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Items: 1 to 50 of 142

1.

Physiologically-Based Pharmacokinetic Model of Sertraline in Human to Predict Clinical Relevance of Concentrations at Target Tissues.

Alhadab AA, Brundage RC.

Clin Pharmacol Ther. 2020 Mar 3. doi: 10.1002/cpt.1824. [Epub ahead of print]

PMID:
32128758
2.

Brain Distributional Kinetics of a Novel MDM2 Inhibitor SAR405838: Implications for Use in Brain Tumor Therapy.

Kim M, Laramy JK, Gampa G, Parrish KE, Brundage R, Sarkaria JN, Elmquist WF.

Drug Metab Dispos. 2019 Dec;47(12):1403-1414. doi: 10.1124/dmd.119.088716. Epub 2019 Oct 16.

PMID:
31619389
3.

Pharmacokinetics-pharmacodynamics of sertraline as an antifungal in HIV-infected Ugandans with cryptococcal meningitis.

Alhadab AA, Rhein J, Tugume L, Musubire A, Williams DA, Abassi M, Nicol MR, Meya DB, Boulware DR, Brundage RC; ASTRO-CM Study Team.

J Pharmacokinet Pharmacodyn. 2019 Dec;46(6):565-576. doi: 10.1007/s10928-019-09657-0. Epub 2019 Oct 4.

PMID:
31584146
4.

Precision medicine in adult and pediatric obesity: a clinical perspective.

Bomberg EM, Ryder JR, Brundage RC, Straka RJ, Fox CK, Gross AC, Oberle MM, Bramante CT, Sibley SD, Kelly AS.

Ther Adv Endocrinol Metab. 2019 Jul 27;10:2042018819863022. doi: 10.1177/2042018819863022. eCollection 2019. Review.

5.

Orphan drug development: the increasing role of clinical pharmacology.

Ahmed MA, Okour M, Brundage R, Kartha RV.

J Pharmacokinet Pharmacodyn. 2019 Oct;46(5):395-409. doi: 10.1007/s10928-019-09646-3. Epub 2019 Jul 23. Review.

PMID:
31338634
6.

Comparative Evaluation of Median Versus Youden Index Dichotomization Methods: Exposure-Response Analysis of Mycophenolic Acid and Acyl-Glucuronide Metabolite.

Okour M, Jacobson PA, Israni A, Brundage RC.

Eur J Drug Metab Pharmacokinet. 2019 Oct;44(5):629-638. doi: 10.1007/s13318-019-00550-2.

PMID:
30879263
7.

A Gallbladder-Based Enterohepatic Circulation Model for Pharmacokinetic Studies.

Okour M, Brundage RC.

Eur J Drug Metab Pharmacokinet. 2019 Aug;44(4):493-504. doi: 10.1007/s13318-018-0535-1.

PMID:
30488336
8.

Iron supplements in nursing home patients associated with reduced carbamazepine absorption.

Ahn JE, Bathena SPR, Brundage RC, Conway JM, Leppik IE, Birnbaum AK.

Epilepsy Res. 2018 Nov;147:115-118. doi: 10.1016/j.eplepsyres.2018.07.015.

PMID:
30327119
9.

Lamotrigine pharmacokinetics following oral and stable-labeled intravenous administration in young and elderly adult epilepsy patients: Effect of age.

Polepally AR, Brundage RC, Remmel RP, Leppik IE, Pennell PB, White JR, Ramsay RE, Kistner BM, Birnbaum AK.

Epilepsia. 2018 Sep;59(9):1718-1726. doi: 10.1111/epi.14519. Epub 2018 Aug 12.

10.

Amikacin Pharmacokinetic-Pharmacodynamic Analysis in Pediatric Cancer Patients.

Alhadab AA, Ahmed MA, Brundage RC.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e01781-17. doi: 10.1128/AAC.01781-17. Print 2018 Apr.

11.

Mycophenolic Acid and Its Metabolites in Kidney Transplant Recipients: A Semimechanistic Enterohepatic Circulation Model to Improve Estimating Exposure.

