Oct 31.


Reply to Vicetti Miguel et al., "Setting Sights on Chlamydia Immunity's Central Paradigm: Can We Hit a Moving Target?"

Johnson RM, Brunham RC.

Infect Immun. 2017 Jun 20;85(7). pii: e00223-17. doi: 10.1128/IAI.00223-17. Print 2017 Jul. No abstract available.


Update on Chlamydia trachomatis Vaccinology.

de la Maza LM, Zhong G, Brunham RC.

Clin Vaccine Immunol. 2017 Apr 5;24(4). pii: e00543-16. doi: 10.1128/CVI.00543-16. Print 2017 Apr. Review.


A double-edged sword: does highly active antiretroviral therapy contribute to syphilis incidence by impairing immunity to Treponema pallidum?

Rekart ML, Ndifon W, Brunham RC, Dushoff J, Park SW, Rawat S, Cameron CE.

Sex Transm Infect. 2017 Aug;93(5):374-378. doi: 10.1136/sextrans-2016-052870. Epub 2017 Jan 16. Review.


Identification of MHC-Bound Peptides from Dendritic Cells Infected with Salmonella enterica Strain SL1344: Implications for a Nontyphoidal Salmonella Vaccine.

Karunakaran KP, Yu H, Jiang X, Chan Q, Goldberg MF, Jenkins MK, Foster LJ, Brunham RC.

J Proteome Res. 2017 Jan 6;16(1):298-306. doi: 10.1021/acs.jproteome.6b00926. Epub 2016 Nov 10.


Using MHC Molecules to Define a Chlamydia T Cell Vaccine.

Karunakaran KP, Yu H, Foster LJ, Brunham RC.

Methods Mol Biol. 2016;1403:419-32. doi: 10.1007/978-1-4939-3387-7_23.


Subunit vaccines for the prevention of mucosal infection with Chlamydia trachomatis.

Yu H, Karunakaran KP, Jiang X, Brunham RC.

Expert Rev Vaccines. 2016 Aug;15(8):977-88. doi: 10.1586/14760584.2016.1161510. Epub 2016 Mar 21. Review.


Tissue-Resident T Cells as the Central Paradigm of Chlamydia Immunity.

Johnson RM, Brunham RC.

Infect Immun. 2016 Mar 24;84(4):868-873. doi: 10.1128/IAI.01378-15. Print 2016 Apr. Review.


Bioinformatic Analysis of Chlamydia trachomatis Polymorphic Membrane Proteins PmpE, PmpF, PmpG and PmpH as Potential Vaccine Antigens.

Nunes A, Gomes JP, Karunakaran KP, Brunham RC.

PLoS One. 2015 Jul 1;10(7):e0131695. doi: 10.1371/journal.pone.0131695. eCollection 2015.


IMMUNOLOGY. A Chlamydia vaccine on the horizon.

Brunham RC.

Science. 2015 Jun 19;348(6241):1322-3. doi: 10.1126/science.aac6528. No abstract available.


Pelvic inflammatory disease.

Brunham RC, Gottlieb SL, Paavonen J.

N Engl J Med. 2015 May 21;372(21):2039-48. doi: 10.1056/NEJMra1411426. Review. No abstract available.


Cost-effectiveness of Chlamydia vaccination programs for young women.

Owusu-Edusei K Jr, Chesson HW, Gift TL, Brunham RC, Bolan G.

Emerg Infect Dis. 2015 Jun;21(6):960-8. doi: 10.3201/eid2106.141270.


Outer membrane proteins preferentially load MHC class II peptides: implications for a Chlamydia trachomatis T cell vaccine.

Karunakaran KP, Yu H, Jiang X, Chan Q, Moon KM, Foster LJ, Brunham RC.

Vaccine. 2015 Apr 27;33(18):2159-66. doi: 10.1016/j.vaccine.2015.02.055. Epub 2015 Mar 1.


Immunity to Chlamydia trachomatis.

Brunham RC.

J Infect Dis. 2013 Jun 15;207(12):1796-7. doi: 10.1093/infdis/jit095. Epub 2013 Mar 7. No abstract available.


Chlamydia trachomatis control requires a vaccine.

Brunham RC, Rappuoli R.

Vaccine. 2013 Apr 8;31(15):1892-7. doi: 10.1016/j.vaccine.2013.01.024. Epub 2013 Jan 29. Review.


Screening and treating Chlamydia trachomatis genital infection to prevent pelvic inflammatory disease: interpretation of findings from randomized controlled trials.

Gottlieb SL, Xu F, Brunham RC.

Sex Transm Dis. 2013 Feb;40(2):97-102. doi: 10.1097/OLQ.0b013e31827bd637. Review.


Chlamydia public health programs and the epidemiology of pelvic inflammatory disease and ectopic pregnancy.

