Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 48

1.

Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood-brain barrier in vitro is dependent on its binding affinity.

Haqqani AS, Thom G, Burrell M, Delaney CE, Brunette E, Baumann E, Sodja C, Jezierski A, Webster C, Stanimirovic DB.

J Neurochem. 2018 Sep;146(6):735-752. doi: 10.1111/jnc.14482. Epub 2018 Aug 16.

2.

Enhanced Delivery of Galanin Conjugates to the Brain through Bioengineering of the Anti-Transferrin Receptor Antibody OX26.

Thom G, Burrell M, Haqqani AS, Yogi A, Lessard E, Brunette E, Delaney C, Baumann E, Callaghan D, Rodrigo N, Webster CI, Stanimirovic DB.

Mol Pharm. 2018 Apr 2;15(4):1420-1431. doi: 10.1021/acs.molpharmaceut.7b00937. Epub 2018 Mar 6.

PMID:
29485883
3.

Endosomal trafficking regulates receptor-mediated transcytosis of antibodies across the blood brain barrier.

Haqqani AS, Delaney CE, Brunette E, Baumann E, Farrington GK, Sisk W, Eldredge J, Ding W, Tremblay TL, Stanimirovic DB.

J Cereb Blood Flow Metab. 2018 Apr;38(4):727-740. doi: 10.1177/0271678X17740031. Epub 2017 Nov 15.

4.

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery.

Pizzo ME, Wolak DJ, Kumar NN, Brunette E, Brunnquell CL, Hannocks MJ, Abbott NJ, Meyerand ME, Sorokin L, Stanimirovic DB, Thorne RG.

J Physiol. 2018 Feb 1;596(3):445-475. doi: 10.1113/JP275105. Epub 2017 Dec 18.

5.

Failure and rescue of preconditioning-induced neuroprotection in severe stroke-like insults.

Tauskela JS, Aylsworth A, Hewitt M, Brunette E, Blondeau N.

Neuropharmacology. 2016 Jun;105:533-542. doi: 10.1016/j.neuropharm.2016.02.007. Epub 2016 Feb 8.

PMID:
26867506
6.

Brain penetration, target engagement, and disposition of the blood-brain barrier-crossing bispecific antibody antagonist of metabotropic glutamate receptor type 1.

Webster CI, Caram-Salas N, Haqqani AS, Thom G, Brown L, Rennie K, Yogi A, Costain W, Brunette E, Stanimirovic DB.

FASEB J. 2016 May;30(5):1927-40. doi: 10.1096/fj.201500078. Epub 2016 Feb 2.

PMID:
26839377
7.

A novel platform for engineering blood-brain barrier-crossing bispecific biologics.

Farrington GK, Caram-Salas N, Haqqani AS, Brunette E, Eldredge J, Pepinsky B, Antognetti G, Baumann E, Ding W, Garber E, Jiang S, Delaney C, Boileau E, Sisk WP, Stanimirovic DB.

FASEB J. 2014 Nov;28(11):4764-78. doi: 10.1096/fj.14-253369. Epub 2014 Jul 28.

PMID:
25070367
8.

Blood-brain barrier transport of amyloid beta peptides in efflux pump knock-out animals evaluated by in vivo optical imaging.

Zhang W, Xiong H, Callaghan D, Liu H, Jones A, Pei K, Fatehi D, Brunette E, Stanimirovic D.

Fluids Barriers CNS. 2013 Feb 25;10(1):13. doi: 10.1186/2045-8118-10-13.

9.

Multiplexed evaluation of serum and CSF pharmacokinetics of brain-targeting single-domain antibodies using a NanoLC-SRM-ILIS method.

Haqqani AS, Caram-Salas N, Ding W, Brunette E, Delaney CE, Baumann E, Boileau E, Stanimirovic D.

Mol Pharm. 2013 May 6;10(5):1542-56. doi: 10.1021/mp3004995. Epub 2012 Dec 6.

