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A subfamily roadmap of the evolutionarily diverse glycoside hydrolase family 16 (GH16).

Viborg AH, Terrapon N, Lombard V, Michel G, Czjzek M, Henrissat B, Brumer H.

J Biol Chem. 2019 Nov 1;294(44):15973-15986. doi: 10.1074/jbc.RA119.010619. Epub 2019 Sep 9.


Adaptation of Syntenic Xyloglucan Utilization Loci of Human Gut Bacteroidetes to Polysaccharide Side Chain Diversity.

Déjean G, Tauzin AS, Bennett SW, Creagh AL, Brumer H.

Appl Environ Microbiol. 2019 Oct 1;85(20). pii: e01491-19. doi: 10.1128/AEM.01491-19. Print 2019 Oct 15.


Substrate specificity, regiospecificity, and processivity in glycoside hydrolase family 74.

Arnal G, Stogios PJ, Asohan J, Attia MA, Skarina T, Viborg AH, Henrissat B, Savchenko A, Brumer H.

J Biol Chem. 2019 Sep 6;294(36):13233-13247. doi: 10.1074/jbc.RA119.009861. Epub 2019 Jul 19.


A family AA5_2 carbohydrate oxidase from Penicillium rubens displays functional overlap across the AA5 family.

Mollerup F, Aumala V, Parikka K, Mathieu Y, Brumer H, Tenkanen M, Master E.

PLoS One. 2019 May 15;14(5):e0216546. doi: 10.1371/journal.pone.0216546. eCollection 2019.


Surface glycan-binding proteins are essential for cereal beta-glucan utilization by the human gut symbiont Bacteroides ovatus.

Tamura K, Foley MH, Gardill BR, Dejean G, Schnizlein M, Bahr CME, Louise Creagh A, van Petegem F, Koropatkin NM, Brumer H.

Cell Mol Life Sci. 2019 Nov;76(21):4319-4340. doi: 10.1007/s00018-019-03115-3. Epub 2019 May 6.


A Cell-Surface GH9 Endo-Glucanase Coordinates with Surface Glycan-Binding Proteins to Mediate Xyloglucan Uptake in the Gut Symbiont Bacteroides ovatus.

Foley MH, Déjean G, Hemsworth GR, Davies GJ, Brumer H, Koropatkin NM.

J Mol Biol. 2019 Mar 1;431(5):981-995. doi: 10.1016/j.jmb.2019.01.008. Epub 2019 Jan 19.


Correction: Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo-xyloglucanases.

Jain N, Attia MA, Offen WA, Davies GJ, Brumer H.

Org Biomol Chem. 2019 Jan 2;17(2):398. doi: 10.1039/c8ob90185f.


Structural enzymology reveals the molecular basis of substrate regiospecificity and processivity of an exemplar bacterial glycoside hydrolase family 74 endo-xyloglucanase.

Arnal G, Stogios PJ, Asohan J, Skarina T, Savchenko A, Brumer H.

Biochem J. 2018 Dec 19;475(24):3963-3978. doi: 10.1042/BCJ20180763.


The sol-gel transition of ultra-low solid content TEMPO-cellulose nanofibril/mixed-linkage β-glucan bionanocomposite gels.

Arola S, Ansari M, Oksanen A, Retulainen E, Hatzikiriakos SG, Brumer H.

Soft Matter. 2018 Nov 28;14(46):9393-9401. doi: 10.1039/c8sm01878b.


Focused Metabolism of β-Glucans by the Soil Bacteroidetes Species Chitinophaga pinensis.

McKee LS, Martínez-Abad A, Ruthes AC, Vilaplana F, Brumer H.

Appl Environ Microbiol. 2019 Jan 9;85(2). pii: e02231-18. doi: 10.1128/AEM.02231-18. Print 2019 Jan 15.


Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo-xyloglucanases.

Jain N, Attia MA, Offen WA, Davies GJ, Brumer H.

Org Biomol Chem. 2018 Nov 21;16(45):8732-8741. doi: 10.1039/c8ob02250j. Erratum in: Org Biomol Chem. 2019 Jan 2;17(2):398.


Structural basis for the flexible recognition of α-glucan substrates by Bacteroides thetaiotaomicron SusG.

Arnal G, Cockburn DW, Brumer H, Koropatkin NM.

