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Items: 1 to 50 of 765

1.

Induction of labor and postpartum blood loss.

Brun R, Spoerri E, Schäffer L, Zimmermann R, Haslinger C.

BMC Pregnancy Childbirth. 2019 Jul 25;19(1):265. doi: 10.1186/s12884-019-2410-8.

2.

An Unusually Broad Series of Seven Cyclombandakamines, Bridged Dimeric Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ealaensis.

Tshitenge DT, Bruhn T, Feineis D, Mudogo V, Kaiser M, Brun R, Bringmann G.

Sci Rep. 2019 Jul 8;9(1):9812. doi: 10.1038/s41598-019-46336-z.

3.

Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents.

Saccoliti F, Madia VN, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet CM, Jennings GK, Podust LM, Pepe G, Cirilli R, Faggi C, Di Marco A, Battista MR, Summa V, Costi R, Di Santo R.

J Med Chem. 2019 Feb 14;62(3):1330-1347. doi: 10.1021/acs.jmedchem.8b01464. Epub 2019 Jan 23.

PMID:
30615444
4.

Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana Ancistrocladus abbreviatus with inhibitory activities against Plasmodium falciparum and PANC-1 human pancreatic cancer cells.

Fayez S, Feineis D, Aké Assi L, Kaiser M, Brun R, Awale S, Bringmann G.

Fitoterapia. 2018 Nov;131:245-259. doi: 10.1016/j.fitote.2018.11.006. Epub 2018 Nov 9.

PMID:
30419265
5.

Validation of a quantitative system for real-time measurement of postpartum blood loss.

Kahr MK, Brun R, Zimmermann R, Franke D, Haslinger C.

Arch Gynecol Obstet. 2018 Dec;298(6):1071-1077. doi: 10.1007/s00404-018-4896-0. Epub 2018 Sep 17.

PMID:
30225686
6.

Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.

Saccoliti F, Madia VN, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet CM, Jennings GK, Podust LM, Costi R, Di Santo R.

Eur J Med Chem. 2018 Aug 5;156:53-60. doi: 10.1016/j.ejmech.2018.06.063. Epub 2018 Jun 28.

PMID:
30006174
7.

Blood group O: A novel risk factor for increased postpartum blood loss?

Kahr MK, Franke D, Brun R, Wisser J, Zimmermann R, Haslinger C.

Haemophilia. 2018 Jul;24(4):e207-e212. doi: 10.1111/hae.13537. Epub 2018 Jun 7.

PMID:
29877601
8.

2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.

Giroud M, Kuhn B, Saint-Auret S, Kuratli C, Martin RE, Schuler F, Diederich F, Kaiser M, Brun R, Schirmeister T, Haap W.

J Med Chem. 2018 Apr 26;61(8):3370-3388. doi: 10.1021/acs.jmedchem.7b01870. Epub 2018 Apr 6.

PMID:
29590751
9.

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

Giroud M, Dietzel U, Anselm L, Banner D, Kuglstatter A, Benz J, Blanc JB, Gaufreteau D, Liu H, Lin X, Stich A, Kuhn B, Schuler F, Kaiser M, Brun R, Schirmeister T, Kisker C, Diederich F, Haap W.

J Med Chem. 2018 Apr 26;61(8):3350-3369. doi: 10.1021/acs.jmedchem.7b01869. Epub 2018 Apr 13.

PMID:
29590750
10.

Isothermal microcalorimetry - A quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time.

Gysin M, Braissant O, Gillingwater K, Brun R, Mäser P, Wenzler T.

Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):159-164. doi: 10.1016/j.ijpddr.2018.03.003. Epub 2018 Mar 16.

11.

Mbandakamine-Type Naphthylisoquinoline Dimers and Related Alkaloids from the Central African Liana Ancistrocladus ealaensis with Antiparasitic and Antileukemic Activities.

