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Items: 29


Long-term metabolic consequences of acute dioxin exposure differ between male and female mice.

Hoyeck MP, Blair H, Ibrahim M, Solanki S, Elsawy M, Prakash A, Rick KRC, Matteo G, O'Dwyer S, Bruin JE.

Sci Rep. 2020 Jan 29;10(1):1448. doi: 10.1038/s41598-020-57973-0.


Functional cytochrome P450 1A enzymes are induced in mouse and human islets following pollutant exposure.

Ibrahim M, MacFarlane EM, Matteo G, Hoyeck MP, Rick KRC, Farokhi S, Copley CM, O'Dwyer S, Bruin JE.

Diabetologia. 2020 Jan;63(1):162-178. doi: 10.1007/s00125-019-05035-0. Epub 2019 Nov 27.


Sex Differences in Maturation of Human Embryonic Stem Cell-Derived β Cells in Mice.

Saber N, Bruin JE, O'Dwyer S, Schuster H, Rezania A, Kieffer TJ.

Endocrinology. 2018 Apr 1;159(4):1827-1841. doi: 10.1210/en.2018-00048.


Hypothyroidism Impairs Human Stem Cell-Derived Pancreatic Progenitor Cell Maturation in Mice.

Bruin JE, Saber N, O'Dwyer S, Fox JK, Mojibian M, Arora P, Rezania A, Kieffer TJ.

Diabetes. 2016 May;65(5):1297-309. doi: 10.2337/db15-1439. Epub 2016 Jan 6.


Differentiation of human pluripotent stem cells into β-cells: Potential and challenges.

Quiskamp N, Bruin JE, Kieffer TJ.

Best Pract Res Clin Endocrinol Metab. 2015 Dec;29(6):833-47. doi: 10.1016/j.beem.2015.10.011. Epub 2015 Oct 30. Review.


Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice.

Bruin JE, Asadi A, Fox JK, Erener S, Rezania A, Kieffer TJ.

Stem Cell Reports. 2015 Dec 8;5(6):1081-1096. doi: 10.1016/j.stemcr.2015.10.013. Epub 2015 Nov 19.


Replacing and safeguarding pancreatic β cells for diabetes.

Bruin JE, Rezania A, Kieffer TJ.

Sci Transl Med. 2015 Dec 2;7(316):316ps23. doi: 10.1126/scitranslmed.aaa9359.


Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation.

Szabat M, Page MM, Panzhinskiy E, Skovsø S, Mojibian M, Fernandez-Tajes J, Bruin JE, Bround MJ, Lee JT, Xu EE, Taghizadeh F, O'Dwyer S, van de Bunt M, Moon KM, Sinha S, Han J, Fan Y, Lynn FC, Trucco M, Borchers CH, Foster LJ, Nislow C, Kieffer TJ, Johnson JD.

Cell Metab. 2016 Jan 12;23(1):179-93. doi: 10.1016/j.cmet.2015.10.016. Epub 2015 Nov 25.


Characterization of Antibodies to Products of Proinsulin Processing Using Immunofluorescence Staining of Pancreas in Multiple Species.

Asadi A, Bruin JE, Kieffer TJ.

J Histochem Cytochem. 2015 Aug;63(8):646-62. doi: 10.1369/0022155415576541.


Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs.

Bruin JE, Saber N, Braun N, Fox JK, Mojibian M, Asadi A, Drohan C, O'Dwyer S, Rosman-Balzer DS, Swiss VA, Rezania A, Kieffer TJ.

Stem Cell Reports. 2015 Apr 14;4(4):605-20. doi: 10.1016/j.stemcr.2015.02.011. Epub 2015 Mar 19.


Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells.

Rezania A, Bruin JE, Arora P, Rubin A, Batushansky I, Asadi A, O'Dwyer S, Quiskamp N, Mojibian M, Albrecht T, Yang YH, Johnson JD, Kieffer TJ.

Nat Biotechnol. 2014 Nov;32(11):1121-33. doi: 10.1038/nbt.3033. Epub 2014 Sep 11.


Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells.

Bruin JE, Erener S, Vela J, Hu X, Johnson JD, Kurata HT, Lynn FC, Piret JM, Asadi A, Rezania A, Kieffer TJ.

Stem Cell Res. 2014 Jan;12(1):194-208. doi: 10.1016/j.scr.2013.10.003. Epub 2013 Oct 16.


Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination.

Tudurí E, Bruin JE, Denroche HC, Fox JK, Johnson JD, Kieffer TJ.

PLoS One. 2013 Aug 1;8(8):e71075. doi: 10.1371/journal.pone.0071075. Print 2013.


Implanted islets in the anterior chamber of the eye are prone to autoimmune attack in a mouse model of diabetes.

Mojibian M, Harder B, Hurlburt A, Bruin JE, Asadi A, Kieffer TJ.

Diabetologia. 2013 Oct;56(10):2213-21. doi: 10.1007/s00125-013-3004-z. Epub 2013 Aug 11.


Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo.

Rezania A, Bruin JE, Xu J, Narayan K, Fox JK, O'Neil JJ, Kieffer TJ.

Stem Cells. 2013 Nov;31(11):2432-42. doi: 10.1002/stem.1489.


Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice.

Bruin JE, Rezania A, Xu J, Narayan K, Fox JK, O'Neil JJ, Kieffer TJ.

Diabetologia. 2013 Sep;56(9):1987-98. doi: 10.1007/s00125-013-2955-4. Epub 2013 Jun 16.


Leptin administration enhances islet transplant performance in diabetic mice.

Denroche HC, Quong WL, Bruin JE, Tudurí E, Asadi A, Glavas MM, Fox JK, Kieffer TJ.

Diabetes. 2013 Aug;62(8):2738-46. doi: 10.2337/db12-1684. Epub 2013 May 8.


Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice.

Rezania A, Bruin JE, Riedel MJ, Mojibian M, Asadi A, Xu J, Gauvin R, Narayan K, Karanu F, O'Neil JJ, Ao Z, Warnock GL, Kieffer TJ.

Diabetes. 2012 Aug;61(8):2016-29. doi: 10.2337/db11-1711. Epub 2012 Jun 27.


Restoring insulin production for type 1 diabetes.

Tudurí E, Bruin JE, Kieffer TJ.

J Diabetes. 2012 Dec;4(4):319-31. doi: 10.1111/j.1753-0407.2012.00196.x. Review.


Maternal antioxidants prevent β-cell apoptosis and promote formation of dual hormone-expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure.

Bruin JE, Woynillowicz AK, Hettinga BP, Tarnopolsky MA, Morrison KM, Gerstein HC, Holloway AC.

J Diabetes. 2012 Sep;4(3):297-306. doi: 10.1111/j.1753-0407.2012.00195.x.


Effect of in utero and lactational nicotine exposure on the male reproductive tract in peripubertal and adult rats.

Lagunov A, Anzar M, Sadeu JC, Khan MI, Bruin JE, Woynillowicz AK, Buhr M, Holloway AC, Foster WG.

Reprod Toxicol. 2011 May;31(4):418-23. doi: 10.1016/j.reprotox.2010.12.004. Epub 2010 Dec 21.


Rosiglitazone improves pancreatic mitochondrial function in an animal model of dysglycemia: role of the insulin-like growth factor axis.

Bruin JE, Petrik JJ, Hyslop JR, Raha S, Tarnopolsky MA, Gerstein HC, Holloway AC.

Endocrine. 2010 Apr;37(2):303-11. doi: 10.1007/s12020-009-9294-8. Epub 2010 Jan 8.


Long-term consequences of fetal and neonatal nicotine exposure: a critical review.

Bruin JE, Gerstein HC, Holloway AC.

Toxicol Sci. 2010 Aug;116(2):364-74. doi: 10.1093/toxsci/kfq103. Epub 2010 Apr 2. Review.


The role of dysregulated glucose metabolism in epithelial ovarian cancer.

Kellenberger LD, Bruin JE, Greenaway J, Campbell NE, Moorehead RA, Holloway AC, Petrik J.

J Oncol. 2010;2010:514310. doi: 10.1155/2010/514310. Epub 2010 Feb 17.


Fetal and neonatal nicotine exposure in Wistar rats causes progressive pancreatic mitochondrial damage and beta cell dysfunction.

Bruin JE, Petre MA, Raha S, Morrison KM, Gerstein HC, Holloway AC.

PLoS One. 2008;3(10):e3371. doi: 10.1371/journal.pone.0003371. Epub 2008 Oct 8.


Maternal nicotine exposure increases oxidative stress in the offspring.

Bruin JE, Petre MA, Lehman MA, Raha S, Gerstein HC, Morrison KM, Holloway AC.

Free Radic Biol Med. 2008 Jun 1;44(11):1919-25. doi: 10.1016/j.freeradbiomed.2008.02.010. Epub 2008 Mar 4.


Increased pancreatic beta-cell apoptosis following fetal and neonatal exposure to nicotine is mediated via the mitochondria.

Bruin JE, Gerstein HC, Morrison KM, Holloway AC.

Toxicol Sci. 2008 Jun;103(2):362-70. doi: 10.1093/toxsci/kfn012. Epub 2008 Jan 17.


Rosiglitazone prevents diabetes by increasing beta-cell mass in an animal model of type 2 diabetes characterized by reduced beta-cell mass at birth.

Holloway AC, Petrik JJ, Bruin JE, Gerstein HC.

Diabetes Obes Metab. 2008 Sep;10(9):763-71. Epub 2007 Oct 26.


Fetal and neonatal nicotine exposure and postnatal glucose homeostasis: identifying critical windows of exposure.

Bruin JE, Kellenberger LD, Gerstein HC, Morrison KM, Holloway AC.

J Endocrinol. 2007 Jul;194(1):171-8.


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