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Propionate-induced changes in cardiac metabolism, notably CoA trapping, are not altered by l-carnitine.

Wang Y, Christopher BA, Wilson KA, Muoio D, McGarrah RW, Brunengraber H, Zhang GF.

Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E622-E633. doi: 10.1152/ajpendo.00081.2018. Epub 2018 Jul 17.


Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism.

Wilson KA, Han Y, Zhang M, Hess JP, Chapman KA, Cline GW, Tochtrop GP, Brunengraber H, Zhang GF.

Am J Physiol Endocrinol Metab. 2017 Oct 1;313(4):E413-E428. doi: 10.1152/ajpendo.00105.2017. Epub 2017 Jun 20.


Glutathione species and metabolomic prints in subjects with liver disease as biological markers for the detection of hepatocellular carcinoma.

Sanabria JR, Kombu RS, Zhang GF, Sandlers Y, Ai J, Ibarra RA, Abbas R, Goyal K, Brunengraber H.

HPB (Oxford). 2016 Dec;18(12):979-990. doi: 10.1016/j.hpb.2016.09.007. Epub 2016 Oct 27.


Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4.

Marsboom G, Zhang GF, Pohl-Avila N, Zhang Y, Yuan Y, Kang H, Hao B, Brunengraber H, Malik AB, Rehman J.

Cell Rep. 2016 Jul 12;16(2):323-332. doi: 10.1016/j.celrep.2016.05.089. Epub 2016 Jun 23.


New mechanisms by which statins lower plasma cholesterol.

Brunengraber H.

J Lipid Res. 2016 Aug;57(8):1325-6. doi: 10.1194/jlr.C070417. Epub 2016 Jun 23. No abstract available.


Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.

Hao Y, Samuels Y, Li Q, Krokowski D, Guan BJ, Wang C, Jin Z, Dong B, Cao B, Feng X, Xiang M, Xu C, Fink S, Meropol NJ, Xu Y, Conlon RA, Markowitz S, Kinzler KW, Velculescu VE, Brunengraber H, Willis JE, LaFramboise T, Hatzoglou M, Zhang GF, Vogelstein B, Wang Z.

Nat Commun. 2016 Jun 20;7:11971. doi: 10.1038/ncomms11971.


Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL, Gropler RJ, Holzhuetter HG, Kizer JR, Lewandowski ED, Malloy CR, Neubauer S, Peterson LR, Portman MA, Recchia FA, Van Eyk JE, Wang TJ; American Heart Association Council on Basic Cardiovascular Sciences.

Circ Res. 2016 May 13;118(10):1659-701. doi: 10.1161/RES.0000000000000097. Epub 2016 Mar 24. Review. Erratum in: Circ Res. 2016 May 13;118(10):e35.


Cholesterol in mouse retina originates primarily from in situ de novo biosynthesis.

Lin JB, Mast N, Bederman IR, Li Y, Brunengraber H, Björkhem I, Pikuleva IA.

J Lipid Res. 2016 Feb;57(2):258-64. doi: 10.1194/jlr.M064469. Epub 2015 Dec 2.


Anaplerotic treatment of long-chain fat oxidation disorders with triheptanoin: Review of 15 years Experience.

Roe CR, Brunengraber H.

Mol Genet Metab. 2015 Dec;116(4):260-8. doi: 10.1016/j.ymgme.2015.10.005. Epub 2015 Oct 24.


Compartmentation of Metabolism of the C12-, C9-, and C5-n-dicarboxylates in Rat Liver, Investigated by Mass Isotopomer Analysis: ANAPLEROSIS FROM DODECANEDIOATE.

Jin Z, Bian F, Tomcik K, Kelleher JK, Zhang GF, Brunengraber H.

J Biol Chem. 2015 Jul 24;290(30):18671-7. doi: 10.1074/jbc.M115.651737. Epub 2015 Jun 12.


A roadmap for interpreting (13)C metabolite labeling patterns from cells.

Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM.

Curr Opin Biotechnol. 2015 Aug;34:189-201. doi: 10.1016/j.copbio.2015.02.003. Epub 2015 Feb 28. Review.


Multiple mass isotopomer tracing of acetyl-CoA metabolism in Langendorff-perfused rat hearts: channeling of acetyl-CoA from pyruvate dehydrogenase to carnitine acetyltransferase.