Okour M, Jacobson PA, Ahmed MA, Israni AK, Brundage RC.

J Clin Pharmacol. 2018 May;58(5):628-639. doi: 10.1002/jcph.1064. Epub 2018 Jan 12.

12.

Pharmacokinetics and Saturable Absorption of Gabapentin in Nursing Home Elderly Patients.

Ahmed GF, Bathena SP, Brundage RC, Leppik IE, Conway JM, Schwartz JB, Birnbaum AK.

AAPS J. 2017 Mar;19(2):551-556. doi: 10.1208/s12248-016-0022-z. Epub 2017 Jan 9.

PMID:
28070716
13.

Prospective studies of infectious mononucleosis in university students.

Grimm JM, Schmeling DO, Dunmire SK, Knight JA, Mullan BD, Ed JA, Brundage RC, Hogquist KA, Balfour HH Jr.

Clin Transl Immunology. 2016 Aug 12;5(8):e94. doi: 10.1038/cti.2016.48. eCollection 2016 Aug.

14.

A hierarchical Bayesian approach for combining pharmacokinetic/pharmacodynamic modeling and Phase IIa trial design in orphan drugs: Treating adrenoleukodystrophy with Lorenzo's oil.

Basu C, Ahmed MA, Kartha RV, Brundage RC, Raymond GV, Cloyd JC, Carlin BP.

J Biopharm Stat. 2016;26(6):1025-1039. Epub 2016 Aug 22.

15.

CYP2C9 Genotype-Dependent Warfarin Pharmacokinetics: Impact of CYP2C9 Genotype on R- and S-Warfarin and Their Oxidative Metabolites.

Flora DR, Rettie AE, Brundage RC, Tracy TS.

J Clin Pharmacol. 2017 Mar;57(3):382-393. doi: 10.1002/jcph.813. Epub 2016 Sep 22.

PMID:
27539372
16.

Epstein-Barr virus dynamics in asymptomatic immunocompetent adults: an intensive 6-month study.

Johnson KH, Webb CH, Schmeling DO, Brundage RC, Balfour HH Jr.

Clin Transl Immunology. 2016 May 13;5(5):e81. doi: 10.1038/cti.2016.28. eCollection 2016 May.

17.

Pharmacokinetic-pharmacodynamic modelling of acute N-terminal pro B-type natriuretic peptide after doxorubicin infusion in breast cancer.

Liang S, Brundage RC, Jacobson PA, Blaes A, Kirstein MN.

Br J Clin Pharmacol. 2016 Sep;82(3):773-83. doi: 10.1111/bcp.12989. Epub 2016 Jun 3.

18.

Personalized fludarabine dosing to reduce nonrelapse mortality in hematopoietic stem-cell transplant recipients receiving reduced intensity conditioning.

Sanghavi K, Wiseman A, Kirstein MN, Cao Q, Brundage R, Jensen K, Rogosheske J, Kurtzweil A, Long-Boyle J, Wagner J, Warlick ED, Brunstein CG, Weisdorf DJ, Jacobson PA.

Transl Res. 2016 Sep;175:103-115.e4. doi: 10.1016/j.trsl.2016.03.017. Epub 2016 Mar 31.

19.

Operational Characteristics of Linear Concentration-QT Models for Assessing QTc Interval in the Thorough QT and Phase I Clinical Studies.

Garnett C, Needleman K, Liu J, Brundage R, Wang Y.

Clin Pharmacol Ther. 2016 Aug;100(2):170-8. doi: 10.1002/cpt.361. Epub 2016 May 9.

PMID:
26946218
20.

A model-based approach to assess the exposure-response relationship of Lorenzo's oil in adrenoleukodystrophy.

Ahmed MA, Kartha RV, Brundage RC, Cloyd J, Basu C, Carlin BP, Jones RO, Moser AB, Fatemi A, Raymond GV.