Protein Sci. 2018 Jun;27(6):1093-1101. doi: 10.1002/pro.3410. Epub 2018 Apr 17.


In vitro and in vivo characterization of three Cellvibrio japonicus glycoside hydrolase family 5 members reveals potent xyloglucan backbone-cleaving functions.

Attia MA, Nelson CE, Offen WA, Jain N, Davies GJ, Gardner JG, Brumer H.

Biotechnol Biofuels. 2018 Feb 17;11:45. doi: 10.1186/s13068-018-1039-6. eCollection 2018.


Molecular Mechanism by which Prominent Human Gut Bacteroidetes Utilize Mixed-Linkage Beta-Glucans, Major Health-Promoting Cereal Polysaccharides.

Tamura K, Hemsworth GR, Déjean G, Rogers TE, Pudlo NA, Urs K, Jain N, Davies GJ, Martens EC, Brumer H.

Cell Rep. 2017 Nov 14;21(7):2030. doi: 10.1016/j.celrep.2017.11.013. No abstract available.


Comprehensive functional characterization of the glycoside hydrolase family 3 enzymes from Cellvibrio japonicus reveals unique metabolic roles in biomass saccharification.

Nelson CE, Attia MA, Rogowski A, Morland C, Brumer H, Gardner JG.

Environ Microbiol. 2017 Dec;19(12):5025-5039. doi: 10.1111/1462-2920.13959. Epub 2017 Dec 7.


Molecular Mechanism by which Prominent Human Gut Bacteroidetes Utilize Mixed-Linkage Beta-Glucans, Major Health-Promoting Cereal Polysaccharides.

Tamura K, Hemsworth GR, Déjean G, Rogers TE, Pudlo NA, Urs K, Jain N, Davies GJ, Martens EC, Brumer H.

Cell Rep. 2017 Oct 10;21(2):417-430. doi: 10.1016/j.celrep.2017.09.049. Erratum in: Cell Rep. 2017 Nov 14;21(7):2030.


Quantitative Kinetic Characterization of Glycoside Hydrolases Using High-Performance Anion-Exchange Chromatography (HPAEC).

McGregor N, Arnal G, Brumer H.

Methods Mol Biol. 2017;1588:15-25. doi: 10.1007/978-1-4939-6899-2_2.


A Low-Volume, Parallel Copper-Bicinchoninic Acid (BCA) Assay for Glycoside Hydrolases.

Arnal G, Attia MA, Asohan J, Brumer H.

Methods Mol Biol. 2017;1588:3-14. doi: 10.1007/978-1-4939-6899-2_1.


Proteomic data on enzyme secretion and activity in the bacterium Chitinophaga pinensis.

Larsbrink J, Tuveng TR, Pope PB, Bulone V, Eijsink VG, Brumer H, McKee LS.

Data Brief. 2017 Feb 17;11:484-490. doi: 10.1016/j.dib.2017.02.032. eCollection 2017 Apr.


The Podospora anserina lytic polysaccharide monooxygenase PaLPMO9H catalyzes oxidative cleavage of diverse plant cell wall matrix glycans.

Fanuel M, Garajova S, Ropartz D, McGregor N, Brumer H, Rogniaux H, Berrin JG.

Biotechnol Biofuels. 2017 Mar 11;10:63. doi: 10.1186/s13068-017-0749-5. eCollection 2017.


Polysaccharide Utilization Loci: Fueling Microbial Communities.

Grondin JM, Tamura K, Déjean G, Abbott DW, Brumer H.

J Bacteriol. 2017 Jul 11;199(15). pii: e00860-16. doi: 10.1128/JB.00860-16. Print 2017 Aug 1. Review.


Proteomic insights into mannan degradation and protein secretion by the forest floor bacterium Chitinophaga pinensis.

Larsbrink J, Tuveng TR, Pope PB, Bulone V, Eijsink VG, Brumer H, McKee LS.

J Proteomics. 2017 Mar 6;156:63-74. doi: 10.1016/j.jprot.2017.01.003. Epub 2017 Jan 6.


Molecular Characterization of N-glycan Degradation and Transport in Streptococcus pneumoniae and Its Contribution to Virulence.

Robb M, Hobbs JK, Woodiga SA, Shapiro-Ward S, Suits MD, McGregor N, Brumer H, Yesilkaya H, King SJ, Boraston AB.