Li Q, Deng S, Ibarra RA, Anderson VE, Brunengraber H, Zhang GF.

J Biol Chem. 2015 Mar 27;290(13):8121-32. doi: 10.1074/jbc.M114.631549. Epub 2015 Feb 2.


Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation.

Anand P, Hausladen A, Wang YJ, Zhang GF, Stomberski C, Brunengraber H, Hess DT, Stamler JS.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18572-7. doi: 10.1073/pnas.1417816112. Epub 2014 Dec 15.


Metabolomics of ApcMin/+ mice genetically susceptible to intestinal cancer.

Dazard JE, Sandlers Y, Doerner SK, Berger NA, Brunengraber H.

BMC Syst Biol. 2014 Jun 23;8:72. doi: 10.1186/1752-0509-8-72.


Metabolomic Analysis of Liver Tissue from the VX2 Rabbit Model of Secondary Liver Tumors.

Ibarra R, Dazard JE, Sandlers Y, Rehman F, Abbas R, Kombu R, Zhang GF, Brunengraber H, Sanabria J.

HPB Surg. 2014;2014:310372. doi: 10.1155/2014/310372. Epub 2014 Mar 2.


A role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic ß-cells.

Guay C, Joly E, Pepin E, Barbeau A, Hentsch L, Pineda M, Madiraju SR, Brunengraber H, Prentki M.

PLoS One. 2013 Oct 10;8(10):e77097. doi: 10.1371/journal.pone.0077097. eCollection 2013.


Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

Charvet CD, Saadane A, Wang M, Salomon RG, Brunengraber H, Turko IV, Pikuleva IA.

J Biol Chem. 2013 Oct 11;288(41):29267-80. doi: 10.1074/jbc.M113.498832. Epub 2013 Aug 22. Erratum in: J Biol Chem. 2013 Nov 22;288(47):34054. Dosage error in article text.


Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats.

D'Agostino DP, Pilla R, Held HE, Landon CS, Puchowicz M, Brunengraber H, Ari C, Arnold P, Dean JB.

Am J Physiol Regul Integr Comp Physiol. 2013 May 15;304(10):R829-36. doi: 10.1152/ajpregu.00506.2012. Epub 2013 Apr 3.


Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate.

Harris SR, Zhang GF, Sadhukhan S, Wang H, Shi C, Puchowicz MA, Anderson VE, Salomon RG, Tochtrop GP, Brunengraber H.

Chem Res Toxicol. 2013 Feb 18;26(2):213-20. doi: 10.1021/tx3003643. Epub 2012 Dec 6.


Metabolism of γ-hydroxybutyrate in perfused rat livers.

Zhang GF, Sadhukhan S, Ibarra RA, Lauden SM, Chuang CY, Sushailo S, Chatterjee P, Anderson VE, Tochtrop GP, Brunengraber H.

Biochem J. 2012 Jun 1;444(2):333-41. doi: 10.1042/BJ20112046.


What is the proper precursor-to-product labeling relationship for calculating the fractional synthetic rate of muscle triglyceride?

Brunengraber H.

J Lipid Res. 2012 Jan;53(1):1-3. doi: 10.1194/jlr.E022426. Epub 2011 Nov 9. No abstract available.


Disturbances in the glutathione/ophthalmate redox buffer system in the woodchuck model of hepatitis virus-induced hepatocellular carcinoma.

Andres Ibarra R, Abbas R, Kombu RS, Zhang GF, Jacobs G, Lee Z, Brunengraber H, Sanabria JR.

HPB Surg. 2011;2011:789323. doi: 10.1155/2011/789323. Epub 2011 Sep 18.


Metabolomics, pathway regulation, and pathway discovery.

Zhang GF, Sadhukhan S, Tochtrop GP, Brunengraber H.

J Biol Chem. 2011 Jul 8;286(27):23631-5. doi: 10.1074/jbc.R110.171405. Epub 2011 May 12. Review.


The dynamics of glutathione species and ophthalmate concentrations in plasma from the VX2 rabbit model of secondary liver tumors.

Abbas R, Kombu RS, Ibarra RA, Goyal KK, Brunengraber H, Sanabria JR.

HPB Surg. 2011;2011:709052. doi: 10.1155/2011/709052. Epub 2011 Feb 17.


Analysis of the citric acid cycle intermediates using gas chromatography-mass spectrometry.