Tshitenge DT, Feineis D, Mudogo V, Kaiser M, Brun R, Seo EJ, Efferth T, Bringmann G.

J Nat Prod. 2018 Apr 27;81(4):918-933. doi: 10.1021/acs.jnatprod.7b01041. Epub 2018 Mar 21.

PMID:
29560715
12.

Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections.

Uliassi E, Piazzi L, Belluti F, Mazzanti A, Kaiser M, Brun R, Moraes CB, Freitas-Junior LH, Gul S, Kuzikov M, Ellinger B, Borsari C, Costi MP, Bolognesi ML.

ChemMedChem. 2018 Apr 6;13(7):678-683. doi: 10.1002/cmdc.201700786. Epub 2018 Feb 16.

PMID:
29451361
13.

Erroneously Suspected Ovarian Cancer in a 38-Year-Old Woman with Pelvic Inflammatory Disease and Chlamydia.

Brun R, Hutmacher J, Fink D, Imesch P.

Case Rep Obstet Gynecol. 2017;2017:2514613. doi: 10.1155/2017/2514613. Epub 2017 Dec 13.

14.

Sesquiterpene Lactones from Vernonia cinerascens Sch. Bip. and Their in Vitro Antitrypanosomal Activity.

Kimani NM, Matasyoh JC, Kaiser M, Brun R, Schmidt TJ.

Molecules. 2018 Jan 27;23(2). pii: E248. doi: 10.3390/molecules23020248.

15.

Small bowel fed response as measured by wireless motility capsule: Comparative analysis in healthy, gastroparetic, and constipated subjects.

Surjanhata B, Brun R, Wilding G, Semler J, Kuo B.

Neurogastroenterol Motil. 2018 May;30(5):e13268. doi: 10.1111/nmo.13268. Epub 2017 Dec 18.

PMID:
29250864
16.

Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata.

Kimani NM, Matasyoh JC, Kaiser M, Brun R, Schmidt TJ.

J Nat Prod. 2018 Jan 26;81(1):124-130. doi: 10.1021/acs.jnatprod.7b00747. Epub 2017 Dec 15.

PMID:
29244495
17.

In Vitro and In Vivo Studies of the Trypanocidal Effect of Novel Quinolines.

Nefertiti ASG, Batista MM, Da Silva PB, Batista DGJ, Da Silva CF, Peres RB, Torres-Santos EC, Cunha-Junior EF, Holt E, Boykin DW, Brun R, Wenzler T, Soeiro MNC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01936-17. doi: 10.1128/AAC.01936-17. Print 2018 Feb.

18.

Antiprotozoal Spirombandakamines A1 and A2, Fused Naphthylisoquinoline Dimers from a Congolese Ancistrocladus Plant.

Lombe BK, Bruhn T, Feineis D, Mudogo V, Brun R, Bringmann G.

Org Lett. 2017 Dec 15;19(24):6740-6743. doi: 10.1021/acs.orglett.7b03473. Epub 2017 Nov 30.

PMID:
29189016
19.

Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT).

Akama T, Zhang YK, Freund YR, Berry P, Lee J, Easom EE, Jacobs RT, Plattner JJ, Witty MJ, Peter R, Rowan TG, Gillingwater K, Brun R, Nare B, Mercer L, Xu M, Wang J, Liang H.

Bioorg Med Chem Lett. 2018 Jan 1;28(1):6-10. doi: 10.1016/j.bmcl.2017.11.028. Epub 2017 Nov 20.

20.

Indole and Benzimidazole Bichalcophenes: Synthesis, DNA Binding and Antiparasitic Activity.

Farahat AA, Ismail MA, Kumar A, Wenzler T, Brun R, Paul A, Wilson WD, Boykin DW.

Eur J Med Chem. 2018 Jan 1;143:1590-1596. doi: 10.1016/j.ejmech.2017.10.056. Epub 2017 Oct 22.

21.

Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana Ancistrocladus ileboensis, with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line.

Li J, Seupel R, Bruhn T, Feineis D, Kaiser M, Brun R, Mudogo V, Awale S, Bringmann G.

J Nat Prod. 2017 Oct 27;80(10):2807-2817. doi: 10.1021/acs.jnatprod.7b00650. Epub 2017 Oct 18.

PMID:
29043798
22.

Erratum: Terpenoids from the Oleo-Gum-Resin of Boswellia serrata and Their Antiplasmodial Effects In Vitro.

Greve HL, Kaiser M, Brun R, Schmidt TJ.

Planta Med. 2017 Oct;83(14-15):E4. doi: 10.1055/s-0043-118649. Epub 2017 Aug 28. No abstract available.

PMID:
28847018
23.

Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles.

Pagliero RJ, Kaiser M, Brun R, Nieto MJ, Mazzieri MR.

Bioorg Med Chem Lett. 2017 Sep 1;27(17):3945-3949. doi: 10.1016/j.bmcl.2017.07.081. Epub 2017 Jul 31.

PMID:
28789893
24.

Terpenoids from the Oleo-Gum-Resin of Boswellia serrata and Their Antiplasmodial Effects In Vitro.

Greve HL, Kaiser M, Brun R, Schmidt TJ.

Planta Med. 2017 Oct;83(14-15):1214-1226. doi: 10.1055/s-0043-116943. Epub 2017 Jul 24. Erratum in: Planta Med. 2017 Oct;83(14-15):E4.

PMID:
28738439
25.

Antiplasmodial Ealapasamines A-C,'Mixed' Naphthylisoquinoline Dimers from the Central African Liana Ancistrocladus ealaensis.

Tshitenge DT, Feineis D, Mudogo V, Kaiser M, Brun R, Bringmann G.

Sci Rep. 2017 Jul 18;7(1):5767. doi: 10.1038/s41598-017-05719-w.

26.

Antileukemic ancistrobenomine B and related 5,1'-coupled naphthylisoquinoline alkaloids from the Chinese liana Ancistrocladus tectorius.

Bringmann G, Seupel R, Feineis D, Xu M, Zhang G, Kaiser M, Brun R, Seo EJ, Efferth T.

Fitoterapia. 2017 Sep;121:76-85. doi: 10.1016/j.fitote.2017.07.001. Epub 2017 Jul 6.

PMID:
28688886
27.

Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense.

Nnadi CO, Nwodo NJ, Kaiser M, Brun R, Schmidt TJ.

Molecules. 2017 Jul 6;22(7). pii: E1129. doi: 10.3390/molecules22071129.

28.

Alkamides from Anacyclus pyrethrum L. and Their in Vitro Antiprotozoal Activity.

Althaus JB, Malyszek C, Kaiser M, Brun R, Schmidt TJ.

Molecules. 2017 May 12;22(5). pii: E796. doi: 10.3390/molecules22050796.

29.

Anti-Trypanosomatid Elemanolide Sesquiterpene Lactones from Vernonia lasiopus O. Hoffm.

Kimani NM, Matasyoh JC, Kaiser M, Brun R, Schmidt TJ.

Molecules. 2017 Apr 8;22(4). pii: E597. doi: 10.3390/molecules22040597.

30.

Synthesis and activity of nucleoside-based antiprotozoan compounds.

Tran HA, Zheng Z, Wen X, Manivannan S, Pastor A, Kaiser M, Brun R, Snyder FF, Back TG.

Bioorg Med Chem. 2017 Apr 1;25(7):2091-2104. doi: 10.1016/j.bmc.2017.02.016. Epub 2017 Feb 16.

PMID:
28284860
31.

Cyclombandakamines A1 and A2, Oxygen-Bridged Naphthylisoquinoline Dimers from a Congolese Ancistrocladus Liana.

Lombe BK, Bruhn T, Feineis D, Mudogo V, Brun R, Bringmann G.