PLoS Pathog. 2017 Jan 5;13(1):e1006090. doi: 10.1371/journal.ppat.1006090. eCollection 2017 Jan.


Crystallographic insight into the evolutionary origins of xyloglucan endotransglycosylases and endohydrolases.

McGregor N, Yin V, Tung CC, Van Petegem F, Brumer H.

Plant J. 2017 Feb;89(4):651-670. doi: 10.1111/tpj.13421. Epub 2017 Feb 11.


Adsorption of Xyloglucan onto Cellulose Surfaces of Different Morphologies: An Entropy-Driven Process.

Benselfelt T, Cranston ED, Ondaral S, Johansson E, Brumer H, Rutland MW, Wågberg L.

Biomacromolecules. 2016 Sep 12;17(9):2801-11. doi: 10.1021/acs.biomac.6b00561. Epub 2016 Aug 17.


Recent structural insights into the enzymology of the ubiquitous plant cell wall glycan xyloglucan.

Attia MA, Brumer H.

Curr Opin Struct Biol. 2016 Oct;40:43-53. doi: 10.1016/ Epub 2016 Jul 28. Review.


Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut.

Hemsworth GR, Thompson AJ, Stepper J, Sobala ŁF, Coyle T, Larsbrink J, Spadiut O, Goddard-Borger ED, Stubbs KA, Brumer H, Davies GJ.

Open Biol. 2016 Jul;6(7). pii: 160142. doi: 10.1098/rsob.160142.


Molecular Dissection of Xyloglucan Recognition in a Prominent Human Gut Symbiont.

Tauzin AS, Kwiatkowski KJ, Orlovsky NI, Smith CJ, Creagh AL, Haynes CA, Wawrzak Z, Brumer H, Koropatkin NM.

mBio. 2016 Apr 26;7(2):e02134-15. doi: 10.1128/mBio.02134-15.


Cellulose-Based Biosensors for Esterase Detection.

Derikvand F, Yin DT, Barrett R, Brumer H.

Anal Chem. 2016 Mar 15;88(6):2989-93. doi: 10.1021/acs.analchem.5b04661. Epub 2016 Feb 25.


Learning from microbial strategies for polysaccharide degradation.

Hemsworth GR, Déjean G, Davies GJ, Brumer H.

Biochem Soc Trans. 2016 Feb;44(1):94-108. doi: 10.1042/BST20150180. Review.


Structure-function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family.

Yin DT, Urresti S, Lafond M, Johnston EM, Derikvand F, Ciano L, Berrin JG, Henrissat B, Walton PH, Davies GJ, Brumer H.

Nat Commun. 2015 Dec 18;6:10197. doi: 10.1038/ncomms10197.


Structure-Function Analysis of a Mixed-linkage β-Glucanase/Xyloglucanase from the Key Ruminal Bacteroidetes Prevotella bryantii B(1)4.

McGregor N, Morar M, Fenger TH, Stogios P, Lenfant N, Yin V, Xu X, Evdokimova E, Cui H, Henrissat B, Savchenko A, Brumer H.

J Biol Chem. 2016 Jan 15;291(3):1175-97. doi: 10.1074/jbc.M115.691659. Epub 2015 Oct 27.


Transcriptional and Hormonal Regulation of Gravitropism of Woody Stems in Populus.

Gerttula S, Zinkgraf M, Muday GK, Lewis DR, Ibatullin FM, Brumer H, Hart F, Mansfield SD, Filkov V, Groover A.

Plant Cell. 2015 Oct;27(10):2800-13. doi: 10.1105/tpc.15.00531. Epub 2015 Sep 26.


Synthesis and analysis of specific covalent inhibitors of endo-xyloglucanases.

Fenger TH, Brumer H.

Chembiochem. 2015 Mar 2;16(4):575-83. doi: 10.1002/cbic.201402663. Epub 2015 Feb 6.


Editorial overview: Carbohydrate-protein interactions: the future is taking shape.

Brumer H, Gilbert HJ.

Curr Opin Struct Biol. 2014 Oct;28:v-vii. doi: 10.1016/ Epub 2014 Sep 24. No abstract available.


A complex gene locus enables xyloglucan utilization in the model saprophyte Cellvibrio japonicus.