Rekart ML, Gilbert M, Meza R, Kim PH, Chang M, Money DM, Brunham RC.

J Infect Dis. 2013 Jan 1;207(1):30-8. doi: 10.1093/infdis/jis644. Epub 2012 Oct 24.


PmpG303-311, a protective vaccine epitope that elicits persistent cellular immune responses in Chlamydia muridarum-immune mice.

Johnson RM, Yu H, Kerr MS, Slaven JE, Karunakaran KP, Brunham RC.

Infect Immun. 2012 Jun;80(6):2204-11. doi: 10.1128/IAI.06339-11. Epub 2012 Mar 19.


Stable Chlamydia prevalence does not exclude increasing burden of disease.

Rekart ML, Brunham RC.

Sex Transm Dis. 2012 Mar;39(3):239; author reply 239-40. doi: 10.1097/OLQ.0b013e318244b79c. No abstract available.


Chlamydia muridarum T cell antigens and adjuvants that induce protective immunity in mice.

Yu H, Karunakaran KP, Jiang X, Shen C, Andersen P, Brunham RC.

Infect Immun. 2012 Apr;80(4):1510-8. doi: 10.1128/IAI.06338-11. Epub 2012 Jan 30.


Vaccination against 2009 pandemic H1N1 in a population dynamical model of Vancouver, Canada: timing is everything.

Conway JM, Tuite AR, Fisman DN, Hupert N, Meza R, Davoudi B, English K, van den Driessche P, Brauer F, Ma J, Meyers LA, Smieja M, Greer A, Skowronski DM, Buckeridge DL, Kwong JC, Wu J, Moghadas SM, Coombs D, Brunham RC, Pourbohloul B.

BMC Public Health. 2011 Dec 14;11:932. doi: 10.1186/1471-2458-11-932.


Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.

Zoraghi R, Worrall L, See RH, Strangman W, Popplewell WL, Gong H, Samaai T, Swayze RD, Kaur S, Vuckovic M, Finlay BB, Brunham RC, McMaster WR, Davies-Coleman MT, Strynadka NC, Andersen RJ, Reiner NE.

J Biol Chem. 2011 Dec 30;286(52):44716-25. doi: 10.1074/jbc.M111.289033. Epub 2011 Oct 26.


Identification of a novel HLA-A allele, A*29:28, in an East African population.

Isabey EP, Pham HM, Peterson TA, Brunham RC, Luo M, Plummer FA.

Tissue Antigens. 2011 Dec;78(6):451-2. doi: 10.1111/j.1399-0039.2011.01741.x. Epub 2011 Jul 26.


Unity in variety--the pan-genome of the Chlamydiae.

Collingro A, Tischler P, Weinmaier T, Penz T, Heinz E, Brunham RC, Read TD, Bavoil PM, Sachse K, Kahane S, Friedman MG, Rattei T, Myers GS, Horn M.

Mol Biol Evol. 2011 Dec;28(12):3253-70. doi: 10.1093/molbev/msr161. Epub 2011 Jun 20.


Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target.

Zoraghi R, See RH, Axerio-Cilies P, Kumar NS, Gong H, Moreau A, Hsing M, Kaur S, Swayze RD, Worrall L, Amandoron E, Lian T, Jackson L, Jiang J, Thorson L, Labriere C, Foster L, Brunham RC, McMaster WR, Finlay BB, Strynadka NC, Cherkasov A, Young RN, Reiner NE.

Antimicrob Agents Chemother. 2011 May;55(5):2042-53. doi: 10.1128/AAC.01250-10. Epub 2011 Feb 28.


Whole-genome sequencing and social-network analysis of a tuberculosis outbreak.

Gardy JL, Johnston JC, Ho Sui SJ, Cook VJ, Shah L, Brodkin E, Rempel S, Moore R, Zhao Y, Holt R, Varhol R, Birol I, Lem M, Sharma MK, Elwood K, Jones SJ, Brinkman FS, Brunham RC, Tang P.

N Engl J Med. 2011 Feb 24;364(8):730-9. doi: 10.1056/NEJMoa1003176. Erratum in: N Engl J Med. 2011 Jun 2;364(22):2174.


Immunization with live and dead Chlamydia muridarum induces different levels of protective immunity in a murine genital tract model: correlation with MHC class II peptide presentation and multifunctional Th1 cells.

Yu H, Karunakaran KP, Kelly I, Shen C, Jiang X, Foster LJ, Brunham RC.

J Immunol. 2011 Mar 15;186(6):3615-21. doi: 10.4049/jimmunol.1002952. Epub 2011 Feb 4.


Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: higher antibody and lower cell-mediated immune responses with advanced age.

Skowronski DM, Hottes TS, McElhaney JE, Janjua NZ, Sabaiduc S, Chan T, Gentleman B, Purych D, Gardy J, Patrick DM, Brunham RC, De Serres G, Petric M.