Org Lett. 2017 Mar 17;19(6):1342-1345. doi: 10.1021/acs.orglett.7b00209. Epub 2017 Feb 23.

PMID:
28231014
32.

In Vitro, Ex Vivo, and In Vivo Activities of Diamidines against Trypanosoma congolense and Trypanosoma vivax.

Gillingwater K, Kunz C, Braghiroli C, Boykin DW, Tidwell RR, Brun R.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02356-16. doi: 10.1128/AAC.02356-16. Print 2017 May.

33.

Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties.

Farahat AA, Kumar A, Say M, Wenzler T, Brun R, Paul A, Wilson WD, Boykin DW.

Eur J Med Chem. 2017 Mar 10;128:70-78. doi: 10.1016/j.ejmech.2017.01.037. Epub 2017 Jan 24.

34.

Dioncophyllines C2, D2, and F and Related Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ileboensis with Potent Activities against Plasmodium falciparum and against Multiple Myeloma and Leukemia Cell Lines.

Li J, Seupel R, Feineis D, Mudogo V, Kaiser M, Brun R, Brünnert D, Chatterjee M, Seo EJ, Efferth T, Bringmann G.

J Nat Prod. 2017 Feb 24;80(2):443-458. doi: 10.1021/acs.jnatprod.6b00967. Epub 2017 Jan 25.

PMID:
28121440
35.

Directed Synthesis of All Four Pure Stereoisomers of the N,C-Coupled Naphthylisoquinoline Alkaloid Ancistrocladinium A.

Seupel R, Hertlein-Amslinger B, Gulder T, Stawski P, Kaiser M, Brun R, Bringmann G.

Org Lett. 2016 Dec 16;18(24):6508-6511. Epub 2016 Dec 1.

PMID:
27978644
36.

Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI.

Farahat AA, Bennett-Vaughn C, Mineva EM, Kumar A, Wenzler T, Brun R, Liu Y, Wilson WD, Boykin DW.

Bioorg Med Chem Lett. 2016 Dec 15;26(24):5907-5910. doi: 10.1016/j.bmcl.2016.11.006. Epub 2016 Nov 3.

PMID:
27843114
37.

Systemic Sclerosis and the Gastrointestinal Tract-Clinical Approach.

Braun-Moscovici Y, Brun R, Braun M.

Rambam Maimonides Med J. 2016 Oct 31;7(4). doi: 10.5041/RMMJ.10258. Review.

38.

Ancistectorine D, a naphthylisoquinoline alkaloid with antiprotozoal and antileukemic activities, and further 5,8'- and 7,1'-linked metabolites from the Chinese liana Ancistrocladus tectorius.

Bringmann G, Seupel R, Feineis D, Zhang G, Xu M, Wu J, Kaiser M, Brun R, Seo EJ, Efferth T.

Fitoterapia. 2016 Dec;115:1-8. doi: 10.1016/j.fitote.2016.09.009. Epub 2016 Sep 19.

PMID:
27646602
39.

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.

Le Bihan A, de Kanter R, Angulo-Barturen I, Binkert C, Boss C, Brun R, Brunner R, Buchmann S, Burrows J, Dechering KJ, Delves M, Ewerling S, Ferrer S, Fischli C, Gamo-Benito FJ, Gnädig NF, Heidmann B, Jiménez-Díaz MB, Leroy D, Martínez MS, Meyer S, Moehrle JJ, Ng CL, Noviyanti R, Ruecker A, Sanz LM, Sauerwein RW, Scheurer C, Schleiferboeck S, Sinden R, Snyder C, Straimer J, Wirjanata G, Marfurt J, Price RN, Weller T, Fischli W, Fidock DA, Clozel M, Wittlin S.

PLoS Med. 2016 Oct 4;13(10):e1002138. doi: 10.1371/journal.pmed.1002138. eCollection 2016 Oct.