Kombu RS, Brunengraber H, Puchowicz MA.

Methods Mol Biol. 2011;708:147-57. doi: 10.1007/978-1-61737-985-7_8.


Metabolism of levulinate in perfused rat livers and live rats: conversion to the drug of abuse 4-hydroxypentanoate.

Harris SR, Zhang GF, Sadhukhan S, Murphy AM, Tomcik KA, Vazquez EJ, Anderson VE, Tochtrop GP, Brunengraber H.

J Biol Chem. 2011 Feb 18;286(7):5895-904. doi: 10.1074/jbc.M110.196808. Epub 2010 Dec 1.


Delineation of substrate selection and anaplerosis in tricarboxylic acid cycle of the heart by 13C NMR spectroscopy and mass spectrometry.

Li W, Bian F, Chaudhuri P, Mao X, Brunengraber H, Yu X.

NMR Biomed. 2011 Feb;24(2):176-87. doi: 10.1002/nbm.1569. Epub 2010 Oct 19.


Using isotopic tools to dissect and quantitate parallel metabolic pathways.

Sadhukhan S, Han Y, Zhang GF, Brunengraber H, Tochtrop GP.

J Am Chem Soc. 2010 May 12;132(18):6309-11. doi: 10.1021/ja100399m.


Dipropionylcysteine ethyl ester compensates for loss of citric acid cycle intermediates during post ischemia reperfusion in the pig heart.

Kasumov T, Sharma N, Huang H, Kombu RS, Cendrowski A, Stanley WC, Brunengraber H.

Cardiovasc Drugs Ther. 2009 Dec;23(6):459-69. doi: 10.1007/s10557-009-6208-1.


Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. II. Effects on lipolysis, glucose production, and liver acyl-CoA profile.

Gu L, Zhang GF, Kombu RS, Allen F, Kutz G, Brewer WU, Roe CR, Brunengraber H.

Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E362-71. doi: 10.1152/ajpendo.00384.2009. Epub 2009 Nov 10.


Catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs.

Zhang GF, Kombu RS, Kasumov T, Han Y, Sadhukhan S, Zhang J, Sayre LM, Ray D, Gibson KM, Anderson VA, Tochtrop GP, Brunengraber H.

J Biol Chem. 2009 Nov 27;284(48):33521-34. doi: 10.1074/jbc.M109.055665. Epub 2009 Sep 15.


Interrelations between C4 ketogenesis, C5 ketogenesis, and anaplerosis in the perfused rat liver.

Deng S, Zhang GF, Kasumov T, Roe CR, Brunengraber H.

J Biol Chem. 2009 Oct 9;284(41):27799-807. doi: 10.1074/jbc.M109.048744. Epub 2009 Aug 8.


Polyethylene glycol modified-albumin enhances the cold preservation properties of University of Wisconsin solution in rat liver and a hepatocyte cell line.

Abbas R, Kombu RS, Dignam D, Gunning W, Stulberg JJ, Brunengraber H, Sanabria JR.

J Surg Res. 2010 Nov;164(1):95-104. doi: 10.1016/j.jss.2009.03.030. Epub 2009 Apr 23.


Is there glucose production outside of the liver and kidney?

Previs SF, Brunengraber DZ, Brunengraber H.

Annu Rev Nutr. 2009;29:43-57. doi: 10.1146/annurev-nutr-080508-141134. Review.


Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans.

Kombu RS, Zhang GF, Abbas R, Mieyal JJ, Anderson VE, Kelleher JK, Sanabria JR, Brunengraber H.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E260-9. doi: 10.1152/ajpendo.00080.2009. Epub 2009 Apr 28.


Carnitine palmitoyltransferase II deficiency: successful anaplerotic diet therapy.

Roe CR, Yang BZ, Brunengraber H, Roe DS, Wallace M, Garritson BK.

Neurology. 2008 Jul 22;71(4):260-4. doi: 10.1212/01.wnl.0000318283.42961.e9.


Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle. I. Interrelation between gluconeogenesis and cataplerosis; formation of methoxamates from aminooxyacetate and ketoacids.

Yang L, Kombu RS, Kasumov T, Zhu SH, Cendrowski AV, David F, Anderson VE, Kelleher JK, Brunengraber H.