PMID:
23150993
10.

Preconditioning induces tolerance by suppressing glutamate release in neuron culture ischemia models.

Tauskela JS, Aylsworth A, Hewitt M, Brunette E, Mealing GA.

J Neurochem. 2012 Jul;122(2):470-81. doi: 10.1111/j.1471-4159.2012.07791.x. Epub 2012 Jun 1.

11.

In vivo optical imaging of ischemic blood-brain barrier disruption.

Abulrob A, Brunette E, Slinn J, Baumann E, Stanimirovic D.

Methods Mol Biol. 2011;763:423-39. doi: 10.1007/978-1-61779-191-8_29.

PMID:
21874469
12.

In vitro and in vivo methods for assessing FcRn-mediated reverse transcytosis across the blood-brain barrier.

Caram-Salas N, Boileau E, Farrington GK, Garber E, Brunette E, Abulrob A, Stanimirovic D.

Methods Mol Biol. 2011;763:383-401. doi: 10.1007/978-1-61779-191-8_26.

PMID:
21874466
13.

Neuroprotection against staurosporine by metalloporphyrins independent of antioxidant capability.

Tauskela JS, Brunette E.

Neurosci Lett. 2009 Nov 27;466(1):41-6. doi: 10.1016/j.neulet.2009.09.028. Epub 2009 Sep 17.

PMID:
19766169
14.

Dynamic analysis of the blood-brain barrier disruption in experimental stroke using time domain in vivo fluorescence imaging.

Abulrob A, Brunette E, Slinn J, Baumann E, Stanimirovic D.

Mol Imaging. 2008 Nov-Dec;7(6):248-62.

PMID:
19123995
15.

Near-field scanning optical microscopy detects nanoscale glycolipid domains in the plasma membrane.

Abulrob A, Lu Z, Brunette E, Pulla D, Stanimirovic D, Johnston LJ.

J Microsc. 2008 Nov;232(2):225-34. doi: 10.1111/j.1365-2818.2008.02093.x.

16.

Elevated synaptic activity preconditions neurons against an in vitro model of ischemia.

Tauskela JS, Fang H, Hewitt M, Brunette E, Ahuja T, Thivierge JP, Comas T, Mealing GA.

J Biol Chem. 2008 Dec 12;283(50):34667-76. doi: 10.1074/jbc.M805624200. Epub 2008 Oct 9.

17.

In vivo time domain optical imaging of renal ischemia-reperfusion injury: discrimination based on fluorescence lifetime.

Abulrob A, Brunette E, Slinn J, Baumann E, Stanimirovic D.

Mol Imaging. 2007 Sep-Oct;6(5):304-14.

PMID:
18092515
18.

Unconventional neuroprotection against Ca2+ -dependent insults by metalloporphyrin catalytic antioxidants.

Tauskela JS, Brunette E, Kiedrowski L, Lortie K, Hewitt M, Morley P.

J Neurochem. 2006 Aug;98(4):1324-42.

19.

Competing approaches to excitotoxic neuroprotection by inert and catalytic antioxidant porphyrins.

Tauskela JS, Brunette E, Hewitt M, Mealing G, Morley P.

Neurosci Lett. 2006 Jul 3;401(3):236-41. Epub 2006 Apr 24.

PMID:
16631306
20.

Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia.

Jiang SX, Lertvorachon J, Hou ST, Konishi Y, Webster J, Mealing G, Brunette E, Tauskela J, Preston E.

J Biol Chem. 2005 Oct 7;280(40):33811-8. Epub 2005 Aug 9.

21.

An alternative Ca2+-dependent mechanism of neuroprotection by the metalloporphyrin class of superoxide dismutase mimetics.

Tauskela JS, Brunette E, O'Reilly N, Mealing G, Comas T, Gendron TF, Monette R, Morley P.

FASEB J. 2005 Oct;19(12):1734-6. Epub 2005 Aug 4.

PMID:
16081500
22.