40.

ent-Pimarane and ent-Kaurane Diterpenes from Aldama discolor (Asteraceae) and Their Antiprotozoal Activity.

Nogueira MS, Da Costa FB, Brun R, Kaiser M, Schmidt TJ.

Molecules. 2016 Sep 15;21(9). pii: E1237. doi: 10.3390/molecules21091237.

41.

The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes.

Ahmad S, Seebacher W, Faist J, Kaiser M, Brun R, Saf R, Weis R.

Arch Pharm Res. 2016 Oct;39(10):1391-1403. Epub 2016 Sep 1.

PMID:
27585596
42.

Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action.

Boss C, Aissaoui H, Amaral N, Bauer A, Bazire S, Binkert C, Brun R, Bürki C, Ciana CL, Corminboeuf O, Delahaye S, Dollinger C, Fischli C, Fischli W, Flock A, Frantz MC, Girault M, Grisostomi C, Friedli A, Heidmann B, Hinder C, Jacob G, Le Bihan A, Malrieu S, Mamzed S, Merot A, Meyer S, Peixoto S, Petit N, Siegrist R, Trollux J, Weller T, Wittlin S.

ChemMedChem. 2016 Sep 20;11(18):1995-2014. doi: 10.1002/cmdc.201600298. Epub 2016 Jul 29.

PMID:
27471138
43.

Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense.

Karaaslan C, Kaiser M, Brun R, Göker H.

Bioorg Med Chem. 2016 Sep 15;24(18):4038-4044. doi: 10.1016/j.bmc.2016.06.047. Epub 2016 Jun 25.

PMID:
27387356
44.

Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead.

Faist J, Seebacher W, Saf R, Brun R, Kaiser M, Weis R.

Bioorg Med Chem. 2016 Aug 15;24(16):3781-9. doi: 10.1016/j.bmc.2016.06.024. Epub 2016 Jun 14.

PMID:
27344215
45.

Novel nucleoside-based antimalarial compounds.

Zheng Z, Tran HA, Manivannan S, Wen X, Kaiser M, Brun R, Snyder FF, Back TG.

Bioorg Med Chem Lett. 2016 Jun 15;26(12):2861-2865. doi: 10.1016/j.bmcl.2016.04.053. Epub 2016 Apr 23.

PMID:
27156774
46.

Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents.

Vanden Eynde JJ, Mayence A, Mottamal M, Bacchi CJ, Yarlett N, Kaiser M, Brun R, Huang TL.

Pharmaceuticals (Basel). 2016 Apr 19;9(2). pii: E20. doi: 10.3390/ph9020020.

47.

Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense.

Patrick DA, Wenzler T, Yang S, Weiser PT, Wang MZ, Brun R, Tidwell RR.

Bioorg Med Chem. 2016 Jun 1;24(11):2451-65. doi: 10.1016/j.bmc.2016.04.006. Epub 2016 Apr 2.

48.

A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes.

Wenzler T, Schumann Burkard G, Schmidt RS, Mäser P, Bergner A, Roditi I, Brun R.

Sci Rep. 2016 Mar 2;6:22451. doi: 10.1038/srep22451.

49.

Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi.

Pirttimaa M, Nasereddin A, Kopelyanskiy D, Kaiser M, Yli-Kauhaluoma J, Oksman-Caldentey KM, Brun R, Jaffe CL, Moreira VM, Alakurtti S.

J Nat Prod. 2016 Feb 26;79(2):362-8. doi: 10.1021/acs.jnatprod.5b00990. Epub 2016 Feb 5.

PMID:
26849852
50.

A novel prepless X-ray imaging capsule for colon cancer screening.

Gluck N, Shpak B, Brun R, Rösch T, Arber N, Moshkowitz M.

Gut. 2016 Mar;65(3):371-3. doi: 10.1136/gutjnl-2015-310893. Epub 2015 Dec 1. No abstract available.

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