Br J Clin Pharmacol. 2016 Jun;81(6):1058-66. doi: 10.1111/bcp.12897. Epub 2016 Apr 3.

21.

Genotype-guided tacrolimus dosing in African-American kidney transplant recipients.

Sanghavi K, Brundage RC, Miller MB, Schladt DP, Israni AK, Guan W, Oetting WS, Mannon RB, Remmel RP, Matas AJ, Jacobson PA.

Pharmacogenomics J. 2017 Jan;17(1):61-68. doi: 10.1038/tpj.2015.87. Epub 2015 Dec 15.

22.

Pharmacokinetic-Pharmacodynamic Modeling of Intravenous and Oral Topiramate and Its Effect on the Symbol-Digit Modalities Test in Adult Healthy Volunteers.

Lim CN, Birnbaum AK, Brundage RC, Leppik IE, Cloyd JC, Clark A, Marino SE.

J Clin Pharmacol. 2016 Jun;56(6):714-22. doi: 10.1002/jcph.646. Epub 2015 Dec 21.

23.

Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: Use of stable isotope methodology.

Polepally AR, Remmel RP, Brundage RC, Leppik IE, Rarick JO, Ramsay RE, Birnbaum AK.

J Clin Pharmacol. 2015 Oct;55(10):1101-8. doi: 10.1002/jcph.522. Epub 2015 Aug 18.

24.

Ethnic and genetic factors in methadone pharmacokinetics: a population pharmacokinetic study.

Bart G, Lenz S, Straka RJ, Brundage RC.

Drug Alcohol Depend. 2014 Dec 1;145:185-93. doi: 10.1016/j.drugalcdep.2014.10.014. Epub 2014 Oct 24.

25.

Pharmacokinetic-pharmacodynamic modelling of intravenous and oral topiramate and its effect on phonemic fluency in adult healthy volunteers.

Ahmed GF, Marino SE, Brundage RC, Pakhomov SV, Leppik IE, Cloyd JC, Clark A, Birnbaum AK.

Br J Clin Pharmacol. 2015 May;79(5):820-30. doi: 10.1111/bcp.12556.

26.

Interrelationships among cortisol, 17-hydroxyprogesterone, and androstenendione exposures in the management of children with congenital adrenal hyperplasia.

Sarafoglou K, Zimmerman CL, Gonzalez-Bolanos MT, Willis BA, Brundage R.

J Investig Med. 2015 Jan;63(1):35-41. doi: 10.1097/JIM.0000000000000121.

PMID:
25386671
27.

Comparison of cortisol exposures and pharmacodynamic adrenal steroid responses to hydrocortisone suspension vs. commercial tablets.

Sarafoglou K, Gonzalez-Bolanos MT, Zimmerman CL, Boonstra T, Yaw Addo O, Brundage R.

J Clin Pharmacol. 2015 Apr;55(4):452-7. doi: 10.1002/jcph.424. Epub 2014 Dec 30.

PMID:
25385533
28.

MODEL-BASED LAMOTRIGINE CLEARANCE CHANGES DURING PREGNANCY: CLINICAL IMPLICATION.

Polepally AR, Pennell PB, Brundage RC, Stowe ZN, Newport DJ, Viguera AC, Ritchie JC, Birnbaum AK.

Ann Clin Transl Neurol. 2014 Feb;1(2):99-106.

29.

Population pharmacokinetics of valganciclovir prophylaxis in paediatric and adult solid organ transplant recipients.

Vezina HE, Brundage RC, Balfour HH Jr.

Br J Clin Pharmacol. 2014 Aug;78(2):343-52. doi: 10.1111/bcp.12343.

30.

SLC28A3 genotype and gemcitabine rate of infusion affect dFdCTP metabolite disposition in patients with solid tumours.

Khatri A, Williams BW, Fisher J, Brundage RC, Gurvich VJ, Lis LG, Skubitz KM, Dudek AZ, Greeno EW, Kratzke RA, Lamba JK, Kirstein MN.