Larsbrink J, Thompson AJ, Lundqvist M, Gardner JG, Davies GJ, Brumer H.

Mol Microbiol. 2014 Oct;94(2):418-33. doi: 10.1111/mmi.12776. Epub 2014 Sep 17.


The devil lies in the details: how variations in polysaccharide fine-structure impact the physiology and evolution of gut microbes.

Martens EC, Kelly AG, Tauzin AS, Brumer H.

J Mol Biol. 2014 Nov 25;426(23):3851-65. doi: 10.1016/j.jmb.2014.06.022. Epub 2014 Jul 12. Review.


Effects of temperature and glycerol and methanol-feeding profiles on the production of recombinant galactose oxidase in Pichia pastoris.

Anasontzis GE, Salazar Penã M, Spadiut O, Brumer H, Olsson L.

Biotechnol Prog. 2014 May-Jun;30(3):728-35. doi: 10.1002/btpr.1878. Epub 2014 Feb 15.


A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes.

Larsbrink J, Rogers TE, Hemsworth GR, McKee LS, Tauzin AS, Spadiut O, Klinter S, Pudlo NA, Urs K, Koropatkin NM, Creagh AL, Haynes CA, Kelly AG, Cederholm SN, Davies GJ, Martens EC, Brumer H.

Nature. 2014 Feb 27;506(7489):498-502. doi: 10.1038/nature12907. Epub 2014 Jan 19.


Visual detection of DNA on paper chips.

Song Y, Gyarmati P, Araújo AC, Lundeberg J, Brumer H 3rd, Ståhl PL.

Anal Chem. 2014 Feb 4;86(3):1575-82. doi: 10.1021/ac403196b. Epub 2014 Jan 17.


Glycoside Hydrolase Activities in Cell Walls of Sclerenchyma Cells in the Inflorescence Stems of Arabidopsis thaliana Visualized in Situ.

Banasiak A, Ibatullin FM, Brumer H, Mellerowicz EJ.

Plants (Basel). 2014 Nov 12;3(4):513-25. doi: 10.3390/plants3040513.


Enzymatic characterization of a glycoside hydrolase family 5 subfamily 7 (GH5_7) mannanase from Arabidopsis thaliana.

Wang Y, Vilaplana F, Brumer H, Aspeborg H.

Planta. 2014 Mar;239(3):653-65. doi: 10.1007/s00425-013-2005-y. Epub 2013 Dec 11.


Targeted allylation and propargylation of galactose-containing polysaccharides in water.

Leppänen AS, Xu C, Parikka K, Eklund P, Sjöholm R, Brumer H, Tenkanen M, Willför S.

Carbohydr Polym. 2014 Jan 16;100:46-54. doi: 10.1016/j.carbpol.2012.11.053. Epub 2012 Nov 29.


Structure-function analysis of a broad specificity Populus trichocarpa endo-β-glucanase reveals an evolutionary link between bacterial licheninases and plant XTH gene products.

Eklöf JM, Shojania S, Okon M, McIntosh LP, Brumer H.

J Biol Chem. 2013 May 31;288(22):15786-99. doi: 10.1074/jbc.M113.462887. Epub 2013 Apr 9.


Structure and activity of the Streptococcus pyogenes family GH1 6-phospho-β-glucosidase SPy1599.

Stepper J, Dabin J, Eklof JM, Thongpoo P, Kongsaeree P, Taylor EJ, Turkenburg JP, Brumer H, Davies GJ.

Acta Crystallogr D Biol Crystallogr. 2013 Jan;69(Pt 1):16-23. doi: 10.1107/S0907444912041005. Epub 2012 Dec 20.


Identification of the acid/base catalyst of a glycoside hydrolase family 3 (GH3) beta-glucosidase from Aspergillus niger ASKU28.

Thongpoo P, McKee LS, Araújo AC, Kongsaeree PT, Brumer H.

Biochim Biophys Acta. 2013 Mar;1830(3):2739-49.


Structural enzymology of Cellvibrio japonicus Agd31B protein reveals α-transglucosylase activity in glycoside hydrolase family 31.

Larsbrink J, Izumi A, Hemsworth GR, Davies GJ, Brumer H.

J Biol Chem. 2012 Dec 21;287(52):43288-99. doi: 10.1074/jbc.M112.416511. Epub 2012 Nov 6.

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