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Items: 1 to 50 of 96

1.

Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis.

Barth P, Bruijnzeel P, Wach A, Sellier Kessler O, Hooftman L, Zimmermann J, Naue N, Huber B, Heimbeck I, Kappeler D, Timmer W, Chevalier E.

J Cyst Fibros. 2019 Sep 6. pii: S1569-1993(19)30878-1. doi: 10.1016/j.jcf.2019.08.020. [Epub ahead of print]

2.

Personalised anti-inflammatory therapy for bronchiectasis and cystic fibrosis: selecting patients for controlled trials of neutrophil elastase inhibition.

Keir HR, Fong CJ, Crichton ML, Barth P, Chevalier E, Brady G, Kennedy G, Zimmermann J, Bruijnzeel PLB, Dicker AJ, Chalmers JD.

ERJ Open Res. 2019 Mar 25;5(1). pii: 00252-2018. doi: 10.1183/23120541.00252-2018. eCollection 2019 Feb.

3.

Phenotypes of symptomatic airways disease in China and New Zealand.

Fingleton J, Huang K, Weatherall M, Guo Y, Ivanov S, Bruijnzeel P, Zhang H, Wang W, Beasley R, Wang C; NZ–China Study Group.

Eur Respir J. 2017 Dec 7;50(6). pii: 1700957. doi: 10.1183/13993003.00957-2017. Print 2017 Dec.

4.

Klotho and smoking--An interplay influencing the skeletal muscle function deficits that occur in COPD.

Patel MS, Donaldson AV, Lewis A, Natanek SA, Lee JY, Andersson YM, Haji G, Jackson SG, Bolognese BJ, Foley JP, Podolin PL, Bruijnzeel PL, Hart N, Hopkinson NS, Man WD, Kemp PR, Polkey MI.

Respir Med. 2016 Apr;113:50-6. doi: 10.1016/j.rmed.2016.02.004. Epub 2016 Feb 15.

5.

Objectively identified comorbidities in COPD: impact on pulmonary rehabilitation outcomes.

Mesquita R, Vanfleteren LE, Franssen FM, Sarv J, Taib Z, Groenen MT, Gaffron S, Bruijnzeel PL, Pitta F, Wouters EF, Spruit MA.

Eur Respir J. 2015 Aug;46(2):545-8. doi: 10.1183/09031936.00026215. Epub 2015 Jun 25. No abstract available.

6.

Targeting neutrophilic inflammation in severe neutrophilic asthma: can we target the disease-relevant neutrophil phenotype?

Bruijnzeel PL, Uddin M, Koenderman L.

J Leukoc Biol. 2015 Oct;98(4):549-56. doi: 10.1189/jlb.3VMR1214-600RR. Epub 2015 May 14. Review.

PMID:
25977288
7.

Study on risk factors and phenotypes of acute exacerbations of chronic obstructive pulmonary disease in Guangzhou, China-design and baseline characteristics.

Zhou Y, Bruijnzeel PL, McCrae C, Zheng J, Nihlen U, Zhou R, Van Geest M, Nilsson A, Hadzovic S, Huhn M, Taib Z, Gu Y, Xie J, Ran P, Chen R, Zhong N.

J Thorac Dis. 2015 Apr;7(4):720-33. doi: 10.3978/j.issn.2072-1439.2015.04.14. Erratum in: J Thorac Dis. 2015 Jul;7(7):E206.

8.

Lower leptin/adiponectin ratio and risk of rapid lung function decline in chronic obstructive pulmonary disease.

Suzuki M, Makita H, Östling J, Thomsen LH, Konno S, Nagai K, Shimizu K, Pedersen JH, Ashraf H, Bruijnzeel PL, Maciewicz RA, Nishimura M; Hokkaido COPD Cohort Study; Danish Lung Cancer Screening Trial Investigators.

Ann Am Thorac Soc. 2014 Dec;11(10):1511-9. doi: 10.1513/AnnalsATS.201408-351OC.

PMID:
25372271
9.

Feasibility assessment of using oxygen-enhanced magnetic resonance imaging for evaluating the effect of pharmacological treatment in COPD.