Br J Cancer. 2014 Jan 21;110(2):304-12. doi: 10.1038/bjc.2013.738. Epub 2013 Dec 3.

31.

Pharmacometric characterization of efavirenz developmental pharmacokinetics and pharmacogenetics in HIV-infected children.

Salem AH, Fletcher CV, Brundage RC.

Antimicrob Agents Chemother. 2014;58(1):136-43. doi: 10.1128/AAC.01738-13. Epub 2013 Oct 21.

32.

Bayesian approach to estimate AUC, partition coefficient and drug targeting index for studies with serial sacrifice design.

Wang T, Baron K, Zhong W, Brundage R, Elmquist W.

Pharm Res. 2014 Mar;31(3):649-59. doi: 10.1007/s11095-013-1187-0. Epub 2013 Oct 3.

33.

Intravenous topiramate: safety and pharmacokinetics following a single dose in patients with epilepsy or migraines taking oral topiramate.

Clark AM, Kriel RL, Leppik IE, White JR, Henry TR, Brundage RC, Cloyd JC.

Epilepsia. 2013 Jun;54(6):1106-11. doi: 10.1111/epi.12165. Epub 2013 Apr 15.

34.

A pilot study assessing the bioavailability and pharmacokinetics of diazepam after intranasal and intravenous administration in healthy volunteers.

Agarwal SK, Kriel RL, Brundage RC, Ivaturi VD, Cloyd JC.

Epilepsy Res. 2013 Aug;105(3):362-7. doi: 10.1016/j.eplepsyres.2013.02.018. Epub 2013 Apr 2.

PMID:
23561287
35.

Intravenous topiramate: comparison of pharmacokinetics and safety with the oral formulation in healthy volunteers.

Clark AM, Kriel RL, Leppik IE, Marino SE, Mishra U, Brundage RC, Cloyd JC.

Epilepsia. 2013 Jun;54(6):1099-105. doi: 10.1111/epi.12134. Epub 2013 Mar 18.

36.

Population pharmacokinetics of unbound and total drug concentrations following intravenously administered carbamazepine in elderly and younger adult patients with epilepsy.

Ahmed GF, Brundage RC, Marino SE, Cloyd JC, Leppik IE, Pennell PB, Ramsay RE, Birnbaum AK.

J Clin Pharmacol. 2013 Mar;53(3):276-84. doi: 10.1002/jcph.8. Epub 2013 Feb 13.

37.

Population pharmacokinetics of rifampicin in Mexican patients with tuberculosis.

Milán Segovia RC, Domínguez Ramírez AM, Jung Cook H, Magaña Aquino M, Vigna Pérez M, Brundage RC, Romano Moreno S.

J Clin Pharm Ther. 2013 Feb;38(1):56-61. doi: 10.1111/jcpt.12016. Epub 2012 Nov 20.

PMID:
23167603
38.

Bioavailability of intranasal vs. rectal diazepam.

Ivaturi V, Kriel R, Brundage R, Loewen G, Mansbach H, Cloyd J.

Epilepsy Res. 2013 Feb;103(2-3):254-61. doi: 10.1016/j.eplepsyres.2012.07.018. Epub 2012 Sep 13.

PMID:
22981338
39.

Validation of tacrolimus equation to predict troughs using genetic and clinical factors.

Passey C, Birnbaum AK, Brundage RC, Schladt DP, Oetting WS, Leduc RE, Israni AK, Guan W, Matas AJ, Jacobson PA.

Pharmacogenomics. 2012 Jul;13(10):1141-7. doi: 10.2217/pgs.12.98.

40.

Population pharmacokinetics of carbamazepine in elderly patients.

Punyawudho B, Ramsay ER, Brundage RC, Macias FM, Collins JF, Birnbaum AK.

Ther Drug Monit. 2012 Apr;34(2):176-81. doi: 10.1097/FTD.0b013e31824d6a4e.

41.

Quantitative Epstein-Barr virus shedding and its correlation with the risk of post-transplant lymphoproliferative disorder.