J Infect Dis. 2011 Jan 15;203(2):158-67. doi: 10.1093/infdis/jiq039.


Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.

Cherkasov A, Hsing M, Zoraghi R, Foster LJ, See RH, Stoynov N, Jiang J, Kaur S, Lian T, Jackson L, Gong H, Swayze R, Amandoron E, Hormozdiari F, Dao P, Sahinalp C, Santos-Filho O, Axerio-Cilies P, Byler K, McMaster WR, Brunham RC, Finlay BB, Reiner NE.

J Proteome Res. 2011 Mar 4;10(3):1139-50. doi: 10.1021/pr100918u. Epub 2011 Jan 28.


Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from methicillin-resistant Staphylococcus aureus.

Zoraghi R, See RH, Gong H, Lian T, Swayze R, Finlay BB, Brunham RC, McMaster WR, Reiner NE.

Biochemistry. 2010 Sep 7;49(35):7733-47. doi: 10.1021/bi100780t.


Summary: The natural history and immunobiology of Chlamydia trachomatis genital infection and implications for Chlamydia control.

Gottlieb SL, Martin DH, Xu F, Byrne GI, Brunham RC.

J Infect Dis. 2010 Jun 15;201 Suppl 2:S190-204.


Development of a Chlamydia trachomatis T cell Vaccine.

Karunakaran KP, Yu H, Foster LJ, Brunham RC.

Hum Vaccin. 2010 Aug;6(8):676-80. Epub 2010 Aug 1. Review.


Birth cohort patterns suggest that infant survival predicts adult mortality rates.

Meza R, Pourbohloul B, Brunham RC.

J Dev Orig Health Dis. 2010 Jun;1(3):174-83. doi: 10.1017/S2040174410000218.


Introduction: The natural history and immunobiology of Chlamydia trachomatis genital infection and implications for chlamydia control.

Gottlieb SL, Brunham RC, Byrne GI, Martin DH, Xu F, Berman SM.

J Infect Dis. 2010 Jun 15;201 Suppl 2:S85-7. doi: 10.1086/652392. No abstract available.


Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada.

Skowronski DM, De Serres G, Crowcroft NS, Janjua NZ, Boulianne N, Hottes TS, Rosella LC, Dickinson JA, Gilca R, Sethi P, Ouhoummane N, Willison DJ, Rouleau I, Petric M, Fonseca K, Drews SJ, Rebbapragada A, Charest H, Hamelin ME, Boivin G, Gardy JL, Li Y, Kwindt TL, Patrick DM, Brunham RC; Canadian SAVOIR Team.

PLoS Med. 2010 Apr 6;7(4):e1000258. doi: 10.1371/journal.pmed.1000258.


Differences in innate immune responses correlate with differences in murine susceptibility to Chlamydia muridarum pulmonary infection.

Jiang X, Shen C, Yu H, Karunakaran KP, Brunham RC.

Immunology. 2010 Apr;129(4):556-66. doi: 10.1111/j.1365-2567.2009.03157.x. Epub 2009 Sep 11.


Evidence that human Chlamydia pneumoniae was zoonotically acquired.

Myers GS, Mathews SA, Eppinger M, Mitchell C, O'Brien KK, White OR, Benahmed F, Brunham RC, Read TD, Ravel J, Bavoil PM, Timms P.

J Bacteriol. 2009 Dec;191(23):7225-33. doi: 10.1128/JB.00746-09. Epub 2009 Sep 11.


Initial human transmission dynamics of the pandemic (H1N1) 2009 virus in North America.

Pourbohloul B, Ahued A, Davoudi B, Meza R, Meyers LA, Skowronski DM, Villaseñor I, Galván F, Cravioto P, Earn DJ, Dushoff J, Fisman D, Edmunds WJ, Hupert N, Scarpino SV, Trujillo J, Lutzow M, Morales J, Contreras A, Chávez C, Patrick DM, Brunham RC.

Influenza Other Respir Viruses. 2009 Sep;3(5):215-22. doi: 10.1111/j.1750-2659.2009.00100.x.


Time evolution of epidemic disease on finite and infinite networks.

Noël PA, Davoudi B, Brunham RC, Dubé LJ, Pourbohloul B.

Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Feb;79(2 Pt 2):026101. Epub 2009 Feb 2.


Infectious disease prevention and control: remembering 1908 and imagining 2108.

Brunham RC.

Can J Public Health. 2009 Jan-Feb;100(1):5-8. English, French. No abstract available.


Considerations on Chlamydia trachomatis disease expression.

Brunham RC, Rekart ML.

FEMS Immunol Med Microbiol. 2009 Mar;55(2):162-6. doi: 10.1111/j.1574-695X.2008.00509.x. Epub 2009 Dec 19. Review.

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