J Biol Chem. 2008 Aug 8;283(32):21978-87. doi: 10.1074/jbc.M803454200. Epub 2008 Jun 10.


Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle: II. Heterogeneity of metabolite labeling pattern.

Yang L, Kasumov T, Kombu RS, Zhu SH, Cendrowski AV, David F, Anderson VE, Kelleher JK, Brunengraber H.

J Biol Chem. 2008 Aug 8;283(32):21988-96. doi: 10.1074/jbc.M803455200. Epub 2008 Jun 10.


Alpha-ketoglutarate is the precursor of L-2-hydroxyglutarate.

Brunengraber H.

J Inherit Metab Dis. 2007 Oct;30(5):628. No abstract available.


Mass isotopomer study of anaplerosis from propionate in the perfused rat heart.

Kasumov T, Cendrowski AV, David F, Jobbins KA, Anderson VE, Brunengraber H.

Arch Biochem Biophys. 2007 Jul 1;463(1):110-7. Epub 2007 Mar 12.


Assay of the activity of malonyl-coenzyme A decarboxylase by gas chromatography-mass spectrometry.

Wang X, Stanley WC, Darrow CJ, Brunengraber H, Kasumov T.

Anal Biochem. 2007 Apr 15;363(2):169-74. Epub 2007 Jan 13. Erratum in: Anal Biochem. 2008 Apr 1;375(1):162. Darrow, Cory J [added].


Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes.

Kovacs WJ, Tape KN, Shackelford JE, Duan X, Kasumov T, Kelleher JK, Brunengraber H, Krisans SK.

Histochem Cell Biol. 2007 Mar;127(3):273-90. Epub 2006 Dec 19.


Competition between acetate and oleate for the formation of malonyl-CoA and mitochondrial acetyl-CoA in the perfused rat heart.

Bian F, Kasumov T, Jobbins KA, Minkler PE, Anderson VE, Kerner J, Hoppel CL, Brunengraber H.

J Mol Cell Cardiol. 2006 Nov;41(5):868-75. Epub 2006 Oct 3.


Anaplerotic molecules: current and future.

Brunengraber H, Roe CR.

J Inherit Metab Dis. 2006 Apr-Jun;29(2-3):327-31. Review.


Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats.

Kinman RP, Kasumov T, Jobbins KA, Thomas KR, Adams JE, Brunengraber LN, Kutz G, Brewer WU, Roe CR, Brunengraber H.

Am J Physiol Endocrinol Metab. 2006 Oct;291(4):E860-6. Epub 2006 May 16.


Differential effects of heptanoate and hexanoate on myocardial citric acid cycle intermediates following ischemia-reperfusion.

Okere IC, McElfresh TA, Brunengraber DZ, Martini W, Sterk JP, Huang H, Chandler MP, Brunengraber H, Stanley WC.

J Appl Physiol (1985). 2006 Jan;100(1):76-82. Epub 2005 Sep 1.


Pyruvate carboxylase deficiency: clinical and biochemical response to anaplerotic diet therapy.

Mochel F, DeLonlay P, Touati G, Brunengraber H, Kinman RP, Rabier D, Roe CR, Saudubray JM.

Mol Genet Metab. 2005 Apr;84(4):305-12.


Probing peroxisomal beta-oxidation and the labelling of acetyl-CoA proxies with [1-(13C)]octanoate and [3-(13C)]octanoate in the perfused rat liver.

Kasumov T, Adams JE, Bian F, David F, Thomas KR, Jobbins KA, Minkler PE, Hoppel CL, Brunengraber H.

Biochem J. 2005 Jul 15;389(Pt 2):397-401.


Peroxisomal and mitochondrial oxidation of fatty acids in the heart, assessed from the 13C labeling of malonyl-CoA and the acetyl moiety of citrate.

Bian F, Kasumov T, Thomas KR, Jobbins KA, David F, Minkler PE, Hoppel CL, Brunengraber H.

J Biol Chem. 2005 Mar 11;280(10):9265-71. Epub 2004 Dec 16.


In vitro modeling of fatty acid synthesis under conditions simulating the zonation of lipogenic [13C]acetyl-CoA enrichment in the liver.

Bederman IR, Kasumov T, Reszko AE, David F, Brunengraber H, Kelleher JK.

J Biol Chem. 2004 Oct 8;279(41):43217-26. Epub 2004 Jul 28.

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