Holman CJ, Karger AB, Mullan BD, Brundage RC, Balfour HH Jr.

Clin Transplant. 2012 Sep-Oct;26(5):741-7. doi: 10.1111/j.1399-0012.2012.01608.x. Epub 2012 Mar 4.

42.

Steady-state carbamazepine pharmacokinetics following oral and stable-labeled intravenous administration in epilepsy patients: effects of race and sex.

Marino SE, Birnbaum AK, Leppik IE, Conway JM, Musib LC, Brundage RC, Ramsay RE, Pennell PB, White JR, Gross CR, Rarick JO, Mishra U, Cloyd JC.

Clin Pharmacol Ther. 2012 Mar;91(3):483-8. doi: 10.1038/clpt.2011.251. Epub 2012 Jan 25.

43.

Affiliation between the American Society of Pharmacometrics and the Journal of Pharmacokinetics and Pharmacodynamics.

D'Argenio DZ, Gastonguay MR, Brundage RC, Miller R, Tannenbaum SJ, Pfister M.

J Pharmacokinet Pharmacodyn. 2012 Feb;39(1):3. doi: 10.1007/s10928-011-9237-x. No abstract available.

PMID:
22219000
44.

Population pharmacokinetics of unbound mycophenolic acid in pediatric and young adult patients undergoing allogeneic hematopoietic cell transplantation.

Kim H, Long-Boyle J, Rydholm N, Orchard PJ, Tolar J, Smith AR, Jacobson P, Brundage R.

J Clin Pharmacol. 2012 Nov;52(11):1665-75. doi: 10.1177/0091270011422814. Epub 2011 Nov 22.

PMID:
22110162
45.

Pharmacodynamic modeling of sequence-dependent antitumor activity of insulin-like growth factor blockade and gemcitabine.

Khatri A, Brundage RC, Hull JM, Williams BW, Yee D, Kirstein MN.

AAPS J. 2012 Mar;14(1):1-9. doi: 10.1208/s12248-011-9308-3. Epub 2011 Nov 19.

46.

Dosing equation for tacrolimus using genetic variants and clinical factors.

Passey C, Birnbaum AK, Brundage RC, Oetting WS, Israni AK, Jacobson PA.

Br J Clin Pharmacol. 2011 Dec;72(6):948-57. doi: 10.1111/j.1365-2125.2011.04039.x.

47.

Atazanavir and atazanavir/ritonavir pharmacokinetics in HIV-infected infants, children, and adolescents.

Kiser JJ, Rutstein RM, Samson P, Graham B, Aldrovandi G, Mofenson LM, Smith E, Schnittman S, Fenton T, Brundage RC, Fletcher CV.

AIDS. 2011 Jul 31;25(12):1489-96. doi: 10.1097/QAD.0b013e328348fc41.

48.

Excretion of the principal urinary metabolites of phenytoin and absolute oral bioavailability determined by use of a stable isotope in patients with epilepsy.

Aliwarga T, Cloyd JC, Goel V, Brundage RC, Marino SE, Leppik IE, Remmel RP.

Ther Drug Monit. 2011 Feb;33(1):56-63. doi: 10.1097/FTD.0b013e3182081089.

PMID:
21233690
49.

Population pharmacokinetic and concentration--QTc models for moxifloxacin: pooled analysis of 20 thorough QT studies.

Florian JA, Tornøe CW, Brundage R, Parekh A, Garnett CE.

J Clin Pharmacol. 2011 Aug;51(8):1152-62. doi: 10.1177/0091270010381498. Epub 2011 Jan 12.

PMID:
21228407
50.

Effect of radiation on the penetration of irinotecan in rat cerebrospinal fluid.

Khatri A, Gaber MW, Brundage RC, Naimark MD, Hanna SK, Stewart CF, Kirstein MN.

Cancer Chemother Pharmacol. 2011 Sep;68(3):721-31. doi: 10.1007/s00280-010-1542-3. Epub 2010 Dec 16.

PMID:
21161529

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