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Items: 17

1.

Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis.

Brumshtein B, Esswein SR, Sawaya MR, Rosenberg G, Ly AT, Landau M, Eisenberg DS.

J Biol Chem. 2018 Dec 21;293(51):19659-19671. doi: 10.1074/jbc.RA118.004142. Epub 2018 Oct 24.

PMID:
30355736
2.

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain.

Brumshtein B, Esswein SR, Salwinski L, Phillips ML, Ly AT, Cascio D, Sawaya MR, Eisenberg DS.

Elife. 2015 Nov 18;4:e10935. doi: 10.7554/eLife.10935.

3.

Formation of amyloid fibers by monomeric light chain variable domains.

Brumshtein B, Esswein SR, Landau M, Ryan CM, Whitelegge JP, Phillips ML, Cascio D, Sawaya MR, Eisenberg DS.

J Biol Chem. 2014 Oct 3;289(40):27513-25. doi: 10.1074/jbc.M114.585638. Epub 2014 Aug 19.

4.

Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues.

Brumshtein B, Aguilar-Moncayo M, Benito JM, García Fernandez JM, Silman I, Shaaltiel Y, Aviezer D, Sussman JL, Futerman AH, Ortiz Mellet C.

Org Biomol Chem. 2011 Jun 7;9(11):4160-7. doi: 10.1039/c1ob05200d. Epub 2011 Apr 11.

PMID:
21483943
5.

Characterization of gene-activated human acid-beta-glucosidase: crystal structure, glycan composition, and internalization into macrophages.

Brumshtein B, Salinas P, Peterson B, Chan V, Silman I, Sussman JL, Savickas PJ, Robinson GS, Futerman AH.

Glycobiology. 2010 Jan;20(1):24-32. doi: 10.1093/glycob/cwp138. Epub 2009 Sep 9.

6.

Control of the rate of evaporation in protein crystallization by the 'microbatch under oil' method.

Brumshtein B, Greenblatt HM, Futerman AH, Silman I, Sussman JL.

J Appl Crystallogr. 2008 Oct 1;41(Pt 5):969-971. Epub 2008 Aug 30.

7.

6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase.

Brumshtein B, Aguilar-Moncayo M, García-Moreno MI, Ortiz Mellet C, García Fernández JM, Silman I, Shaaltiel Y, Aviezer D, Sussman JL, Futerman AH.

Chembiochem. 2009 Jun 15;10(9):1480-5. doi: 10.1002/cbic.200900142. No abstract available.

PMID:
19437524
8.

Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy.

Kacher Y, Brumshtein B, Boldin-Adamsky S, Toker L, Shainskaya A, Silman I, Sussman JL, Futerman AH.

Biol Chem. 2008 Nov;389(11):1361-9. doi: 10.1515/BC.2008.163. Review.

PMID:
18783340
9.

3-D structure of serum paraoxonase 1 sheds light on its activity, stability, solubility and crystallizability.

Harel M, Brumshtein B, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL.

Arh Hig Rada Toksikol. 2007 Sep;58(3):347-53.

PMID:
17913690
10.

Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease.

Brumshtein B, Greenblatt HM, Butters TD, Shaaltiel Y, Aviezer D, Silman I, Futerman AH, Sussman JL.

J Biol Chem. 2007 Sep 28;282(39):29052-8. Epub 2007 Jul 31.

11.

Structural comparison of differently glycosylated forms of acid-beta-glucosidase, the defective enzyme in Gaucher disease.

Brumshtein B, Wormald MR, Silman I, Futerman AH, Sussman JL.

Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1458-65. Epub 2006 Nov 23.

PMID:
17139081
12.

Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.

Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL.

J Med Chem. 2006 Sep 7;49(18):5491-500.

PMID:
16942022
13.

The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase.

Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM.

Chem Biol Interact. 2005 Dec 15;157-158:153-7. Epub 2005 Nov 14.

PMID:
16289500
14.

Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.

Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM.

Chem Biol Interact. 2005 Dec 15;157-158:247-52. Epub 2005 Oct 28.

PMID:
16257398
15.
16.

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes.

Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS.

Nat Struct Mol Biol. 2004 May;11(5):412-9. Epub 2004 Apr 18. Erratum in: Nat Struct Mol Biol. 2004 Dec;11(12):1253.

PMID:
15098021
17.

Preliminary X-ray crystallographic analysis of a soluble form of MntC, a periplasmic manganese-binding component of an ABC-type Mn transporter from Synechocystis sp. PCC 6803.

Adir N, Rukhman V, Brumshtein B, Anati R.

Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1476-8. Epub 2002 Aug 23.

PMID:
12198307

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