Expansion of human embryonic stem cells in defined serum-free medium devoid of animal-derived products.

Li Y, Powell S, Brunette E, Lebkowski J, Mandalam R.

Biotechnol Bioeng. 2005 Sep 20;91(6):688-98.

PMID:
15971228
23.

The dual role of prostaglandin E(2) in excitotoxicity and preconditioning-induced neuroprotection.

Gendron TF, Brunette E, Tauskela JS, Morley P.

Eur J Pharmacol. 2005 Jul 4;517(1-2):17-27.

PMID:
15964567
24.

Serum-free derivation of human embryonic stem cell lines on human placental fibroblast feeders.

Genbacev O, Krtolica A, Zdravkovic T, Brunette E, Powell S, Nath A, Caceres E, McMaster M, McDonagh S, Li Y, Mandalam R, Lebkowski J, Fisher SJ.

Fertil Steril. 2005 May;83(5):1517-29.

PMID:
15866593
25.

Protection by cholesterol-extracting cyclodextrins: a role for N-methyl-D-aspartate receptor redistribution.

Abulrob A, Tauskela JS, Mealing G, Brunette E, Faid K, Stanimirovic D.

J Neurochem. 2005 Mar;92(6):1477-86.

26.

Opposing effects of cyclooxygenase-2 selective inhibitors on oxygen-glucose deprivation-induced neurotoxicity.

Gendron TF, Brunette E, Mealing GA, Nguyen A, Tauskela JS, Morley P.

Eur J Pharmacol. 2004 Jun 16;493(1-3):45-55.

PMID:
15189763
27.

Preconditioning of cortical neurons by oxygen-glucose deprivation: tolerance induction through abbreviated neurotoxic signaling.

Tauskela JS, Brunette E, Monette R, Comas T, Morley P.

Am J Physiol Cell Physiol. 2003 Oct;285(4):C899-911. Epub 2003 Jun 18.

28.

Protection of cortical neurons against oxygen-glucose deprivation and N-methyl-D-aspartate by DIDS and SITS.

Tauskela JS, Mealing G, Comas T, Brunette E, Monette R, Small DL, Morley P.

Eur J Pharmacol. 2003 Mar 7;464(1):17-25.

PMID:
12600690
29.
30.

Transgene expression in dendritic cells to induce antigen-specific cytotoxic T cells in healthy donors.

Philip R, Brunette E, Ashton J, Alters S, Gadea J, Sorich M, Yau J, O'Donoghue G, Lebkowski J, Okarma T, Philip M.

Cancer Gene Ther. 1998 Jul-Aug;5(4):236-46.

PMID:
9694075
31.

Gene modification of primary tumor cells for active immunotherapy of human breast and ovarian cancer.

Philip R, Clary B, Brunette E, Kilinski L, Murugesh D, Sorich M, Yau J, Lebkowski J, Lyerly HK, Philip M.

Clin Cancer Res. 1996 Jan;2(1):59-68.

32.

Management of ADHD in the school setting--a case study.

Brunette EA.

J Sch Nurs. 1995 Oct;11(3):33-8.

PMID:
7580034
33.

Efficient and sustained gene expression in primary T lymphocytes and primary and cultured tumor cells mediated by adeno-associated virus plasmid DNA complexed to cationic liposomes.

Philip R, Brunette E, Kilinski L, Murugesh D, McNally MA, Ucar K, Rosenblatt J, Okarma TB, Lebkowski JS.

Mol Cell Biol. 1994 Apr;14(4):2411-8.

34.

Aerosol gene delivery in vivo.

Stribling R, Brunette E, Liggitt D, Gaensler K, Debs R.

Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11277-81.

35.

Lipofection does not require the removal of serum.

Brunette E, Stribling R, Debs R.

Nucleic Acids Res. 1992 Mar 11;20(5):1151. No abstract available.

36.

Reduction in intensity of Pneumocystis carinii pneumonia in mice by aerosol administration of gamma interferon.