Morgan AR, Parker GJ, Roberts C, Buonaccorsi GA, Maguire NC, Hubbard Cristinacce PL, Singh D, Vestbo J, Bjermer L, Jögi J, Taib Z, Sarv J, Bruijnzeel PL, Olsson LE, Bondesson E, Nihlén U, McGrath DM, Young SS, Waterton JC, Nordenmark LH.

Eur J Radiol. 2014 Nov;83(11):2093-101. doi: 10.1016/j.ejrad.2014.08.004. Epub 2014 Aug 17.

PMID:
25176287
10.

Prevalence of metabolic syndrome in COPD patients and its consequences.

Breyer MK, Spruit MA, Hanson CK, Franssen FM, Vanfleteren LE, Groenen MT, Bruijnzeel PL, Wouters EF, Rutten EP.

PLoS One. 2014 Jun 20;9(6):e98013. doi: 10.1371/journal.pone.0098013. eCollection 2014.

11.

Phenotypic characteristics associated with reduced short physical performance battery score in COPD.

Patel MS, Mohan D, Andersson YM, Baz M, Samantha Kon SC, Canavan JL, Jackson SG, Clark AL, Hopkinson NS, Natanek SA, Kemp PR, Bruijnzeel PLB, Man WD, Polkey MI.

Chest. 2014 May;145(5):1016-1024. doi: 10.1378/chest.13-1398.

PMID:
24337162
12.

Arterial stiffness in patients with COPD: the role of systemic inflammation and the effects of pulmonary rehabilitation.

Vanfleteren LE, Spruit MA, Groenen MT, Bruijnzeel PL, Taib Z, Rutten EP, Op 't Roodt J, Akkermans MA, Wouters EF, Franssen FM.

Eur Respir J. 2014 May;43(5):1306-15. doi: 10.1183/09031936.00169313. Epub 2013 Dec 5.

13.

The protective effect of sunscreens, vitamin E 6% cream, and betamethasone 0.1% cream on solar-simulating radiation-induced erythema and neutrophil influx.

Rijken F, Bihari IC, Guikers KL, van Weelden H, Bruijnzeel PL.

J Am Acad Dermatol. 2013 Mar;68(3):512-3. doi: 10.1016/j.jaad.2012.10.012. No abstract available.

PMID:
23394918
14.

Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease.

Vanfleteren LE, Spruit MA, Groenen M, Gaffron S, van Empel VP, Bruijnzeel PL, Rutten EP, Op 't Roodt J, Wouters EF, Franssen FM.

Am J Respir Crit Care Med. 2013 Apr 1;187(7):728-35. doi: 10.1164/rccm.201209-1665OC.

PMID:
23392440
15.

The pathogenesis of photoaging: the role of neutrophils and neutrophil-derived enzymes.

Rijken F, Bruijnzeel PL.

J Investig Dermatol Symp Proc. 2009 Aug;14(1):67-72. doi: 10.1038/jidsymp.2009.15. Review.

16.

Neutrophil infiltration in normal human skin after exposure to different ultraviolet radiation sources.

Lee PL, van Weelden H, Bruijnzeel PL.

Photochem Photobiol. 2008 Nov-Dec;84(6):1528-34. doi: 10.1111/j.1751-1097.2008.00380.x. Epub 2008 Jun 20.

PMID:
18627525
17.

Pathophysiology of photoaging of human skin: focus on neutrophils.

Rijken F, Kiekens RC, van den Worm E, Lee PL, van Weelden H, Bruijnzeel PL.

Photochem Photobiol Sci. 2006 Feb;5(2):184-9. Epub 2006 Jan 3. Review. Erratum in: Photochem Photobiol Sci. 2006 Mar;5(3):354.

PMID:
16465304
18.
20.

Beneficial effects of TCP on soman intoxication in guinea pigs: seizures, brain damage and learning behaviour.

de Groot DM, Bierman EP, Bruijnzeel PL, Carpentier P, Kulig BM, Lallement G, Melchers BP, Philippens IH, van Huygevoort AH.

J Appl Toxicol. 2001 Dec;21 Suppl 1:S57-65.

PMID:
11920922
21.
22.

An automated method for registering and quantifying scratching activity in mice: use for drug evaluation.

Elliott GR, Vanwersch RA, Bruijnzeel PL.

