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Items: 20


Src Cooperates with Oncogenic Ras in Tumourigenesis via the JNK and PI3K Pathways in Drosophila epithelial Tissue.

Poon CLC, Brumby AM, Richardson HE.

Int J Mol Sci. 2018 May 27;19(6). pii: E1585. doi: 10.3390/ijms19061585.


Quality of recovery after gastroscopy, colonoscopy, or both endoscopic procedures: an observational pilot study.

Brumby AM, Heiberg J, Te C, Royse CF.

Minerva Anestesiol. 2017 Nov;83(11):1161-1168. doi: 10.23736/S0375-9393.17.11916-4. Epub 2017 Jun 14.


BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila.

Doggett K, Turkel N, Willoughby LF, Ellul J, Murray MJ, Richardson HE, Brumby AM.

PLoS One. 2015 Jul 24;10(7):e0132987. doi: 10.1371/journal.pone.0132987. eCollection 2015.


Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis.

Turkel N, Portela M, Poon C, Li J, Brumby AM, Richardson HE.

Biol Open. 2015 Jul 17;4(8):1024-39. doi: 10.1242/bio.012815.


The BTB-zinc finger transcription factor abrupt acts as an epithelial oncogene in Drosophila melanogaster through maintaining a progenitor-like cell state.

Turkel N, Sahota VK, Bolden JE, Goulding KR, Doggett K, Willoughby LF, Blanco E, Martin-Blanco E, Corominas M, Ellul J, Aigaki T, Richardson HE, Brumby AM.

PLoS Genet. 2013;9(7):e1003627. doi: 10.1371/journal.pgen.1003627. Epub 2013 Jul 18.


In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling.

Khoo P, Allan K, Willoughby L, Brumby AM, Richardson HE.

Dis Model Mech. 2013 May;6(3):661-78. doi: 10.1242/dmm.010066. Epub 2013 Jan 11.


An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.

Willoughby LF, Schlosser T, Manning SA, Parisot JP, Street IP, Richardson HE, Humbert PO, Brumby AM.

Dis Model Mech. 2013 Mar;6(2):521-9. doi: 10.1242/dmm.009985. Epub 2012 Sep 20.


Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis.

Brumby AM, Goulding KR, Schlosser T, Loi S, Galea R, Khoo P, Bolden JE, Aigaki T, Humbert PO, Richardson HE.

Genetics. 2011 May;188(1):105-25. doi: 10.1534/genetics.111.127910. Epub 2011 Mar 2.


Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs.

Leong GR, Goulding KR, Amin N, Richardson HE, Brumby AM.

BMC Biol. 2009 Sep 24;7:62. doi: 10.1186/1741-7007-7-62.


Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module.

Humbert PO, Grzeschik NA, Brumby AM, Galea R, Elsum I, Richardson HE.

Oncogene. 2008 Nov 24;27(55):6888-907. doi: 10.1038/onc.2008.341. Review.


Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye.

Grzeschik NA, Amin N, Secombe J, Brumby AM, Richardson HE.

Dev Biol. 2007 Nov 1;311(1):106-23. Epub 2007 Aug 17.


Using Drosophila melanogaster to map human cancer pathways.

Brumby AM, Richardson HE.

Nat Rev Cancer. 2005 Aug;5(8):626-39. Review.


New tricks for old dogs: unexpected roles for cell cycle regulators revealed using animal models.

Humbert PO, Brumby AM, Quinn LM, Richardson HE.

Curr Opin Cell Biol. 2004 Dec;16(6):614-22. Review.


hScrib is a functional homologue of the Drosophila tumour suppressor Scribble.

Dow LE, Brumby AM, Muratore R, Coombe ML, Sedelies KA, Trapani JA, Russell SM, Richardson HE, Humbert PO.

Oncogene. 2003 Dec 18;22(58):9225-30.


Drosophila cyclin E interacts with components of the Brahma complex.

Brumby AM, Zraly CB, Horsfield JA, Secombe J, Saint R, Dingwall AK, Richardson H.

EMBO J. 2002 Jul 1;21(13):3377-89.


The Tum protein of coliphage 186 is an antirepressor.

Shearwin KE, Brumby AM, Egan JB.

J Biol Chem. 1998 Mar 6;273(10):5708-15.


Defining the SOS operon of coliphage 186.

Brumby AM, Lamont I, Dodd IB, Egan JB.

Virology. 1996 May 1;219(1):105-14.


UV induction of coliphage 186: prophage induction as an SOS function.

Lamont I, Brumby AM, Egan JB.

Proc Natl Acad Sci U S A. 1989 Jul;86(14):5492-6.

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