Beck JM, Liggitt HD, Brunette EN, Fuchs HJ, Shellito JE, Debs RJ.

Infect Immun. 1991 Nov;59(11):3859-62.

37.

Biodistribution, tissue reaction, and lung retention of pentamidine aerosolized as three different salts.

Debs R, Brunette E, Fuchs H, Lin E, Shah M, Hargis A, Montgomery AB.

Am Rev Respir Dis. 1990 Nov;142(5):1164-7.

PMID:
2240839
38.

Occupational exposure to aerosolized pentamidine.

Montgomery AB, Corkery KJ, Brunette ER, Leoung GS, Waskin H, Debs RJ.

Chest. 1990 Aug;98(2):386-8.

PMID:
2376170
39.

Monocyte-mediated lysis of HIV-infected tumor cells.

Debs RJ, Krowka J, Stites D, Brunette EN, Düzgünes N, Philip R.

AIDS Res Hum Retroviruses. 1990 Aug;6(8):1005-9.

PMID:
1699572
40.

Lymphocyte proliferative responses to soluble and liposome-conjugated envelope peptides of HIV-1.

Krowka J, Stites D, Debs R, Larsen C, Fedor J, Brunette E, Düzgünes N.

J Immunol. 1990 Apr 1;144(7):2535-40.

PMID:
1969450
41.

Immunomodulatory and toxic effects of free and liposome-encapsulated tumor necrosis factor alpha in rats.

Debs RJ, Fuchs HJ, Philip R, Brunette EN, Düzgüneş N, Shellito JE, Liggitt D, Patton JR.

Cancer Res. 1990 Jan 15;50(2):375-80.

PMID:
2295077
42.

Liposome-associated tumor necrosis factor retains bioactivity in the presence of neutralizing anti-tumor necrosis factor antibodies.

Debs RJ, Düzgüneş N, Brunette EN, Fendly B, Patton J, Philip R.

J Immunol. 1989 Aug 15;143(4):1192-7.

PMID:
2787358
43.

Lung-specific delivery of cytokines induces sustained pulmonary and systemic immunomodulation in rats.

Debs RJ, Fuchs HJ, Philip R, Montgomery AB, Brunette EN, Liggitt D, Patton JS, Shellito JE.

J Immunol. 1988 May 15;140(10):3482-8.

PMID:
3283235
44.

Selective delivery of pentamidine to the lung by aerosol.

Montgomery AB, Debs RJ, Luce JM, Corkery KJ, Turner J, Brunette EN, Lin ET, Hopewell PC.

Am Rev Respir Dis. 1988 Feb;137(2):477-8.

PMID:
3257663
45.

Aerosol administration of antiviral agents to treat lung infection due to murine cytomegalovirus.

Debs RJ, Montgomery AB, Brunette EN, DeBruin M, Shanley JD.

J Infect Dis. 1988 Feb;157(2):327-31.

PMID:
2826613
46.

Aerosolised pentamidine as sole therapy for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome.

Montgomery AB, Debs RJ, Luce JM, Corkery KJ, Turner J, Brunette EN, Lin ET, Hopewell PC.

Lancet. 1987 Aug 29;2(8557):480-3.

PMID:
2887779
47.

Selective enhancement of pentamidine uptake in the lung by aerosolization and delivery in liposomes.

Debs RJ, Straubinger RM, Brunette EN, Lin JM, Lin EJ, Montgomery AB, Friend DS, Papahadjopoulos DP.

Am Rev Respir Dis. 1987 Mar;135(3):731-7.

PMID:
3826898
48.

Successful treatment with aerosolized pentamidine of Pneumocystis carinii pneumonia in rats.

Debs RJ, Blumenfeld W, Brunette EN, Straubinger RM, Montgomery AB, Lin E, Agabian N, Papahadjopoulos D.

Antimicrob Agents Chemother. 1987 Jan;31(1):37-41.

Supplemental Content

Loading ...
Support Center