J Pharmacol Toxicol Methods. 2000 Nov-Dec;44(3):453-9.

PMID:
11395322
23.

Modulation of the atopy patch test reaction by topical corticosteroids and tar.

Langeveld-Wildschut EG, Riedl H, Thepen T, Bihari IC, Bruijnzeel PL, Bruijnzeel-Koomen CA.

J Allergy Clin Immunol. 2000 Oct;106(4):737-43.

PMID:
11031345
24.

Therapeutic interventions in mice with chronic proliferative dermatitis (cpdm/cpdm).

Gijbels MJ, Elliott GR, HogenEsch H, Zurcher C, van den Hoven A, Bruijnzeel PL.

Exp Dermatol. 2000 Oct;9(5):351-8.

PMID:
11016856
25.

Clinical and immunologic variables in skin of patients with atopic eczema and either positive or negative atopy patch test reactions.

Langeveld-Wildschut EG, Bruijnzeel PL, Mudde GC, Versluis C, Van Ieperen-Van Dijk AG, Bihari IC, Knol EF, Thepen T, Bruijnzeel-Koomen CA, van Reijsen FC.

J Allergy Clin Immunol. 2000 May;105(5):1008-16.

PMID:
10808184
26.

Behavioral test systems in marmoset monkeys.

Philippens IH, Melchers BP, Roeling TA, Bruijnzeel PL.

Behav Res Methods Instrum Comput. 2000 Feb;32(1):173-9.

PMID:
10758675
27.

An immunochemical assay to detect DNA damage in bovine sperm.

van der Schans GP, Haring R, van Dijk-Knijnenburg HC, Bruijnzeel PL, den Daas NH.

J Androl. 2000 Mar-Apr;21(2):250-7.

28.

Subchronic physostigmine pretreatment in marmosets: absence of side effects and effectiveness against soman poisoning with negligible postintoxication incapacitation.

Philippens IH, Vanwersch RA, Groen B, Olivier B, Bruijnzeel PL, Melchers BP.

Toxicol Sci. 2000 Jan;53(1):84-91.

PMID:
10653525
29.

Scopolamine augments the efficacy of physostigmine against soman poisoning in guinea pigs.

Philippens IH, Melchers BP, Olivier B, Bruijnzeel PL.

Pharmacol Biochem Behav. 2000 Jan 1;65(1):175-82.

PMID:
10638651
30.

New generic approach to the treatment of organophosphate poisoning: adenosine receptor mediated inhibition of ACh-release.

van Helden HP, Groen B, Moor E, Westerink BH, Bruijnzeel PL.

Drug Chem Toxicol. 1998;21 Suppl 1:171-81.

PMID:
10028409
31.

Efficacy of Curosurf in a rat model of acute respiratory distress syndrome.

van Helden HP, Kuijpers WC, Langerwerf PE, Langen RC, Haagsman HP, Bruijnzeel PL.

Eur Respir J. 1998 Sep;12(3):533-9.

32.

Human eosinophils constitutively express a functional interleukin-4 receptor: interleukin-4 -induced priming of chemotactic responses and induction of PI-3 kinase activity.

Dubois GR, Schweizer RC, Versluis C, Bruijnzeel-Koomen CA, Bruijnzeel PL.

Am J Respir Cell Mol Biol. 1998 Oct;19(4):691-9.

PMID:
9761767
33.

Subchronic physostigmine pretreatment in guinea pigs: effective against soman and without side effects.

Philippens IH, Busker RW, Wolthuis OL, Olivier B, Bruijnzeel PL, Melchers BP.

Pharmacol Biochem Behav. 1998 Apr;59(4):1061-7.

PMID:
9586868
34.

Differential effects of the T helper cell type 2-derived cytokines IL-4 and IL-5 on ligand binding to IgG and IgA receptors expressed by human eosinophils.

Bracke M, Dubois GR, Bolt K, Bruijnzeel PL, Vaerman JP, Lammers JW, Koenderman L.

J Immunol. 1997 Aug 1;159(3):1459-65.

PMID:
9233644
35.

Intratracheal aerosolization of endotoxin (LPS) in the rat: a comprehensive animal model to study adult (acute) respiratory distress syndrome.

van Helden HP, Kuijpers WC, Steenvoorden D, Go C, Bruijnzeel PL, van Eijk M, Haagsman HP.

Exp Lung Res. 1997 Jul-Aug;23(4):297-316.

PMID:
9202956
36.

Evaluation of the atopy patch test and the cutaneous late-phase reaction as relevant models for the study of allergic inflammation in patients with atopic eczema.

Langeveld-Wildschut EG, Thepen T, Bihari IC, ven Reijsen FC, de Vries IJ, Bruijnzeel PL, Bruijnzeel-Koomen CA.

J Allergy Clin Immunol. 1996 Dec;98(6 Pt 1):1019-27.

PMID:
8977500
37.

Pathogenesis of skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm).

Gijbels MJ, Zurcher C, Kraal G, Elliott GR, HogenEsch H, Schijff G, Savelkoul HF, Bruijnzeel PL.

Am J Pathol. 1996 Mar;148(3):941-50.

38.

Pharmacological effects of oximes: how relevant are they?

van Helden HP, Busker RW, Melchers BP, Bruijnzeel PL.

Arch Toxicol. 1996;70(12):779-86. Review.

PMID:
8911635
39.
40.

Evaluation of variables influencing the outcome of the atopy patch test.

Langeveld-Wildschut EG, van Marion AM, Thepen T, Mudde GC, Bruijnzeel PL, Bruijnzeel-Koomen CA.

J Allergy Clin Immunol. 1995 Jul;96(1):66-73.

PMID:
7622765
41.

Dermal absorption of polycyclic aromatic hydrocarbons in the blood-perfused pig ear.

VanRooij JG, Vinke E, De Lange J, Bruijnzeel PL, Bodelier-Bade MM, Noordhoek J, Jongeneelen FJ.

J Appl Toxicol. 1995 May-Jun;15(3):193-200.

PMID:
7560739
42.
43.

IL-4 induces chemotaxis of blood eosinophils from atopic dermatitis patients, but not from normal individuals.

Dubois GR, Bruijnzeel-Koomen CA, Bruijnzeel PL.

J Invest Dermatol. 1994 Jun;102(6):843-6.

44.

IL-4-induced migration of eosinophils in allergic inflammation.

Dubois GR, Bruijnzeel PL.

Ann N Y Acad Sci. 1994 May 28;725:268-73. No abstract available.

PMID:
8030998
45.

Eosinophil tissue mobilization in allergic disorders.

Bruijnzeel PL.

Ann N Y Acad Sci. 1994 May 28;725:259-67. Review. No abstract available.

PMID:
8030997
46.

Non-reactivating effects of HI-6 on hippocampal neurotransmission.

Melchers BP, van der Laaken AL, Busker RW, Bruijnzeel PL, Van Helden HP.

Arch Toxicol. 1994;69(2):118-26.

PMID:
7717860
47.

Interleukin-4 induces tissue eosinophilia in mice: correlation with its in vitro capacity to stimulate the endothelial cell-dependent selective transmigration of human eosinophils.

Moser R, Groscurth P, Carballido JM, Bruijnzeel PL, Blaser K, Heusser CH, Fehr J.

J Lab Clin Med. 1993 Nov;122(5):567-75.

PMID:
8228575
48.

Effects of nedocromil sodium on in vitro induced migration, activation, and mediator release from human granulocytes.

Bruijnzeel PL, Warringa RA, Kok PT, Hamelink ML, Kreukniet H, Koenderman L.

J Allergy Clin Immunol. 1993 Jul;92(1 Pt 2):159-64.

PMID:
8393021
49.

Upregulation of formyl-peptide and interleukin-8-induced eosinophil chemotaxis in patients with allergic asthma.

Warringa RA, Mengelers HJ, Raaijmakers JA, Bruijnzeel PL, Koenderman L.

J Allergy Clin Immunol. 1993 Jun;91(6):1198-205.

PMID:
8509580
50.

Increased expression of CD11b and functional changes in eosinophils after migration across endothelial cell monolayers.

Walker C, Rihs S, Braun RK, Betz S, Bruijnzeel PL.

J Immunol. 1993 May 1;150(9):4061-71.

PMID:
8097228

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